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温针督脉联合感觉统合训练在脑梗死认知障碍患者中的临床研究

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天津中医药 2024年第3期41卷 344-348页

作者：王天赐徐传伟蒋永取赵丹南京中医药大学连云港附属医院连云港222000 江苏省海滨疗养院连云港222042

[目的]探讨温针督脉联合感觉统合训练在脑梗死认知障碍患者中的临床疗效。[方法]选取2022年1月—2023年1月南京中医药大学连云港附属医院脑梗死认知障碍患者98例,根据计算机随机数字法随机分为观察组和对照组,每组各49例。对照组给予感... 详细信息

[目的]探讨温针督脉联合感觉统合训练在脑梗死认知障碍患者中的临床疗效。[方法]选取2022年1月—2023年1月南京中医药大学连云港附属医院脑梗死认知障碍患者98例,根据计算机随机数字法随机分为观察组和对照组,每组各49例。对照组给予感觉统合训练,观察组给予温针督脉联合感觉统合训练。治疗3个月后评价疗效。治疗前、治疗3个月评估中医证候积分,采用蒙特利尔认知评估量表(MoCA)、Rivermead行为记忆测验第2版(RBMT-Ⅱ)评估认知功能,采用美国国立研究所卒中量表(NIHSS)评估神经功能缺损程度,检查脑血流量灌注参数脑血容量(CBV)、脑血流量(CBF)、达峰时间(TTP)、平均通过时间(MTT)和神经传导功能,统计两组治疗期间不良反应。[结果]观察组中医证候疗效总有效率为95.92%,高于对照组73.47%(P<0.05)。治疗3个月两组中医证候积分、NIHSS评分均降低,MoCA、RBMT-Ⅱ评分升高;组间比较,观察组中医证候积分、NIHSS评分低于对照组,MoCA、RBMT-Ⅱ评分高于对照组(P<0.05)。治疗3个月两组CBV、CBF较治疗前增加,TTP、MTT较治疗前缩短(P<0.05);组间比较,观察组CBF大于对照组,TTP短于对照组(P<0.05)。治疗3个月两组P300潜伏期、(δ+θ)/(α+β)比值小于治疗前,P300波幅大于治疗前;组间比较,观察组P300潜伏期、(δ+θ)/(α+β)比值小于对照组,P300波幅大于对照组(P<0.05)。[结论]温针督脉联合感觉统合训练治疗脑梗死认知障碍效果显著,可有效减轻患者症状及认知功能障碍,降低神经功能缺损程度,改善脑血流量灌注,并有助于促进神经传导功能恢复。

关键词：温针督脉感觉统合训练脑梗死认知障碍

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基于自下而上与自上而下的轨迹知识图谱构建

软件导刊 2024年第5期23卷 89-94页

作者：王菁菁姜梦克亚琳潘晓石家庄铁道大学信息科学与技术学院河北石家庄050043

轨迹作为时间序列数据,蕴含着轨迹点的空间和时间信息,并且路网结构与天气状况作为辅助因素也会对轨迹数据分析产生影响。为了实现多源异构数据的有效组织、融合,以及轨迹数据的分析与挖掘,基于真实的车辆轨迹构建轨迹知识图谱。构建轨... 详细信息

轨迹作为时间序列数据,蕴含着轨迹点的空间和时间信息,并且路网结构与天气状况作为辅助因素也会对轨迹数据分析产生影响。为了实现多源异构数据的有效组织、融合,以及轨迹数据的分析与挖掘,基于真实的车辆轨迹构建轨迹知识图谱。构建轨迹知识图谱时分别采用自下而上和自上而下的方法,实现轨迹数据和辅助信息的融合。通过两种方法构建的轨迹知识图谱,最终存储于图数据库中,有助于未来对数据的提取与应用。自下而上构建的知识图谱显示出星型结构,自上而下构建的轨迹知识图谱基于4个空间本体,可较好地反映轨迹空间信息和行驶语义。

关键词：轨迹数据知识图谱轨迹知识图谱图数据库

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Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils

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Cellular & Molecular Immunology 2023年第11期20卷 1339-1351页

作者： Xu jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C.Tsokos Minghong jiang Xuan Zhan Medical Research Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalDepartment of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Department of Rheumatology Key Laboratory of MyositisChina-Japan Friendship HospitalBeijingChina Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Department of Rheumatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineClinical Immunology CenterChinese Academy of Medical SciencesBeijingChina Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalClinical Immunology CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeThe Ministry of Education Key LaboratoryBeijingChina Department of Rheumatology Xiangya HospitalCentral South UniversityHunanChina MOE Key Laboratory of Bioinformatics Center for Synthetic&Systems BiologySchool of Life SciencesTsinghua UniversityBeijingChina Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhouZhejiangChina State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune ***,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune ***,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species ***,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil *** neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive ***,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease *** together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies.

