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Recurrence quantification analysis on pulse morphological changes in patients with coronary heart disease

Journal of Traditional Chinese Medicine 2012年第4期32卷 571-577页

作者： Rui Guo Yiqin Wang jianjun yan Hanxia yan Laboratory of Synthetic Study on TCM Diagnostic Information Shanghai University of Traditional Chinese Medicine Center for Mechatronics Engineering East China University of Science and Technology

OBJECTIVE： To show that the pulse diagnosis used in Traditional Chinese Medicine, combined with nonlinear dynamic analysis, can help identify car- diovascular diseases. METHODS： Recurrence quantification analysis （RQA） was used to study pulse morphological changes in 37 inpatients with coronary heart dis- ease （CHD） and 37 normal subjects （controls）. An in- dependent sample t-test detected significant differ- ences in RQA measures of their pulses. A support vector machine （SVM） classified the groups accord- ing to their RQA measures. Classic time-domain pa- rameters were used for comparison. RESULTS： RQA measures can be divided into two groups. One group of measures [ecurrence rate（RR）, determinism （DEL）, average diagonal line length （L）, maximum length of diagonal structures （Lmax）, Shannon entropy of the frequency distribu- tion of diagonal line lengths （ENTR）, laminarity （LAM）, average length of vertical structures （TT）, maximum length of vertical structures （Vmax）] showed significantly higher values for patients with CHD than for normal subjects （P〈0.0S）. The other measures （RR_std, L_std, Lmaxstd, TT_std, Vmax_std） showed significantly lower values for the CHD group than for normal subjects （P〈0.05）. SVM classification accuracy was higher with RQA measures： With RQA （16 parameters） accuracy was at 88.21%, and with RQA（12 parameters） accuracy was at 84.11%. In contrast, with classic time-do- main （15 parameters） accuracy was 75.73%, and with time-domain （7 parameters） accuracy was 74.7O%. CONCLUSION： Nonlinear dynamic methods such as RQA can be used to study functional and struc- tural changes in the pulse noninvasively. Pulse sig- nals of individuals with CHD have greater regulari- ty, determinism, and stability than normal subjects, and their pulse morphology displays less variabili- ty. RQA can distinguish the CHD pulse from the healthy pulse with an accuracy of 88.21%, thereby providing an early diagnosis of cardiovascular dis- eases such as CHD.

关键词： Pulse-taking Cardiovascular diseases Recurrence quantification analysis

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The Absolute and Convective Secondary Instabilities in the Conduction Regime

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Communications in Nonlinear Science and Numerical Simulation 1999年第1期4卷 34-38页

作者： jianjun TAO and Dachun yan (Dept. of Mechanics & Engineering Sciences,Peking University, Beijing 100871, China) Dept. of Mechanics & Engineering Sciences Peking University Beijing 100871 China

Convective and absolute instabilities in the conduction regime of a vertical heated slot are investigated. It is found that in a large range of Prandtl number (0 12, a secondary instability appears with stationary mo... 详细信息

关键词： absolute instability convective instability conduction regime

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Symptom clustering in chronic gastritis based on spectral clustering

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Journal of Traditional Chinese Medicine 2014年第4期34卷 504-510页

作者： Wenhua Zhu Zhaoxiang Fan Guoping Liu jianjun yan Tao Zhong Wu Zheng Ruiqing Wang Chunying Wang Basic Medical College Shanghai University of Traditional Chinese Medicine Center for Mechatronic Engineering EastChina University of Science and Technology

OBJECTIVE: Apply spectral clustering to analyze the patterns of symptoms in patients with chronic gastritis(CG).METHODS: Based on 919 CG subjects, we applied mutual information feature selection to choose the positively correlated symptoms with each ***, we used the Shi and Malik spectral clustering algorithm to select the top 20 correlated ***: We ascertained the results of six *** were three categories for the pattern of accumulation of damp heat in the spleen-stomach(0.00332). There were six categories for the pattern of dampness obstructing the spleen-stomach(0.02466). There were two categories for the pattern of spleen-stomach Qi deficiency(0.013 89).There were three categories for the pattern of spleen-stomach deficiency cold(0.009 15). There were five categories for the pattern of liver-Qistagnation(0.01910).There were four categories for the pattern of stagnant heat in the liver-stomach(0.00585).CONCLUSION: Most of the spectral clustering results of the symptoms of CG patterns were in accordance with clinical experience and Traditional Chinese Medicine theory. Most categories suggested the nature and/or location of the disease.

