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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

作者： jiang xiao-yan ZHANG Ji-long ZOU Wei Chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li xiao-jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Towards trustworthy blockchain systems in the era of “Internet of value”: development, challenges, and future trends

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Science China(Information Sciences) 2022年第5期65卷 250-260页

作者： Hai JIN jiang xiao National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and Technology

Since the advent of cryptocurrencies such as Bitcoin, blockchain, as their underlying technologies,has drawn a massive amount of attention from both academia and the industry. This ever-evolving technology inherits the “genes” of distributed systems, offering significant advantages of immutability, transparency,auditability, and tamper-resistance. These benefits help blockchain re-establish public confidence, and hold the significant promise of reliable information sharing and value transfer. Therefore, blockchain has become the foundation of crucial strategic deployments in countries across the world, and the fundamental basis for building the next generation Web 3.0 — “Internet of value”. In this article, we will start with unraveling the essential ingredients of blockchain technology, and showing the characteristics of each of these ingredients in the context of distributed systems. We will then present the core technical challenges that need to be addressed prior to unleashing its full potential, including its performance, scalability, and cross-chain interoperability. Finally, we will introduce the recent developments of blockchain systems, and discuss the future trends of the blockchain ecosystem.

关键词： blockchain distributed systems internet of value challenges development

Brill-Noether Theory for Rank Two Vector Bundles Generated by Their Sections

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Acta Mathematica Sinica,English Series 2008年第12期24卷 1995-2010页

作者： Jian Do xiao xiao jiang TAN School of Mathematical Sciences Peking University Beijing 100871 P. R. China School of Mathematics Southwest Jiaotong University Chengdu 611756 P. R. China LMAM and School of Mathematical Sciences Peking University Beijing 100871 P. R. China

We here study the Brill-Noether theory for rank two vector bundles generated by their sections. We generalize the vanishing theorem, the Clifford theorem and the existence theorem to such bundles.

关键词： rank two vector bundle vanishing theorem Clifford theorem existence theorem

Surface roughness modulated resistivity in copper thin films

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Science China(Physics,Mechanics & Astronomy) 2018年第10期61卷 70-77页

作者： HongKang Song Ke Xia jiang xiao Department of Physics Beijing Normal University Beijing 100875 China Department of Physics and State Key Laboratory of Surface Physics Fudan University Shanghai 200433 China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093 China

The surfaces of metallic thin films are never flat. The resistivity in thin films is very different from that in bulk because of the unavoidable rough surfaces. In this study, we apply a quantum-mechanical method to study the resistivity in metallic thin *** resulting resistivity formula for metallic thin films merely involves two parameters: bulk relaxation time and surface roughness. We use the formula to fit a large number of experimental data sets for copper thin films obtained using different growing methods. With an additional tuning parameter for calibrating the film thickness, the quantum formula can provide a universal fitting to most data with a satisfactory precision, regardless of their growing methods or data source.

关键词： thin film thickness dependent resistivity surface roughness

Cross -field Integration of Language Acquisition with Meme Theory

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学术界 2014年第7期 296-302页

作者： jiang xiao School of Humanity Soochow University Suzhou Jiangsu 215123

In strengthening the multi-disciplinary and multi-angle cooperation,the theoretical analysis of linguistics can be improved to a newlevel and also the study of language acquisition can be expanded to a wilder field of view. The secret for the pedagogy of performing another culture to be successful lies in integrating with the theoretical knowledge in other disciplines and fields and promoting the development of the second language pedagogy to a broader space. In this process,the"meme theory"in the field of biology is a theoretical method absorbed and very outstandingly implemented by the pedagogy of performing another culture,so it is worth borrowing and introducing and also is of great significance in language acquisition.

