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Impaired XPO5 function leads to transportation failure of microRNA precursor

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Science China(Life Sciences) 2017年第6期60卷 677-679页

作者： yu-quan Wei State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

MicroRNAs（miRNAs）constitute a class of small non-coding RNAs that participate in various biological processes by repressing protein translation or destabilizing target *** biogenesis begins with the transcription of primary miRNAs（pri-miRNAs）in the cell nucleus,which are then cleaved by the Drosha/DGCR complex into precursor miRNAs（pre-miRNAs）.The pre-miRNAs are transported by exportin-5（XPO5）from the nucleus to the cytoplasm,

关键词： miRNAs nucleus microRNA processed mature Dicer constitute cytoplasm impaired transportation

X射线透视引导下不同方式建立兔椎间盘退变模型的结果对比

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中国组织工程研究 2025年第5期29卷 995-1002页

作者：丁至立黄杰蒋强李土胜刘江丁宇安徽医科大学海军临床学院北京市100048 安徽医科大学第五临床医学院安徽省合肥市230032 解放军总医院第六医学中心中医医学部骨伤科北京市100048

背景:国内外学者认为新西兰大白兔腰椎解剖形态与人类腰椎更为相似,是理想的模型动物。在X射线引导下采用不同方式建立兔椎间盘退变模型目前尚缺乏系统性比较。目的:基于X射线引导采用针刺法、终板注射法以及改良终板注射法建立兔腰椎... 详细信息

背景:国内外学者认为新西兰大白兔腰椎解剖形态与人类腰椎更为相似,是理想的模型动物。在X射线引导下采用不同方式建立兔椎间盘退变模型目前尚缺乏系统性比较。目的:基于X射线引导采用针刺法、终板注射法以及改良终板注射法建立兔腰椎间盘退变模型,比较3种方法造模的效果。方法:6月龄新西兰大白兔16只随机分为4组,分别为针刺组、终板注射组、改良终板注射组及空白对照组,针刺组对3个连续节段(L2/3、L3/4、L4/5)椎间盘进行针刺造模,终板注射组在3个连续节段终板单点注射50μL无水乙醇,改良终板注射组对3个连续节段椎间盘进行针刺并在相应节段终板4个方位点注射50μL无水乙醇,空白对照组不进行干预。术后2,4,8周进行X射线检查,测量椎间隙高度指数,然后取椎间盘组织进行解剖学观察、病理学检查。结果与结论:①解剖学观察显示,针刺组以纤维环破溃为主要表现,终板注射组主要以髓核退变为主要表现,改良终板注射组以全椎间盘结构紊乱为主要表现;②与空白对照组相比,针刺组术后2周椎间隙高度指数降低最明显,终板注射组术后2,4周椎间隙高度指数降低明显,改良终板注射组术后2,4,8周椎间隙高度指数均显著降低;③病理学检查显示,针刺组纤维环结构出现破损,内层纤维环向内凸入,终板注射组表现为终板裂隙、排列混乱及细胞核丢失,改良终板注射组表现为整体椎间盘结构紊乱,髓核失水皱缩,与破损的纤维环无明显边界。结果表明,针刺法、终板注射法及改良终板注射法均能建立兔椎间盘退变模型,改良终板注射法较单一方法可大幅加快并加重椎间盘退变,可有效缩短实验周期。

关键词：组织工程椎间盘退变纤维环穿刺法终板注射法 X射线新西兰大白兔

Optimal Design of Co/In/Cu Sputtering Target Assembly Using Finite Element Method and Taguchi Method

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Acta Metallurgica Sinica(English Letters) 2019年第11期32卷 1407-1414页

作者： Lin jiang Liang Zhang Zhi-quan Liu Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 11016China School of Mechatronic Engineering Jiangsu Normal UniversityXuzhou 221116China

Target assembly is a key consumable material for producing thin fi lm used in the electronic packaging and devices. The residual stresses induced during the process of soldering are detrimental to the performance of target assembly. In this work, the intensity and distribution of the soldering residual stress of Co/In/Cu target assembly subjected to a 20 W/(m^2 K) cooling condition corresponding to the actual air cooling process were studied, based on fi nite element simulation and Taguchi method, to optimize the sputtering target assembly. Effects of different control factors, including solder material, thickness of solder layer, target and backing plate, on the soldering residual stress of target assembly are investigated. The maximum residual stress is calculated as 9.28 MPa in the target located at 0.16 mm from target–solder layer interface and at a distance of 0.78 mm from symmetry axis. The optimal design in target assembly has the combination of indium solder material, cobalt target at 12 mm thick, solder layer at 0.8 mm thick, copper backing plate at 15 mm thick. Moreover, solder material is the most important factor among control factors in the target assembly.

