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Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among People Living With HIV: A Cross-sectional Study in Southern China

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Infectious Microbes & Diseases 2024年第1期6卷 11-19页

作者： Zhaomin Deng Minjuan Shi Yue yuan GuangjinCao Chunyan Wen Lijuan Chen Xueying Fan Linan Wu jianhui yuan Huachun Zou Linghua Li Caijun Sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Department of Diseases Control Panyu District Center for Disease Control and PreventionGuangzhouChina Infectious Disease Center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Nanshan District Center for Disease Control and Prevention ShenzhenChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina

HIV remains a global health challenge,and research efforts directed towards a functional cure require people living with HIV(PLHIV)in-volvement in clinical *** study assessed willingness to participate in HIV functional cure–related clinical trials and associated factors among PLHIV in Guangzhou,China,using a questionnaire survey *** analyzed responses from 718 questionnaires,finding that 71.2%were willing to participate in Phase Ⅲtrials,while 51.7%were willing to participate in Phase I trials and 42.9%expressed acceptability for analytic treatment *** logistic regression demonstrated that male PLHIV,those with awareness of functional cure,and PLHIV,who had been on antiretroviral therapy(ART)for less than 1 year,were more willing to partic-ipate in Phase Ⅲ*** with a body mass index greater than 24,and those without resistance to ART drug were more willing to participate in Phase I *** major motivations for participation in Phase Ⅲtrials were access to cutting-edge treatments(62.6%)and supporting research(55.3%).Safety was the main concern contributing to *** study revealed a high willingness to participate in HIV functional cure–related trials among PLHIV in Guangzhou,China,and willingness varied across different trial phases and was influenced by multiple *** study provides valuable references for future clinical trial recruitment strategies and public health policy formulation.

关键词： people living with HIV functional cure clinical trials willingness

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山西省东南部地区机构养老人群高钾血症患病率及影响因素

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中华疾病控制杂志 2024年第4期28卷 486-489页

作者：段培芬原建慧韩艳波翟艳丽冯向先长治医学院公共卫生与预防医学系长治046000

目的了解山西省东南部地区机构养老人群高钾血症的患病率及影响因素。方法采用随机整群抽样方法于2017年9―11月选取山西省东南部地区16家养老机构人群进行问卷调查,并采集外周血进行实验室检查。采用logistic回归分析模型分析高钾血症... 详细信息

目的了解山西省东南部地区机构养老人群高钾血症的患病率及影响因素。方法采用随机整群抽样方法于2017年9―11月选取山西省东南部地区16家养老机构人群进行问卷调查,并采集外周血进行实验室检查。采用logistic回归分析模型分析高钾血症的影响因素。结果共纳入研究对象523人,平均年龄为(66.20±8.61)岁;平均血钾浓度为(4.50±0.45)mmol/L,高钾血症(血钾>5.0 mmol/L)患病率为13.95%(95%CI:11.02%~16.93%)。Logistic回归分析模型分析结果显示随着肾小球滤过率(estimated glomerular filtration rate,eGFR)的降低,高钾血症发生风险升高(χ^(2)=8.189,P=0.017),与eGFR>90 mL/(min·1.73m2)相比,60~90 mL/(min·1.73m2)与<60 mL/(min·1.73m2)高钾血症发生风险分别为4.11倍(OR=4.11,95%CI:1.06~16.01,P=0.042)和6.04倍(OR=6.04,95%CI:1.64~22.17,P=0.007)。结论山西省东南部地区机构养老人群中高钾血症患病率较高,eGFR低水平为高钾血症发生的危险因素。

关键词：高钾血症患病率影响因素

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丁苯酞胶囊联合针刺对缺血性脑卒中后血管性痴呆患者认知功能及脑血流动力学状态的影响

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中国药物与临床 2024年第14期24卷 895-900页

