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Recent advances in regenerative biomaterials

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Regenerative Biomaterials 2022年第1期9卷 1182-1218页

作者： dinglingge Cao Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Nowadays,biomaterials have evolved from the inert supports or functional substitutes to the bioactive materials able to trigger or promote the regenerative potential of tissues.The interdisciplinary progress has broadened the definition of‘biomaterials’,and a typical new insight is the concept of tissue induction biomaterials.The term‘regenerative biomaterials’and thus the contents of this article are relevant to yet beyond tissue induction biomaterials.This review summarizes the recent progress of medical materials including metals,ceramics,hydrogels,other polymers and bio-derived materials.As the application aspects are concerned,this article introduces regenerative biomaterials for bone and cartilage regeneration,cardiovascular repair,3D bioprinting,wound healing and medical cosmetology.Cell-biomaterial interactions are highlighted.Since the global pandemic of coronavirus disease 2019,the review particularly mentions biomaterials for public health emergency.In the last section,perspectives are suggested:(i)creation of new materials is the source of innovation;(ii)modification of existing materials is an effective strategy for performance improvement;(iii)biomaterial degradation and tissue regeneration are required to be harmonious with each other;(iv)host responses can significantly influence the clinical outcomes;(v)the long-term outcomes should be paid more attention to;(vi)the noninvasive approaches for monitoring in vivo dynamic evolution are required to be developed;(vii)public health emergencies call for more research and development of biomaterials;and(viii)clinical translation needs to be pushed forward in a full-chain way.In the future,more new insights are expected to be shed into the brilliant field-regenerative biomaterials.

关键词： regenerative biomaterial tissue induction biomaterial medical material tissue regeneration

A composite strategy to fabricate high-performance biodegradable stents for tissue regeneration

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Science China Materials 2018年第8期61卷 1132-1134页

作者： Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University

While most of the present medical implants are nonbiodegradable,biodegradable materials are thought to replace many nonbiodegradable ones in the future,which is dependent on development of the corresponding core techniques of biomaterials[1–4].Much progress has been made in the field of biodegradable materials during the last decade[5–7].Besides introducing new materials

关键词： Nature

Multidimensional perovskites enhance solar cell performance

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Journal of Semiconductors 2021年第2期42卷 3-5页

作者： Wenzhe Li jiandong Fan Liming ding Institute of New Energy Technology Department of Electronic Science and EngineeringCollege of Information Science and TechnologyJinan UniversityGuangzhou 510632China Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Organic-inorganic hybrid metal halide perovskite materials have attracted much research interest over the past decade because of their unique electrical and optoelectronic properties, e.g., long diffusion length, high... 详细信息

关键词： states. perovskite inorganic

Finding MicroRNA Targets in Plants: Current Status and Perspectives

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 264-275页

作者： Jiandong Ding Shuigeng Zhou Jihong Guan Shanghai Key Laboratory of Intelligent Information Processing Fudan UniversityShanghai 200433China School of Computer Science Fudan UniversityShanghai 200433China Department of Computer Science and Technology Tongji UniversityShanghai 201804China

MicroRNAs （miRNAs）, a class of ～20-24 nt long non-coding RNAs, have critical roles in diverse biological processes including devel- opment, proliferation, stress response, etc. With the development and availability of experimental technologies and computational approaches, the field of miRNA biology has advanced tremendously over the last decade. By sequence complementarity, miRNAs have been estimated to regulate certain mRNA transcripts. Although it was once thought to be simple and straightforward to find plant miR NA targets, this viewpoint is being challenged by genetic and biochemical studies. In this review, we summarize recent progress in plant miRNA target recognition mechanisms, principles of target prediction, and introduce current experimental and computational tools for plant miRNA target prediction. At the end, we also present our thinking on the outlook for future directions in the development of plant miRNA target finding methods.

关键词： MicroRNA Target prediction Degradome-seq Integration

Coordination Insertion Mechanism of Ring-Opening Polymerization of Lactide Catalyzed by Stannous Octoate

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Chinese Journal of Chemistry 2021年第7期39卷 1965-1974页

作者： Weihan Rao Caiyun Cai Jingyu Tang Yiman Wei Caiyun Gao Lin Yu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438 China Zhuhai Fudan Innovation Institute ZhuhaiGuangdong519000 China

Main observation and conclusion Ring-opening polymerization(ROP)of cyclic esters in the presence of stannous octoate(Sn(Oct)2)is the main way to obtain biodegradable aliphatic polyesters,an important family of biodegradable polymers which have been widely used and still rapidly developed in the fields of biomedical polymers and environment-friendly materials.

