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A Simulation Engine for Stochastic Timed Petri Nets and Application to Emergency Healthcare Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 969-980页

作者： jiani zhou Jiacun Wang Jun Wang Monmouth University New Jersey 07764-1898 USA the School of Automation Nanjing University of Science and TechnologyNanjing 210094China

In many service delivery systems,the quantity of available resources is often a decisive factor of service *** can be personnel,offices,devices,supplies,and so on,depending on the nature of the services a system *** service computing has been an active research topic for decades,general approaches that assess the impact of resource provisioning on service quality matrices in a rigorous way remain to be *** nets have been a popular formalism for modeling systems exhibiting behaviors of competition and concurrency for almost a half *** timed Petri nets(STPN),an extension to regular Petri nets,are a powerful tool for system performance ***,we did not find any single existing STPN software tool that supports all timed transition firing policies and server types,not to mention resource provisioning and requirement *** paper presents a generic and resource oriented STPN simulation engine that provides all critical features necessary for the analysis of service delivery system quality *** *** power of the simulation system is illustrated by an application to emergency health care systems.

关键词： Emergency department healthcare resource requirements simulation sojourn time stochastic timed Petri nets(STPNs) workflows

微小RNA-26a-5p对氧化型低密度脂蛋白处理的血管平滑肌细胞增殖、迁移和泡沫化的影响

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现代实用医学 2024年第4期36卷 428-432页

作者：赵妙惠周佳妮吴超群宁波市医疗中心李惠利医院宁波315040

目的探究微小RNA-26a-5p(miR-26a-5p)对动脉粥样硬化(AS)过程中血管平滑肌细胞(VSMCs)增殖、迁移和泡沫化的影响。方法使用氧化型低密度脂蛋白(ox-LDL)处理VSMCs,模拟AS过程中的VSMCs细胞模型,向细胞中转染miR-26a-5p模拟物(miR-26a-5p ... 详细信息

目的探究微小RNA-26a-5p(miR-26a-5p)对动脉粥样硬化(AS)过程中血管平滑肌细胞(VSMCs)增殖、迁移和泡沫化的影响。方法使用氧化型低密度脂蛋白(ox-LDL)处理VSMCs,模拟AS过程中的VSMCs细胞模型,向细胞中转染miR-26a-5p模拟物(miR-26a-5p mimic)及其阴性对照(NC mimic),将细胞分为对照组、ox-LDL组、ox-LDL+NC mimic组、ox-LDL+miR-26a-5p mimic组。通过qRT-PCR检测细胞miR-26a-5p表达水平,采用CCK-8和EDU染色检测细胞活力和增殖,通过划痕实验和Transwell实验检测细胞迁移和侵袭能力,使用油红O染色观察细胞中脂滴聚集情况,采用免疫荧光实验检测细胞中α-SMA的表达。结果VSMCs中miR-26a-5p水平随着ox-LDL浓度的增加和作用时间的延长而降低。与对照组比较,ox-LDL组VSMCs细胞增殖、迁移、侵袭能力显著增强,脂滴聚集增多,α-SMA信号减弱,泡沫化程度增强。与oxLDL+NC mimic组比较,ox-LDL+miR-26a-5p mimic组细胞增殖、迁移、侵袭能力显著减弱,脂滴聚集减少,α-SMA信号增强,泡沫化程度减弱。结论过表达miR-26a-5p可以下调血管平滑肌细胞的增殖、迁移和泡沫化,miR-26a-5p可能成为AS治疗的新靶点。

关键词：动脉粥样硬化 miR-26a-5p ox-LDL VSMCs 泡沫细胞

环索奈德鼻喷剂治疗季节性过敏性鼻炎疗效与安全的Meta分析

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山东大学耳鼻喉眼学报 2024年第1期38卷 13-20页

作者：张真杨卓莹周佳妮张大为陈仁杰南京医科大学第二附属医院耳鼻咽喉头颈外科南京江苏210011

目的系统评价环索奈德鼻喷剂治疗季节性过敏性鼻炎的临床疗效和安全性,为临床合理用药提供循证依据。方法通过检索Cochrane library、Web of Science、Pubmed、ClinicalTrials、中国知网(CNKI)、万方、维普及中国生物医学数据库(CBM),... 详细信息