关键词： Systemic lupus erythematosus ROS VSTM1 Galectin-1 Glutathione

The nature of the deactivation of hydrothermally stable Ni/SiO2–Al2O3 catalyst in long-time aqueous phase hydrogenation of crude 1,4-butanediol

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2960-2967页

作者： Haitao Li Yin Zhang Hongxi Zhang Xiaoqin Qin Yalin Xu RuifangWu Zheng jiang Yongxiang Zhao Engineering Research Center of Ministry of Education for Fine Chemicals Shanxi UniversityTaiyuan 030006China Faculty of Engineering and the Environment University of SouthamptonSouthampton SO171BJUK

The deactivation of Ni/SiO2-Al2 O3 catalyst in hydrogenation of crude 1,4-butanediol was *** the operation time of 2140 h,the catalyst showed slow activity *** results,for four spent catalysts used at different time,indicated that the main reason of the catalyst deactivation was the deposition of carbonaceous species that covered the active Ni and blocked mesopores of the *** TPO and SEM measurements revealed that the carbonaceous species included both oligomeric and polymeric species with high C/H ratio and showed *** carbonaceous species might be eliminated through either direct H2 reduction or the combined oxidation-reduction methodologies.

关键词： 1,4-Butanediol Hydrogenation Ni/SiO2–Al2O3 catalyst Deactivation Regeneration

An end-capped strategy for crystalline polymer donor to improve the photovoltaic performance of non-fullerene solar cells

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Science China Chemistry 2022年第5期65卷 964-972页

作者： Bing Zheng Yuchen Yue Jianling Ni Rui Sun Jie Min Jingxia Wang Lei jiang Lijun Huo School of Chemistry Beihang UniversityBeijing 100191China Key Laboratory of Bioinspired Smart Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The effects of end-capped modifications of a polymer donor with high molecular weight on non-fullerene solar cells are largely ignored,even if the chain-end-functionalized method of conjugated polymers is an effective strategy in modulating polymeric optical-electronic *** this study,we design and synthesize an end-capped polymer,PM6TPO,via a reaction with the parent polymer ***,the conventional detection methods of X-ray photoelectron spectroscopy(XPS),matrix-assisted laser desorption/ionization time-of-flight(MALDI-TOF),and ^(1)H nuclear magnetic resonance(^(1)H NMR) were replaced by simple solution-based inductively coupled plasma-mass spectrometry(ICP-MS) to evaluate the end-capped efficacy of *** introducing end-capped groups on a high molecular weight polymer donor,we could finely tune the aggregated behavior,strengthen the miscibility between the donor and acceptor without sacrificing the strong aggregated properties,and reduce the non-radiative recombination with a lower energy ***,the PM6TPO-based organic solar cell(OSC)realized a higher open-circuit voltage of 0.843 V and PCE of 17.26% than that of the non-end-capped parent polymer,PM6(0.824 V and 16.21%,respectively).This work not only provides a straightforward method for verifying the end-capped efficacy of a high molecular weight polymer but also indicates a new research direction for improving the photovoltaic performance of non-fullerene-based solar cells.

关键词： end-capped polymer ICP-MS miscibility energy loss non-fullerene solar cells

“酉芯一号”在地方鸡遗传多样性和结构分析中的应用效力研究

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遗传 2024年第8期46卷 640-648页

作者：王梦燏周成浩薛倩殷建玫蒋一秀张会永李国辉韩威中国农业科学院家禽研究所扬州225125 江苏省家禽科学研究所扬州225125 江苏省家禽科学研究所科技创新有限公司扬州225125

我国地方鸡品种资源丰富,且在长期的选择进化过程中形成了各异的种质特性。科学评估群体遗传多样性,明确品种间遗传结构,对地方鸡品种资源的保护与创新利用具有重要价值。为了评估23K SNP芯片“酉芯一号”在地方鸡遗传多样性和遗传结构... 详细信息