关键词： Gastritis Cluster analysis Pattern Symptom complex

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Fine-mapping and primary analysis of candidate genes associated with seed coat color in mung bean(Vigna radiata L.)

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Journal of Integrative Agriculture 2024年第8期23卷 2571-2588页

作者： Qian Wang Huimin Cao Jingcheng Wang Zirong Gu Qiuyun Lin Zeyan Zhang Xueying Zhao Wei Gao Huijun Zhu Hubin yan jianjun yan Qingting Hao Yaowen Zhang College of Agronomy Shanxi Agricultural UniversityTaiyuan 030031China 2 Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

Seed coat color affects the appearance and commodity quality of mung beans(Vigna radiata L.).The substances that affect mung bean seed coat color are mainly flavonoids,which have important medicinal *** the seed coat color gene in mung beans would facilitate the development of new varieties and improve their *** this study,an F2 mapping population consisting of 546 plants was constructed using Jilv9(black seed coat)and BIS9805(green seed coat).Using bulk segregated analysis(BSA)sequencing and kompetitive allele-specific PCR(KASP)markers,the candidate region related to seed coat color was finally narrowed to 0.66 Mb on chromosome(Chr.)4 and included eight candidate *** transcriptome and metabolome analyses showed that three of the eight candidate genes(LOC106758748,LOC106758747,and LOC106759075)were differentially expressed,which may have caused the differences in flavonoid metabolite content between Jilv9 and *** findings can provide a research basis for cloning the genes related to seed coat color and accelerate molecular markerassisted selection breeding in mung beans.

关键词： mung bean seed coat color bulk segregated analysis sequencing transcriptome metabolism flavonoids

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Detecting Non-Stationarity for Auscultation Signal of Traditional Chinese Medicine

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Wuhan University Journal of Natural Sciences 2011年第1期16卷 83-87页

作者： yan jianjun SHEN Qingwei WANG Yiqin LI Fufeng GUO Rui CHEN Chunfeng SHEN Yong Center for Mechatronics Engineering East China Universityof Science and Technology Shanghai 200237 China Center for Traditional Chinese Medicine InformationScience and Technology Shanghai University of TraditionalChinese Medicine Shanghai 201203 China

The information about the nonstationarity of the aus-cultation signal is utilized in this paper to objectively and auto-matically identify healthy people and patients with qi-deficiency or yin-deficiency. In order to characterize the nonstationarity of the sound signal,the nonlinear cross-prediction method is used to extract features from the signal. A feature selection method based on conditional mutual information maximization criterion （CMIM） is implemented to find an optimal feature set. By means of the support vector machine （SVM） classifier,three common states （healthy,qi-deficiency and yin-deficiency） in traditional Chinese medicine are distinguished using the feature set,and a satisfactory classification accuracy of 80% is achieved in the experiment. In conclusion,the analysis based on the nonstationarity of the sound signal provides an alternative and outstanding approach to the objective auscultation of traditional Chinese medicine （TCM）.

关键词： auscultation nonstationarity support vector ma-chine (SVM) traditional Chinese medicine (TCM)

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Relationship of GSTM1 and GSTT1 genetic variant and markers of oxidative stress and inflammation in smokers with coronary artery disease

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Journal of Nanjing Medical University 2009年第5期23卷 300-304页