目的系统评价环索奈德鼻喷剂治疗季节性过敏性鼻炎的临床疗效和安全性,为临床合理用药提供循证依据。方法通过检索Cochrane library、Web of Science、Pubmed、ClinicalTrials、中国知网(CNKI)、万方、维普及中国生物医学数据库(CBM),收集比较环索奈德(试验组)和安慰剂(对照组)治疗过敏性鼻炎的随机对照试验,检索时限均为从建库至2022年10月。由2位评价员按照纳入及排除标准对文献进行严格筛选,并进行质量评估,使用RevMan5.4版软件进行统计分析。结果纳入8项研究的Meta分析结果显示,环索奈德具有降低瞬时总鼻症状评分[WMD=-0.43,95%CI(-0.63,-0.23),P<0.01]、瞬时鼻腔单项评分[WMD=-0.19,95%CI(-0.23,-0.05),P<0.01]、反映性总鼻症状评分[WMD=-0.66,95%CI(-0.80,-0.52),P<0.01]、反映性鼻腔单项评分[WMD=-0.23,95%CI(-0.26,-0.21),P<0.01]、瞬时眼部单项积分[WMD=-0.19,95%CI(-0.22,-0.15),P<0.01]、瞬时眼部症状总积分[WMD=-0.28,95%CI(-0.56,-0.00),P=0.05]、反映性眼部症状总积分[WMD=-0.27,95%CI(-0.54,-0.00),P=0.05]、反映性眼部单项积分[WMD=-0.17,95%CI(-0.21,-0.14),P<0.01]、鼻结膜炎生存质量量表[WMD=-0.61,95%CI(-0.76,-0.47),P<0.01]的相关评分的作用。试验组与对照组相比,不良反应事件的发生率[OR=0.96,95%CI(0.76,1.20),P=0.72]无变化。结论环索奈德鼻喷剂对季节性过敏性鼻炎的治疗卓有成效,且不良反应事件的发生率无变化,有良好的安全性及耐受性,具有进一步临床推广的价值。

关键词：环索奈德过敏性鼻炎 Meta分析

GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： jiani Zhong Hang Chen Qiming Liu Shenghua zhou Zhenguo Liu Yichao Xiao Department of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism

重庆市与贵州省基本公共卫生服务NCD健康管理影响因素调查研究

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重庆医学 2024年第2期53卷 276-280,285页

作者：刘诗莉周佳妮袁全王赓陈勇黄庆宁李颖陆军军医大学军事预防医学系社会医学与卫生事业管理学教研室重庆400038

目的分析重庆市与贵州省慢性非传染性疾病(NCD)健康管理情况及其影响因素。方法采用分层随机抽样,从重庆市和贵州省抽取16个有代表性的基层医疗卫生机构作为研究地点,通过定性和定量研究相结合的方法收集资料。结果共调查760例NCD患者,... 详细信息

目的分析重庆市与贵州省慢性非传染性疾病(NCD)健康管理情况及其影响因素。方法采用分层随机抽样,从重庆市和贵州省抽取16个有代表性的基层医疗卫生机构作为研究地点,通过定性和定量研究相结合的方法收集资料。结果共调查760例NCD患者,NCD健康管理项目的知晓率、利用率、满意度均超过84.2%,随访和分类干预的知晓率、利用率、满意度最低。<60岁患者的高血压体检知晓率低于60~<70岁患者(OR=4.28,95%CI:1.43~12.81)和≥70岁患者(OR=3.16,95%CI:1.12~8.91);<60岁患者的糖尿病筛查利用率低于≥70岁患者(OR=2.70,95%CI:1.08~6.76),体检知晓率低于60~<70岁患者(OR=4.24,95%CI:1.01~17.75);重庆市患者的高血压体检知晓率高于贵州省(OR=0.15,95%CI:0.04~0.54),利用情况好于贵州省(OR=0.13,95%CI:0.05~0.34)。访谈结果发现,部分社区未开展分类干预项目,农村患者的满意度高于城市。结论重庆市和贵州省NCD管理服务总体情况较好,但随访和分类干预项目服务质量有待进一步提高。

关键词：基本公共卫生服务慢性非传染性疾病健康管理相关因素

维普期刊数据库博看期刊

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大数据资源规划研究框架的构建

图书情报知识 2017年第4期34卷 59-70页

作者：周耀林赵跃 zhou jiani 武汉大学信息资源研究中心武汉430072 MSc UZH ETH in Quantitative Finance University of Zurich

大数据资源规划是组织和国家管理大数据资源初期解决"如何开始,从哪里开始"的关键环节。基于对国内外大数据资源规划研究进展的系统梳理,本文从实践视角和理论视角对大数据资源规划研究进行了科学定位,并结合战略规划理论与信息资源规... 详细信息

