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iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage induced by reducing dietary loading

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Frontiers of Medicine 2017年第1期11卷 97-109页

作者： liting jiang Yinyin Xie li Wei Qi Zhou ning li Xinquan jiang Yiming Gao Department of Stomatology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Prosthodontics Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai 200011 China State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Shanghai Institute of Traumatology and Orthopedics Shanghai 200025 China

As muscle activity during growth is considerably important for mandible quality and morphology, reducing dietary loading directly influences the development and metabolic activity of mandibular condylar cartilage （MCC）. However, an overall investigation of changes in the protein composition of MCC has not been fully described in literature. To study the protein expression and putative signaling in vivo, we evaluated the structural changes of MCC and differentially expressed proteins induced by reducing functional loading in rat MCC at developmental stages. Isobaric tag for relative and absolute quantitation-based 2D nano-high performance liquid chromatography （HPLC） and matrix-assisted laser desorption/ionization time-of-flight/ time-of-flight （MALDI-TOF/TOF） technologies were used. Global protein profiling, KEGG and PANTHER pathways, and functional categories were analyzed. Consequently, histological and tartrate-resistant acid phosphatase staining indicated the altered histological structure of condylar cartilage and increased bone remodeling activity in hard-diet group. A total of 805 differentially expressed proteins were then identified. GO analysis revealed a significant number of proteins involved in the metabolic process, cellular process, biological regulation, localization, developmental process, and response to stimulus. KEGG pathway analysis also suggested that these proteins participated in various signaling pathways, including calcium signaling pathway, gap junction, ErbB signaling pathway, and mitogen-activated protein kinase signaling pathway. Collagen types I and II were further validated by immunohistochemical staining and Western blot analysis. Taken together, the present study provides an insight into the molecular mechanism of regulating condylar growth and remodeling induced by reducing dietary loading at the protein level.

关键词： condylar cartilage mechanical loading proteomic analysis iTRAQ bioinformatics analysis

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The response of intestinal stem cells and epithelium after alemtuzumab administration

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Cellular & Molecular Immunology 2011年第4期8卷 325-332页

作者： Qiurong li Qiang Zhang Chenyang Wang Shaojun jiang ning li Jieshou li Department of Surgery Jinling HospitalNanjing University School of MedicineNanjingChina Department of Pathology Jinling HospitalNanjingChina

Qiurong li1,Qiang Zhang1,Chenyang Wang1,Shaojun jiang2,ning li1,Jieshou li1 Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue *** is a humanized anti-CD52 lymphocytic antibody that is increasingly being used to induce immunosuppression;intestinal barrier function is impaired during treatment with *** investigated the response of intestinal stem cells to epithelial damage resulting from alemtuzumab *** epithelial cell loss and abnormal Paneth cell morphology were found following a single dose of *** animals receiving alemtuzumab exhibited increased apoptosis in the villi 3 days after alemtuzumab treatment and in the crypt on day 9,but apoptosis was scarce on day *** assessed expression of Musashi-1-and Lgr5-positive stem cells following alemtuzumab *** numbers of cells staining positive for both Musashi-1 and Lgr5 were found in the stem cell zone after alemtuzumab treatment for 3 and 9 *** data indicated that the epithelial cells were injured following alemtuzumab treatment,with the associated expansion of intestinal stem *** alemtuzumab treatment for 35 days,the numbers of intestinal epithelial cells and intestinal stem cells returned to *** study suggests that alemtuzumab treatment induced the increase in stem cells,resulting in the availability of more enterocytes for repair.

关键词： alemtuzumab intestinal stem cells intestinal stem cell marker Musashi-1 Lgr5

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正畸牵引向移动龈下残根的临床应用

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北京口腔医学 2012年第3期20卷 164-166页

作者：张宝茹李江宁邹石泉范亚贤首都医科大学口腔医学院口腔正畸科首都医科大学口腔医学院口腔修复科首都医科大学口腔医学院牙周科

目的探讨一种采用正畸方法向牵引龈下牙根后再修复的方法。方法选择龈下牙折患者8名,共10颗患牙,断端最低处距牙槽嵴顶的距离为1.5～2.0mm。经完善的根管治疗4周后,采用正畸固定矫治技术向牵引龈下牙根,平均疗程4～6个月,然后桩冠... 详细信息

