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Microparticle collection for water purification based on laser-induced convection

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Chinese Physics B 2018年第5期27卷 252-256页

作者： Zhi-Hai Liu Jiao-Jie Lei Yu zhang Ya-Xun zhang Xing-Hua Yang jian-zhong zhang Yun Yang Li-Bo Yuan Photonics Research Center School of Science Harbin Engineering University Harbin 150001 China

Water purification is required for environmental protection. In this paper, we propose and demonstrate a rapid, effective and low-cost approach to collect numerous impurities（microparticles） in water on the basis of laser-induced thermal convection. We introduce a heat source by using a fiber tip, which is fabricated into a non-adiabatic-tapered shape. In order to improve the laser power absorption efficiency, we coat a gold film with a thickness of 300 nm on the fiber tip. Due to absorption, the laser power transferred from the fiber to the water results in thermal convection. The forces generated from the thermal convection drive the microparticles to move towards the fiber tip, thereby performing microparticle collection and achieving water purification. Laser-induced thermal convection provides a simple, high-efficiency and low-cost method of collecting microparticles, which is a suitable and convenient for local water purification.

关键词： optical trapping microstructures and particles water purification

Effects of Appropriate Prolonged Sacral Neuromodulation Testing in Improving Implantation Rate of a Permanent Implantable Pulse Generator in Patients with Refractory Lower Urinary Tract Dysfunctions in China's Mainland

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Chinese Medical Journal 2017年第4期130卷 439-444页

作者： Peng zhang jian-zhong zhang Li-Yang Wu Xiao-Dong zhang Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background： Sacral neuromodulation （SNM） has become an effective method for treating lower urinary tract voiding dysfunction during the past 20 years. Because of the expensive cost, the number of implantable pulse generator （IPG） implantations per year in China is far lower than that in Western developed countries since 2012. This study was to summarize the effects of the appropriate prolonged SNM testing time in improving the implantation rate of a permanent IPG in patients with refractory lower urinary tract symptoms （LUTS） in China's Mainland. Methods： From January 2013 to June 2016, 51 patients with refractory LUTS received SNM therapy, in this study, we compared the conversion rate 2 weeks after the Stage I test and final actual conversion rate. We also observed the complications （such as pain, infection, and electrode displacement） and effectiveness. We tried to improve an appropriate prolonged test time which was favorable for improving the SNM conversion rate while ensuring safety and effectiveness. Results： Among 51 patients receiving SNM therapy, 19 patients （mean age 45.0 ±16.9 years） had poor Stage I test results, and on an average, the electrode was removed 27.4 ± 9.6 days after the surgery. In one patient, the electrode was removed within 2 weeks; when the remaining 18 patients were questioned 2 weeks after testing, none of the patients wanted to terminate the test, and all the 18 patients desired to prolong the testing time to further observe the treatment effect. The remaining 32 patients （mean age 46.7 ± 15.3 years） received Stage If permanent implantation at 19.6 ± 10.4 days after the surgery. The overall Stage Ⅰ-Ⅱ conversion was 62.7% （32/51） in this study. Within 2 weeks after the surgery, only eight patients received Stage II permanent implantation, and the conversion rate was only 15.7% （8/51 ）, which was much lower than the overall conversion rate of 62.7%. Nearly 84.4% （27/32） of the patients received Stage 11 implantation within 4 weeks. Non

关键词： Lower Urinary Tract Symptoms Sacral Neuromodulation Wound Infection

Photonic lantern with multimode fibers embedded

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Research in Astronomy and Astrophysics 2014年第8期14卷 1046-1054页

作者： Hai-Jiao Yu Qi Yan Zong-Jun Huang He Tian Yu jiang Yong-Jun Liu jian-zhong zhang Wei-Min Sun Key Laboratory of In-Fiber Integrated Optics Ministry of EducationHarbin Engineering University

