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Construction of a biotin-targeting drug delivery system and its near-infrared theranostic fluorescent probe for real-time image-guided therapy of lung cancer

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Chinese Chemical Letters 2022年第3期33卷 1567-1571页

作者： Xinyu Song Rui Wang Junfang Gao Xiaoyue Han jianfeng jin Changjun Lv Fabiao Yu Department of Respiratory Medicine Department of Pediatric Gastroenterology and NephrologyBinzhou Medical University HospitalBinzhou 256603China Key Laboratory of Hainan Trauma and Disaster Rescue Department of NeurologyThe First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 571199China Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of PharmacyCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medicine UniversityGuangzhou 510120China

The therapy of non-small lung cancer(NSCLC) is limited by wide metastasis and chemotherapy resistance, herein, we present a new cancer-targeting prodrug PBG with the integration of real-time fluorescence visualization. The potent anticancer drug Gefitinib conjugates a biotin recognition ligand yielding the prodrug PBG via a GSH-activatable disulfide bond linker. Once coupling a near-infrared azo-BODIPY fluorophore into the molecular structure of PBG, we obtain its fluorescent theranostic TBG. The prodrug PBG can sustain Gefitinib release by the high level of GSH in the pathophysiological milieu. We evaluate the drug delivery of the prodrug PBG using fluorescent TBG in PC9 cancer bearing nude mice models,which indicate that TBG can be utilized to monitor the in vivo drug release process. Prodrug PBG can be targeted to accumulate in the cancer lesion with a better and efficaciously therapeutic result compared with the single Gefitinib treatment in cells and in vivo. The fluorescence images also reveal that the targeting accumulation and longitudinal retention of anticancer drug in cancer lesions will contribute to the superior therapeutic effects. The above applications of our new prodrug PBG and its fluorescent theranostic TBG have the potential contribution to the research in biology and the clinical medicine.

关键词： Fluorescent probe Drug delivery Theranostics In vivo imaging Lung cancer

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Two-dimensional interface superstructures assembled by well-ordered solute atoms

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Journal of Materials Science & Technology 2023年第11期142卷 253-259页

作者： Peijun Yang Shanshan Li Hongbo Xie jianfeng jin Chuangwei Liu Hucheng Pan Yuping Ren Weitao Jia Yaping Zong Gaowu Qin Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang 110142China College of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China

Segregation of solutes/impurities in the interfaces plays a decisive role in material performances.However,the segregation of solutes/impurities remains elusive due to the diversity of interfacial structures.Here,in a Mg-Nd-Mn ternary model system,two ordered novel two-dimensional(2D)interfacial superstructures formed by periodic segregation of solute atoms in special symmetric and asymmetric tilt grain boundaries(GBs)have been systematically investigated.Z-Contrast high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)observations provided the atomic-level details on how solute atoms were arranged on these special partially coherent tilt GBs.The strained conditions of each atomic site at the tilt GBs were accurately reproduced by molecular dynamics(MD)simulations plus Voronoi analysis,and the rationality of solute segregation in each atomic-site was evaluated carefully based on the first-principles calculations.These findings expand our knowledge of solute/impurity segregation behaviors in the interfaces,especially the co-segregation behaviors in multi-component materials.

关键词： Magnesium alloy Interfacial segregation Molecular dynamics First-principles HAADF-STEM

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农光互补电站的生态产品价值核算——以正泰江山200 MW农光互补电站为例

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农业资源与环境学报 2024年第1期41卷 197-211页

作者：魏宇帆金建峰丁倩周金莺张芳明杨武浙江大学环境与资源学院杭州310058 国网浙江省电力有限公司湖州供电公司浙江安吉313000 浙江九亩智慧农业科技有限公司杭州310000

为定量评估农光互补电站的生态效益,本研究基于生态产品价值核算的功能价值法,以华东地区最大的农光互补电站——正泰江山200 MW农光互补电站作为案例区开展了农光互补电站生态产品价值的核算。研究基于农光互补电站的特点对生态产品指... 详细信息

