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Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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Genes & Diseases 2024年第2期11卷 535-538页

作者： Xi Kong peng Lu Jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie jianhua peng Ning Ma Yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

Crustal structure in the Anyuan Coal Mine and its adjacent areas of Jiangxi Province by P-wave receiver functions

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Earthquake Research Advances 2024年第1期4卷 47-58页

作者： Xingmian Zhang Meng Gong Jian Lü Hongxing Li Jie Hu Junwen He jianhua peng Bingyue Liu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang330013China Nanchang Key Laboratory of Intelligent Sensing Technology and Instruments for Geological Hazards East China University of TechnologyNanchang330013China Jiangxi Earthquake Agency Nanchang330026China East China University of Technology School of Geophysics and Measurement-Control TechnologyNanchang330013China Hunan Earthquake Agency Changsha410004China

We collected high-quality teleseismic events recorded by 12 broadband seismographs deployed in the Anyuan Coal Mine and its adjacent areas in Pingxiang City,Jiangxi Province for nearly two *** H-κ-c stacking method was employed to obtain the crustal thickness and Poisson's ratio distribution,then the characteristics of crustal structure below the stations were obtained by using the time-domain linear inversion *** crustal thickness in the Anyuan Coal Mine and its adjacent areas ranges from approximately 32~35 km,with an average thickness of 33 km,which is consistent with the crustal thickness results in South China from previous studies using the receiver function *** average Poisson's ratio of the crustal bulk composition in the study area varies between 0.22 and 0.25,which is lower than the global value with a 0.27 average,indicating a predominantly intermediate-acidic or felsic crustal *** is a weak negative correlation between Poisson's ratio and crustal thickness estimates in the Anyuan Coal Mine and its adjacent areas,suggesting that the absence of mafic-ultramafic materials in the lower crust is associated with the process of crustal *** velocity inversion results indicate that the crustal structure including three velocity discontinuity interfaces,with the first at a depth of approximately 1.5 km,the second at about 10~15 km,and the third being the *** study also indicates that the results obtained by the H-κ-c stacking method are significantly better than those obtained by the H-κmethod,effectively reducing the standard deviation and dispersion of crustal thickness and vP/vSratio.

关键词： Anyuan Coal Mine Receiver function H-κ-c stacking Crustal thickness Poisson's ratio

A Review on the Classification and Grading Criteria of Road Transport Natural Disasters

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Journal of Architectural Research and Development 2018年第5期2卷 10-12页

作者： Yizhou Jiang jianhua peng Wenwen Feng China Academy of Transportation Sciences Beijing 100029China

This review summarizes and analyzes the basic information of various types of road transport natural disaster emergencies,refers to various types of road transport emergency plans,and combines the actual needs of road transport emergency rescue with national emergency related *** also proposes the classification criteria and grading standard for the emergencies of road transport natural disasters based on the classification and grading standard of the regulations,which provide a basis to take reasonable and effective disposal measures in the emergency response of road transport emergencies under natural disaster conditions.

关键词： road transport emergencies classification criteria grading standard natural disasters

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我国4种运输方式安全生产水平比较研究

中国安全科学学报 2019年第10期29卷 135-140页

作者：彭建华交通运输部科学研究院交通运输安全研究中心北京100029

为全面掌握我国交通运输安全生产整体现状,促进我国综合运输体系安全协调发展,分析我国铁路、道路、水路和航空等4种运输方式的安全生产水平。采用比较研究法,从事故总量、事故率、重特大及较大事故情况以及国际比较等4个维度,对我国4... 详细信息

为全面掌握我国交通运输安全生产整体现状,促进我国综合运输体系安全协调发展,分析我国铁路、道路、水路和航空等4种运输方式的安全生产水平。采用比较研究法,从事故总量、事故率、重特大及较大事故情况以及国际比较等4个维度,对我国4种运输方式的安全生产水平进行全方位比较。结果表明:4种运输方式安全生产水平存在较为明显的差异性。从事故总量和事故率指标来看,从高到低依次是道路运输、铁路运输、水路运输和航空运输;从重特大及较大事故情况来看,从高到低依次是道路运输、水路运输、铁路运输和航空运输;从国际来看,我国铁路运输安全状况与发达国家基本在同一水平,道路运输安全状况与发达国家相比有较大差距,水路运输安全状况与发达国家相比有一定差距,航空运输安全状况明显优于世界平均水平,也优于发达国家水平。

