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Journal of Meteorological Research 2024年第3期38卷 542-557页

作者： Rui WANG Yihong DUAN jianing feng Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai200438China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China

Cloud microphysics plays an important role in determining the intensity and precipitation of tropical cyclones(TCs).In this study,a high-resolution numerical simulation by WRF(version 4.2)of Typhoon Meranti(2016)during its rapid intensification(RI)period was conducted and validated by multi-source observations including Cloud-Sat and Global Precipitation Mission satellite *** snow and ice particles content were found to increase most rapidly compared with other hydrometeors during the RI *** all hydrometeors continued to *** graupel content only increased in the initial RI stage,and then decreased afterwards due to precipitation during the RI *** addition,sea surface temperature(SST)sensitivity experiments showed that,although the intensity of the TC increased with a higher SST,not all hydrometeors *** graupel content continued to increase with the increase in SST,mainly due to the accumulation of more lower-temperature supercooled water vapor at the corresponding *** content of snow decreased with the increase in SST because stronger vertical motion at the corresponding height affected the aggregation of ice crystals.

关键词： tropical cyclone rapid intensification cloud microphysical characteristics sea surface temperature(SST)

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中药调控自噬干预高血压肾病研究进展

世界中医药 2024年第10期19卷 1515-1519,1525页

作者：方震罗玉蔺晓源地娜拉·加力肯冯佳宁方祝元南京中医药大学附属医院南京210029 湖南中医药大学第一附属医院长沙410007 大连医科大学大连116000

肾脏是高血压并发症的重要靶器官之一,临床上高血压肾病患者的血压常常难以控制、病情迁延不愈,严重危害患者的生命质量。自噬是维持细胞稳态的机制之一,是高度分化细胞的一种自我清理方式,以清除不必要的蛋白质等细胞内成分,自噬过度... 详细信息

肾脏是高血压并发症的重要靶器官之一,临床上高血压肾病患者的血压常常难以控制、病情迁延不愈,严重危害患者的生命质量。自噬是维持细胞稳态的机制之一,是高度分化细胞的一种自我清理方式,以清除不必要的蛋白质等细胞内成分,自噬过度及自噬抑制均会导致不同程度的细胞损伤。自噬在高血压肾病中的发病机制,主要涉及足细胞、内皮细胞等的自噬水平,以及中药通过影响自噬水平以治疗高血压肾病。

关键词：自噬高血压肾病作用机制中医药阴阳理论足细胞内皮细胞综述

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基于心流理论的美育类APP设计研究

设计 2024年第10期37卷 126-129页

作者：刘建军李思熠冯佳宁大连理工大学建筑与艺术学院

研究可优化美育类App用户体验与学习效果的设计策略。从心流理论的视角出发,结合案例深度分析用户在使用美育类App时的心流体验,梳理出适于美育类App的设计思路。构建以心流理论为基础的美育类App设计策略,为美育类App的设计提供了新的... 详细信息

研究可优化美育类App用户体验与学习效果的设计策略。从心流理论的视角出发,结合案例深度分析用户在使用美育类App时的心流体验,梳理出适于美育类App的设计思路。构建以心流理论为基础的美育类App设计策略,为美育类App的设计提供了新的设计思路,丰富素质教育的在线教学支持体系。

关键词：心流体验美育类App 用户体验界面设计设计策略

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全胸腔镜食管癌根治术治疗食管癌的效果及对患者血清炎症因子水平和肺功能的影响

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当代医学 2024年第3期30卷 80-82页

作者：查健冯家宁陆剑豪广东同江医院心胸乳腺外科广东佛山528300

目的探讨全胸腔镜食管癌(EC)根治术治疗食管癌的效果及对患者血清炎症因子水平和肺功能的影响。方法选取2019年7月至2020年10月广东同江医院接诊且行全胸腔镜食管癌根治术的38例EC患者作为观察组,另选取同期接诊且行传统开胸手术的38例E... 详细信息