为定量评估农光互补电站的生态效益,本研究基于生态产品价值核算的功能价值法,以华东地区最大的农光互补电站——正泰江山200 MW农光互补电站作为案例区开展了农光互补电站生态产品价值的核算。研究基于农光互补电站的特点对生态产品指标进行了筛选,选取了农业产品、水源涵养、土壤保持、固碳、释氧和空气净化6个核算指标,同时结合遥感和地理信息数据、实地采样数据以及农业种植数据,量化了农光互补电站的生态效益。根据光伏板下种植类型的差异,将案例区划分为山茶区、蔬菜区、中药区、养殖区和猕猴桃区5个区域。核算结果表明:2021年该电站的生态产品价值量为1605.64万元,其中,供给产品为169.37万元,占10.55%,调节服务为1436.27万元,占89.45%;从不同分区来看,山茶区的生态产品价值最高,其次是猕猴桃区、蔬菜区和养殖区,中药区最低;从单位面积生态产品价值来看,2021年案例区的单位面积生态产品价值为3.79元·m^(-2)。农光互补电站的生态产品价值核算定量地展示了农光互补模式良好的生态效益,填补了定量评估农光互补电站生态效益的研究空白,对进一步提升农光互补电站的综合效益提供了技术支撑,同时为光伏资源和生态产品价值协同实现提供了新思路。

关键词：生态产品价值实现生态系统服务农业光伏可再生能源碳达峰碳中和

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无创机械通气治疗慢性阻塞性肺疾病急性加重期合并高碳酸血症临床疗效及对血气分析炎性因子的影响

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河北医学 2024年第4期30卷 593-597页

作者：关文霞靳建峰马小军山西省临汾市中心医院呼吸与危重症和睡眠医学科山西临汾041000

目的:分析无创机械通气(NIV)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并高碳酸血症的临床疗效及对血气分析、炎性因子的影响。方法:回顾性分析我院2022年4月至2023年4月治疗的118例AECOPD合并高碳酸血症患者进行研究,根据治疗的差异... 详细信息

目的:分析无创机械通气(NIV)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并高碳酸血症的临床疗效及对血气分析、炎性因子的影响。方法:回顾性分析我院2022年4月至2023年4月治疗的118例AECOPD合并高碳酸血症患者进行研究,根据治疗的差异将其分为对照组58例(采用氧疗与常规药物治疗)和观察组60例(采用NIV治疗)。对比两组临床疗效、血气指标[酸碱度(pH)、动脉血氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))]、炎性因子[白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]以及T淋巴细胞亚群[CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)]。结果:对照组(63.79%)的总有效率低于观察组(81.67%)(P0.05)。两组治疗前后PaO_(2)、pH、PaCO_(2)差值比较(P>0.05);两组治疗前IL-6、IL-10、TNF-α水平比较(P>0.05);观察组治疗前后IL-6、IL-10、TNF-α差值大于对照组(P0.05);观察组治疗前后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)差值大于对照组(P<0.05)。结论:采用NIV治疗可提高AECOPD合并高碳酸血症患者的临床治疗疗效,有效改善炎性因子指标与T淋巴细胞亚群,有助于促进患者全面康复。

关键词：无创机械通气慢性阻塞性肺疾病急性加重期高碳酸血症血气分析

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我国高速动车组源头质量安全管控研究

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智慧轨道交通 2024年第1期61卷 5-9,19页

作者：张增勇龚明金剑锋中车工业研究院有限公司北京100160 中国中车集团有限公司北京100039

截至2022年底,我国高铁的运营里程已达到4.2万公里,到2035年高铁运营里程将达到7万公里,庞大的高铁网络规模给行车安全带来了前所未有的挑战,开展高速动车组源头质量安全管控研究至关重要。首先总结了我国高速动车组质量安全管控的现状... 详细信息

