Recent progress in the structural study of ion channels as insecticide targets

作     者：Hadiatullah Hadiatullah Yongliang Zhang Arthur Samurkas Yunxuan Xie Rajamanikandan Sundarraj Han Zuilhof Jianjun Qiao Zhiguang Yuchi Hadiatullah Hadiatullah;Yongliang Zhang;Arthur Samurkas;Yunxuan Xie;Rajamanikandan Sundarraj;Han Zuilhof;Jianjun Qiao;Zhiguang Yuchi

作者机构：Tianjin Key Laboratory for Modern Drug Delivery&High-EfficiencyCollaborative Innovation Center of Chemical Science and EngineeringSchoolof Pharmaceutical Science and TechnologyTianjin UniversityTianjinChina Department of MolecularPharmacologyTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Laboratory of Organic Chemistry Wageningen University&ResearchWageningenThe Netherlands Department of Environmental ScienceTianjin UniversityTianjinChina Key Laboratory of Systems Bioengineering(Ministry of Education)Tianjin UniversityTianjinChina 

出 版 物：《Insect Science》 (昆虫科学（英文版）)

年 卷 期：2022年第29卷第6期

页      面：1522-1551页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：provided by the NationalNatural Science Foundation of China(no.32022073 and 31972287 to Z.Y.) the Natural Science Foundation of Tianjin(no.19JCYBJC24500 to Z.Y.) 

主　　题：cryo-electron microscopy structure crystal structure insecticide ion chan-nel resistance 

摘      要：Ion channels,many expressed in insect neural and muscular systems,have drawn huge attention as primary targets of *** the recent technical breakthroughs in structural biology,especially in cryo-electron microscopy(cryo-EM),many new high-resolution structures of ion channel targets,apo or in complex with insecticides,have been solved,shedding light on the molecular mechanism of action of the insecticides and resistance *** structures also provide accurate templates for structure-based insecticide screening and rational *** review summarizes the recent progress in the structural studies of 5 ion channel families:the ryanodine receptor(RyR),the nicotinic acetylcholine receptor(nAChR),the voltage-gated sodium channel(VGSC),the transient receptor potential(TRP)channel,and the ligand-gated chloride channel(LGCC).We address the selectivity of the channel-targeting insecticides by examining the conservation of key coordinating residues revealed by the *** possible resistance mechanisms are proposed based on the locations of the identified resistance mutations on the 3D structures of the target channels and their impacts on the binding of ***,we discuss how to develop“greeninsecticides with a novel mode of action based on these high-resolution structures to overcome the resistance.