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Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 430-441页

作者： Juncheng HUANG Wenxia QIN Baoyang XU Haihui SUN Fanghua JING Yunzheng XU jianan zhao Yuwen CHEN Libao MA Xianghua YAN State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070China Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Wuhan 430070China Yichun Dahaigui Life Science Co. Ltd.Yichun 336000China

Early weaned piglets suffer from oxidative stress and enteral infection,which usually results in gut microbial dysbiosis,serve diarrhea,and even death.Rice bran oil(RBO),a polyphenol-enriched by-product of rice processing,has been shown to have antioxidant and anti-inflammatory properties both in vivo and in vitro.Here,we ascertained the proper RBO supplementation level,and subsequently determined its effects on lipopolysaccharide(LPS)-induced intestinal dysfunction in weaned piglets.A total of 168 piglets were randomly allocated into four groups of seven replicates(42 piglets each group,(21±1)d of age,body weight(7.60±0.04)kg,and half males and half females)and were given basal diet(Ctrl)or basal diet supplemented with 0.01%(mass fraction)RBO(RBO1),0.02%RBO(RBO2),or 0.03%RBO(RBO3)for 21 d.Then,seven piglets from the Ctrl and the RBO were treated with LPS(100μg/kg body weight(BW))as LPS group and RBO+LPS group,respectively.Meanwhile,seven piglets from the Ctrl were treated with the saline vehicle(Ctrl group).Four hours later,all treated piglets were sacrificed for taking samples of plasma,jejunum tissues,and feces.The results showed that 0.02%was the optimal dose of dietary RBO supplementation based on diarrhea,average daily gain,and average daily feed intake indices in early weaning piglets.Furthermore,RBO protected piglets against LPS-induced jejunal epithelium damage,which was indicated by the increases in villus height,villus height/crypt depth ratio,and Claudin-1 levels,as well as a decreased level of jejunal epithelium apoptosis.RBO also improved the antioxidant ability of LPS-challenged piglets,which was indicated by the elevated concentrations of catalase and superoxide dismutase,and increased total antioxidant capacity,as well as the decreased concentrations of diamine oxidase and malondialdehyde in plasma.Meanwhile,RBO improved the immune function of LPS-challenged weaned piglets,which was indicated by elevated immunoglobulin A(IgA),IgM,β-defensin-1,and lysozyme levels in the plasma.In addition,RBO supp

关键词： Rice bran oil Gut microbiota Weaned piglets Oxidative stress Lipopolysaccharide

Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin(Manis javanica)

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Integrative Zoology 2023年第2期18卷 289-298页

作者： Fang JI Shelan LIU Xue WANG jianan zhao Jiayue ZHU Jianchun YANG Chenglin ZHANG Zhongxin JIA Ruili zhao Guocheng HU Jing WANG Jianhua QIN Gang LI Bin WU Chengmin WANG Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of ScienceGuangzhouChina Department of Infectious Diseases Zhejiang Center of Disease Control and PreventionHangzhouZhejiangChina School of Bioengineering East China University of Science and TechnologyShanghaiChina Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijingChina College of Animal Science and Veterinary Medicine Tianjin Agricultural UniversityTianjinChina South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhouChina Department of Infectious Diseases Hangzhou Center of Disease Control and PreventionHangzhouChina College of Veterinary Medicine Agricultural University of HebeiBaodingChina

Potential zoonotic pathogens may be transmitted from wildlife to humans through the illegal wild meat trade,which has become a pressing issue.However,research on the antimicrobial resistance genes(ARGs)of Malayan pangolin(Manis javanica)intestinal bacteria is limited.Here,multidrug-resistant Escherichia coli M172-1(ST354)isolated from Malayan pangolin feces in 2019 was found to be resistant to 13 antibiotics.BGWAS analysis revealed 4 plas-mids,namely,pM172-1.1,pM172-1.2,pM172-1.3,and pM172-1.4,in the isolate.The pM172-1.2,pM172-1.3,and pM172-1.4 plasmids carried ARGs,namely,IncHI2-HI2A,IncX1-X1,and IncX1,respectively.pM172-1.3 and pM172-1.4 contained intact IntI1 integrons(Is26/IntI1/arr2/cmlA5/blaOXA-10/ant(3′′)-IIA/dfrA14/Is26).No-tably,pM172-1.3 resulted from the fusion of 2 pM172-1.4 copies and carried many more ARGs.In addition to pM172-1.3 from the same host,other drug-resistant bacteria(E.coli M159-1(ST48),E.coli S171-1(ST206),and Klebsiella pneumoniae S174-1(ST2354))in the same Malayan pangolin fecal samples also carried 3 plasmids with 100%gene coverage of pM172-1.4 and 99.98%identity.Therefore,ARGs in IncX1 might spread in the intestinalﬂora of Malayan pangolin and between species via the illegal food chain,posing a potential threat to public health and safety.

