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Journal of Biomedical Research 2024年第4期38卷 382-396页

作者： Muhammad Zubair Hafiz Jie Pan Zhiwei Gao Ying huo Haobin Wang Wei Liu Jian Yang Department of Pharmacology Nanjing Medical UniversityNanjingJiangsu 211166China

The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer *** in vivo experiments were conducted on nude and ICR *** a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver *** the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ *** in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)*** with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 ***,other CAR target genes also showed a significant increase in the *** up-regulation of murine CAR was observed in the liver tissues of both nude and ICR *** findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator *** of the ERK1/2 signaling pathway was also observed in ***,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and *** the nude mice,T-AⅢ also inhibited EGFR *** results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.

关键词： timosaponin AⅢ CAR metabolism enzyme ERK1/2 signaling pathway EGFR signaling pathway

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极地高密度烧结雪层无侧限压缩离散元分析

极地研究 2024年第2期36卷 240-253页

作者：李涛霍海峰胡彪贾汶韬陈庆炜中国民航大学交通科学与工程学院天津300300 交通部机场工程安全与长期性能科研基地天津300300

从新雪变成老雪的过程叫作“烧结”,对雪层进行人工压实和烧结是建设极地机场跑道的主要方法,雪层烧结使雪颗粒间胶结尺寸增加,雪层强度增强。为探究人工压实烧结雪层在无侧限压缩荷载下的胶结接触破坏规律和承力机理,本研究采用三维离... 详细信息

从新雪变成老雪的过程叫作“烧结”,对雪层进行人工压实和烧结是建设极地机场跑道的主要方法,雪层烧结使雪颗粒间胶结尺寸增加,雪层强度增强。为探究人工压实烧结雪层在无侧限压缩荷载下的胶结接触破坏规律和承力机理,本研究采用三维离散元方法模拟了密实烧结雪层无侧限压缩试验,在室内试验结果基础上构建雪的胶结接触模型并标定接触参数,通过建立压实烧结雪离散元模型,进行了无侧限压缩加载模拟。模拟的结果验证了离散元模拟的有效性并表明:(1)在无侧限压缩下,密实烧结雪试样在剪切带区域发生集中胶结破坏,胶结断裂主要归因于接触在受拉状态下受剪;(2)冰雪颗粒的破碎会影响冰雪道面的抗剪强度,因此需要慎重考虑高应力对内摩擦角的影响。本研究将为极地地区通过压实烧结雪层简单现场试验预测其复杂应力路径下的力学特征提供科学支持。

关键词：极地压实雪雪烧结离散元无侧限压缩试验

Curative effect of wrist-ankle acupuncture on postpartum abdominal pain and its influence on serum β-EP level in puerpera

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 7-8页

作者：霍艳 1st Clin Med Sch Henan CM UnivZhengzhou 450000

Objective To observe the clinical effect of wristankle acupuncture on postpartum abdominal pain and its influence on serum beta-endorphin (β-EP) level in *** Seventy patients with postpartum abdominal pain were randomly divided into an acupuncture+herbal medication group (35 cases,1 case dropped out) and a herbal medication group(35 cases,2cases dropped out).In the herbal medication group.

关键词： acupuncture herbal pain

High-entropy alloys in thermoelectric application:A selective review

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Chinese Physics B 2024年第5期33卷 1-11页

作者：任凯霍文燚陈帅程渊王彪张刚 Zhengzhou University Advanced Medical Research Center Luoyang Central HospitalLuoyang 471099China School of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing 210037China Materials Genome Institute Shanghai UniversityShanghai 200444China Monash Suzhou Research Institute Monash UniversitySuzhou 215000China Department of Materials Science and Engineering Monash UniversityClayton VIC 3800Australia Research Institute of Interdisciplinary Science Dongguan University of TechnologyDongguan 523808China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019China

Since the superior mechanical,chemical and physical properties of high-entropy alloys(HEAs)were discovered,they have gradually become new emerging candidates for renewable energy *** review presents the novel applications of HEAs in thermoelectric energy ***,the basic concepts and structural properties of HEAs are ***,we discuss a number of promising thermoelectric materials based on ***,the conclusion and outlook are *** article presents an advanced understanding of the thermoelectric properties of HEAs,which provides new opportunities for promoting their applications in renewable energy.

