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Current status of liver transplantation for human immunodeficiency virus-infected patients in China's Mainland

World Journal of Gastroenterology 2024年第14期30卷 1958-1962页

作者： jian-xin tang Dong Zhao Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

According to the report from the Chinese Center for Disease Control and Prevention,the prevalence of human immunodeficiency virus(HIV)infection exceeded 1.2 million individuals by the year 2022,with an annual increase of about 80000 *** overall prevalence of hepatitis B surface antigen among individuals co-infected with HIV reached 13.7%,almost twice the rate of the general population in *** addition to the well-documented susceptibility to opportunistic infections and new malignancies,HIV infected patients frequently experience liver-related organ damage,with the liver and kidneys being the most commonly *** often leads to the development of end-stage liver and kidney ***,organ transplantation has emerged as an important part of active treatment for HIV infected ***,the curative effect is not *** infection has been considered a contraindication for organ *** the emergence of highly active anti-retroviral therapy in 1996,the once intractable replication of retrovirus was effectively *** prolonged survival,the failure of important organs has become the main cause of death among HIV ***,transplant centers worldwide have resu-med exploration of organ transplantation for HIV-infected individuals and reached a positive *** study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation(LT)in main-land *** date,our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV,and all but one,who died two months postoperatively due to sepsis and progressive multi-organ failure,have *** analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions,cytomegalovirus infection,bacteremia,pulmonary infections,acute kidney injury,new-onset cancers,or vascular and biliary co

关键词： Liver transplantation Human immunodeficiency virus Infection Hepatitis B virus End-stage liver disease China'Mainland

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Interface energetics and engineering of organic heterostructures in organic photovoltaic cells

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Science China Chemistry 2016年第4期59卷 422-435页

作者： Yan-Qing Li Qian-Kun Wang Qing-Dong Ou jian-xin tang Institute of Functional Nano & Soft Materials Collaborative Innovation Center of Suzhou Nano Science and TechnologyJiangsu Key Laboratory for Carbon-based Functional Materials & Devices Soochow University

The reliable information about interface energetics of organic materials, especially the energy level alignment at organic heterostructures is of pronounced importance for unraveling the photon harvesting and charge separation process in organic photovoltaic(OPV) cells. This article provides an overview of interface energetics at typical planar and mixed donor-acceptor heterostructures, perovskite/organic hybrid interfaces, and their contact interfaces with charge collection layers. The substrate effect on energy level offsets at organic heterostructures and the processes that control and limit the OPV operation are presented. Recent efforts on interface engineering with electrical doping are also discussed.

关键词： organic photovoltaic cell organic heterostructure energy level alignment substrate effect interface engineering

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A novel strategy for in situ maskless synthesis of biochips:Self-driving micro-fluid porous type printing (SMPTP)

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Chinese Chemical Letters 2007年第1期18卷 111-114页

作者： Nong Yue He Ya Fei Guo Song Li jian-xin tang State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China Key Laboratory of Green-Packaging and Application of Bionanotechnology of Hunan Province Zhuzhou Institute of Technology Zhuzhou 412008 China

A novel maskless technique, self-driving micro-fluid porous type printing （SMPTP）, was reported to in situ synthesize oligonucleotide arrays on glass slide, which has the merits of low cost, high quality and simple craft. In SMPTP for fabricating gene- chips, porous fiber tubes with a number of nanometric or micron channels functioned as ＂active letters＂ and were assembled in designed patterns, which are identical to the distribution of monomers in each layer of the array, and four patterns were needed for each layer. By means of capillarity, the synthesis solution was automatically taken into porous tubes assembled in a printing plate and reached the surface. An oligonucleotide array of 160 features with four different 15-mer probes was in situ synthesized using this technique. The four specific oligonucleotide probes, including the matched and the mismatched by the fluorescent target sequence, gave obviously different hybridization fluorescent signals.

