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Journal of Environmental sciences 2010年第8期22卷 1189-1194页

作者： jianjie fu, yawei wang, qunfang zhou, {3. jiang state key laboratory of Environmental chemistry and ecotoxicology, research center for eco-Environmental {13., chinese academy of sciences, beijing 100085, china. state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Gaobeidian Lake, located in beijing, china. serves as a recipient lake for efluents from a large municipal sewage treatment plant （MSTP）. In order to evaluate the effects of discharging MSTP efluent on the mercury contamination of the local aquatic ecosystem, sediment cores, water, plankton, fish, and turtle samples were collected from Gaobeidian Lake for mercury speciation analysis. High concentrations of total mercury （T-Hg） were detected in sediment cores （5.24–17.0 μg/g dry weight （dw）, average： 10.1 μg/g）. The ratio of methylmercury （MeHg） to T-Hg was less than 0.3. in sediments and ranged from 3.% to 76% in biota samples. The highest level of T-Hg and MeHg were found in aquatic bryophyte and crucian carp （3.73.and 43. ng/g dw, respectively）. The relative contents of MeHg were significantly correlated with trophic levels （R2 = 0.5506, p 0.001）, which confirmed that MeHg can be bio-transferred and biomagnified via food chain in this aquatic ecosystem.

关键词： methylmercury total mercury trophic levels aquatic ecosystem municipal sewage treatment plants

Response of ocean acidification to atmospheric carbon dioxide removal

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Journal of Environmental sciences 2024年第6期140卷 79-90页

作者： Jiu jiang Long Cao Xiaoyu Jin Zechen Yu Han Zhang jianjie fu guibin jiang School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China key laboratory of Geoscience Big Data and Deep Resources of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhou 310058China Zhejiang Climate center Hangzhou 310052China

Artificial CO_(2)removal from the atmosphere(also referred to as negative CO_(2)emissions)has been proposed as a potential means to counteract anthropogenic climate *** we use an Earth system model to examine the response of ocean acidification to idealized atmospheric CO_(2)removal *** our simulations,atmospheric CO_(2)is assumed to increase at a rate of 1%per year to four times its pre-industrial value and then decreases to the pre-industrial level at a rate of 0.5%,1%,2%per year,*** results show that the annual mean state of surface ocean carbonate chemistry fields including hydrogen ion concentration([H^(+)]),pH and aragonite saturation state respond quickly to removal of atmospheric CO_(2).However,the change of seasonal cycle in carbonate chemistry lags behind the decline in atmospheric CO_(2).When CO_(2)returns to the pre-industrial level,over some parts of the ocean,relative to the pre-industrial state,the seasonal amplitude of carbonate chemistry fields is substantially *** results also show that changes in deep ocean carbonate chemistry substantially lag behind atmospheric CO_(2)*** CO_(2)returns to its pre-industrial value,the whole-ocean acidity measured by[H^(+)]is 15%-18%larger than the pre-industrial level,depending on the rate of CO_(2)*** study demonstrates that even if atmospheric CO_(2)can be lowered in the future as a result of net negative CO_(2)emissions,the recovery of some aspects of ocean acidification would take decades to centuries,which would have important implications for the resilience of marine ecosystems.

关键词： Carbon dioxide removal Net negative CO_(2)emission Ocean acidification Climate change Earth system modeling

Environmental Obesogens and Their Perturbations in Lipid Metabolism

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Environment & Health 2024年第5期2卷 253-268页

作者： Xiaoyun wang Zhendong Sun Qian S.Liu qunfang zhou {3. jiang state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

Epidemiological data show that obesity is now a *** homeostasis requires the coordination of multiple tissues and organs,including the liver,kidney,cardiovascular system,and adipose tissues,to maintain bodily *** increasing amounts of chemicals are being synthesized,applied,and released into the environment,their obesogenic effects have triggered serious ***,more than 50 types of chemicals with high human exposure levels have been identified as environmental obesogens that can interfere with lipid metabolism and induce *** studies have shown that the lipid metabolism interference effects of obesogens have multiple targets,including nuclear receptors,transcription factors,cytokines,and *** interfering factors of environmental obesogeninduced obesity include transgenerational effects,susceptibility windows,gender differences,structure−effect relationships,and diet *** research approaches have been established to conduct obesogenic effect *** comprehensive review summarizes the mechanisms underlying obesogen actions and the research progress on obesogen-disrupted lipid metabolism,along with the influencing factors and research approaches,aiming to provide a framework for understanding the effects of environmental obesogens on lipid metabolism.

