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Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-yi Zhu Xiu-hong Huang Hui-Qing jiang Li Liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients with ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new prognostic model for patients with ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in *** The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all P<0.001).The consistency between actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score was excellent and superior to that of existing *** net benefit of MIMIC ACLF was greater than that achieved using existing scores within the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external *** We developed and validated a new prognostic model with satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores

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Recent progress in hair follicle stem cell markers and their regulatory roles

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World Journal of Stem Cells 2024年第2期16卷 126-136页

作者： yi-Zhan Xing Hai-ying Guo Fei Xiang Yu-hong Li Department of Cell Biology Army Medical UniversityChongqing 400038China Institute of Burn Research Southwest HospitalArmy Medical UniversityChongqing 400038China

Hair follicle stem cells(HFSCs)in the bulge are a multipotent adult stem cell *** can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound *** increasing number of biomarkers have been used to isolate,label,and trace HFSCs in recent *** more detailed data from single-cell transcriptomics technology,we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

关键词： Hair follicle stem cells Bulge Secondary hair germ Marker Single-cell RNA-sequencing

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Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

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World Journal of Diabetes 2024年第3期15卷 378-391页

作者： Yan yi Tao Wang Wei Xu San-hong Zhang Department of Ultrasonography The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Clinical Molecular Immunology Center Yangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Pediatric Xiantao First People’s HospitalXiantao 433000Hubei ProvinceChina

Gestational diabetes mellitus(GDM)is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal *** a bridge between the mother and the fetus,the placenta has nutrient transport functions,endocrine functions,etc.,and can regulate placental nutrient transport and fetal growth and development according to maternal metabolic *** by means of placental transmission can changes in maternal hyperglycemia affect the *** are many reports on the placental pathophysiological changes associated with GDM,the impacts of GDM on the growth and development of offspring,and the prevalence of GDM in offspring after *** epigenetic changes in GDM are involved in the programming of fetal development and are involved in the pathogenesis of later chronic *** paper summarizes the effects of changes in placental nutrient transport function and hormone secretion levels due to maternal hyperglycemia and hyperinsulinemia on the development of offspring as well as the participation of changes in placental epigenetic modifications due to maternal hyperglycemia in intrauterine fetal programming to promote a comprehensive understanding of the impacts of placental epigenetic modifications on the development of offspring from patients with GDM.

关键词： Gestational diabetes mellitus Placental functions Epigenetics Offspring development

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Free-Standing Multiscale Porous High Entropy NiFeCoZn Alloy as the Highly Active Bifunctional Electrocatalyst for Alkaline Water Splitting

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Chinese Journal of Chemistry 2024年第13期42卷 1465-1473页

作者： Qiuping Zhang Xu Wang Tianzhen jian Wenqing Ma Caixia Xu Qiuxia Zhou hong Liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinanShandong 250022China School of Medical Information and Engineering Southwest Medical UniversityLuzhouSichuan 646000China State Key Laboratory of Crystal Materials Shandong UniversityJinanShandong 250100China

In the endeavor of searching for highly active and stable electrocatalysts toward overall water splitting,high-entropy-alloys have been the intense subjects owing to their advanced physicochemical *** non-noble metal free-standing multiscale porous NiFeCoZn high-entropy-alloy is in situ constructed on the surface layer of NiZn intermetallic and Ni heterojunction over nickel foam(NiFeCoZn/NiZn-Ni/NF)by one scalable dealloying protocal to fulfill the outstanding bifunctional electrocatalytic performances toward overall water *** of the high-entropy effects and specific hierarchical porous architecture,the as-made NiFeCoZn/NiZn-Ni/NF displays high intrinsic catalytic activities and durability toward both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alkaline *** particular,the in-situ construction of bimodal porous NiFeCoZn high-entropy-alloy results in the small overpotentials(η1000=254/409 mV for HER and OER),low Tafel slopes,and exceptional long-term catalytic durability for 400 ***,the electrolyzer constructed with NiFeCoZn/NiZn-Ni/NF as both cathode and anode exhibits a low cell voltage of 1.72 V to deliver the current density of 500 mA·cm^(–2) for overall water *** work not only provides a facile and scalable protocol for the preparation of self-supporting high-entropy-alloy nanocatalysts but also enlightens the engineering of high performance bifunctional electrocatalysts toward water splitting.