我国地方鸡品种资源丰富,且在长期的选择进化过程中形成了各异的种质特性。科学评估群体遗传多样性,明确品种间遗传结构,对地方鸡品种资源的保护与创新利用具有重要价值。为了评估23K SNP芯片“酉芯一号”在地方鸡遗传多样性和遗传结构分析中的应用效力,本文利用RADseq鉴定21个地方鸡种基因组遗传变异,并研发23K芯片“酉芯一号”。基于两组SNP数据集计算各品种的遗传统计量,开展相关性、拟合及系统发育分析,以评估芯片的应用效力。结果表明,基于两组SNP数据集计算的观察杂合度(Ho)、多态信息含量(PIC)、近交系数(F_(ROH))和遗传分化系数(F_(st)),在21个地方鸡种中趋势基本一致。琅琊鸡(LA)、瓢鸡(PJ)、文昌鸡(WC)的遗传多样性较为丰富;边鸡(bj)、狼山鸡(LS)、固始鸡(GS)、东乡绿壳蛋鸡(DX)和北京油鸡(BY)的遗传多样性相对匮乏,两组Ho、PIC、F_(ROH)和平均Fst的相关系数分别为0.794、0.901、0.926和0.984,均达到极显著水平(P<0.01),且拟合度较高(P<0.001),R^(2)分别为0.644、0.827、0.916和0.927。针对两组SNP数据集,采用邻接法(NJ)和极大似然法(ML)构建的进化树较为合理,将21个地方鸡种总体上分为6大类,与品种的形成历史和地理分布相吻合;23K芯片对5个新增品种亦实现有效聚类,没有出现个体偏离。利用不同密度的SNP估算遗传统计量会存在一定差异,需要进行数据和分析方法的标准化,23K芯片在地方鸡遗传多样性和结构分析中具有较好的效力。

关键词： RADseq SNP芯片遗传多样性遗传结构

Estimation and Spatio-temporal Patterns of Carbon Emissions from Grassland Fires in Inner Mongolia,China

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Chinese Geographical Science 2020年第4期30卷 572-587页

作者： YU Shan jiang Li DU Wala ZHAO Jianjun ZHANG Hongyan ZHANG Qiaofeng LIU Huijuan Key Laboratory o f Geographical Processes and Ecological Security^in Changbai Mountains Ministry o f EducationSchool o f Geographical SciencesNortheast Normal UniversityChangchun 130024China School of Geographical Sciences Inner Mongolia Normal UniversityHohhot 010022China Grassland Research Institute Chinese Academy of Agricultural SciencesHohhot 010010China Urban Remote Sensing Application Innovation Center School of Geographical SciencesNortheast Normal UniversityChangchun 130024China

Grassland fires results in carbon emissions,which directly affects the carbon cycle of ecosystems and the carbon *** grassland area of Inner Mongolia accounts for 22%of the total grassland area in China,and many fires occur in the area every ***,there are few models for estimation of carbon emissions from grassland *** estimation of direct carbon emissions from grassland fires is critical to quantifying the contribution of grassland fires to the regional balance of atmospheric *** this study,the regression equations for aboveground biomass(AGB)of grassland in growing season and MODIS NDVI(Normalized Difference Vegetation Index)were established through field experiments,then AGB during Nov.–*** retrieved based on that in *** decline rate,finally surface fuel load was obtained for whole *** on controlled combustion experiments of different grassland types in Inner Mongolia,the carbon emission rate of grassland fires for each grassland type were determined,then carbon emission was estimated using proposed method and carbon emission *** revealed that annual average surface fuel load of grasslands in Inner Mongolia during 2000–2016 was approximately 1.1978×1012 *** total area of grassland which was burned in the Inner Mongolia region over the 17-year period was 5298.75 km2,with the annual average area of 311.69 *** spatial distribution of grassland surface fuel loads is characterized by decreasing from northeast to southwest in Inner *** total carbon emissions from grassland fires amounted to 2.24×107 kg with an annual average of 1.32×106 for the study *** areas with most carbon emissions were mainly concentrated in Old Barag Banner and New Barag Right Banner and on the right side of the Oroqin Autonomous *** spatial characteristics of carbon emission depend on the location of grassland fire,mainly in the northeast of Inner Mongolia include Hulunbuir City,Hinggan League,Xilin Gol Leagu

关键词： grassland fires surface fuel load area burned estimation of carbon emissions Inner Mongolia China