作者：陈顺喜沈涌刘菲菲袁健辉杭州市中医院针灸康复科浙江杭州310007 杭州市中医院神经内科浙江杭州310007 杭州市中医院干部保健办公室浙江杭州310007

目的探究丁苯酞胶囊联合针刺在缺血性脑卒中后血管性痴呆患者中的应用效果及对脑血流动力学状态及认知功能的影响。方法收集2021年3月至2023年12月于杭州市中医院就诊的缺血性脑卒中后血管性痴呆患者作为研究对象,按照不同治疗方式分为... 详细信息

目的探究丁苯酞胶囊联合针刺在缺血性脑卒中后血管性痴呆患者中的应用效果及对脑血流动力学状态及认知功能的影响。方法收集2021年3月至2023年12月于杭州市中医院就诊的缺血性脑卒中后血管性痴呆患者作为研究对象,按照不同治疗方式分为对照组(52例,行常规治疗+针刺治疗)和联合组(48例,在对照组的基础上联合丁苯酞胶囊治疗)。观察比较2组患者临床疗效、血流动力学状态[大脑中动脉血流速度(Vm)、阻力指数(RI)、脉动指数(PI)]、血清相关指标[血清降钙素基因相关肽(CGRP)、血管内皮素(ET)、缺氧诱导因子-1α(HIF-1α)]、蒙特利尔认知评估量表(MoCA)评分、生活能力量表(ADL)评分以及不良反应发生情况。结果联合组治疗总有效率为95.8%,高于对照组的82.7%(χ^(2)=4.403,P=0.036);治疗后,2组患者的MMSE评分、MoCA评分均有所升高,联合组MMSE评分、MoCA评分分别为(29.0±1.0)分、(25.9±1.0)分,均高于对照组的(27.7±1.1)分、(23.1±1.2)分(t=5.950、12.442,P<0.001);治疗后2组患者的血清相关指标均有所变化,联合组CGRP为(31±6)ng/L,高于对照组的(29±6)ng/L(t=2.266,P=0.026),联合组ET、HIF-1α分别为[(69±7)pg/ml、(254±45)pg/ml],均低于对照组的[(73±7)pg/ml、(288±52)pg/ml](t=3.413、3.479,P=0.001、0.001);治疗后联合组Vm、RI、PI分别为[(19.8±1.6)cm/s、(1.59±0.19)、(0.71±0.21)],均低于对照组的[(19.2±1.3)cm/s、RI(1.74±0.23)、PI(0.78±0.11)](t=2.121、3.539、2.111,P=0.036、0.001、0.037);治疗后,联合组ADL评分为(27±6)分,低于对照组的(31±5)分(t=4.283,P<0.001);2组患者治疗期间的不良反应发生率差异无统计学意义(χ^(2)=2.211,P=0.137)。结论丁苯酞胶囊联合针刺应用于缺血性脑卒中后血管性痴呆患者效果显著,可改善患者脑缺血性及神经损伤情况,调节血流动力参数,提高患者认知水平及日常生活能力,安全可靠,有应用价值。

关键词：缺血性脑卒中血管性痴呆针刺丁苯酞胶囊脑血流动力学

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Effect of the contact distance on transport properties of an organic molecular device

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Chinese Science Bulletin 2007年第21期52卷 3016-3019页

作者： ZHANG ZhenHua YANG ZhongQin yuan jianhui QIU Ming School of Physics and Electronic Science Changsha University of Science and Technology Changsha 410076 China Surface Physics Laboratory (National Key Laboratory) Fudan University Shanghai 200433 China

Using a spatially symmetric phenyldithiolate molecule sandwiched between two gold electrodes as model system and through shifting one electrode from symmetric contact site to form asymmetric contact, we investigated the properties of electronic transport in such a device by the first-principles. It was found that the I(G )-V characteristics of a device show significant asymmetry and the magnitudes of current and conductance depend remarkably on the variation of molecule-metal distance at one of the two contacts. Namely, an asymmetric contact would lead to the weak rectifying effects on the cur- rent-voltage characteristics of a molecular device. The analysis shows that the HOMO is responsible for the resonant tunneling and its shift due to the charging of the device while the bias voltage is the intrinsic origin of asymmetric I(G)-V characteristics.