关键词：铁路运输道路运输水路运输航空运输安全生产水平事故比较

Apolipoprotein E-mimetic peptide COG1410 enhances retinal ganglion cell survival and vision restoration by reducing inflammation and apoptosis in a mouse model of traumatic optic nerve injury

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Apolipoprotein E-mimetic peptide COG1410 enhances retinal ga...

基于Lyapunov优化的隐私感知计算卸载方法

第十四届中国医师协会神经外科医师年会

作者： jianhua peng Jinwei Pang Yong Jiang Department of Neurosurgery the Affiliated Hospital of Southwest Medical University

Vision loss after traumatic optic nerve injury（TONI） is considered irreversible because of the retrograde loss of retinal ganglion cells（RGCs）, which undergo inflammation and apoptosis. Previous studies have shown that COG1410, a mimic peptide derived from the apolipoprotein E（apoE） receptor binding region, shows neuroprotective activity in acute brain injury. However, the detailed role and mechanisms of COG1410 in RGC survival and vision restoration after TONI are poorly understood. The current study aimed to investigate the effects of COG1410 on inflammation and apoptosis in a mouse model of TONI. The results showed that TONI-induced visual impairment was accompanied by optic nerve inflammation, apoptosis, edema and RGC loss. COG1410 significantly improved visual function, suppressed inflammation and apoptosis, and reduced optic nerve edema and RGC loss compared with vehicle treatment. These data identify protective roles of COG1410 in the inflammatory and apoptotic processes of TONI, as well as strategies for its treatment.

关键词： traumatic optic nerve injury inflammation,apoptosis COG1410

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电子与信息学报 2020年第3期42卷 704-711页

作者：赵星彭建华游伟国家数字交换系统工程技术研究中心

移动边缘计算(MEC)中计算卸载决策可能暴露用户特征,导致用户被锁定。针对此问题,该文提出一种基于Lyapunov优化的隐私感知计算卸载方法。首先,该方法定义卸载任务中的隐私量,并引入隐私限制使各MEC节点上卸载任务的累积隐私量尽可能小... 详细信息

移动边缘计算(MEC)中计算卸载决策可能暴露用户特征,导致用户被锁定。针对此问题,该文提出一种基于Lyapunov优化的隐私感知计算卸载方法。首先,该方法定义卸载任务中的隐私量,并引入隐私限制使各MEC节点上卸载任务的累积隐私量尽可能小;然后,提出假任务机制权衡终端能耗和隐私保护的关系,当系统因隐私限制无法正常执行计算卸载时,在MEC节点生成虚假的卸载任务以降低累积隐私量;最后,建立隐私感知计算卸载模型,并基于Lyapunov优化原理求解。仿真结果表明,基于Lyapunov优化的隐私感知卸载算法(LPOA)能使用户的累积隐私量稳定在0附近,且总卸载频率与不考虑隐私的决策一致,有效保护了用户隐私,同时保持了较低的平均能耗。

关键词：移动边缘计算计算卸载卸载决策隐私保护 Lyapunov优化

XPS Investigation of Segregation of Sb in SnO_2 Powders

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Journal of Wuhan University of Technology(Materials Science) 2008年第1期23卷 95-99页

作者：王剑华 peng Guanghuai GUO Yuzhong YANG Xikun Key Lab of Advanced Material of Yunnan Kunming University of Science ＆ Technology Kunming 650093 China Normal College of Gannan Ganzhou 341000 China

Antimony doped tin-oxide powders were prepared by controlled precipitation. Surface compositions were determined by X-ray photoelectron spectroscopy （XPS）. The results indicate that enrichment of dopant at the surface of nanoparticles depends on total doping concentration and annealing temperature. Doped antimony shows the tendency to diffuse to surface when annealing at high temperatures. But same amount of Sb atoms are retained on the surface for powders annealing at different temperatures. The higher enrichment at higher temperature is caused by the decreasing of surface areas. Variation of the conductivities of SnO2 powders is also discussed.