目的探讨一种采用正畸方法向牵引龈下牙根后再修复的方法。方法选择龈下牙折患者8名,共10颗患牙,断端最低处距牙槽嵴顶的距离为1.5～2.0mm。经完善的根管治疗4周后,采用正畸固定矫治技术向牵引龈下牙根,平均疗程4～6个月,然后桩冠修复治疗。采用临床检查评价正畸前后牙齿松动度、牙龈形态和牙周状况,并通过X线片测量比较正畸前后断根根尖区相对骨密度的变化、断根倾斜度的变化和修复后冠根比。结果 10颗患牙经正畸治疗后向移动距离平均为3.99 mm,牵引后的牙根唇倾度减小,但与治疗前比较无统计学意义(P>0.05)。修复后患牙冠根比与对侧同名牙相比无统计学差异(P>0.05)。结论对于伤及牙槽嵴顶下的前牙牙根,在一定条件下可通过正畸方法向牵引龈下牙根,经修复治疗后,可达到美观和功能的效果。

关键词：正畸 向牵引龈下牙根

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姜黄素对甲醛致A549细胞氧化损伤拮抗作用

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中国公共卫生 2012年第4期28卷 491-492页

作者：陈鑫江中发李宁石玉琴隋妍张本延武汉科技大学医学院预防医学系湖北武汉430065 湖北省疾病预防控制中心

目的探讨姜黄素对甲醛致细胞氧化损伤的拮抗效应。方法采用A549细胞株作为实验材料,实验设对照组、0.1 mmol/L甲醛染毒组,姜黄素组(0.1 mmol/L甲醛+2.5～20.0 mg/L姜黄素),检测A549细胞中一氧化氮合酶(NOS),丙二醛(MDA),超氧化物歧化酶(... 详细信息

目的探讨姜黄素对甲醛致细胞氧化损伤的拮抗效应。方法采用A549细胞株作为实验材料,实验设对照组、0.1 mmol/L甲醛染毒组,姜黄素组(0.1 mmol/L甲醛+2.5～20.0 mg/L姜黄素),检测A549细胞中一氧化氮合酶(NOS),丙二醛(MDA),超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-Px)活性。结果甲醛染毒组A549细胞SOD、NOS和GSH-Px活性分别为(21.79±1.13)、(1.88±0.16)与(27.83±0.2)U/mgprot,与对照组比较,SOD、NOS和GSH-Px活性明显下降(P0.05)。结论姜黄素可提高A549细胞抗氧化酶活性,并存在剂量效应关系。

关键词：甲醛姜黄素氧化损伤拮抗作用

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Flower-like NiCo_(2)S_(4)/NiFeP/NF composite material as an effective electrocatalyst with high overall water splitting performance

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Chinese Chemical Letters 2022年第9期33卷 4367-4374页

作者： Jing jiang Fengyan li Hui Su Yangqin Gao ning li Lei Ge State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum BeijingBeijing 102249China Department of Materials Science and Engineering College of New Energy and MaterialsChina University of Petroleum BeijingBeijing 102249China

Rational design and building of high efficiency,secure and inexpensive electrocatalyst is a pressing demand and performance to promote sustainable improvement of hydrogen *** bifunctional electrocatalysts for oxygen evolution reaction(OER)and hydrogen evolution response(HER)with high catalytic performance and steadiness in the equal electrolyte are extra treasured and ***,a unique three-dimensional(3D)structure electrocatalyst for NiCo_(2)S_(4)growing on the flower-like NiFeP was designed and synthesized in this *** results show that the flower-like NiCo_(2)S_(4)/NiFeP/NF composite electrocatalyst has large specific surface area,appropriate electrical conductivity,and greater lively websites uncovered in the three-dimensional structure,and affords extraordinary electrocatalytic overall performance for the ordinary water *** alkaline solution,the OER and HER overpotentials of NiCo_(2)S_(4)/NiFeP/NF only need 293 mV and 205 mV overpotential to provide the current densities of 100 mA/cm^(2)and 50 mA/cm^(2),*** high electrocatalytic activity exceeds the catalytic activity of most nickel-iron based electrocatalysts for OER and HER ***,the optimized NiCo_(2)S_(4)/NiFeP/NF sample has higher stability(24 h)at 1.560 and 10 mA/cm^(2),which extensively speeds up the overall water splitting *** view of the above performance,this work offers a fine approach for the further improvement of low fee and excessive effectivity electrocatalyst.