关键词： environmental obesogens lipid metabolism risk assessment influencing factors research approaches

Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling

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Journal of Environmental sciences 2024年第3期137卷 443-454页

作者： Zhihua Ren Xiaoxi Yang Tingting Ku Qian S.Liu Jiefeng Liang qunfang zhou Francesco Faiola guibin {3. state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China College of Sino-Danish University of Chinese Academy of SciencesBeijing 100049China

Investigating the development toxicity of perfuorinated iodine alkanes(PFIs)is critical,given their estrogenic effects through binding with estrogen receptors(ERs).In the present study,two PFIs,including dodecafuoro-1,6-diiodohexane(PFHx DI)and tridecafuorohexyl iodide(PFHx I),with binding preference to ERαand ERβ,respectively,were selected to evaluate their effects on proliferation and differentiation of the mouse embryonic stem cells(m ESCs).The results revealed that,similar to E_(2),50μmol/L PFHx DI accelerated the cell proliferation of the m *** PFI stimulation at the exposure concentrations of 2–50μmol/L promoted the differentiation of the m ESCs as characterized by the upregulation of differentiation-related biomarkers(i.e.,Otx2 and Dnmt3.)and downregulation of pluripotency genes(i.e.,Oct4,Nanog,Sox2,Prdm14 and Rex1).Comparatively,PFHx DI exhibited higher induction effect on the differentiation of the m ESCs than did PFHx *** tests on ER signaling indicated that both PFI compounds induced exposure concentration-dependent expressions of ER signaling-related biomarkers(i.e.,ERα,ERβand Caveolin-1)in the m ESCs,and the downstream ER responsive genes(i.e.,c-fos,c-myc and c-jun)well responded to PFHx I *** role of ER in PFI-induced effects on the m ESCs was further validated by the antagonistic experiments using an ER inhibitor(ICI).The findings demonstrated that PFIs triggered ER signaling,and perturbed the differentiation program of the m ESCs,causing the potential health risk during early stage of development.

关键词： Perfuorinated iodine alkanes(PFIs) Embryonic stem cells(ESCs) Developmental toxicity Cell differentiation Estrogen receptor-related signaling

Subchronic toxicological effects of aquatic nitrobenzene on Medaka and chinese rare minnow

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Science china.chemistry 2007年第5期50卷 707-717页

作者： zhou qunfang1, fu {3.1,2, MENG HaiZhen1,2, ZHU XueYan1,2, jiang guibin1, ZHANG JianBin1, LIU JieMin2 & SHI GuoQing2 1 state key laboratory of Environmental chemistry and ecotoxicology, research center for {13.-environmental sciences, chinese academy of sciences, beijing 100085, china.2 Department of chemistry, School of Applied Science, University of Science and Technology beijing, beijing 100083. china state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing China Department of chemistry School of Applied Science University of Science and Technology Beijing Beijing China

Based on the simulative exposure experiments of nitrobenzene to two small experimental fishes, Medaka (Oryzias latipes) and chinese Rare Minnow (Gobiocypris rarus), it was found that nitrobenzene could decrease in a linear way in the static aquatic system. Both fishes could accumulate dose-related levels of nitrobenzene quickly and eliminate the compound rapidly when they were transferred to clean water. The chinese rare minnow showed more sensitivity to the acute toxicity exposure of nitrobenzene than Medaka. Typical molecular biomarkers in oxidative defense system including superoxide dismu- tase (SOD), catalase (CAT) showed the chemical induced alterations. The changes of acetylcholi- nesterase (AChE) activities indicated that nitrobenzene might affect the normal neural function. Nitro- benzene exposure could also lead to obvious damaging effects on the target organs, such as gill and liver by hitopathological studies.

关键词： nitrobenzene, Medaka, chinese rare minnow, bioaccumulation, elimination, molecular biomarkers, histopathological effects

Enhanced research Needed on the Structural Analogues of Chlorinated Paraffins as Emerging Contaminants of Concern

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Environment & Health 2024年第10期2卷 681-683页

作者： Weifang Chen Dazhou Ren Qian Liu qunfang zhou Jiyan Liu {3. jiang School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China the research center for eco-Environmental {3. Chinese Academy of Sciences(RCEESCAS).

INTRODUCTION Structural analogues of chlorinated paraffins(CPs)are compounds that contain the chlorinated n-alkanes skeleton of CPs and other functional ***,some structural analogues of CPs at high levels were detected in the environment and general population.1−5 The atmospheric concentrations of unsaturated short,medium,and long chain chlorinated olefins(COs)were 0.01−0.27,0.02−0.56,and 0.01−0.55 ng/m3.in china.1 Over 700 brominated-chlorinated paraffin and brominated-chlorinated olefin congeners(BCPs and BCOs)were found in different matrices in *** concentrations of BCPs and BCOs in dust samples(median concentrations of 5.4 and 0.18μg/g,respectively)are comparable to CPs,and 1−2 orders of magnitude higher than those in the atmosphere and sediments at some sites.