关键词： ARG Manis javanica multiple-replicon plasmid IncX1-X1 plasmid IncX1

基于Smartbi的评标专家库管理系统设计

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信息与电脑 2024年第6期36卷 114-117页

作者：赵佳男河南省机场集团有限公司河南郑州450000

将Smartbi和MySQL数据库相结合,建立评标专家信息库,采用合理的随机算法从专家库中抽取专家参与招投标工作,并实现自动出发短信通知被抽中的评标专家,可降低信息泄露的风险,提升采购的透明度和公开化水平,并提高招投标工作效率。

关键词： Smartbi 专家库抽取招投标

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网络背景下青少年心理问题成因及对策研究

大学（研究与管理） 2024年第3期 181-184页

作者：赵佳楠刘凤林佳木斯大学教育科学学院黑龙江佳木斯154002

网络对处于人生转折点的青少年产生了不可估量的影响,既使他们获得了全新的观念,丰富了他们的知识,激发了他们的创造性思维,也改变了他们的行为方式、价值取向、心理发展以及道德观念,并带来了诸多心理问题。因此,在网络环境下,探讨青... 详细信息

网络对处于人生转折点的青少年产生了不可估量的影响,既使他们获得了全新的观念,丰富了他们的知识,激发了他们的创造性思维,也改变了他们的行为方式、价值取向、心理发展以及道德观念,并带来了诸多心理问题。因此,在网络环境下,探讨青少年的心理健康问题产生的原因和应对措施,是不可忽视和迫切需要解决的重要课题。文章首先阐明了网络背景下青少年心理问题的压力源、中介系统、问题表现之间的逻辑关系;其次从压力源和中介系统两个层面以及它们之间的相互关系来对青少年产生心理问题的原因进行探讨;最后从网络道德教育、心理问题干预、家庭学校教育、学生自我教育、制度化法律化建设、社会综合治理六个方面针对如何培养青少年健康的网络心理提出了建议。

关键词：网络背景青少年网络心理问题心理健康教育

Multidrug-resistant Proteus mirabilis isolates carrying blaOXA-1 and blaNDM-1 from wildlife in China:increasing public health risk

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Integrative Zoology 2021年第6期16卷 798-809页

作者： Qian KANG Xue WANG jianan zhao Zhihui LIU Fang JI Han CHANG Jianchun YANG Shijia HU Ting JIA Xiaojia WANG Jiagui TANG Guoying DONG Guocheng HU Jing WANG Yanyu ZHANG Jianhua QIN Chengmin WANG Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of ScienceGuangzhouGuangdongChina College of Veterinary Medicine Agricultural University of HebeiBaodingHebeiChina Institute of zoology Chinese Academy of SciencesBeijingChina Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijingChina Chongqing Zoo Chongqing College of Global Change and Earth System Science Beijing Normal UniversityBeijingChina South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhouGuangdongChina Department of Infectious Diseases Hangzhou Center of Disease Control and PreventionZhejiangChina Beijing Key Laboratory of Blood Safety and Supply Technologies Institute of Health Service and Transfusion MedicineBeijingChina

The emergence of multidrug resistance(MDR)in Proteus mirabilis clinical isolates is a growing public health concern and has serious implications for wildlife.What is the role of wildlife has been become one of the hot issues in disseminating antimicrobial resistance.Here,54 P.mirabilis isolates from 12 different species were identified.Among them,25 isolates were determined to be MDR by profile of antimicrobial susceptibility;10 MDR P.mirabilis isolates were subjected to comparative genomic analysis by whole genome sequencing.Comprehensive analysis showed that chromosome of P.mirabilis isolates mainly carries multidrug-resistance complex elements harboring resistance to carbapenem genes blaOXA-1,blaNDM-1,and blaTEM-1.Class I integron is the insertion hotspot of IS26;it can be inserted into type I integron at different sites,thus forming a variety of multiple drug resistance decision sites.At the same time,Tn21,Tn7,and SXT/R391 mobile elements cause widespread spread of these drug resistance genes.In conclusion,P.mirabilis isolates from wildlife showed higher resistance to commonly used clinic drugs comparing to those from human.Therefore,wild animals carrying MDR clinical isolates should be paid attention to by the public health.