Pavement structure and materials design for sea-crossing bridges and tunnel:Case study of the Hong Kong-Zhuhai-Macao Bridge

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Journal of Road Engineering 2022年第2期2卷 99-113页

作者： Aimin Sha Wei jiang Jinhuan Shan Wangjie Wu Yupeng Li Shuangjiao Zhang Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China School of Highway Chang'an UniversityXi'an 710064China

With the continuous development of bridge and tunnel construction technologies,large-scale sea-crossing bridges and tunnels have gradually become the preferred choice for regional *** construction technology of Hong Kong-Zhuhai-Macao Bridge(HZMB),one of the most representative sea-crossing passageways,is instructive for the construction of other large sea-crossing *** present,the pavement design method of sea-crossing passageways lacks pertinence as it still refers to specifications for design of common ***,it is necessary to consider the bridge and tunnel pavement of HZMB as a typical example to analyze key technical problems encountered in its design,construction and *** solutions for material selection and structural design built upon the analysis of such critical problems should thus follow *** on comprehensive literature research,it can be found that environmental variability,tunnel closure,structural differential settlement and expansion deformation are the key technical problems faced by pavement of sea-crossing *** view of the environmental variability,the steel deck-paving material and structure design of GMA-10 t SMA-13 is innovatively *** for the closure of immersed tube tunnel,warm-mix flame retardant asphalt mixture is used to control pavement design through key indexes such as temperature and limit oxygen *** the deformation of immersed pipe joints,bj200 asphalt seamless expansion joint material is introduced,which effectively satisfies the multi-directional deformation between pipe joints and ensures the smoothness of the road surface and driving *** segmental joints,double-layer waterproof-coiled material is used to effectively prevent reflective cracks while ensuring the continuity of asphalt concrete ***,this paper provides a panel of ideas and methods for the pavement design of the same type of sea-crossing passageways.

关键词： Hong Kong-Zhuhai-Macao Bridge Steel deck paving Immersed tunnel pavement GMA Flame retardant and smoke suppression Seamless expansion joint

超高龄持续性心房颤动患者心率变异性与基础临床特征的关系分析

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实用临床医药杂志 2024年第9期28卷 67-72页

作者：王小艳许健钱进姜苏蓉王森江苏省人民医院老年心血管科江苏南京210029

目的探讨超高龄(≥80岁)持续性心房颤动(简称房颤)患者的心率变异性(HRV)与基础临床特征的关系。方法选取108例超高龄持续性房颤患者纳入房颤组,另选取127例超高龄窦性心律老人纳入对照组,监测24 h动态心电图,比较2组心率、HRV时域指... 详细信息

目的探讨超高龄(≥80岁)持续性心房颤动(简称房颤)患者的心率变异性(HRV)与基础临床特征的关系。方法选取108例超高龄持续性房颤患者纳入房颤组,另选取127例超高龄窦性心律老人纳入对照组,监测24 h动态心电图,比较2组心率、HRV时域指标[正常RR间期标准差(SDNN)、全程每5 min RR间期平均值的标准差(SDANN)、相邻NN间期差值的均方根(RMSSD)、全程记录中5 min NN间期标准差平均值(SDNN index)、心率变异指数(HRV index)和相邻NN间期差值>50 ms的心搏数占NN间期总搏数的百分比(PNN50)]。收集房颤患者的基础临床特征,采用多元线性回归分析探讨HRV时域指标与心率、基础临床特征的相关性。结果房颤组的SDNN、RMSSD、HRV index、PNN50、SDNN index均高于对照组,差异有统计学意义(P<0.01)。多元线性回归分析结果显示,SDNN升高与高血压(P=0.001)、服用β受体阻滞剂(P=0.003)、心率慢(P<0.001)显著相关,RMSSD升高与高血压(P=0.040)、服用β受体阻滞剂(P=0.002)、心率慢(P<0.001)显著相关,HRV index升高与心力衰竭(P=0.003)、心率慢(P<0.001)显著相关,PNN50升高与心率慢(P=0.004)显著相关;SDNN index升高与服用β受体阻滞剂(P=0.002)、心率慢(P<0.001)显著相关,SDANN升高与高血压(P=0.006)、心率慢(P<0.001)、服用达比加群(P=0.021)显著相关。结论超高龄持续性房颤患者的HRV与基础临床特征存在相关性,该现象可能源于自主神经系统的活动状态。

关键词：超高龄房颤心率变异性高血压 β受体阻滞剂达比加群