作者： Changgao Zhou Jianjin Tang Mingwei Wang jianjun yan Qiming Wang Jun Zhu Zhijian yang Liansheng Wang Department of Cardiology the People' s Hospital of Shu yang Shu yang 223600 China Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective： To investigate the role of glutathione S-transferase （GST） genetic variants and markers of oxidative stress and inflammation in smokingrelated coronary artery disease （CAD） patients. Methods： Five hundred and thirty-five Chinese CAD patients were successfully genotyped. Plasma total antioxidant status （TAOS）, glutathione, C-reactive protein （CRP）, fibrinogen（FIB） and white blood cell count （WBC） were determined to evaluate the oxidative stress and inflammatory response. Results： GSTM1-0/ GSTT1-0 subjects had a higher CRP, FIB, WBC and GSH and a lower TAOS compared to patients with wild-type GSTM1/GSTT1 genes, but there was significant difference only with regards to TAOS. Smokers with the null genotype of GSTT1 had the highest CRP and the lowest TAOS and GSH when compared to the GSTTI-1 genotype with smoking status, or the GSTT1-0 genotype with non-smoking status, or the GSTTI-I genotype with non-smoking status. However, we found no significant difference between these groups. Also, no significant interaction was observed between genotypes and smoking status in determining CRP levels. Conclusion： Our results suggest that GST polymorphisms do not modify the effect of smoking on markers of oxidative stress and inflammation in Chinese CAD patients.

关键词： Glutathione S-transferase Genetic variant Smoking Oxidative stress Glutathione Coronary artery disease

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An early screening model of pulse detection technology for hepatic steatosis

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Intelligent Medicine 2023年第4期3卷 280-286页

作者： Wenjie Wu Chunke Zhang Xiaotian Ma Rui Guo jianjun yan Yiqin Wang Haixia yan Yeqing Zhang Department of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Intelligent Perception and Diagnosis School of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Chinese Internal Medicine Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China

Background The increasing prevalence of hepatic steatosis presents a considerable challenge to public *** is a critical need for the development of novel preventive and screening strategies for this *** evaluated the potential applications of wrist pulse detection technology for the early detection of *** pulse time-domain features of a medical exam population with and without hepatic steatosis wereassessed to develop a screening model for this *** Participants were consecutively recruited from March 2021 to March 2022 in the medical examinationcenters of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and the Shanghai Municipal Hospital of Traditional Chinese *** data from 255 participants,including general information(sex,age,and body mass index),and data related to glucose and blood lipids(fasting plasma glucose,triglyceride,total cholesterol,high-density lipoprotein,and low-density lipoprotein levels)were *** pulse signalswere acquired using a pulse detection device,and the pulse time-domain features,including t_(1),t_(4),t_(5),T,w_(1),w_(2),h_(2)/h_(1),h_(3)/h_(1),and h5/h_(1) were *** were assigned to hepatic steatosis and non-hepatic steatosisgroups according to their abdominal ultrasound examination *** clinical data and pulse time-domainfeatures were compared using chi-square and parametric or non-parametric statistical *** datasetswere used to construct screening models for hepatic steatosis based on the random forest *** datasetsfor modeling were defined as Dataset 1,containing blood glucose and lipid data and general information;Dataset2,containing time-domain features and general information;Dataset 3,containing time-domain features,bloodglucose and lipid data,and general *** evaluation metrics,accuracy,precision,recall,F1-score,andareas under the receiver operating characteristic curve(AUC

关键词： Pulse detection technology Time-domain method Hepatic steatosis Early screening Random forest

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Prognostic analysis of patients suffering from intrahepatic cholangiocarcinoma

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The Chinese-German Journal of Clinical Oncology 2011年第3期10卷 150-152页

作者： Zhong Chen jianjun yan Liang Huang Yiqun yan Department of Hepatobiliary Surgery Jinan Military Hospital Jinan 250031 China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Objective： The outcome of surgical treatment of patients with intrahepatic cholangiocarcinoma （ICC） is poor. This study was designed to analyze prognostic factors after surgical procedure for ICCs. Methods： A retrospective clinical analysis was made in 183 cases of ICC, admitted to Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, from December 1996 to July 2003. Fifteen clinicopathologic factors that could possibly influence survival were selected. A multivariate analysis of these individuals was performed using the Cox Proportional Hazards Model. Results： The accumulative 1-, 3-and 5-year survival rates of the patients were 51.3%, 21.6% and 11.8% respectively. The statistical analysis showed that surgical procedure, lymph node metastasis, serum level of CA19-9 and pathological differentiation grade affected postoperative survival significantly, but transfusion, postoperative radiotherapy and chemotherapy, diameter of tumor, serum level of AFP, cirrhosis, preoperative total serum bilirubin level （TBIL）, ratio of albumin to globulin （A/G）, sex and age were not significant factors influencing postoperative survival. Conclusion： Major hepatectomy with systematic lymph node dissection may be recommended for the surgical treatment of ICC. Aggressive treatment and prevention on postoperative intrahepatic recurrence and lymph node metastasis are important strategy to improve the survival for ICC.