关键词： blaNDM-1 blaOXA-1 multidrug-resistant Proteus mirabilis wildlife

粤北铀矿控矿断裂活动年代学特征与找矿规律——以南雄断裂带为例

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金属矿山 2024年第3期 158-171页

作者：赵佳楠刘冲昊邱际玮苏宏亮崔永春曾凡杰广东省核工业地质局二九一大队广东广州510800 广东省地质局广东广州510080 中国地质科学院矿产资源研究所北京100037

为研究粤北地区铀矿控矿断裂活动特征和控矿规律以指导找矿,以南雄盆地北缘南雄断裂带为研究对象,通过野外地质剖面调查、LA-ICP-MS锆石U-Pb年代学研究和显微构造变形分析,讨论南雄断裂带活动特征和铀矿找矿规律。研究结果表明:南雄盆... 详细信息

为研究粤北地区铀矿控矿断裂活动特征和控矿规律以指导找矿,以南雄盆地北缘南雄断裂带为研究对象,通过野外地质剖面调查、LA-ICP-MS锆石U-Pb年代学研究和显微构造变形分析,讨论南雄断裂带活动特征和铀矿找矿规律。研究结果表明:南雄盆地北缘南雄断裂带在三叠纪的构造变形特征以韧性变形为主,岩浆期后热液石英脉和长英质脉于晚三叠世交切断裂带内花岗质糜棱岩和糜棱岩化花岗岩,脉体锆石U-Pb加权平均年龄分别为(230.2±1.7)Ma、(228.9±5.8)Ma和(210.0±2.1)Ma;断裂带内发育典型韧性变形显微构造特征,韧性变形运动特征以左行剪切为主,且具有高温变形和中低温变形2个阶段。认为南雄盆地北缘南雄断裂带内210 Ma韧性变形区段不具备铀矿质沉淀的临界转换成矿机理条件,推断125~120 Ma和110~105 Ma韧性变形强烈并叠加同期区域伸展运动、基性岩脉侵入和铀矿化特征的区段可能是铀成矿有利区段。分析结果为进一步提高诸广山南部整装勘查区铀资源量提供了可行的找矿思路和有效的铀矿查证区段。

关键词：铀矿南雄断裂带韧性变形电子背散射衍射锆石U-Pb年代学找矿规律

In-situ Moissanite in Dunite: Deep Mantle Origin of Mantle Peridotite in Luobusa Ophiolite, Tibet

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Acta Geologica Sinica(English Edition) 2014年第2期88卷 517-529页

作者： LIANG Fenghua XU Zhiqin zhao jianan State Key Laboratory of Continental Tectonics and Dynamics Institute of GeologyChinese Academy of Geological Sciences School of Earth Sciences and Resources China University of Geosciences

We report the discovery of an in-situ natural moissanite as an inclusion in the Cr-spinel from the dunite envelope of a chromitite deposit in Luobusa ophiolite,Tibet.The moissanite occurs as a twin crystal interpenetrated by two quadrilateral signal crystals with sizes of 17 pm × 10 μm and 20 μm × 7 μm,respectively.The moissanite is green with parallel extinction.The absorption peaks in its Raman spectra are at 967-971 cm-1,787-788 cm-1,and 766 cm-1.The absorption peaks in the infrared spectra are at 696 cm-1,767 cm-1,1450 cm-1,and 1551 cm-1,which are distinctly different from the peaks for synthetic silicon carbide.Moissanites have been documented to form in ultra-high pressure,high temperature,and extremely low fO2 environments and their 13C-depleted compositions indicate a lower mantle origin.Combined with previous studies about other ultra-high pressure and highly reduced minerals in Luobusa ophiolite,the in-situ natural moissanite we found indicates a deep mantle origin of some materials in the mantle sequence of Luobusa ophiolite.Further,we proposed a transformation model to explain the transfer process of UHP materials from the deep mantle to ophiolite sequence and then to the supra-subduction zone environment.Interactions between the crown of the mantle plume and mid-ocean ridge are suggested to be the dominant mechanism.

关键词： moissanite deep mantle origin mantle peridotite Luobusa ophiolite Tibet

In-situ Moissanite in Dunite of the Luobusa Ophiolite, Tibet: Implications for Deep Mantle Origin

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Acta Geologica Sinica(English Edition) 2015年第A2期89卷 47-49页

作者： LIANG Fenghua XUZhiqin zhao jianan State Key Laboratoty of Continental Tectonics and Dynamics Institute of Geology Chinese Academy of GeologicalSciences Beijing 100037 China School of Earth Sciences and Resources Chine1 University of Geosciences Beijing 100083 China

We report the discovery of an in-situ natural moissanite in Cr-spinel hosted by dunite of the Luobusa ophiolite, Tibet. The dunite envelopes a poditbrm chromitite, separating it from the harzburgite in which the chrom... 详细信息

关键词： MOISSANITE OPHIOLITES DUNITE CARBON isotopes EARTH'S mantle

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： jianan Wang Yuanyuan Ran Zihan Li Tianyuan zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's disease.However,the mechanism by which Sal mediates dopaminergic neuronal death remains unclear.In this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling pathway.The m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling pathway.Additionally,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to neurotoxicity.These findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and autophagy.Our results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2