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Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

Bone Research 2024年第1期12卷 137-152页

作者： Weicheng Lu jianfei Yan Chenyu Wang Wenpin Qin Xiaoxiao Han Zixuan Qin Yu Wei Haoqing Xu Jialu Gao Changhe Gao Tao ye Franklin R.Tay Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury.Inflammasome-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal tissues.These proteins initiate inflammatory dysfunction,such as neurogenic heterotopic ossification.This recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention strategies.Accordingly,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two issues.Histological examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast pyroptosis.The relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in vivo.Intravenous injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in vivo.The present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

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Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America

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National Science Review 2022年第6期9卷 38-42页

作者： Haihua Hu jianfei ye Bing Liu Lingfeng Mao Stephen A.Smith Russell L.Barrett Pamela S.Soltis Douglas E.Soltis Zhiduan Chen Limin Lu State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Sino-Africa Joint Research Center Chinese Academy of Sciences Beijing Botanical Garden Institute of BotanyChinese Academy of Sciences Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the Environment Nanjing Forestry University Department of Ecology and Evolutionary Biology University of Michigan National Herbarium of New South Wales Royal Botanic Gardens and Domain Trust Florida Museum of Natural History University of Florida Department of Biology University of Florida

Comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA; see definitions of EA and NA in Fig. S1 A) share similar geographical environments with comparable latitude, land area and climate,

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基于TCN和迁移学习的混凝土坝变形预测方法

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人民黄河 2024年第4期46卷 142-147页

作者：张健飞叶亮王磊河海大学力学与材料学院江苏南京211100

混凝土坝变形测点数据丢失或者新增测点测量时间太短都会导致这部分测点的数据量不足,使得变形预测精度受到影响。为了提高这些小数据量测点的变形预测精度,提出了将时域卷积网络(TCN)与迁移学习相结合的变形预测方法。以数据量充足的... 详细信息

混凝土坝变形测点数据丢失或者新增测点测量时间太短都会导致这部分测点的数据量不足,使得变形预测精度受到影响。为了提高这些小数据量测点的变形预测精度,提出了将时域卷积网络(TCN)与迁移学习相结合的变形预测方法。以数据量充足的测点为源域,以缺少数据的测点为目标域,将在源域上训练好的TCN模型的结构和参数迁移到目标域模型中,固定其中的冻结层参数,利用目标域中的数据对目标域模型可调层参数进行调整。同时,采用动态时间规整选择与目标域数据序列相似度最高的监测数据作为最佳源域数据,提升迁移学习效果。工程实例分析表明:迁移学习后的目标域模型的均方根误差和平均绝对误差与利用足量数据训练的TCN模型的预测误差相比,差异仅分别为1.73%和8.09%,小数据量情况下TCN预测模型的精度得到了提高。

关键词：时域卷积网络迁移学习动态时间规整变形预测

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基于用户长短期偏好的个性化推荐

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吉林大学学报（理学版） 2024年第3期62卷 615-628页

作者：叶榕邵剑飞邵建龙昆明理工大学信息工程与自动化学院昆明650500

针对现有序列推荐模型忽略用户的长期偏好和短期偏好,导致推荐模型不能充分发挥作用,推荐效果不佳的问题,提出一种基于用户长短期偏好的个性化推荐模型.首先,针对长期偏好序列长且不连续的特点,采用BERT(bidirectional encoder represen... 详细信息

针对现有序列推荐模型忽略用户的长期偏好和短期偏好,导致推荐模型不能充分发挥作用,推荐效果不佳的问题,提出一种基于用户长短期偏好的个性化推荐模型.首先,针对长期偏好序列长且不连续的特点,采用BERT(bidirectional encoder representations from transformers)对长期偏好建模;针对短期偏好序列短且与用户交互的间隔时间较短,具有易变性,采用垂直水平卷积网络对短期偏好建模;在得到用户的长期偏好和短期偏好后,利用激活函数进行动态建模,然后利用门控循环网络对长短期偏好进行平衡.其次,针对用户在日常交互中的误碰行为,采用稀疏注意力网络进行建模,在对长短期偏好建模前使用稀疏注意力网络进行用户行为序列处理;用户特征偏好对推荐结果也会有影响,使用带有偏置编码的多头注意力机制对用户特征进行提取.最后,将各部分得到的结果输入到全连接层得到最后的输出结果.为验证本文模型的可行性,在数据集yelp和MovieLens-1M上进行实验,实验结果表明该模型优于其他基线模型.