关键词： analogues chlorinated alkanes

Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches

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Journal of Environmental sciences 2014年第4期26卷 900-908页

作者： Weijin Yang jianjie fu Thanh wang Hanxia Liu yawei wang qunfang zhou guibin jiang state key laboratory of Environmental {3. and ecotoxicology research center for eco-Environmental sciences Chinese Academy of Sciences

There is large usage of polybrominated diphenyl ethers （PBDEs） especially for decabromodiphenyl ether （BDE-209, Deca-BDE） in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on IH NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days＇ exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated-BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment.

关键词： decabromodiphenyl ether metabonomic approaches endogenous metabolites

An analytical method for chlorinated paraffins and their determination in soil samples

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chinese Science Bulletin 2010年第22期55卷 2396-2402页

作者： YUAN Bo wang yawei fu {3. ZHANG QingHua jiang guibin state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Short chain chlorinated paraffins (SCCPs) are possibly persistent organic pollutants (POPs), and are candidate POPs of the Stockholm Convention. In this study, three quantitative methods for analyzing CPs were compared using a gas chromatograph-electron capture detector (GC-ECD), gas chromatograph-electron capture negative ion low resolution mass spectrometry (GC-ECNI-LRMS) and gas chromatograph-electron ionization tandem mass spectrometry (GC-EI-MS2). A quantitative method for the analysis of total CPs in soil samples was established. The environmental levels of CPs in an e-waste dismantling area in china.were evaluated.

关键词：氯化石蜡土壤样品持久性有机污染物电子捕获检测器气相色谱仪斯德哥尔摩公约串联质谱法测定

Environmental and biological influences on the stability of silver nanoparticles

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chinese Science Bulletin 2011年第19期56卷 2009-2015页

作者： LIU Wei zhou qunfang LIU JiYan fu {3. LIU SiJin jiang guibin state key laboratory of Environmental {3. and ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy ofSciences Beijing 100085 China

Silver nanoparticles (Ag NPs) are easily dispersed and stable, and their application has become widespread. Consequently, concern has arisen regarding their potential effects on the environment and human health. However, the current understanding on the stability of Ag NPs is limited. Therefore, in this study the influence of environmental and biological factors, such as ionic strength, valence, biological molecules, pH and temperature, on the properties of Ag NPs was investigated. The absorption spectra, size, zeta potential, and release of silver ions were evaluated. Ionic strength, valence, Dulbecco’s Modified Eagle’s Medium (DMEM), without fetal bovine serum (FBS), reduced the stability of the Ag NPs. However, in DMEM with 10% FBS, the Ag NPs maintained their stability and nanoscale characteristics. These findings provide an essential insight into the environmental and biological factors that should be evaluated in a risk assessment of Ag NPs.

关键词：银纳米粒子生物因素稳定性环境 Zeta电位离子强度胎牛血清 DMEM

合成酚类化合物的脂代谢干扰效应与致肥胖作用

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色谱 2024年第2期42卷 131-141页

作者：刘惠楠孙振东刘倩周群芳江桂斌中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085 中国科学院大学资源与环境学院北京100049 国科大杭州高等研究院环境学院浙江杭州310024

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞... 详细信息

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞形成、引起体内脂质累积增加等,这类物质被称为“环境致肥胖物质”。合成酚类化合物广泛用于工业生产和日常生活用品中,如塑料制品、消毒剂、杀虫剂和食品添加剂等,它们可通过饮食、饮水或皮肤接触等方式进入人体,是影响人体健康的潜在威胁。研究显示,合成酚类化合物具有内分泌干扰效应,可以影响脂肪生成过程、干扰脂代谢,具有致肥胖作用。由于这类物质都具有类似的苯酚结构,因此系统梳理这类化合物脂代谢干扰效应与致肥胖作用,有助于理解其构效关系与潜在健康风险。本文阐述了筛选环境致肥胖物质的3.常用研究模型,即体外分子互作研究模型、细胞成脂分化模型和动物脂代谢实验模型,并比较了各种模型的适用场景和优缺点。在此基础上,针对3.合成酚类化合物,即双酚A及其类似物、烷基酚和酚类抗氧化剂,结合其体外细胞与动物实验数据,对这些化合物的暴露现状和脂代谢干扰效应进行了分类描述,从它们对脂肪生成和代谢、肝组织脂代谢的影响等方面展开讨论。基于近年来脂代谢和致肥胖效应的相关研究,本文归纳总结了环境内分泌干扰物干扰脂代谢的内在毒理机制,主要包括核受体调控作用、炎症和氧化应激、肠道微环境、表观遗传和其他信号通路。最后本文指出了当前针对环境污染物,特别是新污染物,影响机体脂代谢引起肥胖效应研究中的不足,并对该领域研究进行了展望。

关键词：合成酚类化合物肥胖环境致肥胖物质脂代谢综述