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3D digital-image correlation insight into generalized relaxation behavior of sandstone under stress and pore pressure coupling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2516-2536页

作者： Cancan Chen Heping xie jiang Xu Seisuke Okubo Shoujian Peng Cunbao Li Minghui Li State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen518060China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and GreenEnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China

The occurrence of geological hazards and the instability of geotechnical engineering structures are closely related to the time-dependent behavior of ***,the idealization boundary condition for constant stress in creep or constant strain in relaxation is not usually attained in natural geological ***,generalized relaxation tests that explore the simultaneous changes of stress and strain with time under different stress levels with constant pore-water pressure are conducted in this *** results show that in area Ⅰ,area Ⅱ,and area Ⅲ,the stress and strain both change synchronously with time and show similar evolutionary laws as the strain-time curve for creep or the stress-time curve for *** the applied stress level surpasses the δ_(ci) or δ_(cd) threshold,the variations in stress and strain and their respective rates of change exhibit a significant *** radial deformation and its rate of change exhibit greater sensitivity in response to stress *** apparent strain deforms homogeneously at the primary stage,and subsequently,gradually localizes due to the microcrack development at the secondary ***,interconnection of the microcracks causes the formation of a shear-localization zone at the tertiary *** strain-time responses inside and outside the localization zone are characterized by local strain accumulation and inelastic unloading during the secondary and tertiary stages,*** width of the shear-localization zone is found to range from 4.43 mm to 7.08 mm and increased with a longer *** electron microscopy(SEM)reveals a dominant coalescence of intergranular cracks on the fracture surface,and the degree of physiochemical deterioration caused by water-rock interaction is more severe under a longer *** brittle sandstone’s time-dependent deformation is essentially controlled by microcrack development during generalized relaxation,and its expectancy-life is dete

关键词： Generalized relaxation Stress level Direction coefficient Major-strain field Microcrack damage Stress threshold

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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： jiang Xiao-ying SHI Li-ping ZHU Jun-long BAI Ren-ren xie Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. xie Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui jiang Dong-Xu Liang Zhi-Sen jiang Huai-Na Yu Hua Wang Cheng-Wen Mao Jia-Nan xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

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A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

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Engineering 2024年第6期37卷 138-151页

作者： Peng Wang Liping Qian Huixin Liang Jianhao Huang Jing Jin Chunmei xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng jiang Lan Li Qing jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China jiangsu Engineering Research Center for 3D Bioprinting Nanjing 210008China Institute of Medical 3D Printing Nanjing UniversityNanjing 210093China Centre for Experimental Animals Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China College of Aeroplane Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA Department of Orthopedic Surgery The Second Affiliated Hospital Zhejiang University School of MedicineOrthopedic Research Institute of Zhejiang UniversityKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang ProvinceHangzhou 310009China

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of ***,the mechanical properties of hydrogel scaffolds and natural skin are substantially ***,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed *** Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine ***,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional *** results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the *** modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic *** an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound ***,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the ***,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress *** together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

关键词： Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways

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Inserting the Ulnar Prosthesis into Radius as a Novel Salvage Surgery for Revision Total Elbow Arthroplasty with Massive Bone Defect

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Chinese Medical Journal 2016年第16期129卷 1917-1921页

作者： Mao-Qi Gong Ji-Le jiang xie-Yuan jiang Ye-Jun Zha Ting Li Department of Orthopedic Trauma Beijing Jishuitan Hospital Beijing 100035 China

Background： Infection and aseptic loosening are common complications of total elbow arthroplasty （TEA） and often require revision surgery. However, bone defects, along with other complications, bring an extra difficulty to the second surgery, especially for patients with a massive bone defect in the proximal ulna. Several methods including allograft or autograft have been introduced into practice, but none sufficiently solves these problems. Methods： We conducted a new surgical method for patients with a massive ulnar bone defect needing revision TEA. During revision arthroplasty, the ulnar prosthesis was inserted into the radius as a salvage procedure. Four consecutive patients received revision arthroplasty with this method between 2013 and 2016. Patients＇ data were collected to evaluate the clinical outcome. Results： All patients had a Grade Ill ulnar bone defect. At the last follow-up session, all patients reported a painless, functional elbow joint. Three patients suffered from a periprosthetic infection that was completely cured using the two-stage method. No major complications, including infection, aseptic loosening, or wound problems were found. One patient had a transient ulnar neuritis, and another had a transient radial neuritis. Both patients had full recovery at the last follow-up session. Conclusions： Inserting an ulnar prosthesis into the radius is a novel procedure for patients with a massive bone defect due to infection or aseptic loosening. It is a safe, quick, and effective treatment with a promising short-term outcome. This method should be provided as a salvage procedure for patients with a nonreconstructable ulnar bone defect.

关键词： Massive Bone Defect Prosthesis Radius Revision Surgery Salvage Surgery Total Elbow Arthroplasty

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Research and design of matrix operation accelerator based on reconfigurable array

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High Technology Letters 2024年第2期30卷 128-137页

作者：邓军勇 ZHANG Pan jiang Lin xie Xiaoyan DENG Jingwen School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China School of Computer Science and Technology Xi’an University of Science and TechnologyXi’an 710054P.R.China School of Computer Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China

In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system *** the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in *** address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with *** experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.