关键词： intrahepatic cholangiocarcinoma (ICC) surgical procedures operative prognosis

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Sorafenib in hepatocellular carcinoma:efficacy and predictive factors

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Journal of Medical Colleges of PLA(China) 2011年第6期26卷 324-334页

作者： Li Jing Huang Liang yan jianjun Zhou Feiguo Liu Caifeng yan Yiqu Department of Hepatic Surgery I Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Objective:To evaluate the efficacy and safety in patients with hepatocellular carcinoma treated with sorafenib and determine the predictive factors for ***:From April 2009 to December 2010,all patients with hepatocellular carcinoma treated with sorafenib were included in the *** data and survival time were *** analysis was conducted using the Kaplan-Meier method,and predictive factors for survival were analysed using the Cox's ***:A total of 51 patients were included in the study,the median time of follow-up was 10 months(range 1-22).All the 51 patients had one or more adverse events,of which 2 patients died of upper gastrointestinal bleeding and 6 patients discontinued *** mean survival time was 11 months and 1-year survival was 60.8%.On univariate analysis,the median survival time of patients with tumors of BCLC A,B and C were 17,12.5 and 8.5 months,and 1-year survival were 71.4%,61.1%,and 23.1%, respectively(P=0.006).Compared with those with mild and poor arterial supply tumors,patients with good arterial supply tumors had longer median survival time(12 months vs 8 months and 9 months) and higher 1-year survival(52.0%vs 30.8%and 38.5%)(P=0.037).Patients with portal invasion had shorter median survival time and lower 1-year survival(8.5 months vs 13 months and 57.6%vs 16.7%,respectively) than those without(P=0.012).Patients with prealbumin≥170 mg/L had longer median survival time and higher 1-year survival(13.5 months vs 9 months and 55.6%vs 36.4%,respectively) than those with prealbumin<170 mg/L(P=0.016).Early tumor BCLC staging and high level of prealbumin were independent predictive factors for survival on multivariate analysis using Cox's regression model,the hazard ratio were 3.69(95%CI:1.30-10.53,P=0.015) and 3.53(95%CI:1.40-8.91,P=0.008) ***:Upper gastrointestinal bleeding was a severe event need to be concerned in patients with hepatocellular carcinoma treated with ***

关键词： Hepatocellular carcinoma Sorafenib Adverse events Prealbumin

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政府基本医保对商业健康保险有“促进效应”吗?

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金融评论 2018年第2期10卷 1-14,122页

作者：阎建军中国社会科学院金融研究所

现有文献发现政府基本医保对中国商业健康保险有"促进效应",但是理论解释模糊不清,可以称之为"中国商业健康保险发展之谜"。本文推导出商业健康保险在医疗服务体系中发挥精细化管理功能需要的条件,基于此,从供给端揭示了政府基本医保对... 详细信息

现有文献发现政府基本医保对中国商业健康保险有"促进效应",但是理论解释模糊不清,可以称之为"中国商业健康保险发展之谜"。本文推导出商业健康保险在医疗服务体系中发挥精细化管理功能需要的条件,基于此,从供给端揭示了政府基本医保对商业健康保险的结构性影响,进而对"中国商业健康保险发展之谜"提出以下解释——政府基本医保对商业健康保险"促进效应"仅体现在储蓄型险种上。而我国财产保险公司健康保险业务仅经营保障型险种,人身险公司健康保险业务则以储蓄型险种为主,使用省级动态面板模型进行实证检验,结果显示:政府基本医保对财产保险公司健康保险业务没有促进效应,对人身险公司的健康保险业务则有显著的正向影响。

关键词：基本医保商业健康保险管理型医疗

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