A photonic lantem is studied which is formed by seven multimode fibers inserted into a pure silica capillary tube. The core of the tapered end has a uniform refractive index because the polymer claddings are removed before the fibers are inserted. Consequently, the light distribution is also *** theories describing a slowly varying waveguide and multimode coupling are used to analyze the photonic lantern. The transmission loss decreases as the length of the tapered part increases. For a device with a taper length of 3.4 cm, the loss is about 1.06 dB on average for light propagating through the taper from an inserted fiber to the tapered end and 0.99 dB in the reverse direction. For a device with a taper length of 0.7 cm, the two loss values are 2.63 dB and 2.53 dB, respectively. The results show that it is possible to achieve a uniform light distribution with the tapered end and a low-loss transmission in the device if parameters related to the lantern are reasonably defined.

关键词： techniques radial velocities -- methods laboratory -- instrumentation spectrographs

Aryl hydrocarbon receptor expression in serum,peripheral blood mononuclear cells,and skin lesions of patients with atopic dermatitis and its correlation with disease severity

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Chinese Medical Journal 2020年第2期133卷 148-153页

作者： Yu-Qing Hu Ping Liu zhang-Lei Mu jian-zhong zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China

Background:The aryl hydrocarbon receptor(AhR)is a ligand-activated transcription factor,which is critically involved in the pathogenesis of a variety of skin *** aim of this study was to detect AhR and its downstream regulators including cytochrome P450(CYP1A1),AhR nuclear translocation(ARNT),and aryl hydrocarbon receptor repressor(AhRR)in serum,peripheral blood mononuclear cells(PBMCs),and skin lesions in patients with atopic dermatitis(AD).Methods:Twenty-nine AD patients defined according to the criteria of Hanifin and Rajka and Chinese criteria of AD were *** without allergic and chronic diseases were recruited as *** and controls were selected from the dermatology outpatient clinic of Peking University People’s Hospital from August 1 to December 31 in ***-linked immunosorbent assay was performed to detect serum AhR *** of AhR,AhRR,ARNT,and CYP1A1 in PBMCs were measured by realtime quantitative polymerase chain *** expression in skin lesions was measured by ***:AhR was significantly higher expressed in serum(41.26±4.52 vs.33.73±2.49 pmol/L,t=6.507,P<0.001)and skin lesions(0.191±0.041 vs.0.087±0.017,t=10.036,P<0.001)of AD patients compared with those of *** mRNA levels of AhR(1.572±0.392 vs.1.000±0.173,t=6.819,P<0.001),AhRR(2.402±1.716 vs.1.000±0.788,t=3.722,P<0.001),CYP1A1(2.258±1.598 vs.1.000±0.796,t=3.400,P=0.002)in PBMCs of AD patients were higher compared with those of *** difference in mRNA levels of ARNT was not statistically significant between the patients and controls(1.383±0.842 vs.1.000±0.586,t=1.653,P=0.105).AhR mRNA levels in PBMCs positively correlated with eczema area and severity index score and serum interleukin-6 ***:AhR and its downstream regulators were highly expressed in serum,PBMCs,and skin of AD patients,which might contribute to the pathogenesis of AD.

关键词： Aryl hydrocarbon receptor Cytochrome P450 Atopic dermatitis Peripheral blood mononuclear

Topical Tetracycline Improves MC903-induced Atopic Dermatitis in Mice through Inhibition of Inflammatory Cytokines and Thymic Stromal Lymphopoietin Expression

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Chinese Medical Journal 2016年第12期129卷 1483-1490页

作者： Xiao-Jing Liu zhang-Lei Mu Yan Zhao jian-zhong zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China