关键词：分子器件不对称触点电流电压

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麦粒灸配合头穴久留针对卒中恢复期非痴呆型认知障碍认知功能及血清标志物的影响

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上海针灸杂志 2024年第7期43卷 730-733页

作者：曾友华袁健辉逄锦熙周文姬包烨华杭州市中医院杭州310007

目的观察五脏俞麦粒灸配合头穴久留针治疗脑卒中恢复期非痴呆型认知障碍的临床疗效及其对血清标志物超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、同型半胱氨酸(homocysteine, Hcy)的影响。方法将78例脑卒中恢复期合并... 详细信息

目的观察五脏俞麦粒灸配合头穴久留针治疗脑卒中恢复期非痴呆型认知障碍的临床疗效及其对血清标志物超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、同型半胱氨酸(homocysteine, Hcy)的影响。方法将78例脑卒中恢复期合并蒙特利尔认知评估量表(Montreal cognitive assessment, MoCA)评分为18~26分的患者随机分成治疗组40例和对照组38例。治疗组以五脏俞麦粒灸配合头穴久留针治疗,对照组采用单纯头穴久留针治疗。观察两组治疗前后MoCA评分及血清标志物各项指标(hs-CRP、Hcy水平)的变化情况。结果两组治疗后Mo CA评分较同组治疗前均显著提高,血清hs-CRP、Hcy水平均显著降低,差异均具有统计学意义(P<0.05)。治疗组治疗后Mo CA评分明显高于对照组,血清hs-CRP水平明显低于对照组,差异均具有统计学意义(P<0.05)。结论五脏俞麦粒灸联合头穴久留针的综合疗法能改善脑卒中恢复期非痴呆型认知障碍患者的认知功能,有效降低血清Hcy、hs-CRP水平。

关键词：针灸疗法脑卒中认知障碍麦粒灸头皮针超敏C反应蛋白同型半胱氨酸

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俞募配穴联合脐针疗法治疗脑卒中后昼夜节律失调性睡眠-觉醒障碍的临床研究

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中国现代医生 2024年第7期62卷 30-33,79页

作者：曾友华周文姬逄锦熙袁健辉包烨华杭州市中医院针灸康复科浙江杭州310000

目的探讨俞募配穴联合脐针疗法治疗脑卒中后昼夜节律失调性睡眠-觉醒障碍(circadian rhythm sleep-wake disorder,CRSWD)的临床疗效。方法选取2020年5月至2022年8月就诊于杭州市中医院的脑卒中后CRSWD患者87例为研究对象,根据随机数字... 详细信息

目的探讨俞募配穴联合脐针疗法治疗脑卒中后昼夜节律失调性睡眠-觉醒障碍(circadian rhythm sleep-wake disorder,CRSWD)的临床疗效。方法选取2020年5月至2022年8月就诊于杭州市中医院的脑卒中后CRSWD患者87例为研究对象,根据随机数字表法将其分为治疗组(n=44)和对照组(n=43)。对照组患者予艾司唑仑片治疗,治疗组患者予俞募配穴联合脐针疗法治疗,观察两组患者治疗前、治疗5d、治疗2周的匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)和清晨型-夜晚型量表(morningness-eveningness questionnaire,MEQ)评分。结果两组患者的PSQI总分、PSQI-D、PSQI-G评分、MEQ评分以时点因素、时点与组别交互、组别为源的主体间效应比较,差异均有统计学意义(P<0.05);治疗2周后,治疗组患者的PSQI总分、PSQI-C、PSQI-D、PSQI-G评分均显著低于对照组,MEQ评分显著高于对照组(P<0.05)。结论俞募配穴联合脐针疗法治疗脑卒中后CRSWD可显著改善患者的睡眠质量,延长睡眠时间,改善日间功能状态,调整昼夜节律,有良好的临床疗效。

关键词：脑卒中睡眠障碍昼夜节律失调性睡眠-觉醒障碍针灸俞募配穴脐针疗法

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Effect of surface Nd-rich phase and oxygen content of melt-spun flakes on formation of coarse grains in hot-pressed Nd-Fe-B magnet

