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CHARACTERISTICS OF CHANGE IN TEMPERATURE DURING THE PAST 50 YEARS IN JILIN PROVINCE OF CHINA

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Chinese Geographical Science 2002年第4期12卷 329-332页

作者： ZHAO Xin -yi,WAN Jun,WU Xiu -qin(Department of Urban and Environment al Sciences,Peking University,Beijing 100871,P.R.China) Department of Urban and Environmental Sciences Peking University Beijing P. R. China

Based on the monthly mean temperatu re,the changing processes and tendencies of temperature during1951-2000in Jilin Province,which i s in Northeast China,are analyzed.A nd the spatial characteristics of th e change are *** the past 50years the te mperature of Jilin Province was increasing just like the other areas in th e *** 1990,the increasing of temperature has been more obvious th an that in the previous *** the west to the east,the province has larger tem perature *** to Principal Component Analysis(PCA)of temperature field,Jilin Province is divided int o 3regions and the degree of becoming warmer is different from region to re *** the period of 1951to 2000,the annual temperature in Jilin Province has been rising,so has the temperature in winter and *** average temperature in t he 1990s was 0.5-2.0℃higher than that in the *** the west to the east,the increasing of temperature becam e smaller.

关键词： temperature change spatial characteristics jilin province

Review on contaminants in edible oil and analytical technologies

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Oil Crop Science 2021年第1期6卷 23-27页

作者： qing Xia Zhaolin Du Dasong Lin Lili Huo Li qin Wei Wang Liwen Qiang Yanpo Yao yi An Innovative Team of Monitoring and Precaution for Cropland Environment Agro-Environmental Protection InstituteTianjin300191China

Edible oil is an important part of the human daily diet,which is popular in the food *** are paying increasing attention to the safety of edible oil as flawed oils have caused enormous international losses and posed a huge threat to consumer health ***,it is necessary and important to analyze the quality and safety of oil *** the present study,we particularly reviewed recent literature on analysis of emerging pollutants in edible oil including mycotoxins,pesticide residues and heavy *** addition,a series of emerging analytical technologies(HPLC,LC-MS/MS and GC-MS)for these contaminants were also summarized in this paper.

关键词： Edible oil Mycotoxins Pesticide residues Heavy metals Analytical method

Characteristics of the TCR Vβ repertoire in imatinib-resistant chronic myeloid leukemia patients with ABL mutations

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Science China(Life Sciences) 2015年第12期58卷 1276-1281页

作者： XU Ling LU Yu Hong LAI Jing YU Wei ZHANG yi Kai JIN Zhen yi XU Yan CHEN Jie ZHA Xian Feng CHEN Shao Hua YANG Li jian LI Yang Qiu Institute of Hematology Jinan University Department of Hematology First Affiliated Hospital Jinan University Department of Hematology Guangzhou No.12 People's Hospital Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University Department of clinical laboratory First Affiliated Hospital Jinan University

Diversity in the T cell receptor(TCR) repertoire provides a miniature defense ability for the T cell immune system that may be related to tumor initiation and progression. Understanding the T cell immune status of leukemia patients is critical for establishing specific immunotherapies. Previous studies have reported abnormal TCR repertoires and clonally expanded TCR V? T cells in chronic myeloid leukemia in chronic phase(CP-CML). In this study, we investigated the distribution and clonality of the TCR V? repertoire in 4 cases with imatinib-resistant CML in blast crisis(BC-CML) with abelson murine leukemia viral oncogene homolog 1(ABL1) kinase domain mutations(KDMs). Examination of TCR V? expression and clonality was performed by reverse transcription-polymerase chain reaction(RT-PCR) and Gene Scan analysis. Significantly skewed TCR V? repertoires were observed in BC-CML patients with different KDMs, and 4 to 8 oligoclonally expanded TCR V? subfamilies could be identified in each sample. Intriguingly, a relatively highly expanded V?9 clone with the same length as complementarity-determining region 3(CDR3)(139 bp) was found in all three CML patients in lymphoid blast crisis(LBC-CML) who had different KDMs, but the clone was not detected in the only CML patient in myeloid blast crisis(MBC-CML). In conclusion, restricted TCR V? repertoire expression and decreased clone complexity was a general phenomenon observed in the BC-CML patients with different KDMs, indicating the T-cell immunodeficiency of these patients. In addition, clonally expanded V?9 T cell clones may indicate a specific immune response to leukemia-associated antigens in LBC-CML patients.