关键词： matrix factorization(MF) recommender system(RS) array processor reconfigurable matrix multiplication

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A deep learning based fine-grained classification algorithm for grading of visual impairment in cataract patients

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Optoelectronics Letters 2024年第1期20卷 48-57页

作者： jiang Jiewei ZHANG Yi xie He YANG Jingshi GONG Jiamin LI Zhongwen School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhou 325000China Ningbo Eye Hospital Wenzhou Medical UniversityNingbo 315000China

Recent advancements in artificial intelligence(AI)have shown promising potential for the automated screening and grading of ***,the different types of visual impairment caused by cataracts exhibit similar phenotypes,posing significant challenges for accurately assessing the severity of visual *** address this issue,we propose a dense convolution combined with attention mechanism and multi-level classifier(DAMC_Net)for visual impairment ***,the double-attention mechanism is utilized to enable the DAMC_Net to focus on lesions-related ***,a hierarchical multi-level classifier is constructed to enhance the recognition ability in distinguishing the severities of visual impairment,while maintaining a better screening rate for normal *** addition,a cost-sensitive method is applied to address the problem of higher false-negative rate caused by the imbalanced *** results demonstrated that the DAMC_Net outperformed ResNet50 and dense convolutional network 121(DenseNet121)models,with sensitivity improvements of 6.0%and 3.4%on the category of mild visual impairment caused by cataracts(MVICC),and 2.1%and 4.3%on the category of moderate to severe visual impairment caused by cataracts(MSVICC),*** comparable performance on two external test datasets was achieved,further verifying the effectiveness and generalizability of the DAMC_Net.

关键词： visual classifier algorithm

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miR-933 accelerates the growth of liver cancer cells by enhancing pyruvate kinase isoform M2

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Genes & Diseases 2024年第4期11卷 31-34页

作者： Liyan Wang Shujie Li Xinlei Liu Sijie xie Shuting Song Xiaoxue jiang Dongdong Lu Shanghai Putuo People's Hospital School of Life Science and TechnologyTongji UniversityShanghai 200092China

MicroRNAs(miRNAs)have been found to play an important role in human tumorigenesis.A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably,miR-933(RS79402775)may contribute t... 详细信息

关键词： elevated cancer liver

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Pollution characteristics and quantitative source apportionment of heavy metals within a zinc smelting site by GIS-based PMF and APCS-MLR models

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Journal of Environmental Sciences 2024年第10期144卷 100-112页

作者： Huagang Lv Zhihuang Lu Guangxuan Fu Sifang Lv Jun jiang Yi xie Xinghua Luo Jiaqing Zeng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Zhuzhou Qingshuitang Technology Co. Ltd.Zhuzhou 412000China New World Environment Protection Group of Hunan Changsha 410083China

The abandoned smelters present a substantial pollution threat to the nearby soil and *** this study,63 surface soil samples were collected from a zinc smelter to quantitatively describe the pollution characteristics,ecological risks,and source apportionment of heavy metal(loid)s(HMs).The results revealed that the average contents of Zn,Cd,Pb,As,and Hg were 0.4,12.2,3.3,5.3,and 12.7 times higher than the risk screening values of the construction sites,***,the smelter was accumulated heavily with Cd and Hg,and the contribution of Cd(0.38)and Hg(0.53)to ecological risk was 91.58%.ZZ3 and ZZ7 were the most polluted workshops,accounting for 25.7%and 35.0%of the pollution load and ecological risk,*** influence of soil parent materials on pollution was minor compared to various workshops within the *** with PMF,APCS-MLR and GIS analysis,four sources of HMs were identified:P1(25.5%)and A3(18.4%)were atmospheric deposition from the electric defogging workshop and surface runoff from the smelter;P2(32.7%)and A2(20.9%)were surface runoff of As-Pb foul acid;P3(14.5%)and A4(49.8%)were atmospheric deposition from the leach slag drying workshop;P4(27.3%)and A1(10.8%)were the smelting process of zinc *** paper described the distribution characteristics and specific sources of HMs in different process workshops,providing a new perspective for the precise remediation of the smelter by determining the priority control factors.

关键词： Smelter site Heavy metal(loid)s Source apportionment Positive matrix factorization Absolute principal component score-multiple linear regression

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Regulating the intrinsic electronic structure of carbon nanofibers with high-spin state Ni for sodium storage with high-power density

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Journal of Materials Science & Technology 2024年第4期171卷 16-23页

作者： Zhijia Zhang Gang xie Yuefang Chen Yanhao Wei Mengmeng Zhang Shulei Chou Yunxiao Wang Yifang Zhang Yong jiang School of Materials Science and Engineering Institute of Quantum Materials and DevicesState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia

Carbon nanofibers(CNFs)with high specific surface area show great potential for sodium storage as a hard carbon ***,CNFs anchored with Ni nanoparticles(CNFs/Ni)were prepared through chemical vapor deposition and impregnation reduction methods,in situ growing on the three-dimensional porous copper current collector(3DP-Cu).The coupling effect of high-spin state Ni nanopar-ticles leads to the increase of defect density and the expansion of lattice spacing of ***,the 3DP-Cu ensures a high loading capacity of CNFs and short ion/electron transport *** an integral binder-free anode,the 3DP-Cu/CNFs/Ni exhibits excellent electrochemical performance,which demon-strates a high specific capacity with 298.5 mAh g^(-1)at 1000 mA g^(-1)after 1500 cycles,and a high power density with 200 mAh g^(-1)over 1000 cycles at 5000 mA g^(-1).Density functional theory calculation re-sults show that the high-spin state Ni regulates the electronic structure of CNFs,which significantly reduces the adsorption energy for Na^(+)(-2.7 Ev)and thus enables high-rate *** regulation of the electronic structure of carbon materials by high-spin state metal provides a new strategy for developing high-power carbonaceous anode materials for sodium-ion batteries.

关键词： Carbon nanofibers Ni nanoparticles High-spin state Sodium-ion batteries Anode materials Density functional theory calculation

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