关键词： Ring-opening polymerization Transition states Curtin-Hammett principle Polylactide Density functional theory

Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer

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Bioactive Materials 2022年第9期7卷 288-304页

作者： Yingning He Yue Yu Yuqian Yang Yexin Gu Tianjiao Mao Yang Shen Qiong Liu Ruili Liu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai200434China

While most studies of mechanical stimulation of cells are focused on two-dimensional(2D)and three-dimensional(3D)systems,it is rare to study the effects of cyclic stretching on cells under a quasi-3D microenvironment as a linkage between 2D and 3D.Herein,we report a new method to prepare an elastic membrane with topographic microstructures and integrate the membrane into a microfluidic chip.The fabrication difficulty lay not only in the preparation of microstructures but also in the alignment and bonding of the patterned membrane to other layers.To resolve the problem,we designed and assembled a fast aligner that is cost-effective and convenient to operate.To enable quasi-3D microenvironment of cells,we fabricated polydimethylsiloxane(PDMS)microwell arrays(formed by micropillars of a few microns in diameter)with the microwell diameters close to the cell sizes.An appropriate plasma treatment was found to afford a coating-free approach to enable cell adhesion on PDMS.We examined three types of cells in 2D,quasi-3D,and 3D microenvironments;the cell adhesion results showed that quasi-3D cells behaved between 2D and 3D cells.We also constructed transgenic human mesenchymal stem cells(hMSCs);under cyclic stretching,the visualizable live hMSCs in microwells were found to orientate differently from in a 3D Matrigel matrix and migrate differently from on a 2D flat plate.This study not only provides valuable tools for microfabrication of a microfluidic device for cell studies,but also inspires further studies of the topological effects of biomaterials on cells.

关键词： Microfluidic chip Biomaterials Cell-material interaction Polymer Cell stretching

Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals

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Regenerative Biomaterials 2024年第1期3卷 132-148页

作者： Hongjie Zhang Xin Li Zehua Qu Wanqian Zhang Qunsong Wang dinglingge Cao Yaoben Wang Xin Wang Yang Wang Lin Yu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Corrodible metals are the newest kind of biodegradable materials and raise a new problem of the corrosion products.However,the removal of the precipitated products has been unclear and even largely ignored in publications.Herein,we find that albumin,an abundant macromolecule in serum,enhances the solubility of corrosion products of iron in blood mimetic Hank’s solution significantly.This is universal for other main biodegradable metals such as magnesium,zinc and polyester-coated iron.Albumin also influences corrosion rates in diverse trends in Hank’s solution and normal saline.Based on quantitative study theoretically and experimentally,both the effects on corrosion rates and soluble fractions are interpreted by a unified mechanism,and the key factor leading to different corrosion behaviors in corrosion media is the interference of albumin to the Ca/P passivation layer on the metal surface.This work has illustrated that the interactions between metals and media macromolecules should be taken into consideration in the design of the next-generation metal-based biodegradable medical devices in the formulism of precision medicine.The improved Hank’s solution in the presence of albumin and with a higher content of initial calcium salt is suggested to access biodegradable metals potentially for cardiovascular medical devices,where the content of calcium salt is calculated after consideration of chelating of calcium ions by albumin,resulting in the physiological concentration of free calcium ions.

关键词： biodegradable metal macromolecule albumin corrosion bioabsorbability iron polylactide magnesium zinc

Is polydopamine beneficial for cells on the modified surface?

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Regenerative Biomaterials 2022年第1期9卷 928-941页

作者： Yue Yu Xiuli Wang Yi Zhu Yingning He Hongrui Xue Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Since the pioneering work of Messersmith’s group discovering that polydopamine(PDA)can serve to adhere to many types of materials,the PDA coating has,as a biomimetic approach,been widely used to enhance cell adhesion by surface modification to bind biologically active substances to a bioinert substrate.Nevertheless,it is unclear whether or not the PDA itself is beneficial for cells.Herein,we report that a PDA coating decreases viability of cells under normal culture and observation conditions.Such an inhibition effect was not caused by the free PDA or any inherent cytotoxicity of this chemical substance but a contactdependent phenomenon.Human bone marrow mesenchymal stem cells were employed as the default cell type and tissue culture plates were used as the default substrate,although some other cell types and substrates were also examined to confirm the universality of such an‘abnormal’phenomenon of a superstar molecule.The viability of cells on the PDA coating exhibited time dependence,and the decreased cell viability during the normal observation time was found to come from the decrease of cell number instead of the decrease of average viability per cell.The PDA coating led to less cell global migration yet more local motility of cells.Based on the concept of‘background adhesion’of cells on a surface without significant motifs of specific cell adhesion,we supposed that cells adhered to the PDA coating better,which influenced mobility and eventually proliferation.Hence,the cell behaviors on the PDA coating are reasonable,albeit a bit complicated.

关键词： biomaterial polymer polydopamine surface modification cell viability

Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

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Bioactive Materials 2021年第12期6卷 4717-4728页

作者： Xiaohui Wu Xin Wang Xiaobin Chen Xiaowei Yang Qian Ma Guohua Xu Lin Yu Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceShanghai Stomatological HospitalFudan UniversityShanghai200438China Department of Orthopedic Surgery Spine CenterChangzheng HospitalNaval Medical UniversityShanghai200003China Zhuhai Fudan Innovation Institute ZhuhaiGuangdong519000China

It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues.Herein,we designed a novel macromolecular contrast agent with ultrahigh radiopacity(iodinate content>50%)via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol)(PEG).A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us,which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature,were selected as the demonstration materials.The addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels,but conferred them with excellent X-ray opacity,enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or Micro-CT.In a mouse model,the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging,and their injection volume could be accurately obtained.Furthermore,the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative manner.In particular,the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric method.These findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels,and can nondestructively trace and quantify their degradation in vivo.Meanwhile,the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials.

关键词： Thermosensitive hydrogels Radiopacity Block copolymers In vivo degradation Non-invasive deep tissue imaging