关键词： T cell repertoire chronic myeloid leukemia blast crisis imatinib resistance BCR-ABL mutation

Effect of Hypoxia on Ca^(2+) Concentration in Broiler's Cardiac Muscle Cells

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Agricultural Sciences in China 2007年第9期6卷 1133-1137页

作者： DONG Shi-shan WANG ying-chun MALi-qin LI Kai ZHANG jian-jun OU De-yuan ZHAO Li-hong LIU Ju-xiang QIAO jian College of Animal Science and Technology Agricultural University ofHebei Baoding 071001 P.R.China College of Veterinary Medicine China Agricultural University Beijing 100094 P.R.China College of Animal Science and Technology Hebei North University Zhangjiakou 075001 P.R.China

The purpose of this research was to study the effect of hypoxia on the Ca^2＋ concentration in broiler＇s cardiac muscle cells （CMCs）. The concentration of Ca^2＋ in the CMC was observed using a laser scanning confocal microscope （LSCM）. The results showed that hypoxia could significantly increase intracellular Ca^2＋（normal oxygen, 99.3 ＋_ 13.1; hypoxia, 129.4 ＋_ 24.3, P 〈 0.01） in CMCs. The Ca^2＋ antagonist （nifedipine, verapamil） could significantly restrain the Ca^2＋ influx across the cell membrane of CMC treated by hypoxia （CMC： hypoxia ＋ verapamil, 100.9± 28.2; hypoxia ＋ nifedipine, 107.6± 27.7; P 〈 0.01）. The results showed hypoxia could increase intracellular Ca^2＋ concentration of CMC, and the Ca^2＋ antagonist could restrain the Ca^2＋ influx across the cell membrane of CMC treated by hypoxia.

关键词： broiler chicken cardiac muscle cell,Ca^2+ hypoxia

Roles of lncRNAs in pancreatic ductal adenocarcinoma: Diagnosis,treatment, and the development of drug resistance

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 128-139页

作者： Xiao-yin jiang Qi-Cong Zhu Xiao-jian Zhang Ting Duan Jiao Feng Xin-Bing Sui Xue-Ni Sun yi-Ping Mou The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals Zhejiang University of TechnologyHangzhou 310014China Department of Gastrointestinal and Pancreatic Surgery Key Laboratory of Gastroenterology of Zhejiang ProvinceZhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China

Background: Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal cancers, primarily due to its late diagnosis, high propensity to metastasis, and the development of resistance to chemo-/radiotherapy. Accumulating evidence suggests that long non-coding RNAs(lnc RNAs) are intimately involved in the treatment resistance of pancreatic cancer cells via interacting with critical signaling pathways and may serve as potential diagnostic/prognostic markers or therapeutic targets in PDAC. Data sources: We carried out a systematic review on lnc RNAs-based research in the context of pancreatic cancer and presented an overview of the updated information regarding the molecular mechanisms underlying lnc RNAs-modulated pancreatic cancer progression and drug resistance, together with their potential value in diagnosis, prognosis, and treatment of PDAC. Literature mining was performed in Pub Med with the following keywords: long non-coding RNA, pancreatic ductal adenocarcinoma, pancreatic cancer up to January 2022. Publications relevant to the roles of lnc RNAs in diagnosis, prognosis, drug resistance, and therapy of PDAC were collected and systematically reviewed. Results: Lnc RNAs, such as HOTAIR, HOTTIP, and PVT1, play essential roles in regulating pancreatic cancer cell proliferation, invasion, migration, and drug resistance, thus may serve as potential diagnostic/prognostic markers or therapeutic targets in PDAC. They participate in tumorigenesis mainly by targeting mi RNAs, interacting with signaling molecules, and involving in the epithelial-mesenchymal transition process. Conclusions: The functional lnc RNAs play essential roles in pancreatic cancer cell proliferation, invasion, migration, and drug resistance and have potential values in diagnosis, prognostic prediction, and treatment of PDAC.

关键词： Long non-coding RNA Pancreatic ductal adenocarcinoma Drug resistance Diagnostic indicator Therapeutic targets Molecular mechanism

Cobalt-catalyzed Photochemical Methoxycarbonylation of Olefins with Carbon Dioxide under Ambient Conditions

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Chinese Chemical Letters 2000年第3期11卷 223-224页

作者： Jing Mei yiN Ming GUO Rui WANG Guang Yun ZHOU Da Bin GAO Xiang Sheng WANG Xin Wen GUO jian qin ZHUANG Department of Chemisiry&Chemical Engineering Dalian UniversityDalian 116622 Open Laboratory of Carbon Resource Utilization Dalian University of TechnologyDalian 116012 Dalian Institute of Chemical Physics The Chinese Academy of SciencesDalian 116023

The methoxycarbonylations of cyclohexene and 1-decene with CO2 can take place under ambient conditions by catalysis of [Co]([Co]=Co(acac)(2), Co(OAc)(2), CoCl2) in the presence of ultraviolet irradiation.