关键词： Co target assembly Solder Residual stress Simulation Taguchi method Optimal design

Effect of Al content on modification behavior of non-metallic inclusions in high-strength steel treated with rare earth

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Journal of Iron and Steel Research International 2024年第8期31卷 1886-1899页

作者： Zhan-peng Tie Xue-yuan jiang Hai-yan Tang ·Gen Li yu-hang Wang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Continuous Casting Business Section CISDI Engineering Co.Ltd.Chongqing 401122China Special Steel Institute Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

The influence of Al content(0.0053,0.0171,and 0.0578 wt.%)on the modification behavior of non-metallic inclusions in 20CrMoVTiB steel treated with rare earth elements was studied through high-temperature experiments and thermodynamic *** results showed that the modification products varied with the Al content in steel under 0.01 wt.%of Ce *** formation sequence of typical rare earth inclusions in steel with the increase in Al content was Ce_(2)O_(3)→CeAlO_(3)→CeAl_(11)O_(18),and the final stable products were highly Al content *** the Al content was 0.0053 wt.%,the stable phase in steel was Ce2O3;while the[Al]reached 0.0171 wt.%,the stable phase became CeA1O_(3).As the A1 content reached 0.0578 wt.%,CeAl_(11)O_(18) became the stable *** a result,increasing the Al content could inhibit the precipitation of Ce_(2)O_(3) inclusions in steel while promote the formation of CeAIO3 and CeAl_(11)O_(18) *** addition,both Ca treatment and Ce treatment could effectively refine the size of inclusions in steel by changing their ***,the feeding amount of Ca wire into molten steel should be appropriately reduced under the condition of adding Ce simultaneously,which is expected to be beneficial for an improved Ce treatment effect.

关键词： Rare earth Al content Steel Inclusion Thermodynamics Ca treatment

Synthesis and electrochemical properties of Mn-substituted high-capacity nickel hydroxide

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Rare Metals 2022年第6期41卷 1977-1982页

作者： Hao Lei Yang Pan Rong-Gui Guo Jing Zhang Xue Han Li-Min yu Wen-quan jiang Research Institute of Rare Earth Metallurgical Materials and Applied Technology General Research Institute for Nonferrous MetalsBeijing 100088China

Nickel hydroxide is widely used as cathode materials in nickel-metal secondary *** this work,Mn-substituted nickel hydroxide samples with a special α/βmixed phase structure were synthesized by chemical co-precipitation *** physical properties were char-acterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC)and field emission scanning electron microscopy(FE-SEM).The results show that the structure of the samples and the amount of intercalated anions and water molecules are highly related to the content of the Mn *** electrochemical performances were characterized by charge/discharge tests and electrochemi-cal cycle *** results demonstrate that the Mn-sub-stituted samples with a α/β mixed phase structure perform a much higher discharge capacity than normal β-nickel *** specific discharge capacity reaches 330 mAh·g^(-1) after 50 cycles of charge/discharge in charging rate of 0.2C under ambient ***-while,the samples show no capacity loss in electrochem-ical cycles,which indicates that the mixed phase nickel hydroxide maintains high structure stability.

关键词： Nickel hydroxide Cathode material Nickel-metal battery Mixed phase Electrochemical performance

人胶质细胞源性神经营养因子在肌萎缩性脊髓侧索硬化症小鼠模型基因治疗中的作用

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山东大学学报（医学版） 2011年第11期49卷 25-29页

作者：张文华吴承远李新钢徐淑军李刚江玉泉周茂德刘猛山东大学齐鲁医院神经外科山东大学脑科学研究所济南250012

目的探讨人胶质细胞源性神经营养因子(GDNF)基因治疗在肌萎缩性脊髓侧索硬化症(ALS)中的作用。方法 ALS小鼠随机分成AdCMVlacz对照组和AdCMVgdnf治疗组各12只。第9周肌肉注射AdCMVgdnf或AdCMVlacz病毒。第10周测试运动能力,并记录发病... 详细信息