Background： Tetracycline （TET） has been found to have both antibiotic and anti-inflammatory properties. The anti-inflammatory effect of topical TET on atopic dermatitis （AD） has not been reported. The purpose of this study was to explore the potential role of topical TET and its anti-inflammatory effects in a mouse model of AD. Methods： The 2% TET was applied topically to ears of MC903-induced AD-like BALB/c mice once a day. AD-like symptoms and severity were evaluated by assessing skin scoring of dermatitis, ear thickness, and frequency of scratching. Serum lgE and thymic stromal lymphopoietin （TSLP） levels were measured by enzyme-linked immunosorbent assay. Western blot was used for analyzing the expressions of TSLP, protease-activated receptor 2 （PAR2）, and nuclear factor-kappa B （NF-~：B） in skin lesions. Real-time polymerase chain reaction was performed to assess the mRNA levels of TSLP and inflammatory cytokines including interleukin （IL）-4, IL-13, tumor necrosis factor （TNF）-α, and IL-1β in skin lesions. Results： Scoring of dermatitis （9.00 ± 0.63 vs. 6.67± 1.03, P = 0.001）, ear thickness （0.44± 0.02 mm vs. 0.40±0.03 mm, P = 0.018）, and serum IgE level （421.06 ± 212.13 pg/ml vs. 244.15±121.39 pg/ml, P 0.047） were all improved in the 2% TET treatment group compared with AD group. Topical TET significantly reduced the serum level of TSLP （119.04 ±38.92 pg/ml vs. 65.95± 54.61 μg/ml, P = 0.011） and both mRNA and protein expressions of TSLP in skin lesions compared with AD group （P = 0.003 and 0.011, respectively）, and NF-κB and PAR2 expression in skin lesions were also suppressed （P = 0.016 and 0.040, respectively）. Furthermore, expressions of inflammatory cytokines IL-4, IL- 13, and TNF-α in skin lesions were down-regulated in 2% TET group compared with AD group （P = 0.035, 0.008, and 0.044, respectively）. Conclusions： Topical TET exerted anti-inflammatory effects through suppression of TSLP and inflammatory cytokines in AD mouse model, suggesting TET as a potent

关键词： Atopic Dermatitis Tetracycline Thymic Stromal Lymphopoietin

Multiple spider angiomas in a patient with chronic hepatic graftversus- host disease

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Chinese Medical Journal 2020年第6期133卷 749-750页

作者： Ying Gu Kun Li Xia Wu jian-zhong zhang Department of Dermatology Peking University People's HospitalBeijing 100044China

To the Editor:Spider angiomas are benign vascular lesions mostly associated with decompensated liver ***,we report multiple spider angiomas in a patient with chronic hepatic graft-versus-host disease(GVHD).

关键词： hepatic angioma patient

Assessment of Comparative Genomic Hybridization Experiment by an in situ Synthesized CombiMatrix Microarray with Yersinia pestis Vaccine Strain EV76 DNA

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Biomedical and Environmental Sciences 2010年第5期23卷 384-390页

作者： YUAN-HAI YOU PENG WANG YAN-HUA WANG HAI-BIN WANG DONG-ZHENG YU RONG HAI jian-zhong zhang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective The quality of microarray data influences the accuracy of comparative genomic analyses to a large *** ensure that the results obtained by using an in situ synthesized microarray are accurate,data quality is to be assessed by evaluating the melting temperature (Tm) of probes,probability of false synthesis rates,and fragmentation of labeled *** DNA from the Yersinia pestis vaccine strain EV76 was used for microarray *** results were confirmed by *** and bioinformatics methods were employed to perform microarray data analyses and *** Correlation coefficients of the three datasets were above 0.95 after two-time stripping and hybridization with a labeled DNA with the size of fragmentation being 200 bp-2 kb,which showed that the hybridization results were highly *** coefficients were lower with the values ranging from 0.87 to 0.92 between the datasets generated from hybridization with different sizes of the labeled DNA *** the relationship between Tm and signal intensity,there was a different distribution of Tm in the lowest 300 or 3 000 probes with a range of 70 ℃-72 ℃ and the highest 300 or 3 000 probes with a range of 72 ℃-74 ℃.Conclusion The results of this study suggest that the initial microarray design may affect the accuracy of final analyses and that the probe Tm and the size of the labeled fragment may be the two factors of the greatest importance.