关键词：序列推荐长期偏好短期偏好稀疏注意力网络垂直水平卷积网络

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芳纶纤维与树脂基体改性对复合材料剪切性能的影响

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高分子材料科学与工程 2024年第2期40卷 91-100页

作者：梁起睿叶金蕊颜丙越刘凯何剑飞姬晓龙侯晓先进输电技术国家重点实验室北京102209 沈阳建筑大学材料科学与工程学院辽宁沈阳110168 北京理工大学宇航学院北京100081 北京理工大学唐山研究院河北唐山063000

芳纶纤维表面惰性会影响其与树脂间的浸润性能和界面结合强度,因此限制了芳纶纤维复合材料在航空、航天、输电等领域的应用。为了对比纤维表面改性和树脂基体改性技术对芳纶纤维复合材料层间剪切性能的影响,文中结合光学和力学测试方法... 详细信息

芳纶纤维表面惰性会影响其与树脂间的浸润性能和界面结合强度,因此限制了芳纶纤维复合材料在航空、航天、输电等领域的应用。为了对比纤维表面改性和树脂基体改性技术对芳纶纤维复合材料层间剪切性能的影响,文中结合光学和力学测试方法对不同改性技术及处理过程对芳纶纤维表面刻蚀的影响机制开展了深入研究。结果表明,乙酸酐化学刻蚀会对芳纶纤维表面基团产生影响且增加表面粗糙度。热氧化刻蚀处理后表面粗糙度显著增加,具有明显“沟壑”状。然而,当乙酸酐化学刻蚀处理时间高于6 h、热氧化刻蚀处理时间高于4 min时,纤维内部结构就会受到损伤,导致复合材料层间剪切性能降低。超声浸渍改性处理后,纤维表面粗糙度有一定增加,纤维表面附着的气体将会排出,超过20 min后改性效果趋于稳定。使用偶联剂改性树脂基体可以增加纤维表面的键合作用,当添加量超过3%时,树脂分子间的过度交联导致复合材料层间剪切性能下降。研究结果为提高芳纶复合材料浸润性能和界面强度提供了理论依据,对航空航天、电力系统中芳纶复合材料设计及制造研究具有参考价值。

关键词：芳纶纤维表面改性界面强度树脂基体改性微观形貌浸润性能

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微牛级电磁力标定装置仿真与测试研究

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推进技术 2024年第5期45卷 208-216页

作者：成烨龙建飞罗威王嘉彬黄丹徐禄祥郭宁杨威国科大杭州高等研究院基础物理与数学科学学院浙江杭州310024 国科大杭州高等研究院引力波太极实验室(杭州) 浙江杭州310024 国科大杭州高等研究院浙江省引力波精密测量重点实验室浙江杭州310024 重庆科技学院电气工程学院重庆401331

如何获得高精度标定力是微牛级推力测量的重要基础。本文构建了C型磁路结构和矩形线圈组合方式以产生高精度宽范围电磁标定力。利用有限元方法分析了该装置特征区域磁场分布,对矩形线圈与磁体相对位置影响进行了讨论,最后搭建标定实验... 详细信息

如何获得高精度标定力是微牛级推力测量的重要基础。本文构建了C型磁路结构和矩形线圈组合方式以产生高精度宽范围电磁标定力。利用有限元方法分析了该装置特征区域磁场分布,对矩形线圈与磁体相对位置影响进行了讨论,最后搭建标定实验平台并进行标定实验。得到主要结论:在特征区域范围内磁场分布均匀性较好,最大差异率仅为0.7%;电流在10μA~20.2 mA范围调节时,电磁力标定范围为0.097~237.32μN,实验测量数据与仿真结果最大误差为1.73%;当线圈电流分辨率为10μA时,标定力实测分辨率优于0.1μN。

关键词：微推力测量微牛级电磁力标定系统参数标定仿真模拟

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Mesopause temperatures and relative densities at midlatitudes observed by the Mengcheng meteor radar

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Earth and Planetary Physics 2023年第6期7卷 665-674页

作者： Wen Yi XiangHui Xue MaoLin Lu Jie Zeng HaiLun ye jianfei Wu Chong Wang TingDi Chen Chinese Academy of Sciences Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for the Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The atmospheric temperatures and densities in the mesosphere and lower thermosphere(MLT)region are essential for studying the dynamics and climate of the middle and upper atmosphere.In this study,we present more than 9 years of mesopause temperatures and relative densities estimated by using ambipolar diffusion coefficient measurements observed by the Mengcheng meteor radar(33.4°N,116.5°E).The intercomparison between the meteor radar and Thermosphere Ionosphere Mesosphere Energetics and Dynamics/Sounding of the Atmosphere by Broadband Emission Radiometry(TIMED/SABER)and Earth Observing System(EOS)Aura/Microwave Limb Sounder(MLS)observations indicates that the meteor radar temperatures and densities agree well with the simultaneous satellite measurements.Annual variations dominate the mesopause temperatures,with the maximum during winter and the minimum during summer.The mesopause relative densities also show annual variations,with strong maxima near the spring equinox and weak maxima before the winter solstice,and with a minimum during summer.In addition,the mesopause density exhibits a structure similar to that of the zonal wind:as the zonal wind flows eastward(westward),the mesopause density decreases(increases).At the same time,the meridional wind shows a structure similar to that of the mesopause temperature:as the meridional wind shows northward(southward)enhancements,the mesopause temperature increases(decreases).Simultaneous horizontal wind,temperature,and density observations provide multiple mesospheric parameters for investigating mesospheric dynamics and thermodynamic processes and have the potential to improve widely used empirical atmospheric models.