关键词： high-entropy alloys thermoelectric materials thermal conduction

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内烯烃与普通醛的区域和对映选择性氢酰基化

有机化学 2024年第2期44卷 668-669页

作者：万响霍浩华厦门大学化学化工学院福建厦门361005

含有α-手性中心的非环烷酮是一类重要的基础合成砌块,它们广泛存在于天然产物、药物以及精细化学品中[1].在众多的合成方法中,过渡金属催化的烯烃与醛的C—H酰基化反应是一种直接从两个常见的官能团出发构建手性酮的高效方法[2].尽管... 详细信息

含有α-手性中心的非环烷酮是一类重要的基础合成砌块,它们广泛存在于天然产物、药物以及精细化学品中[1].在众多的合成方法中,过渡金属催化的烯烃与醛的C—H酰基化反应是一种直接从两个常见的官能团出发构建手性酮的高效方法[2].尽管分子内的不对称烯烃氢酰化反应已经有较多报道,相应的分子间催化不对称转化依然极富挑战性,这是因为在此类过渡金属催化的转化中醛非常容易发生脱羰基化副反应,特别是没有配位基团的醛[3].目前成功例子主要受限于使用具有配位基团的醛(例如水杨醛)和特定的烯烃(例如环丙烯和烯基硫醚)[4-6].高效的内烯烃与普通醛的区域和对映选择性的催化酰基化未见报道[7].

关键词：配位基团手性中心过渡金属催化对映选择性天然产物手性酮烯基酰基化

球磨法制备铁改性生物炭吸附水溶液中磷酸盐研究

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环境科学学报 2024年第5期44卷 37-47页

作者：高兴霍守亮同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室上海200092 中国环境科学研究院环境基准与风险评估国家重点实验室北京100012

采用吸附法降低水体中磷酸盐浓度是目前治理和控制水体富营养化的常见手段之一.生物炭(BC)作为一种廉价的化学稳定型吸附材料,尤其适用于对阳离子型污染物的吸附与去除,但生物炭表面负电性和有限的吸附位点限制了其对磷酸盐的吸附性能.... 详细信息

采用吸附法降低水体中磷酸盐浓度是目前治理和控制水体富营养化的常见手段之一.生物炭(BC)作为一种廉价的化学稳定型吸附材料,尤其适用于对阳离子型污染物的吸附与去除,但生物炭表面负电性和有限的吸附位点限制了其对磷酸盐的吸附性能.本研究使用球磨法将氧化铁负载于玉米秸秆生物炭得到一种具备高效除磷性能的复合材料.使用X射线衍射光谱仪、扫描电子显微镜、氮气吸附-解吸、傅里叶红外光谱仪、X射线电子能谱、Zeta电位仪对复合材料进行了表征检测,采用系列批次实验考察了材料对水溶液中正磷酸盐(PO_(4)^(3-))的吸附性能和吸附机制.结果表明,球磨处理成功将氧化铁(Fe_(2)O_(3))负载至生物炭表面,极大地提高了生物炭比表面积(210 m^(2)·g^(-1))、Zeta电势和含氧官能团种类和数量.溶液初始pH和吸附剂投加量是影响磷酸盐去除率的关键因素.Langmuir方程能更好地拟合等温吸附过程:当溶液pH=5.0,投加量为2.0 g·L^(-1)时,制备的球磨氧化铁改性生物炭达到对磷酸盐的理论最大吸附量(45.03 mg·g^(-1)).吸附动力学过程更加符合假二级动力学方程,表明化学过程主导整个吸附过程.共存离子(Cl^(-)、NO_(3)^(-)和SO_(4)^(2-))对磷酸盐吸附性能的影响可忽略不计.连续6次的吸附-解吸实验结果说明球磨氧化铁负载生物炭具备较好的化学稳定性和可循环使用性.系列表征分析结果显示:主要的吸附机制包括表面络合、金属-磷桥接和配位吸附.本研究为水体中磷素控制提供了一种可行策略,也为高效吸附材料的制备提供了新的思路.