关键词： Typography Oligonucleotide In situ synthesis DNA microarrays Biochips

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Anterior vs conventional approach right hepatic resection for large hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2017年第44期23卷 7917-7929页

作者： jian-xin tang Jin-Jun Li Rui-Hui Weng Zi-Ming Liang Nan jiang Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen University Department of Neurology The Third Affiliated Hospital of Sun Yat-sen University

AIM To compare the clinical outcomes of right hepatectomy for large hepatocellular carcinoma via the anterior and conventional *** We comprehensively performed an electronic search of Pub Med, EMBASE, and the Cochrane Library for randomized controlled trials(RCTs) or controlled clinical trials(CCTs) published between January 2000 and May 2017 concerning the anterior approach(AA) and the conventional approach(CA) to right hepatectomy. Studies that met the inclusion criteria were included, and their outcome analyses were further assessed using a fixed or random effects *** This analysis included 2297 patients enrolled in 16 studies(3 RCTs and 13 CTTs). Intraoperative blood loss [weighted mean difference =-255.21; 95% confidence interval(95%CI):-371.3 to-139.12; P < 0.0001], intraoperative blood transfusion [odds ratio(OR) = 0.42; 95%CI: 0.29-0.61; P < 0.0001], mortality(OR = 0.59; 95%CI: 0.38-0.92; P = 0.02), morbidity(OR = 0.77; 95%CI: 0.62-0.95; P = 0.01), and recurrencerate(OR = 0.62; 95%CI: 0.47-0.83; P = 0.001) were significantly reduced in the AA group. Patients in the AA group had better overall survival(hazard ratio [HR] = 0.71; 95%CI: 0.50-1.00; P = 0.05) and disease-free survival(HR = 0.67; 95%CI: 0.58-0.79; P < 0.0001) than those in the CA *** The AA is safe and effective for right hepatectomy for large hepatocellular carcinoma and could accelerate postoperative recovery and achieve better survival outcomes than the CA.

关键词： Anterior approach Conventional approach Right hepatectomy Hepatocellular carcinoma Postoperative complication Survival

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Outcomes of ABO-incompatible liver transplantation in end-stage liver disease patients co-infected with hepatitis B and human immunodeficiency virus

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World Journal of Gastroenterology 2023年第11期29卷 1745-1756页

作者： jian-xin tang Kang-Jun Zhang Tai-Shi Fang Rui-Hui Weng Zi-Ming Liang Xu Yan xin Jin Lin-Jie Xie xin-Chen Zeng Dong Zhao Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Neurology The Third People’s Hospital of Shenzhen(The Second Affiliated Hospital of Southern University of Science and Technology)Shenzhen 518000Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center National Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-positive patients coinfected with hepatitis B virus(HBV)are eligible for liver transplantation(LT)in Africa and Southeast Asia,particularly ***,the outcome of HIV-HBV coinfected patients referred for ABO-incompatible LT(ABOi-LT)is *** To clarify the outcome of ABOi-LT for HIV-HBV coinfected patients with endstage liver disease(ESLD).METHODS We report on two Chinese HIV-HBV coinfected patients with ESLD who underwent A to O brain-dead donor LT and reviewed the literature on HIV-HBV coinfected patients treated with ABO-compatible *** pretransplantation HIV viral load was undetectable,with no active opportunistic *** therapy consisted of two sessions of plasmapheresis and a single dose of rituximab in two split doses,followed by an intraoperative regimen of intravenous immunoglobulin,methylprednisolone,and ***-transplant maintenance immunosuppressive agents consisted of tacrolimus and mycophenolate mofetil,and *** At the intermediate-term follow-up,patients showed undetectable HIV viral load,CD4(+)T cell counts greater than 150 cells/μL,no HBV recurrence,and stable liver function.A liver allograft biopsy showed no evidence of acute cellular *** patients survived at 36-42 mo of *** This is the first report of ABOi-LT in HIV-HBV recipients with good intermediate-term outcomes,suggesting that ABOi-LT may be feasible and safe for HIV-HBV coinfected patients with ESLD.

关键词： ABO incompatibility liver transplantation Human immunodeficiency virus Hepatitis B virus End-stage liver disease Immunosuppression

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Topological approach of liver segmentation based on 3D visualization technology in surgical planning for split liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1141-1149页