关键词： tin-oxide XPS nanoparticles surface segregation

Expression profiles of circRNAs and mRNAs in early brain injury following experimental subarachnoid hemorrhage

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Expression profiles of circRNAs and mRNAs in early brain inj...

Operable Breast Cancer： a Clinical Analysis of 6,263 Cases

第十四届中国医师协会神经外科医师年会

作者： jianhua peng Jinwei Pang Ligang Chen Yong Jiang

Circular RNAs（circRNAs） are a special novel type of a stable, diverse and conserved noncoding RNA in the mammalian brain, well conserved in sequence and involved in many nervous system diseases. This study aims to reveal the expression profiles of circRNAs and mRNAs in subarachnoid hemorrhage（SAH） brain tissue of mice by high-throughput sequencing. Male C57BL/6J mice were used to construct the SAH model. At 24 h post-SAH, the cortex around perforation site was collected. The total RNA was extracted to construct the cDNA library. High-throughput sequencing and bioinformatics analysis were carried out. The results showed that a total of 26 circRNA transcripts and 804 mRNA transcripts were aberrantly expressed after SAH. RT-qPCR further validated the gene expression. Bioinformatics predicted that these 26 circRNAs contain binding sites for many microRNA. Gene ontology（GO） enrichment and Kyoto Encyclopedia of Genes and genomes（KEGG） analysis showed that most mRNAs originated from the parent genes of circRNAs are involved in axon guidance, inflammatory and immune response, protein binding and other pathophysiological process. In conclusion, in mice with SAH, the circRNA profile in brain tissue differs markedly from that in normal brains. These changes could be associated to the possible functional implication to post-SAH pathophysiology.

关键词： subarachnoid hemorrhage early brain injury circRNA high-throughput sequencing

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Chinese Journal of Clinical Oncology 2005年第5期2卷 761-766页

作者： Mingtian Yang Tiehua Rong Zhifan Huang Changuang Zeng Hao Long jianhua Fu peng Lin Xin Wang Siyu Wang Xi Wang Jun Tang Department of Thoracic Oncology Cancer Center Sun Yat-sen UniversityGuangzhou 510060 China.

OBJECTIVE In Europe and America breast cancer commonly occurs in women of middle and old age, with a median age of about 57 years. Modified radical mastectomy now called standard radical mastectomy, has taken the place of traditional radical mastectomy. Patients with breast cancer at an early stage commonly receive BCT （breast conservative therapy）. The TNM stage （especially the lymph node status） affects the prognosis, and adjuvant therapy can improve survival. In China, only a few reports have been published studying large numbers of breast cancer patients. This study was designed to analyze the clinical features, surgical pattern and treatment outcome of resectable breast cancer, as well as to explore the prognostic factors and the effect of adjuvant therapy, with a goal to improve the level of diagnosis and treatment. METHODS Records of the 6,263 patients with resectable breast cancer who had been admitted into our hospital from June 1964 to June 2003 were analyzed retrospectively. RESULTS Of the 6,263 cases, 98.8% were female. Breast cancer occurred most frequently in patients of ages 40-49 years （41.0%）, especially in patients 45-49 years old （25.2%）. A breast lump, which occurred in 96.2% of the patients, was the main clinical manifestation. The overall 5- and 10-year survival rates were 75.16% and 40.44%. Of the patients in TNM stages 0-1, Ⅱ, and Ⅲ, the 5-year survival rates were 96.8%, 73.7% and 46.4% respectively and the 10-year survival rates were 78.7%, 64.6% and 33.5% respectively. The 5-, and 10-year survival rates were higher in the lymph node negative group than in the lymph node positive group （80.3% vs. 55.6%, and 59.2% vs. 31.9%, P〈0.01）. Since the 1980s there was no significant difference in survival rates of patients who received a radical mastectomy compared to a modified radical mastectomy（P〉0.05）. Of the 73 patients who underwent breast conservative therapy, no local recurrence or metastasis occurred during a maximal follow-up of 17 years. Of

关键词： breast neoplasms surgery adjuvant therapy prognosis.