Safety and Immunogenicity of SARS-CoV-2 Vaccines in People Living With HIV:A Systematic Review and Meta-analysis of Real-World Studies
作者机构:School of Public Health(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Nanshan District Center for Disease Control and PreventionShenzhenChina School of Public Health(Shenzhen)Sun Yat-sen UniversityShenzhenChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University)Ministry of EducationGuangzhouChina
出 版 物:《Infectious Microbes & Diseases》 (感染微生物与疾病(英文))
年 卷 期:2023年第5卷第4期
页 面:159-166页
核心收录:
学科分类:0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金:supported by the National Natural Science Foundation of China(81971927) the National Key R&D Program of China(2022YFE0203100,2021YFC2300103) the Science and Technology Planning Project of Guangdong Province,China(2021B1212040017) the Science and Technology Planning Project of Shenzhen City(JCYJ20190807155009482,JSGG20200225152008136,JCYJ20200109142601702) the Sanming Project ofMedicine in Shenzhen Nanshan(No.SZSM202103008) the Key Subject of Nanshan district of Shenzhen for AIDS surveillance and prevention.The funders had no role in study design,data collection or analysis,decision to publish or preparation of the manuscript
主 题:COVID-19 HIV immunogenicity safety vaccination meta-analysis
摘 要:The safety and immunogenicity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines in people living with HIV(PLWH)in real-world studies remain ***,we conducted a comprehensive systematic review and meta-analysis to address this *** search were conducted from PubMed,Web of Science and *** events following vaccination,the risk ratio(RR)of SARS-CoV-2–specific IgG seroconversion and the level of anti–SARS-CoV-2 neutralizing antibodies were compared between the PLWH group and a healthy control group.A total of 10,582 PLWH from 22 studies were *** our analysis,the incidence of local or systemic adverse events after the first SARS-CoV-2 vaccine dose was not statistically different between PLWH and healthy ***,there was a statistical difference after the second dose(RR,0.83;95%CI,0.71–0.98).The seroconversion rate of SARS-CoV-2 IgGantibodies in PLWH was significantly lower than that in the healthy control group(RR,0.94;95%CI,0.89–0.98;I2=80%,P0.01).The anti–SARS-CoV-2 neutralizing antibody titers in PLWH after full immunization were also significantly lower than those in the healthy control group(RR,0.91;95%CI,0.85–0.98;I2=81%,P0.01).The safety and tolerance of COVID-19 vaccines in PLWHare ***,their immunogenicitymay be impaired to a certain extent,characterized by a lower IgGseroconversion rate and neutralizing antibody titers compared with healthy *** findings should provide guidance for optimizing future COVID-19 vaccination strategies among PLWH.