截至2022年底,我国高铁的运营里程已达到4.2万公里,到2035年高铁运营里程将达到7万公里,庞大的高铁网络规模给行车安全带来了前所未有的挑战,开展高速动车组源头质量安全管控研究至关重要。首先总结了我国高速动车组质量安全管控的现状,重点包括质量管理体系、质量管控机制、产品交付质量把关、质量问题管理、数字技术支撑五大方面,其次根据历年事故和隐患数据统计,梳理总结出当前高速动车组质量安全管控的产业、产品、技术、供应链等方面的突出问题,提出高速动车组源头质量基础能力支撑、过程管控、技术保障、避免人为的管控方法,最后从国家和行业层面提出构建高速动车组信用体系、形成中国特色技术标准体系、政策助推深度自主化、完善人才队伍建设等对策建议。

关键词：高速动车组源头质量安全自主化战略

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基于宫颈多点活检与宫颈管搔刮术构建并验证宫颈阳性病变的诊断模型

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中国性科学 2024年第7期33卷 83-87页

作者：蒋彬彬王丽利金建峰浙江省杭州市富阳区妇幼保健院病理科杭州311400 浙江省杭州市富阳区妇幼保健院宫颈诊治中心杭州311400

目的基于宫颈多点活检(CDB)、宫颈管搔刮术(ECC)构建并验证宫颈阳性病变的诊断模型。方法选取2020年1月至2021年4月浙江省杭州市富阳区妇幼保健院收治的798例行阴道镜下CDB和ECC的宫颈疾病患者作为研究对象,分为训练集(n=559)和测试集(n... 详细信息

目的基于宫颈多点活检(CDB)、宫颈管搔刮术(ECC)构建并验证宫颈阳性病变的诊断模型。方法选取2020年1月至2021年4月浙江省杭州市富阳区妇幼保健院收治的798例行阴道镜下CDB和ECC的宫颈疾病患者作为研究对象,分为训练集(n=559)和测试集(n=239)。根据CDB、ECC活检最差结果,将训练集患者分为CDB+ECC阴性组(n=401)和CDB+ECC阳性组(n=158),分析宫颈阳性病变影响因素并构建验证诊断模型。结果对于训练集患者,Logistic回归结果显示:人乳头瘤病毒(HPV)状态(OR=2.385,95%CI:1.578~3.604)、液基薄层细胞学检查(TCT)结果(OR=2.644,95%CI:2.080~3.361)、宫颈萎缩(OR=0.351,95%CI:0.218~0.566)、阴道镜检查(OR=2.388,95%CI:1.606~3.548)是宫颈阳性病变的独立影响因素(P0.05)。结论HPV状态、TCT结果、宫颈萎缩、阴道镜检查结果是宫颈阳性病变的相关影响因素。以CDB和ECC结果为基础的宫颈阳性病变诊断模型具有一定的临床参考价值。

关键词：宫颈多点活检技术宫颈管搔刮术液基薄层细胞学检查模型诊断价值

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Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

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Nano-Micro Letters 2024年第3期16卷 183-211页

作者： jin Zhou Shenghan Zhou Peidi Fan Xunjia Li Yibin Ying jianfeng Ping Yuxiang Pan Laboratory of Agricultural Information Intelligent Sensing College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200People’s Republic of China

In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.

关键词： Electrochemical microsensors Implantable sensors In vivo monitoring Animal physiological information

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Optimization of Fixture Number in Large Thin-Walled Parts Assembly Based on IPSO

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 213-227页

作者： Changhui Liu jing Wang Ying Zheng Ke jin Jianbo Yu jianfeng Liu School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Jiaotong University Shanghai 200240China Shanghai Waigaoqiao Shipbuilding Co. Ltd.Shanghai 200137China