关键词： carbon dioxide methoxycarbonylation cobalt catalyst

A pure blue light emitting binaphthyl derivative:Synthesis and properties

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Chinese Chemical Letters 2008年第4期19卷 431-434页

作者： qing Guo He Zeng Ze Chu Gang Tie Lei An Jun qin Hong Zhen Lin Feng Lian Bai jian Gong Cheng Yong Qiu Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Key Laboratory of Organic Solids Centre for Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080China Department of Chemistry Tsinghua UniversityBeijing 100084China

A binaphthyl derivative with pyrene on 3 and 3＇ positions was synthesized and characterized via Suzuki coupling reaction. Emission maximum in solution was located at 390 nm with a quantum efficiency of 68% by taking 9,10-diphenyl anthracene as reference,while it is shifted to 450 nm with FWHM of 104 nm resulting from aggregation state in solid *** transition temperature（Tg）and decomposition temperature were measured to be 184 and 447℃,respectively,by DSC and *** its photoluminescence spectrum,electroluminescent spectrum peaked at about 460 nm and shows a FWHM of 69 nm corresponding to a pure blue *** turn-on voltage,luminance and efficiency maximum were 5 V,2953 cd/m^2 and 1.37cd/A with CIE color coordinate of（0.16,0.15）,in the device structure of ITO/NPB（40nm）/PY-BN-PY（15nm）/BPhen（40nm）/Mg：Ag.

关键词： Binaphthyl Pyrene Suzuki reaction Photoluminescence Electroluminescence

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车载储氢瓶分级加注流热固耦合仿真研究

化工装备技术 2024年第5期45卷 21-26页

作者：杨力宁杨健肖宗亮丁毅柳伟杰钟泉鸣张林浙江省白马湖实验室有限公司杭州市310058 浙江大学能源工程学院安赢(浙江)智能科技有限公司中国人民解放军海军潜艇学院

针对新开发的III型车载快充储氢气瓶,建立了气瓶快速加注的三维数值模型,并基于CFD软件研究了不同分级控制方式和预冷温度对加注流量、储氢压力及瓶内氢气温升的影响规律,揭示了等流量加注和等压加注两种分级加注方式在各级加注过程中... 详细信息

针对新开发的III型车载快充储氢气瓶,建立了气瓶快速加注的三维数值模型,并基于CFD软件研究了不同分级控制方式和预冷温度对加注流量、储氢压力及瓶内氢气温升的影响规律,揭示了等流量加注和等压加注两种分级加注方式在各级加注过程中及切换加注压力时的流量、压力和温升变化规律,提出了高压加注的分级控制策略。结果表明:3级加注各级内加注过程的流量、压力和温升变化趋势相似,但中压和高压加注相较于前1级加注,压力上升和温升幅度减小。相较于分级等压加注过程时间短、瞬时流量大、升压和升温迅速,分级等流量加注过程符合标准要求,能够显著降低瓶内温升。

关键词：储氢瓶分级加注耦合仿真

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我国近年来煤矿瓦斯防治发展动态图谱分析

煤炭科技 2024年第3期45卷 11-18页

作者：叶青马磊王健朱兵兵吴义泉吴永涛苏毅中安联合煤矿分公司安徽淮南232000 中国矿业大学(北京)隧道工程灾变防控与智能建养全国重点实验室北京100083 中国矿业大学(北京)力学与土木工程学院北京100083

为全面掌握我国煤矿瓦斯防治发展动态,以2000年以来CNKI收录的2397篇文献为依据,运用CiteSpace软件绘制可视化图谱,对煤矿瓦斯防治领域的文献发文量、期刊分布、研究人员、研究机构、关键词和突现词等进行统计。分析结果表明,煤矿瓦斯... 详细信息

为全面掌握我国煤矿瓦斯防治发展动态,以2000年以来CNKI收录的2397篇文献为依据,运用CiteSpace软件绘制可视化图谱,对煤矿瓦斯防治领域的文献发文量、期刊分布、研究人员、研究机构、关键词和突现词等进行统计。分析结果表明,煤矿瓦斯防治文献发文量分为快速增长期(2000—2011年)与平稳波动期(2012—2023年);发文最多的期刊多为经济与管理科学类、矿业工程类、环境科学与资源利用类等期刊;文献合作网络由2个主要合作群和系列作者构成;研究力量集中在中国矿业大学、中国矿业大学(北京)、河南理工大学等高校和中煤科工集团重庆研究院、中煤科工集团沈阳研究院等科研院所;瓦斯防治成为研究热点,形成了以瓦斯含量、保护层、综合防治等为代表的关键词聚类;从研究前沿来看,关于煤矿瓦斯的赋存规律、涌出机理、事故原因、智能化预警及防治技术、抽采、综合利用等一直是研究的热点,也将是未来研究的热点。

关键词：煤矿瓦斯防治发展动态 CiteSpace 图谱可视化分析