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Journal of Rare Earths 2021年第11期39卷 1389-1395,I0003页

作者： Yeyuan Du Wenzong Yin Renjie Chen Xu Tang Jinyun Ju Bin Chen Longquan Hou Aru Yan jianhui yuan School of Materials Engineering Shanghai Collaborative Innovation Center of Laser Advanced Manufacturing TechnologyShanghai University of Engineering ScienceShanghai 201620China Key Laboratory of Magnetic Materials and Devices.Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

Nd-Fe-B hot-pressed(HP) magnet prepared from melt-spun MQU-F flakes features coarse grains(CG)with the average size of both 200 nm(CGS) and 700 nm(CGL) at flake *** grain growth at the flake boundary of Nd2 Fe14B/α-Fe composite HP magnet before and after diffusion of low-melting-point Pr82Cu18 phase was investigated,revealing the indispensable role of surface RE-rich phase of meltspun flakes in the formation of CG in HP *** dominant role of surface oxygen content of melt-spun flakes in the formation of CGL has been clarified with etching *** HP magnet prepared from the etched flakes with dramatically decreased oxygen content exhibits the CG regions merely with homoge neous equiaxed CGS at flake ***,the coercivity(μ0 Hc) shows significant increase while remanent magnetization(μ0 Mr) inappreciable *** investigation with sieving method reveals the elimination of CGL via removal of the fine Nd-Fe-B flakes smaller than 54 μm due to their much higher oxygen content,confirming the dominant role of oxygen content in the formation of *** quantitative analysis on the magnetic properties of the above HP magnets reveals the monotonic increase of coercivity(μ0 Hc) and negligible change of remanent magnetization(μ0 Mr) with decreased oxygen contents of Nd-Fe-B *** maximum value of coercivity(μ0 Hc) increases from2.26 to 2.47 T as the oxygen content decreases from 0.1692 wt% to 0.079 wt%.

关键词： Coarse grain Hot pressing Nd-Fe-B Oxygen content Nd-rich phase Rare earths

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Synergistic enhancement of Ce-ZnO/g-C_(3)N_(4)photocatalytic performance using N,O-bis-vacancy induction and S-scheme heterojunctions

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Journal of Rare Earths 2024年第5期42卷 817-826,I0001页

作者： Guyu Zhang yuan Zhang Xinlei Zhao Yujiang Jiao Yumin Yan jianhui Jiang Engineering Laboratory of Chemical Resources Utilization in South Xinjiang of Xinjiang Production and Construction Corps College of Chemistry a Chemical EngineeringTarimUniversityAlar843300China

The photocatalytic decontamination of organic pollutants is an environmentally friendly and efficient water treatment *** introduction of vacancies,heterojunctions,and doping can enhance the performance of photocatalysts for such *** this study,N,O double-vacancy Ce-ZnO/g-C_(3)N_(4)S-scheme heterojunction photocatalysts were prepared,It is found that the electron separation and transfer efficiencies are considerably improved by the presence of nitrogen vacancies in graphitic ca rbon nitride(g-C_(3)N_(4))and oxygen vacancies in ZnO,in addition to the S-scheme heterojunction created between the two *** the degradation of methylene blue and ciprofloxacin,the degradation rates exhibited by Ce-ZnO/g-C_(3)N_(4)are significantly higher than those of the g=C_(3)N_(4)/ZnO *** remarkable photocatalytic performance of Ce-ZnO/g-C_(3)N_(4)may result from three key factors;(ⅰ)Ce doping,which produces impurity energy levels;(ⅱ)the generation of electron capture centres by the N and O vacancies;and(ⅲ)the synergistic effect of the S-type heterojunction formed at the interface between the two materials,This study therefore provides new approaches for the use of doping,vacancies,and heterojunctions to induce the efficient degradation of organic pollutants.