There are lots of researches on fixture layout optimization for large thin-walled parts.Current researches focus on the positioning problem,i.e.,optimizing the positions of a constant number of fixtures.However,how to determine the number of fixtures is ignored.In most cases,the number of fixtures located on large thin-walled parts is determined based on engineering experience,which leads to huge fixture number and extra waste.Therefore,this paper constructs an optimization model to minimize the number of fixtures.The constraints are set in the optimization model to ensure that the part deformation is within the surface profile tolerance.In addition,the assembly gap between two parts is also controlled.To conduct the optimization,this paper develops an improved particle swarm optimization(IPSO)algorithm by integrating the shrinkage factor and adaptive inertia weight.In the algorithm,particles are encoded according to the fixture position.Each dimension of the particle is assigned to a sub-region by constraining the optional position range of each fixture to improve the optimization efficiency.Finally,a case study on ship curved panel assembly is provided to prove that our method can optimize the number of fixtures while meeting the assembly quality requirements.This research proposes a method to optimize the number of fixtures,which can reduce the number of fixtures and achieve deformation control at the same time.

关键词： Assembly quality Large thin-walled parts Fixture layout PSO FEM

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Investigation of the block toppling evolution of a layered model slope by centrifuge test and discrete element modeling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 112-122页

作者： Leilei jin Hongkai Dong Fei Ye Yufeng Wei jianfeng Liu Changkui Wang State Key Laboratory of Hydraulic and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China

Primary toppling usually occurs in layered rock slopes with large anti-dip angles.In this paper,the block toppling evolution was explored using a large-scale centrifuge system.Each block column in the layered model slope was made of cement mortar.Some artificial cracks perpendicular to the block column were prefabricated.Strain gages,displacement gages,and high-speed camera measurements were employed to monitor the deformation and failure processes of the model slope.The centrifuge test results show that the block toppling evolution can be divided into seven stages,i.***.layer compression,formation of major tensile crack,reverse bending of the block column,closure of major tensile crack,strong bending of the block column,formation of failure zone,and complete failure.Block toppling is characterized by sudden large deformation and occurs in stages.The wedge-shaped cracks in the model incline towards the slope.Experimental observations show that block toppling is mainly caused by bending failure rather than by shear failure.The tensile strength also plays a key factor in the evolution of block toppling.The simulation results from discrete element method(DEM)is in line with the testing results.Tensile stress exists at the backside of rock column during toppling deformation.Stress concentration results in the fragmented rock column and its degree is the most significant at the slope toe.

关键词： Block toppling Centrifuge Anti-dip slope Failure mechanism Discrete element method

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Highly efficient ternary organic solar cells with excellent open-circuit voltage and fill factor via precisely tuning molecular stacking and morphology

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Science China Chemistry 2024年第3期67卷 963-972页

作者： Dinghong Sun Zhenyu Chen jianfeng Zhang Wei Song jingyu Shi jintao Zhu Yuanyuan Meng Fei jin Shuncheng Yang Ziyi Ge Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China Faculty of Material Science and Chemical Engineering Ningbo UniversityNingbo 315211China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049China Department of Chemical and Environmental Engineering University of Nottingham NingboNingbo 315100China

The micro-morphology and molecular stacking play a key role in determining the charge transport process and nonradiative energy loss, thus impacting the performances of organic solar cells(OSCs). To address this issue, a non-fullerene acceptor PhC6-IC-F with alkylbenzene side-chain, possessing optimized molecular stacking, complementary absorption spectra and forming a cascade energy level alignment in the PM6:BTP-eC9 blend, is introduced as guest acceptor to improve efficiency of ternary OSCs. The bulky phenyl in the side-chain can regulate crystallinity and optimizing phase separation between receptors in ternary blend films, resulting in the optimal phase separations in the ternary films. As a result, high efficiencies of 18.33% as photovoltaic layer are obtained for PhC6-IC-F-based ternary devices with excellent fill factor(FF) of 78.92%. Impressively, the ternary system produces a significantly improved open circuit voltage(V_(oc)) of 0.857 V compared with the binary device,contributing to the reduced density of trap states and suppressed non-radiative recombination result in lower energy loss. This work demonstrates an effective approach for adjusting the aggregation, molecular packing and fine phase separation morphology to increase V_(oc) and FF, paving the way toward high-efficiency OSCs.

关键词： alkylbenzene side-chain morphology regulation ternary blends organic solar cells

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