关键词： NiCo_(2)S_(4) Electrocatalyst NiFeP Hydrogen evolution reaction Water splitting

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Sensing Matrix Optimization for Multi-Target Localization Using Compressed Sensing in Wireless Sensor Network

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China Communications 2022年第3期19卷 230-244页

作者： Xinhua jiang ning li Yan Guo Jie liu Cong Wang College of Communications Engineering Army Engineering UniversityNanjing 210007China College of Field Engineering Army Engineering UniversityNanjing 210007China

In the multi-target localization based on Compressed Sensing(CS),the sensing matrix's characteristic is significant to the localization *** improve the CS-based localization approach's performance,we propose a sensing matrix optimization method in this paper,which considers the optimization under the guidance of the t%-averaged mutual ***,we study sensing matrix optimization and model it as a constrained combinatorial optimization ***,the t%-averaged mutual coherence is adopted as the optimality index to evaluate the quality of different sensing matrixes,where the threshold t is derived through the K-means *** the settled optimality index,a hybrid metaheuristic algorithm named Genetic Algorithm-Tabu Local Search(GA-TLS)is proposed to address the combinatorial optimization problem to obtain the final optimized sensing *** simulation results reveal that the CS localization approaches using different recovery algorithms benefit from the proposed sensing matrix optimization method,with much less localization error compared to the traditional sensing matrix optimization methods.

关键词： compressed sensing hybrid metaheuristic K-means clustering multi-target localization t%-averaged mutual coherence sensing matrix optimization

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Simultaneous Feammox and anammox process facilitated by activated carbon as an electron shuttle for autotrophic biological nitrogen removal

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Frontiers of Environmental Science & Engineering 2022年第7期16卷 87-99页

作者： Yingbin Hu ning li Jin jiang Yanbin Xu Xiaonan Luo Jie Cao Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou510006China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou510006China

Ferric iron reduction coupled with anaerobic ammonium oxidation(Feammox)is a novel ferric-dependent autotrophic process for biological nitrogen removal(BNR)that has attracted increasing attention due to its low organic carbon ***,extracellular electron transfer limits the nitrogen transformation *** this study,activated carbon(AC)was used as an electron shuttle and added into an integrated autotrophic BNR system consisting of Feammox and anammox *** nitrogen removal performance,nitrogen transformation pathways and microbial communities were investigated during 194 days of *** the stable operational period(days 126–194),the total nitrogen(TN)removal efficiency reached 82.9%±6.8%with a nitrogen removal rate of 0.46±0.04 kg-TN/m^(3)/*** contributions of the Feammox,anammox and heterotrophic denitrification pathways to TN loss accounted for 7.5%,89.5%and 3.0%,*** experiments showed that AC was more effective in accelerating the Feammox rate than the anammox rate.X-ray photoelectron spectroscopy(XPS)analyses showed the presence of ferric iron(Fe(III))and ferrous iron(Fe(II))in secondary minerals.X-ray diffraction(XRD)patterns indicated that secondary iron species were formed on the surface of iron-AC carrier(Fe/AC),and Fe(III)was primarily reduced by ammonium in the Feammox *** phyla Anaerolineaceae(0.542%)and Candidatus Magasanikbacteria(0.147%)might contribute to the Feammox process,and Candidatus Jettenia(2.10%)and Candidatus Brocadia(1.18%)were the dominative anammox phyla in the ***,the addition of AC provided an effective way to enhance the autotrophic BNR process by integrating Feammox and anammox.

关键词： Feammox Anammox Extracellular electron transfer Electron shuttle Activated carbon

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New process development and process evaluation for capturing CO2 in flue gas from power plants using ionic liquid[emim][Tf2N]

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Chinese Journal of Chemical Engineering 2020年第3期28卷 721-732页

作者： Lan li Xiaoting Huang Quanda jiang Luyue Xia Jiawei Wang ning Ai College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Province Key Laboratory of Biomass Fuel Hangzhou 310014China Biodiesel Laboratory of China Petroleum and Chemical Industry Federation Hangzhou 310014China Zhejiang Supcon Software Co. LtdHangzhou 310014China School of Engineering&Applied Science Aston UniversityBirmingham B47ETW MidlandsEnglandUK