关键词： High-entropy-alloys Bifunctional electrocatalyst Dealloying/Electrocatalysis Oxygen evolution reaction Hydrogen evolution reaction

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Jetting of a near-wall cavitation bubble induced by another tandem bubble

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Journal of Hydrodynamics 2024年第3期36卷 444-456页

作者： Hui Han Jing-zhu Wang jian-lin Huang Peng-bo Bai Yong-gang Chen yi-wei Wang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China Guangdong Aerospace Research Academy Guangzhou511458China School of Future Technology University of Chinese Academy of SciencesBeijing100049China jianghuai Advance Technology Center Hefei230088China

Double bubbles near a rigid wall surface collapse to produce a significant jet impact,with potential applications in surface cleaning and ultrasonic ***,the dynamic behaviors of near-wall bubbles remain *** this study,we investigate the jetting of a near-wall bubble induced by another tandem *** define two dimensionless standoff distances,γ_(1),γ_(2),to represent the distances from the center of the near-wall bubble to the rigid wall and the center of controlling bubble to the center of the near-wall bubble,*** observations reveal three distinct jetting regimes for the near-wall bubble:transferred jetting,double jetting,and directed *** further investigate the jetting mechanism,numerical simulations are conducted using the compressibleInterFoam solver in the open-source framework of OpenFOAM.A detailed analysis shows that the transferred jet flow is caused by the pinch-off resulting from the axial contraction velocity at the lower end of the near-wall bubble being greater than the vertical contraction velocity,leading to a maximum jet velocity of 682.58 m/*** the case of double jetting,intense stretching between the controlling bubble and the wall leads to a pinch-off and a double jetting with a maximum velocity of 1096.29 m/*** directed jet flow is caused by the downward movement of the high-pressure region generated by the premature collapse of the controlling bubble,with the maximum jet velocity reaching 444.62 m/s.

关键词： Jetting of near-wall bubble controlling bubble impact velocity

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Cobalt-based heterogeneous catalysts for photocatalytic carbon dioxide reduction

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Tungsten 2024年第2期6卷 410-421页

作者： hong Yuan jian-Hua Mei Yun-Nan Gong Di-Chang Zhong Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Solar light-driven CO_(2)reduction to high value-added chemicals has considered as an outstanding way to solve energy crisis and climate ***,various photocatalysts have been developed to achieve this *** them,cobaltbased heterogeneous catalysts have attracted great interest because of their promising performance,product selectivity and ***,we systematically summarize the research progress of various cobalt-based heterogeneous catalysts for the photoreduction of CO_(2),such as single-atom cobalt,and cobalt-based oxides,nitrides,sulfi des,phosphides,metal-organic frameworks and covalent-organic ***,the advantages and structure-activity relationship of these catalysts in photocatalytic CO_(2)reduction reaction are ***,the challenges and prospects for constructing cobaltbased heterogeneous catalysts with high effi ciency are highlighted.

关键词： Cobalt Heterogeneous catalysts CO_(2)reduction Photocatalysis

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Recent progress in ternary mixed matrix membranes for CO_(2) separation

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Green Energy & Environment 2024年第5期9卷 831-858页

作者： Zikang Qin Yulei Ma Jing Wei hongfang Guo Bangda Wang Jing Deng Chunhai yi Nanwen Li Shouliang yi yi Deng Wentao Du jian Shen Wenju jiang Lu Yao Lin Yang Zhongde Dai College of Architecture and Environment Sichuan UniversityChengdu610065China College of Carbon Neutrality Future Technology Sichuan UniversityChengdu610065China National Engineering Research Centre for Flue Gas Desulfurization Chengdu610065China Carbon Neutral Technology Innovation Center of Sichuan Chengdu610065China School of Chemical Biological and Materials EngineeringUniversity of OklahomaNormanOK73019USA Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China US DOE Natl Energy Technol Lab626 Cochrans Mill RdPittsburghPA 15236USA DongFang Boiler Co. Ltd.China Clean Combustion and Flue Gas Purification Key Laboratory of Sichuan Province Chengdu611731China College of Environment and Resources Xiangtan UniversityXiangtan411105China

Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousﬁllers,making them an effective alternative to conventional polymer ***,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsﬁllers and the polymer matrix,currently limit the gas sep-aration performance of *** phase MMMs(consisting of aﬁller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation *** review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanoﬁllers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy *** on this separation data,the challenges of ternary MMMs are also ***,future directions for ternary MMMs are proposed.

关键词： CO_(2) separation Mixed matrix membranes Ternary phase

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Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92

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Nuclear Science and Techniques 2024年第5期35卷 186-199页