作者： Dong Zhao Kang-Jun Zhang Tai-Shi Fang Xu Yan xin Jin Zi-Ming Liang jian-xin tang Lin-Jie Xie Department of Liver Surgery and Organ Transplantation Center The Third People's Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Split liver transplantation(SLT)is a complex *** left-lateral and right tri-segment splits are the most common surgical approaches and are based on the Couinaud liver segmentation ***,the liver surface following right trisegment splits may exhibit different degrees of ischemic changes related to the destruction of the local portal vein blood flow *** is currently no consensus on preoperative evaluation and predictive strategy for hepatic segmental necrosis after *** To investigate the application of the topological approach in liver segmentation based on 3D visualization technology in the surgical planning of *** Clinical data of 10 recipients and 5 donors who underwent SLT at Shenzhen Third People’s Hospital from January 2020 to January 2021 were retrospectively *** surgery,all the donors were subjected to 3D modeling and *** on the 3D-reconstructed models,the liver splitting procedure was simulated using the liver segmentation system described by Couinaud and a blood flow topology liver segmentation(BFTLS)*** addition,the volume of the liver was also *** indexes mainly included the hepatic vasculature and expected volume of split grafts evaluated by 3D models,the actual liver volume,and the ischemia state of the hepatic segments during the actual *** Among the 5 cases of split liver surgery,the liver was split into a left-lateral segment and right trisegment in 4 cases,while 1 case was split using the left and right half liver *** operations were successfully implemented according to the preoperative *** to Couinaud liver segmentation system and BFTLS methods,the volume of the left lateral segment was 359.00±101.57 mL and 367.75±99.73 mL,respectively,while that measured during the actual surgery was 397.50±37.97 *** volume of segment IV(the portion of ischemic liver lobes)allocated to the right tri-segment was 136.31±86.10 mL

关键词： Three-dimensional visualization Couinaud liver segmentation Blood flow topology liver segmentation Split liver transplantation Surgical planning

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Ultrasound-assisted tandem synthesis of tri-and tetra-substituted pyrrole-2-carbonitriles from alkenes,TMSCN and N,N-disubstituted formamides

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Chinese Chemical Letters 2020年第12期31卷 3241-3244页

作者： Qing-Wen Gui Fan Teng Sheng-Neng Ying Yang Liu Tao Guo jian-xin tang Jin-Yang Chen Zhong Cao Wei-Min He College of Chemistry and Materials Science Hunan Agricultural UniversityChangsha 410128China School of Life Scienices and Chenistry Hunan University of Technologyzhuzhou 412007China Hunan Provincial Key Laboratory of Materials Protection for Flectric Power and Tramnsportation Changsha Univerity of Sciene and TechnologyChangsha 410114China

An energy-saving and eco-friendly method for the efficient construction of various tri-and tetrasubstituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes,TMSCN and N,N-disubstituted formamides within 40 min under metal-,solvent-free and mild conditions was *** dual role of iodine(catalyst and oxidant)notably simplified the reaction conditions and reduced the chemical waste generated.

关键词： Green chemistry Solvent-free Tandem reaction Dual role Ultrasound

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How to apply ex-vivo split liver transplantation safely and feasibly: A three-step approach

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1691-1699页

作者： Dong Zhao Qiu-Hua Xie Tai-Shi Fang Kang-Jun Zhang jian-xin tang Xu Yan xin Jin Lin-Jie Xie Wen-Gui Xie Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina Department of Organ Procurement Organizations Shenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Given the current organ shortage crisis,split liver transplantation(SLT)has emerged as a promising alternative for select end-stage liver disease *** To introduce an ex-vivo liver graft splitting approach and evaluate its safety and feasibility in *** A retrospective analysis was conducted on the liver transplantation data from cases performed at our center between April 1,2022,and May 31,*** study included 25 SLT cases and 81 whole liver transplantation(WLT)*** ex-vivo liver splitting was employed for SLT graft procurement in three *** outcomes were determined,including liver function parameters,postoperative complications,and perioperative *** comparisons for categorical variables were performed using theχ²-*** In the study,postoperative complications in the 25 SLT cases included hepatic artery thrombosis(n=1)and pulmonary infections(n=3),with no perioperative *** contrast,among the 81 patients who underwent WLT,complications included perioperative mortality(n=1),postoperative pulmonary infections(n=8),abdominal infection(n=1),hepatic artery thromboses(n=3),portal vein thrombosis(n=1),and intra-abdominal bleeding(n=5).Comparative analysis demonstrated significant differences in alanine aminotransferase(176.0 vs 73.5,P=0.000)and aspartate aminotransferase(AST)(42.0 vs 29.0,P=0.004)at 1 wk postoperatively,and in total bilirubin(11.8 vs 20.8,P=0.003)and AST(41.5 vs 26.0,P=0.014)at 2 wk ***,the overall incidence of complications was comparable between the two groups(P>0.05).CONCLUSION Our findings suggest that the total ex-vivo liver graft splitting technique is a safe and feasible approach,especially under the expertise of an experienced transplant *** approach developed by our center can serve as a valuable reference for other transplantation centers.