关键词： Array CGH Data quality Assessment

Chaos generation by a hybrid integrated chaotic semiconductor laser

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Chinese Physics B 2018年第5期27卷 122-130页

作者： Ming-jiang zhang Ya-Nan Niu Tong Zhao jian-zhong zhang Yi Liu Yu-Hang Xu Jie Meng Yun-Cai Wang An-Bang Wang Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024China Institute of Optoelectronic Engineering College of Physics&OptoelectronicsTaiyuan University of TechnologyTaiyuan 030024China

We design a hybrid integrated chaotic semiconductor laser with short-cavity optical *** can be assembled in a commercial butterfly shell with just three *** of them is coated by a transflective film to provide the optical feedback for chaos generation while insuring regular laser *** prove the feasibility of the chaos generation in this compact structure and provide critical external parameters for the fabrication by theoretical *** than the usual changeless internal parameters used in previous simulation research,we extract the real parameters of the chip by ***,the maps of the largest Lyapunov exponent with varying bias current and feedback intensity Kap demonstrate the dynamic characteristics under different external-cavity *** laser chip has its own optimal external cavity length(L)and feedback intensity(Kap)to generate chaos because of the different internal *** have acquired two ranges of optimal parameters(L=4 mm,0.12〈Kap〈0.2 and L=5 mm,0.07〈Kap〈0.12)for two different chips.

关键词： chaotic dynamic characteristics integrated chaotic semiconductor laser short-cavity optical feedback extraction of internal parameters

Assessing taxane-associated adverse events using the FDA adverse event reporting system database

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Chinese Medical Journal 2021年第12期134卷 1471-1476页

作者： Dong-Hui Lao Ye Chen Jun Fan jian-zhong zhang Department of Pharmacy Zhongshan HospitalFudan UniversityShanghai 200032China

Background:Taxanes are an essential class of antineoplastic agents used to treat various cancers and are a fundamental cause of hypersensitivity *** addition,other adverse events,such as bone marrow toxicity and peripheral neuropathy,can lead to chemotherapy *** study aimed to evaluate the safety of taxanes in the real ***:Taxane-associated adverse events were identified by the Medical Dictionary for Regulatory Activities Preferred Terms and analyzed and compared by mining the US Food and Drug Administration Adverse Event Reporting System pharmacovigilance database from January 2004 to December *** adverse events,such as hypersensitivity reaction,bone marrow toxicity,and peripheral neuropathy,were analyzed with the following signal detection algorithms:reporting odds ratio(ROR),proportional reporting ratio(PRR),multi-item gamma Poisson shrinker(MGPS),Bayesian confidence propagation neural network(BCPNN),and logistic regression *** outcome events and death outcome rates were compared between different taxane groups using Pearson'sχ^(2) test,whereas significance was determined at P<0.05 with a 95%confidence interval(CI).Results:A total of 966 reports of hypersensitivity reactions,1109 reports of bone marrow toxicity,and 1374 reports of peripheral neuropathy were *** with paclitaxel and docetaxel,bone marrow toxicity following the use of nab-paclitaxel had the highest ROR of 6.45(95%two-sided CI,6.05–6.88),PRR of 5.66,(χ^(2)=4342.98),information component of 2.50(95%one-sided CI=2.34),and empirical Bayes geometric mean of 5.64(95%one-sided CI=5.34).Peripheral neuropathy following the use of nab-paclitaxel showed a higher ROR of 12.78(95%two-sided CI,11.55–14.14),PRR of 12.16(χ^(2)=4060.88),information component of 3.59(95%one-sided CI=3.25),and empirical Bayes geometric mean of 12.07(95%one-sided CI=11.09).Conclusions:The results showed that bone marrow toxicity and peripheral neuropathy were the m

关键词： Taxane Pharmacovigilance Bone marrow toxicity Peripheral neuropathy