作者： Lei Peng Shang-Ming Chen Jing-yi Shi Yong-Jie Sun yi-Fei Liu yin-Zhong Shen hong-Ya He Hui-Juan Wang Jie Tian State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China School of Materials Engineering Shanghai University of Engineering Science333 Long Teng RoadShanghai 201620China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Ferritic/martensitic(F/M)steel is widely used as a structural material in thermal and nuclear power ***,it is susceptible to intergranular damage,which is a critical issue,under service *** this study,to improve the resistance to intergranular damage of F/M steel,a thermomechanical process(TMP)was employed to achieve a grain boundary engineering(GBE)microstructure in F/M steel *** TMP,including cold-rolling thickness reduction of 6%,9%,and 12%,followed by austenitization at 1323 K for 40 min and tempering at 1053 K for 45 min,was applied to the as-received(AR)P92 *** prior austenite grain(PAG)size,prior austenite grain boundary character distribution(GBCD),and connectivity of prior austenite grain boundaries(PAGBs)were *** to the AR specimen,the PAG size did not change *** fraction of coincident site lattice boundaries(CSLBs,3≤Σ≤29)and Σ3^(n) boundaries along PAGBs decreased with increasing reduction ratio because the recrystallization fraction increased with increasing reduction *** PAGB connectivity of the 6%deformed specimen slightly deteriorated compared with that of the AR ***,potentiodynamic polarization studies revealed that the intergranular damage resistance of the studied steel could be improved by increasing the fraction of CSLBs along the PAGBs,indicating that the TMP,which involves low deformation,could enhance the intergranular damage resistance.

关键词： Grain boundary engineering Ferritic/martensitic steel Prior austenite grain boundary character distribution Grain boundary connectivity Intergranular damage resistance

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Stable Cycling of All-Solid-State Lithium Batteries Enabled by Cyano-Molecular Diamond Improved Polymer Electrolytes

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Nano-Micro Letters 2024年第10期16卷 561-575页

作者： Yang Dai Mengbing Zhuang yi-Xiao Deng Yuan Liao jian Gu Tinglu Song Hao Yan Jin-Cheng Zheng Department of Chemical Engineering Shanghai UniversityShangda Road 99Shanghai 200444People's Republic of China Department of Physics Xiamen UniversityXiamen 361005People's Republic of China Experimental Center of Advanced Materials School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People's Republic of China Department of Physics and Department of New Energy Science and Engineering Xiamen University Malaysia43900 SepangMalaysia

The interfacial instability of the poly(ethylene oxide)(PEO)-based electrolytes impedes the long-term cycling and further application of all-solid-state lithium metal *** this work,we have shown an effective additive 1-adaman-tanecarbonitrile,which con-tributes to the excellent per-formance of the poly(ethylene oxide)-based *** to the strong interaction of the 1-Adamantanecarboni-trile to the polymer matrix and anions,the coordination of the Li^(+)-EO is weakened,and the binding effect of anions is strengthened,thereby improving the Li^(+)conductivity and the electrochemical *** diamond building block on the surface of the lithium anode can sup-press the growth of lithium ***,the 1-Adamantanecarbonitrile also regulates the formation of LiF in the solid electrolyte interface and cathode electrolyte interface,which contributes to the interfacial stability(especially at high voltages)and protects the electrodes,enabling all-solid-state batteries to cycle at high voltages for long periods of ***,the Li/Li symmetric cell undergoes long-term lithium plating/stripping for more than 2000 h.1-Adamantanecarbonitrile-poly(ethylene oxide)-based LFP/Li and 4.3 V Ni_(0.8)Mn_(0.1)Co_(0.1)O_(2)/Li all-solid-state batteries achieved stable cycles for 1000 times,with capacity retention rates reaching 85%and 80%,respectively.

关键词： 1-Adamantanecarbonitrile(ADCN) Poly(ethylene oxide) All-solid-state batteries Interfacial stability High voltage

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Optimization of the co-closing law of guide vanes and blades for bulb turbines based on CFD

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Journal of Hydrodynamics 2024年第2期36卷 363-377页

作者： Hui Liu Yun-fa Lin Yong-guang Cheng Song Xue Mao-jia Tang jian Zhang Jia-yi Fan State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Dongfang Electric Machinery Co. Ltd.Deyang618000China

The load rejection transient process of bulb turbine units is critical to safety of hydropower stations,and determining appropriate closing laws of guide vanes(GVs)and runner blades(RBs)for this process is of *** this study,we proposed a procedure to optimize the co-closing law of GVs and RBs by using computational fluid dynamics(CFD),combined with the design of experiment(DOE)method,approximation model,and genetic optimization *** sensitivity of closing law parameters on the histories of head,speed,and thrust was analyzed,and a two-stage GVs’closing law associating with a linear RBs’closing law was *** results show that GVs dominate the transient characteristics by controlling the change of *** GVs’first-stage closing speed while shortening first-stage closing time can not only significantly reduce the maximum rotational speed but also suppress the water hammer pressure;slowing GVs’second-stage closing speed is conducive to controlling the maximum reverse axial *** directly affect the runner *** RBs’closing speed can further reduce the rotational speed and the maximum reverse axial *** safety margin of each control parameter,flow patterns,and pressure pulsations of a practical hydropower station were all improved after optimization,demonstrating the effectiveness of this method.

关键词： Bulb turbine load rejection transient process double regulation closing law optimization computational fluid dynamics(CFD)

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