关键词：生物炭球磨法吸附磷酸盐

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一类p-双调和方程的Berestycki-Lions结果

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西华师范大学学报（自然科学版） 2024年第3期45卷 261-266页

作者：陶钬李麟重庆工商大学数学与统计学院重庆400067

本文研究了一个带有p-双调和算子的拟线性椭圆方程的Beresticki-Lions型问题。首先,给出方程对应的Pohozaev恒等式;其次,给出对应的辅助方程,且利用变分法证明辅助方程解的存在性;最后,利用单调性技巧、Palais对称临界原理和变分法,证... 详细信息

本文研究了一个带有p-双调和算子的拟线性椭圆方程的Beresticki-Lions型问题。首先,给出方程对应的Pohozaev恒等式;其次,给出对应的辅助方程,且利用变分法证明辅助方程解的存在性;最后,利用单调性技巧、Palais对称临界原理和变分法,证明了原问题非平凡解的存在性。该结果完善了p-双调和方程解的存在性结果,并给出这类问题新的可解性条件。

关键词： p-双调和算子 Pohozaev恒等式 Berestycki-Lions条件椭圆方程变分法

Engagement of N^(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： Ying Bai Di Chang Hui Ren Minzi Ju Yu Wang Biling Chen Han Li Xue Liu Daxing Li Xinchen huo Xiaofei Guo Mengze Tong Ying Tan Honghong Yao Bing Han Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China Department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine Depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction

Solar Energy for Value-Added Chemical Production by LightPowered Microbial Factories

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CCS Chemistry 2024年第7期6卷 1776-1788页

作者： Haibo Wu Xilong Feng Liangjun Wang Cheng Chen Peng Wu Linpo Li Jinjie Xu Fan Qi Suoying Zhang Fengwei huo Weina Zhang Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing 211816

The light-driven material-microorganism biohybrid system has the potential to transfer solar energy for chemical ***,few studies have reported the construction of biohybrid systems using light-responsive materials with nonmodel strains that have been widely used in practical industrial production for value-added chemicals,especially with regard to the mechanism of action of photogenerated charges in the cytoplasm,probably due to the complexity of their anabolic ***,a biohybrid system as a research mode was constructed by electrostatically self-assembling a highly efficient light-harvesting material of graphite-phase nitrided carbon(g-C_(3)N_(4))nanosheets with nonmodel strains(Phaffia rhodozyma)for synthesis of nutritional chemical *** biohybrid interface enabled efficient separation,transfer,and transport of photogenerated charges from g-C_(3)N_(4) into the interior of ***,which improved the substance metabolism and the energy metabolism of ***,photogenerated charges can significantly promote the accumulation of precursors along the astaxanthin anabolic pathway and enhance the cytoplasmic redox environment and ATP levels in the interior of ***,even under adverse conditions(such as enzyme inhibitors),thus increasing the yield of astaxanthin compared to the traditional culture of *** study not only provides new ideas for converting solar energy into value-added chemicals,but it also provides guidance for regulating microbial synthesis plants.

关键词： biohybrid system light-driven graphitephase nitrided carbon Phaffia rhodozyma astaxanthin

Chiral electron transporting material for circularly polarized organic light-emitting diode

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Science China Chemistry 2024年

作者： Peihao huo Tianyu Yang Peiyu Fang Yujia Li Nanlong Zheng Min Gong Zuqiang Bian Zhiwei Liu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular Engineering Peking University

Circularly polarized organic light-emitting diode（CP-OLED） has attracted increasing interest for its efficient ability to generate circularly polarized light directly. So far, many CP-OLEDs were successfully fabricated with chiral emitters or chiral hosts. In this study, a new strategy based on chiral electron transporting layer is proposed to construct CP-OLEDs. A pair of chiral electron transporting materials, 1,3,5-tris(（R/S）-4-isopropyl-4,5-dihydrooxazol-2-yl)benzene(（R/S）-TOxiPr), are firstly designed and synthesized. The crystalline films of（R/S）-TOxiPr show circularly polarized photoluminescence with photoluminescence dissymmetry factors of-0.067 and +0.041, respectively. The CP-OLEDs based on（R/S）-TOxiPr and three types of achiral emitters all exhibit circularly polarized electroluminescence, showing feasibility and strong versatility of this new strategy. The mechanism is attributed to in-situ electrical excitation instead of simply light filtering of non-circularly polarized light. This work demonstrates a new approach for realizing circularly polarized electroluminescence which may provide a valuable strategy to develop CP-OLEDs.

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