关键词： meteor radar mesopause horizontal wind temperature density

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A comparison of MLT wind between meteor radar chain data and SDWACCM results

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Earth and Planetary Physics 2022年第5期6卷 451-464页

作者： BaoZhu Zhou XiangHui Xue Wen Yi HaiLun ye Jie Zeng JinSong Chen jianfei Wu TingDi Chen XianKang Dou CAS Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for the Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Electronic Information School Wuhan UniversityWuhan 430072China

A meteor radar chain located along the 120°E meridian in the Northern Hemisphere from low to middle latitudes provides longterm horizontal wind observations of the mesosphere and lower thermosphere(MLT)region.In this study,we report a seasonal variation and its latitudinal feature in the horizontal mean wind in the MLT region observed by six meteor radar instruments located at Mohe(53.5°N,122.3°E),Beijing(40.3°N,116.2°E),Mengcheng(33.4°N,116.5°E),Wuhan(30.6°N,114.4°E),Kunming(25.6°N,108.3°E),and Fuke(19.5°N,109.1°E)stations.In addition,we compare the wind in the MLT region measured by the meteor radar stations with those simulated by the Whole Atmosphere Community Climate Model(WACCM).In general,the WACCM appears to capture well the seasonal and latitudinal variations in the zonal wind component.In particular,the temporal evolution of the eastward zonal wind maximum shifts from July to May as the latitude decreases.However,the simulated WACCM meridional wind exhibits differences from the meteor radar observations.

关键词： meteor radar chain MLT horizontal wind tide SD-WACCM

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Simultaneous bilateral retroperitoneoscopic nephroureterectomy in renal recipients： a single-center experience

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Chinese Medical Journal 2014年第22期127卷 3993-3995页

作者： Ma Lulin ye jianfei Tang Wenhao Department of Urology Peking University Third Hospital Beijing 100191 China

Conventional simultaneous bilateral open nephroureterectomy combined with resection of bladder cuffs seems not optimal for bilateral upper tract urothelial carcinoma （UTUC） in renal transplant and dialysis patients with enormous invasion related to large morbidity,delayed gastrointestinal function,and late recovery.1 This study reports the largest series of minimally invasive procedures of simultaneous bilateral retroperitoneoscopic nephroureterectomy （SBRNU） via a midline lower abdominal incision in renal recipients.

关键词： retroperitoneoscopy bilateral nephroureterectomy urothelial carcinoma renal transplantation

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Magneto-mechanical effect of magnetic microhydrogel for improvement of magnetic neuro-stimulation

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Nano Research 2023年第5期16卷 7393-7404页

作者： Le Xue Qing ye Linyuan Wu Dong Li Siyuan Bao Qingbo Lu Sha Liu Dongke Sun Zonghai Sheng Zhijun Zhang Ning Gu jianfei Sun State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Mechanic Engineering Southeast UniversityNanjing 211189China Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjing 210009China Paul C.Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong ProvinceShenzhen Key Laboratory of Ultrasound Imaging and TherapyCAS Key Laboratory of Health InformaticsInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mental Health and Public Health Faculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Medicine Nanjing UniversityNanjing 210008China

Superparamagnetic iron oxide(SPIO)nanoparticles play an important role in mediating precise and effective magnetic neurostimulation and can help overcome limitations related to penetration depth and spatial resolution.However,nanoparticles readily diffuse in vivo,decreasing the spatial resolution and activation efficiency.In this study,we employed a microfluidic means to fabricate injectable microhydrogels encapsulated with SPIO nanoparticles,which significantly improved the stability of nanoparticles,increased the magnetic properties,reinforced the stimulation effectivity.The fabricated magnetic microhydrogels were highly uniform in size and sphericity,enabling minimally invasive injection into brain tissue.The long-term residency in the cortex up to 22 weeks and the safety of brain tissue were shown using a mouse model.In addition,we quantitatively determined the magneto-mechanical force yielded by only one magnetic microhydrogel using a video-based method.The force was found to be within 7–8 pN under 10 Hz magnetic stimulation by both theoretical simulation and experimental measurement.Lastly,electrophysiological measurement of brain slices showed that the magnetic microhydrogels offer significant advantages in terms of neural activation relative to dissociative SPIO nanoparticles.A universal strategy is thus offered for performing magnetic neuro-stimulation with an improved prospect for biomedical translation.

关键词： magnetic stimulation superparamagnetic iron oxide(SPIO)nanoparticles magnetic microhydrogel long-term residency magneto-mechanical effect

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