目的探讨全胸腔镜食管癌(EC)根治术治疗食管癌的效果及对患者血清炎症因子水平和肺功能的影响。方法选取2019年7月至2020年10月广东同江医院接诊且行全胸腔镜食管癌根治术的38例EC患者作为观察组,另选取同期接诊且行传统开胸手术的38例EC患者作为对照组,比较两组围手术期指标、血清炎症因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、肺功能指标[每分钟最大通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)]及并发症发生率。结果两组清扫淋巴结数比较差异无统计学意义;观察组术中失血量、总引流量少于对照组,手术时间短于对照组,差异有统计学意义(P<0.05)。术前,两组CRP、TNF-α水平比较差异无统计学意意义;术后72h,两组CRP、TNF-α水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05)。术前,两组MVV、FVC、FEV1比较差异无统计学意意义;术后2周,两组MVV、FVC、FEV1均低于术前,但观察组MVV、FVC、FEV1均高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论全胸腔镜食管癌根治术治疗EC疗效显著,能改善患者术后炎症因子水平,对患者肺功能影响小,且并发症少,值得临床推广应用。

关键词：全胸腔镜食管癌根治术治疗效果 C反应蛋白肿瘤坏死因子-α 肺功能

重组鼠过氧化物还原酶-5体内抗胰腺癌作用研究

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中国免疫学杂志 2024年第5期40卷 905-909页

作者：杨琳解辉平王淼冯佳宁金媛媛张志斐杨兆勇华北理工大学药学院唐山063000 中国医学科学院医药生物技术研究所北京100050

目的:探讨鼠源重组过氧化物还原酶-5(mPRDX5)在小鼠体内是否具有抗肿瘤活性,从而进一步确证PRDX5的抗肿瘤活性和作用机制。方法:通过体外异源表达和纯化获得高纯度的mPRDX5。小鼠左侧腋背部皮下接种胰腺癌Pan02细胞建立荷瘤小鼠模型。... 详细信息

目的:探讨鼠源重组过氧化物还原酶-5(mPRDX5)在小鼠体内是否具有抗肿瘤活性,从而进一步确证PRDX5的抗肿瘤活性和作用机制。方法:通过体外异源表达和纯化获得高纯度的mPRDX5。小鼠左侧腋背部皮下接种胰腺癌Pan02细胞建立荷瘤小鼠模型。小鼠随机分为PBS(溶剂对照)组、GEM(吉西他滨)50.0 mg/kg组和mPRDX510.0 mg/kg组,每组10只,检测小鼠肿瘤相关指标。结果:与PBS组比较,GEM组荷瘤小鼠体质量降低明显,mPRDX5组小鼠体质量有一定程度的增加。PBS组肿瘤生长良好,根据肿瘤体积计算,与PBS组相比,GEM组、mPRDX510.0 mg/kg组在D7肿瘤生长抑制率分别为87.07%和52.82%;按瘤重计算,与PBS组相比,GEM组、mPRDX510.0 mg/kg组在D7肿瘤生长抑制率分别为95.39%和48.33%。对PBS组和mPRDX5组小鼠肿瘤组织中的巨噬细胞极化状态进行分析,发现相较于PBS组,mPRDX5组小鼠肿瘤组织中表达CD86的M1型巨噬细胞显著增加,而表达CD206的M2型巨噬细胞显著减少。结论:mPRDX5在小鼠体内具有显著的抗胰腺癌活性,且活性的发挥是通过促进肿瘤微环境中的巨噬细胞向M1型极化实现。

关键词：鼠源过氧化物还原酶-5 蛋白表达胰腺癌抗肿瘤巨噬细胞极化

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Application of Lightning Data Assimilation to Numerical Forecast of Super Typhoon Haiyan (2013)

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Journal of Meteorological Research 2020年第5期34卷 1052-1067页