关键词： Photocatalysis Vacancy S-scheme Ce-ZnO/g-C_(3)N_(4) Degradation Rare earths

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Safety and Immunogenicity of SARS-CoV-2 Vaccines in People Living With HIV:A Systematic Review and Meta-analysis of Real-World Studies

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Infectious Microbes & Diseases 2023年第4期5卷 159-166页

作者： Xueying Fan Yangguo Zhao Fan Wu Yue yuan Bing Lang Di Yin Zhongliang Xu Shiqiang Jiang Huachun Zou jianhui yuan Caijun Sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Nanshan District Center for Disease Control and Prevention ShenzhenChina School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina

The safety and immunogenicity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines in people living with HIV(PLWH)in real-world studies remain ***,we conducted a comprehensive systematic review and meta-analysis to address this *** search were conducted from PubMed,Web of Science and *** events following vaccination,the risk ratio(RR)of SARS-CoV-2–specific IgG seroconversion and the level of anti–SARS-CoV-2 neutralizing antibodies were compared between the PLWH group and a healthy control group.A total of 10,582 PLWH from 22 studies were *** our analysis,the incidence of local or systemic adverse events after the first SARS-CoV-2 vaccine dose was not statistically different between PLWH and healthy ***,there was a statistical difference after the second dose(RR,0.83;95%CI,0.71–0.98).The seroconversion rate of SARS-CoV-2 IgGantibodies in PLWH was significantly lower than that in the healthy control group(RR,0.94;95%CI,0.89–0.98;I2=80%,P<0.01).The anti–SARS-CoV-2 neutralizing antibody titers in PLWH after full immunization were also significantly lower than those in the healthy control group(RR,0.91;95%CI,0.85–0.98;I2=81%,P<0.01).The safety and tolerance of COVID-19 vaccines in PLWHare ***,their immunogenicitymay be impaired to a certain extent,characterized by a lower IgGseroconversion rate and neutralizing antibody titers compared with healthy *** findings should provide guidance for optimizing future COVID-19 vaccination strategies among PLWH.

关键词： COVID-19 HIV immunogenicity safety vaccination meta-analysis

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HIV新近感染的检测技术现状及其在艾滋病防控中的作用

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中华实验和临床病毒学杂志 2024年第2期38卷 193-201页

作者：崔明婷李顺然王浩航袁建辉周毅孙彩军中山大学公共卫生学院(深圳) 深圳518107 深圳市南山区疾病预防控制中心深圳518054 珠海市疾病预防控制中心艾滋病防制所珠海519060 中山大学热带病防治研究教育部重点实验室广州510030

目前,艾滋病监测主要通过哨点监测和艾滋病病例报告系统来计算人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染率、艾滋病新报告病例数和HIV相关死亡率,以及开展全国性研究调查HIV耐药毒株特征,但这些措施不能估算HIV新近感染... 详细信息

目前,艾滋病监测主要通过哨点监测和艾滋病病例报告系统来计算人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染率、艾滋病新报告病例数和HIV相关死亡率,以及开展全国性研究调查HIV耐药毒株特征,但这些措施不能估算HIV新近感染率。HIV感染的病程隐蔽且具有长期潜伏感染的特性,急性期感染者难以被发现,常规监测手段难以确定感染者的感染时间,从而使得新近感染率的计算存在潜在偏倚,影响对疾病危险因素的深入探究以及评价干预措施的效果。近年来,使用HIV-1新近感染检测(test for recent infection,TRI)基于横断面样本估算HIV新近感染率已成为监测HIV传播、评估干预手段的重要方法之一,其可以将HIV-1感染者分为新近感染与长期感染,提高HIV新近感染率测量的准确性。TRI分为血清学检测与分子检测,其中血清学检测因其成本低、估算HIV新近感染率准确、发展历史较长而被广泛使用,近年来在准确度与简便性方面取得较大进展。本文通过对TRI的原理、准确度以及应用的介绍,系统综述TRI技术的最新研究进展及优缺点。

关键词：艾滋病人类免疫缺陷病毒新近感染新近感染检测

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