大数据资源规划是组织和国家管理大数据资源初期解决"如何开始,从哪里开始"的关键环节。基于对国内外大数据资源规划研究进展的系统梳理,本文从实践视角和理论视角对大数据资源规划研究进行了科学定位,并结合战略规划理论与信息资源规划理论,从宏观、中观和微观三个层面构建了大数据资源规划的研究框架。通过研究,得出如下结论:(1)大数据应用尚处在起步阶段,在此阶段研究大数据资源规划具有现实意义;(2)国内外学者已经着手研究大数据资源管理与规划,但研究视角有所差异,研究内容尚未系统化;(3)大数据资源、大数据资源管理需要从广义和狭义明晰地界定;(4)战略规划与信息资源规划理论都经历一个从微观到宏观的发展历程,为大数据资源规划研究提供了理论参考;(5)需要从国家、领域、组织三个视角构建大数据资源规划的研究框架,探索其研究的共性与个性问题。

关键词：大数据资源大数据管理战略规划信息资源规划大数据资源规划

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奇异线性二次最优控制的线性迭代计算方法

同济大学学报（自然科学版） 2013年第4期41卷 637-640页

作者：周佳妮朱经浩同济大学数学系上海200092

利用经典线性二次最优控制的Riccati方程的线性迭代法研究一类奇异线性二次最优控制问题.对于线性迭代序列的收敛性进行了分析并且给出了算法.该算法通过3个例子得到验证.

关键词：奇异线性二次最优控制经典线性二次最优控制 Riccati矩阵微分方程

Distribution and sources of sedimentary organic matter in different aquaculture areas of northeastern Zhanjiang Bay using stable carbon and nitrogen isotopes

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Acta Oceanologica Sinica 2024年第6期43卷 38-48页

作者： Fengxia zhou Shuangling Wang Han Fang jiani He Liang Ye Zhaohai Ding Cuiting Li Fajin Chen Xuan Lu Chunqing Chen Yafei Meng College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China Key Laboratory for Coastal Ocean Variation and Disaster Prediction Guangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea of Department of Education of Guangdong ProvinceGuangdong Ocean UniversityZhanjiang 524088China

Zhanjiang Bay is a major aquaculture area in China with many types of mariculture products(such as oysters,fish,and shrimp).The culture area and shrimp output in Zhanjiang Bay are ranked first in *** investigated the total organic carbon(TOC),total nitrogen(TN),TOC/TN ratio,and stable isotopes(δ^(13)C and δ^(15)N) of the fish and shrimp feed,fish and shrimp feces,and sedimentary organic matter(SOM) in and around different aquaculture areas of northeastern Zhanjiang B ay to study the impact of aquaculture activities on *** average TOC contents of fish and shrimp feed were 39.20%±0.91% and 39.29%±0.21%,*** average TOC content in the surface sediments of the oyster culture area,the mixed(fish and shrimp) culture area,and the cage fish farm area were 0.66%,0.88%±0.10%,and 0.58%±0.19%,respectively,which may indicate that mixed culture had a greater impact on *** relatively high TOC and TN contents and relatively low TOC/TN ratios,and δ^(15)N values in the upper layer of the core sediment in the mixed culture area could also support the significant influence of mixed *** average δ^(13)C and δ^(15)N values of fish and shrimp feed were -20.6‰±2.2‰ and 1.8‰±1.2‰,respectively,which were different from the isotopic values of SOM in the study area.δ^(13)C and δ^(15)N values for SOM in different aquaculture areas were different from those of nearby reference stations,probably reflecting the influence of *** δ^(13)C and δ^(15)N values in the oyster culture area(-25.9‰ and6.0‰,respectively) seemed to have reduced δ^(13)C and enriched δ^(15)N relative to those of the reference station(-24.6‰ and 5.8‰,respectively).This may reflect the influence of organic matter on oyster *** δ^(15)N value of the station in the mixed culture area(7.1‰±0.4‰) seemed to be relatively enriched in δ^(15)N relative to that of the reference station(6.6‰).Sedimentation and the subsequent degradation of organic matter from mixed cultures may have contrib

关键词： sedimentary organic matter aquaculture stable isotopes sources Zhanjiang Bay

Study of Inhibitory Effects of Quercetin and its Major Metabolite Q3GA on Human UDP-glucuronosyltransferase 1A Isoforms by Liquid Chromatography-tandem Mass Spectrometry

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Study of Inhibitory Effects of Quercetin and its Major Metab...