关键词：知识整合语言学教学发展生物学领域教学方法文化

Evaluation of self-healing ability of Ce-V conversion coating on AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2016年第3期4卷 230-241页

作者： xiao jiang Ruiguang Guo Shuqin jiang Key Lab of Northwest Water Resources Environment and EcologyMinistry of EducationXi’an University of Architecture and TechnologyXi’an 710055China

This study investigated the influence of cerium nitrate in vanadate solutions on the properties of Ce–V conversion coatings on AZ31 magnesium alloys,and evaluated the self-healing behavior of the Ce–V conversion coating for AZ31 magnesium *** results showed that the additions of cerium nitrate prevented pentavalent vanadium from reducing to tetravalent vanadium in the coatings during conversion reaction *** appropriate cerium nitrate to vanadate solution led to a thicker coating with a more compact CeVO_(4) *** corrosion behavior of the Ce–V conversion coating was investigated by the electrochemical tests and the scratch immersion test in 3.5 wt.%NaCl *** self-healing ability of the coating was confirmed from all *** surface analysis revealed that the self-healing effect of the Ce–V conversion coating was only provided by the release and migration of vanadium compounds.

关键词： AZ31 magnesium alloy Vanadium Cerium Self-healing Electrochemical impedance spectroscopy

Stereoselective Ring-Opening Polymerization of rac-Lactide Catalyzed by Squaramide Derived Organocatalysts at Room Temperature

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Chinese Journal of Chemistry 2021年第9期39卷 2403-2409页

作者： xiao jiang Na Zhao Zhibo Li Key Laboratory of Biobased Polymer Materials Shandong Provincial Education DepartmentCollege of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdaoShandong 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoShandong 266042China

Substa ntial progresses have bee n made toward the developme nt of meta I-free catalysts for stereoselective rin g-ope ning polymeriza-tion(ROP)of *** the discovery of organic catalysts effective at ambient temperature remains a major ***,the bifunctional H-bonding catalyst SQ-1 containing a basic tertiary amine and squaramide motif proved to be good candidate for the stereoselective ROP of rac-lactide at room temperature,yielding stereoregular polylactide with controlled molecular weights(up to 21.1 kg/mol)and high tacticity(PjESC up to 0.88).Furthermore,binary H-b on ding catalytic system con sisti ng of squaramides(SQ-2 to SQ-6)and 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU)could efficiently promote the ROP of rac-lactide at room temperature within short reaction *** them,the most bulky squaramide SQ-2 exhibited the best steroselectivity towards the ROP of rac-lactide without transesterification side reactions during the polymerization *** resulting polylactides were proved to have controlled molecular weights as high as 22.2 kg/mol and narrow distributions(1.10-1.24).

关键词： Ring-opening polymerization Organocatalysis Squaramide Polymers Stereoselective

Bilinear Pseudo-differential Operators on Local Hardy Spaces

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Acta Mathematica Sinica,English Series 2012年第2期28卷 255-266页

作者： jiang Wei xiao Yin Sheng jiang Wen Hua GAO College of Mathematics and Systems Science Xinjiang UniversityUrumqi 830046P.R.China School of Appied Mathematics Beijing Normal University ZhuhaiZhuhai 519085 P.R.China

In this paper, the authors consider a class of bilinear pseudo-differential operators with symbols of order 0 and type （1, 0） in the sense of HSrmander and use the atomic decompositions of local Hardy spaces to establish the boundedness of the bilinear pseudo-differential operators and the bilinear singular integral operators on the product of local Hardy spaces.

关键词： Bilinear pseudo-differential operators local Hardy spaces singular integrals

Split Quasi-adequate Semigroups

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Acta Mathematica Sinica,English Series 2012年第2期28卷 425-438页

作者： xiao jiang GUO Ting Ting PENG Department of Mathematics Jiangxi Normal UniversityNanchang 330022P.R.China Department of Base Jiangxi V&T College of CommunicationNanchang 330013P.R.China

The so-called split IC quasi-adequate semigroups are in the class of idempotent-connected quasi-adequate semigroups. It is proved that an IC quasi-adequate semigroup is split if and only if it has an adequate transversal. The structure of such semigroup whose band of idempotents is regular will be particularly investigated. Our obtained results enrich those results given by McAlister and Blyth on split orthodox semigroups.

关键词： Quasi-adequate semigroup adequate semigroup adequate transversal regular band,type-A semigroup