目的探讨人胶质细胞源性神经营养因子(GDNF)基因治疗在肌萎缩性脊髓侧索硬化症(ALS)中的作用。方法 ALS小鼠随机分成AdCMVlacz对照组和AdCMVgdnf治疗组各12只。第9周肌肉注射AdCMVgdnf或AdCMVlacz病毒。第10周测试运动能力,并记录发病时间和生存时间。利用ELISA和免疫组织化学检测骨骼肌肉和脊髓中GDNF的表达,对脊髓运动神经元细胞数目和腓肠肌质量变化进行定量分析。结果①AdCMVgdnf治疗组ALS小鼠注射部位肌肉中GDNF水平为(6 589.0±325.0)pg/mg,而对照组为(75.3±18.9)pg/mg,治疗组高于对照组近100倍(P<0.01)。②对照组的腓肠肌质量为(88.6±14.5)mg,治疗组为(174.9±18.7)mg,差异有统计学意义(P<0.01)。③治疗组脊髓运动神经元细胞中GDNF较对照组明显增加,并且神经元细胞数目也明显增加(P<0.01)。④与对照组的发病时间(96.2±5.8)d比较,治疗组为(123.0±6.9)d,差异有统计学意义(P<0.01)。与对照组生存期(127.3±4.6)d比较,治疗组为(155.2±4.1)d,差异有统计学意义(P<0.01)。结论 AdCMVgdnf基因治疗对ALS小鼠脊髓运动神经元有保护作用,缓解肌肉萎缩,改善神经运动功能,延缓疾病的发生和延长生存期。

关键词：肌萎缩性脊髓侧索硬化症基因治疗胶质细胞源性神经营养因子腺病毒运动神经元

Effect of Temperature on Scale Morphology of Fe-1.5Si Alloy

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Journal of Iron and Steel Research International 2013年第11期20卷 73-78页

作者： LIU Xiao-jiang CAO Guang-ming HE Yong-quan JIA Tao LIU Zhen-yu State Key Laboratory of Rolling and Automation Northeastern University

Because of the effect of silicon on the formation of oxide scale, red scale is the main surface defect of hot rolled Fe-Si plate, making the scale difficult for descaling compared with carbon steel. Thermogravimetric analyzer （TGA） is used to simulate isothermal oxidation process of Fe-1.5Si alloy for 60 min under air condition, and the temperature range is from 700 to 1 200 ℃. Electron probe microanalysis （EPMA） is used to observe cross-sectional scale morphology and analyze elemental distribution of the scale. Relational graph of temperature, scale thickness and scale structure is obtained. It is found that scale structure （outer Fe oxide layer＋inner FeO/Fe2SiO4 layer＋internal Si oxide precipitates） is almost unchanged with temperature except at 1000 and 1 200 ℃. At 1000 ℃ internal Si ox- ide precipitates cannot be found at the subsurface of the alloy, and at 1200 ℃ FeO/Fe2SiO4 not only forms a layer as usual but also penetrates into the outer Fe oxide layer deeply.

关键词： Fe 1.5Si alloy scale morphology internal oxide precipitate Fe2SiO4

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen Ji yu Chen Zheng Shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

Cloud-Verhulst hybrid prediction model for dam deformation under uncertain conditions

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Water Science and Engineering 2018年第1期11卷 61-67页

作者： Jin-ping He Zhen-xiang jiang Cheng Zhao Zheng-quan Peng yu-qun Shi School of Water Resources and Hydropower Engineering Wuhan UniversityWuhan 430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Large Dam Safety Supervision Center National Energy AdministrationHangzhou 311122China

Uncertainties existing in the process of dam deformation negatively influence deformation prediction. However, existing deformation pre- diction models seldom consider uncertainties. In this study, a cloud-Verhulst hybrid prediction model was established by combing a cloud model with the Verhulst model. The expectation, one of the cloud characteristic parameters, was obtained using the Verhulst model, and the other two cloud characteristic parameters, entropy and hyper-entropy, were calculated by introducing inertia weight. The hybrid prediction model was used to predict the dam deformation in a hydroelectric project. Comparison of the prediction results of the hybrid prediction model with those of a traditional statistical model and the monitoring values shows that the proposed model has higher prediction accuracy than the traditional sta- tistical model. It provides a new approach to predicting dam deformation under uncertain conditions.

关键词： Dam deformation prediction Cloud model Verhulst model Uncertainty Inertia weight