作者： Rong ZHANG Wenjuan ZHANG Yijun ZHANG jianing feng Liangtao XU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological Administration(CMA)Beijing 100081 Key Laboratory for Cloud Physics of CMA Chinese Academy of Meteorological SciencesCMABeijing 100081 Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438

Previous observations from World Wide Lightning Location Network(WWLLN) and satellites have shown that typhoon-related lightning data have a potential to improve the forecast of typhoon intensity. The current study was aimed at investigating whether assimilating TC lightning data in numerical models can play such a role. For the case of Super Typhoon Haiyan in 2013, the lightning data assimilation(LDA) was realized in the Weather Research and Forecasting(WRF) model, and the impact of LDA on numerical prediction of Haiyan’s intensity was *** data from WWLLN were used to adjust the model’s relative humidity(RH) based on the method developed by Dixon et al.(2016). The adjusted RH was output as a pseudo sounding observation, which was then assimilated into the WRF system by using the three-dimensional variational(3DVAR) method in the cycling mode at 1-h intervals. Sensitivity experiments showed that, for Super Typhoon Haiyan(2013), which was characterized by a high proportion of the inner-core(within 100 km from the typhoon center) lightning, assimilation of the inner-core lightning data significantly improved its intensity forecast, while assimilation of the lightning data in the rainbands(100–500 km from the typhoon center) led to no obvious improvement. The improvement became more evident with the increase in LDA cycles, and at least three or four LDA cycles were needed to achieve obvious intensity forecast improvement. Overall, the improvement in the intensity forecast by assimilation of the inner-core lightning data could be maintained for about 48 h. However, it should be noted that the LDA method in this study may have a negative effect when the simulated typhoon is stronger than the observed, since the LDA method cannot suppress the spurious convection.

关键词： lightning three-dimensional variational(3DVAR)data assimilation Typhoon Haiyan typhoon intensity

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PET包装材料中聚酯低聚物的研究进展

包装工程 2024年第1期45卷 118-127页

作者：冯佳宁常世敏吴刚仇凯夏伊宁张敏赵宇晖河北工程大学生命科学与食品工程学院河北邯郸056038 中国食品发酵工业研究院北京100015 中国农业科学院农产品加工研究所北京100193 南京海关危险货物与包装检测中心江苏常州213000 奥瑞金科技股份有限公司北京101407

目的综述PET包装材料中聚酯低聚物的研究现状,包括筛查识别、迁移检测、风险评估及政策法规。方法PET包装材料中聚酯低聚物的筛查识别主要采用液相色谱-高分辨率质谱技术进行,结合靶向筛查和非靶向筛查手段。聚酯低聚物的迁移检测主要... 详细信息

目的综述PET包装材料中聚酯低聚物的研究现状,包括筛查识别、迁移检测、风险评估及政策法规。方法PET包装材料中聚酯低聚物的筛查识别主要采用液相色谱-高分辨率质谱技术进行,结合靶向筛查和非靶向筛查手段。聚酯低聚物的迁移检测主要是测定不同条件聚酯低聚物从PET包装材料向食品模拟物的迁移。结果部分研究开展了真实食品中低聚物的含量测定,并采用合适的方法对食品样品进行前处理。聚酯低聚物的风险评估通常是将食品/食品模拟物中的迁移量和法规中的迁移限量进行比较。对法规中未列出的低聚物,通常采用毒理学关注阈值(TTC)方法结合Cramer决策树进行风险评估。由于实验数据的缺乏,针对PET内聚酯低聚物的法规还十分有限。结论随着PET包装材料的广泛使用,特别是新型PET包装材料的出现,有必要对PET中聚酯低聚物的潜在风险进行深入研究,以确保食品安全。应注重高分辨率质谱在聚酯低聚物筛查及迁移检测中发挥的作用,为后续风险评估提供重要数据支持。

关键词： PET包装聚酯低聚物筛查识别迁移检测风险评估政策法规

Nutritional and lipid profile status of children with spinal muscular atrophy in China:A retrospective case-control study