关键词： Split liver transplantation Transplantation Liver splitting Ex-vivo In-situ

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Reconstructing the portal vein through a posterior pancreatic tunnel:New choice for portal vein thrombosis during liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1131-1140页

作者： Dong Zhao Yi-Ming Huang Zi-Ming Liang Kang-Jun Zhang Tai-Shi Fang Xu Yan xin Jin Yi Zhang jian-xin tang Lin-Jie Xie xin-Chen Zeng Department of Liver Surgery and Organ Transplantation Center The Third People’s Hospital of ShenzhenThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

BACKGROUND Thrombectomy and anatomical anastomosis(TAA)has long been considered the optimal approach to portal vein thrombosis(PVT)in liver transplantation(LT).However,TAA and the current approach for non-physiological portal reconstructions are associated with a higher rate of complications and mortality in some *** To describe a new choice for reconstructing the portal vein through a posterior pancreatic tunnel(RPVPPT)to address cases of unresectable *** Between August 2019 and August 2021,245 adult LTs were ***-five(18.4%)patients were confirmed to have PVT before surgery,among which seven underwent PV reconstruction via the RPVPPT *** retrospectively analyzed the surgical procedure and postoperative complications of these seven recipients that underwent PV reconstruction due to *** During the procedure,PVT was found in all the seven cases with significant adhesion to the vascular wall and could not be *** portal vein proximal to the superior mesenteric vein was damaged in one case when attempting thrombolectomy,resulting in massive *** was successfully performed in all patients with a mean duration of 585 min(range 491-756 min)and mean intraoperative blood loss of 800 mL(range 500-3000 mL).Postoperative complications consisted of chylous leakage(n=3),insufficient portal venous flow to the graft(n=1),intra-abdominal hemorrhage(n=1),pulmonary infection(n=1),and perioperative death(n=1).The remaining six patients survived at 12-17 mo *** The RPVPPT technique might be a safe and effective surgical procedure during LT for complex ***,follow-up studies with large samples are still warranted due to the relatively small number of cases.

关键词： Liver transplantation Portal vein thrombosis Portal vein reconstruction Retropancreatic tunnel Computer tomography angiography Three-dimensional visualization

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Hot-electron emission-driven energy recycling in transparent plasmonic electrode for organic solar cells

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InfoMat 2022年第3期4卷 121-130页

作者： Jing-De Chen Ling Li Chao-Chao Qin Hao Ren Yan-Qing Li Qing-Dong Ou Jia-Jia Guo Shi-Jie Zou Feng-Ming Xie Xianjie Liu jian-xin tang jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsuChina College of Physics and Materials Science Henan Normal UniversityXinxiangHenanChina School of Physics and Electronic Science Ministry of Education Nanophotonics&Advanced Instrument Engineering Research CenterEast China Normal UniversityShanghaiChina Department of Materials Science and Engineering Monash UniversityClaytonVictoriaAustralia Laboratory of Organic Electronics Department of Science and Technology(ITN)Linköping UniversityNorrköpingSweden Macao Institute of Materials Science and Engineering(MIMSE) Macao University of Science and TechnologyTaipaMacao SARChina

Plasmonic metal electrodes with subwavelength nanostructures are promising for enhancing light harvesting in ***,the nonradiative damping of surface plasmon polaritons(SPPs)during coupling with sunlight results in the conversion of the excited hot-electrons to heat,which limits the absorption of light and generation of ***,an energy recycling strategy driven by hotelectron emission for recycling the SPP energy trapped in the plasmonic electrodes is proposed.A transparent silver-based plasmonic metal electrode(A-PME)with a periodic hexagonal nanopore array is constructed,which is combined with a luminescent organic emitter for radiative recombination of the injected *** to the suppressed SPP energy loss via broadband hot-electron emission,the A-PME achieves an optimized optical transmission with an average transmittance of over 80%from 380 to 1200 ***,the indium-tin-oxide-free organic solar cells yield an enhanced light harvestingwith a power conversion efficiency of 16.1%.

关键词： energy recycling hot-electron emission organic solar cells plasmonic electrode surface plasmon polariton

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