Using the ionic liquid[emim][Tf2N]as a physical solvent,it was found by Aspen Plus simulation that it was possible to attempt to capture CO2 from the flue gas discharged from the coal-fired unit of the power *** the combination of model calculation and experimental determination,the density,isostatic heat capacity,viscosity,vapor pressure,thermal conductivity,surface tension and solubility of[emim][Tf2N]were *** on the NRTL model,the Henry coefficient and NRTL binary interaction parameters of CO2 dissolved in[emim][Tf2N]were obtained by correlating[emim][Tf2N]with the gas–liquid equilibrium data of ***,the calculated relevant data is imported into Aspen Plus,and the whole process model of the ionic liquid absorption process is *** the absorption process is optimized according to the temperature distribution in the absorption tower to obtain a new absorption ***,the density,constant pressure heat capacity,surface tension,thermal conductivity,and viscosity of[emim][Tf2N]were changed to investigate the effect of ionic liquid properties on process energy consumption,solvent circulation and heat exchanger *** results showed that based on the composition of the inlet gas stream to the absorbers,CO2 with a capture rate of 90%and a mass purity higher than 99.5%was *** results indicate that the[emim][Tf2N]could be used as a physical solvent for CO2 capture from coal-fired *** addition,the results will provide a theoretical basis for the design of new ionic liquids for CO2 capture.

关键词： Ionic liquids CO2 capture Aspen Plus process simulation New green physical solvents Flue gas

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Minimizing Carbon Content with Three-in-One Functionalized Nano Conductive Ceramics:Toward More Practical and Safer S Cathodes of li-S Cells

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Energy & Environmental Materials 2023年第3期6卷 31-39页

作者： ning li Chang Sun Jianhui Zhu Shun li Yanlong Wang Maowen Xu Changming li Jian jiang School of Materials and Energy and Chongqing Key Lab for Advanced Materials and Clean Energies of TechnologiesSouthwest UniversityChongqing 400715China School of Physical Science and Technology Southwest UniversityChongqing 400715China Key Laboratory of Chemical Lasers Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry and Chemical Engineering Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Provinceand Key Laboratory of Functional Materials and Photoelectrochemistry of HaikouHainan Normal UniversityHaikou 571158China

Using porous carbon hosts in cathodes of li-S cells can disperse S actives and offset their poor electrical ***,such reservoirs would in turn absorb excess electrolyte solvents to S-unfilled regions,causing the electrolyte overconsumption,specific energy decline,and even safety hazards for battery *** build better cathodes,we propose to substitute carbons by In-doped SnO_(2)(ITO)nano ceramics that own three-in-one functionalities:1)using conductive ITO enables minimizing the total carbon content to an extremely low mass ratio(~3%)in cathodes,elevating the electrode tap density and averting the electrolyte overuse;2)polar ITO nanoclusters can serve as robust anchors toward li polysulfide(liPS)by electrostatic adsorption or chemical bond interactions;3)they offer catalysis centers for liquid–solid phase conversions of S-based ***,such ceramics are intrinsically nonflammable,preventing S cathodes away from thermal runaway or *** merits entail our configured cathodes with high tap density(1.54 g cm^(−3)),less electrolyte usage,good security for flame retardance,and decent li-storage *** lean and liNO_(3)-free electrolyte,packed full cells exhibit excellent redox kinetics,suppressed liPS shuttling,and excellent *** may trigger great research enthusiasm in rational design of low-carbon and safer S cathodes.

关键词： flame retardance li-S cells minimized carbon ratio nano conductive ceramics three-in-one functionality

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Experimental investigation on the spread of aqueous foam over ethanol surface

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Chinese Journal of Chemical Engineering 2020年第11期28卷 2946-2954页

作者： Xiaoyang Yu Fan li Xuyang Miao ning jiang Ruowen Zong Shouxiang Lu Changhai li State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

The presence of ethanol has an adverse effect on foam spreading,and ethanol fire is difficult to extinguish with aqueous fire-fighting ***,it is necessary to explore the foam formulation suitable for ethanol fuels and study the spreading behavior of foam over ethanol *** the current work,stable foams based on hydrocarbon surfactant(SDS),fluorocarbon surfactant(FC1157),and polymers(XG)were prepared by using the compressed-air foam *** spreading behaviors of foam on polar ethanol and non-polar heptane surface were observed and ***,the effects of stabilizer concentrations,foam flow rates and expansion ratios on foam spreading performance were investigated,*** results indicate that aqueous SDS foam can spread on the heptane layer continuously,but it is difficult to cover the ethanol *** addition of XG and FC1157 can synergistically improve the spreading performance of aqueous foam over *** on stabilizer concentrations,there are remarkable differences in foam spreading ***,different foam application parameters including expansion ratios and foam flow rates significantly affect the foam spreading rate,despite the same foam *** research methods and results guide the optimal design of foam formulations as well as the practical application of aqueous foam for ethanol fire extinguishment.

关键词： Aqueous foam Ethanol Spreading behavior Fluorocarbon surfactant Xanthan gum polymer

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