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Chinese Medical Journal 2024年第10期137卷 1243-1245页

作者： Yijie feng Jia Wei Mei Yao jianing Jin Yiqin Cui Qi Long Fei Chen Yi Hong Dongming Zhou Jingjing Hu Xiao Chen feng Gao Changzheng Yuan Shanshan Mao Department of Neurology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Infection Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Nutrition Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China School of Public Health Zhejiang University School of MedicineHangzhouZhejiang 310012China Children’s Hospital School of Public HealthZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China

To the Editor:5q spinal muscular atrophy(5qSMA)is an autosomal recessive neuromuscular disorder caused by the lack of the survival motor neuron(SMN)protein encoded by the SMN1 gene,located at 5q11.2-q13.3.[1]The incidence is 1/10,000-1/6000 live births,and the mutation carrier rate in China is 1/42.[1]Spinal muscular atrophy(SMA)is mainly divided into four subtypes:SMA type I,II,III,and IV,based on the motor milestones ever *** I-III occur in children,[1]which often result in progressive muscular atrophy and weakness as well as multi-system dysfunction,including nutritional and metabolic issues.[2]Children with SMA may have hidden nutritional and lipid imbalances,despite normal body appearance and anthropometric measurements,making it difcult to detect early and intervene.

关键词： atrophy muscular children

Optimizing support acidity of NiMo catalysts for increasing the yield of benzene, toluene and xylene in tetralin hydrocracking

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 71-84页

作者： feng Chen jianing Huo Liang Zhao Jinsen Gao Chunming Xu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China

To enhance the yields of benzene,toluene,and xylene in tetralin hydrocracking,the effect of the support acid properties of NiMo catalysts on hydrocracking performance of tetralin were investigated in this *** zeolites were modified by hydrothermal treatment to form USY zeolites at different temperatures and adjust the type and amount of *** addition,H-Beta was loaded into the USY to further adjust the acidic properties of the *** result shows that when the total B acid content of the catalyst is maintained between 150 and 200μmol·g^(-1),the total acid amount is maintained between 1.7 and 1.9 mmol·g^(-1),and the L/B(L and B acids)ratio is maintained between 1.5 and 2,the catalysts have favorable performances on tetralin *** this condition,the catalysts have a yield of benzene,toluene,and xylene higher than 30 wt%and a selectivity for benzene,toluene,and xylene higher than 35%.The tetralin conversion is greater than 85 wt%.The AB6 catalyst obtains the best hydrocracking effect with the conversion of tetralin reaching 90.24 wt%,the yields of benzene,toluene,and xylene reaching 33.58 wt%,and the selectivity of benzene,toluene,and xylene reaching 37.21%,respectively.

关键词： hydrocracking tetralin benzene toluene and xylene acid properties reaction pathways

商业综合体消费者行为决策机制及空间优化模拟研究

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现代城市研究 2023年第9期38卷 50-58页

作者：毛超张路鸣冯佳宁重庆大学管理科学与房地产学院

商业综合体的业态组合及空间布局呈现同质化趋势,难以与电商网络背景下消费者体验式随机消费行为相匹配。研究通过分析商业综合体内消费者行为的影响因素建立离散选择模型,并运用多智能体仿真建模技术模拟空间优化策略的实施效果。针对... 详细信息

商业综合体的业态组合及空间布局呈现同质化趋势,难以与电商网络背景下消费者体验式随机消费行为相匹配。研究通过分析商业综合体内消费者行为的影响因素建立离散选择模型,并运用多智能体仿真建模技术模拟空间优化策略的实施效果。针对不同类型消费者存在的消费偏好差异,通过提升品牌知名度、调整业态布局,可以有效改善商业空间的客流分布,为商业动态运营提供可视化的决策工具。

关键词：商业综合体消费者行为离散选择模型多智能体模拟空间优化