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Kinetic Pattern Formation with Intermolecular Interactions:A Modified Brusselator Model

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Chinese Journal of Polymer Science 2021年第12期39卷 1673-1679页

作者： Rui-Qi Sun jian-feng Li Hong-Dong Zhang Yu-Liang yang Department of Macromolecular Science State Key Laboratory of Macromolecular Engineering of PolymersFudan UniversityShanghai 200438China

In this work,we modify the traditi onal Brusselator model to in corporate the intermolecular interactions,based on which a systematic study is performed on the pattern formation mediated by chemical reaction and phase *** is found that if the chemical reaction dominates,the pattern formation will be inhibited by the phase separation while if the phase separation dominates,the chemical reaction will preve nt,un der certain conditi ons,the domain size from growing which results in dissipative patter ns other tha n macroscopic phase separations.

关键词： Brusselator model Regular solution Phase separation

FingerDTA:A Fingerprint-Embedding Framework for Drug-Target Binding Affinity Prediction

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Big Data Mining and Analytics 2023年第1期6卷 1-10页

作者： Xuekai Zhu Juan Liu jian Zhang Zhihui yang feng yang Xiaolei Zhang School of Computer Science Wuhan UniversityWuhan 430072China

Many efforts have been exerted toward screening potential drugs for targets,and conducting wet experiments remains a laborious and time-consuming *** intelligence methods,such as Convolutional Neural Network(CNN),are widely used to facilitate new drug *** to the structural limitations of CNN,features extracted from this method are local patterns that lack global ***,global information extracted from the whole sequence and local patterns extracted from the special domain can influence the drugtarget affinity.A fusion of global information and local patterns can construct neural network calculations closer to actual biological *** paper proposes a Fingerprint-embedding framework for Drug-Target binding Affinity prediction(FingerDTA),which uses CNN to extract local patterns and utilize fingerprints to characterize global *** fingerprints are generated on the basis of the whole sequence of drugs or ***,FingerDTA achieves comparable performance on Davis and KIBA data *** the case study of screening potential drugs for the spike protein of the coronavirus disease 2019(COVID-19),7 of the top 10 drugs have been confirmed potential by ***,the docking experiment demonstrates that FingerDTA can find novel drug candidates for *** codes are available at http://***:9099/mszjaas/***.

关键词： drug-target binding affinity fingerprint new drug discovery

CAR T Cell Therapy for Hematological Malignancies

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Current Medical Science 2019年第6期39卷 874-882页

作者： Xin yang Gao-xiang WANG jian-feng ZHOU Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

As a rapidly progressing field in oncology,the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors(CARs)has shown striking efficacy in the management of hematological malignancies and has been reported in a number of clinical *** note,CAR T cell therapy has shown extraordinary potential,especially in relapsed/refractory ***,there are still challenges regarding the further development of this strategy,spanning from engineering and manufacturing issues,to limited applications,to accompanying *** this review,we will summarize the general knowledge of this novel method,including receptor composition,applications,adverse events and ***,we will propose several comprehensive recommendations.

关键词： immune therapy chimeric antigen receptor T cells hematological malignancies

Antifibrotic Effect of Total Flavonoids of Astmgali Radix on Dimethylnitrosamine-lnduced Liver Cirrhosis in Rats

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Chinese Journal of Integrative Medicine 2017年第1期23卷 48-54页

作者： CHENG yang MAI Jing-yin WANG Mei-feng CHEN Gao-feng PING jian Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Pudong New Area Hospital of Traditional Chinese Medicine Shanghai 201299China

Objective：To study the effect of total flavonoids of Astmgali Radix（TFA）on liver cirrhosis induced with dimethylnitrosamine（DMN）in rats,and the effect on peroxisome proliferator-activated receptorγ（PPARγ）,uncoupling protein 2（UCP2）and farnesoid X receptor（FXR）.Methods：Fifty-three Sprague-Dawley rats were randomly divided into a control group（10 rats）and a DMN group（43 rats）.Rats in the DMN group were given DMN for 4 weeks and divided randomly into a model group（14 rats）,a low-dosage TFA group（14 rats）and a high-dosage TFA group（15 rats）in the 3rd *** were given TFA for 4 weeks at the dosage of 15 and 30 mg/kg in the low-and high-TFA groups,*** the end of the experiment blood and liver samples were *** liver function and liver tissue hydroxyproline content were ***-eosin（HE）,Sirus red and immunohistochemical stainings of collagenⅠ,smooth muscle actin（α-SMA）was conducted in paraffinembedded liver tissue *** time polymerase chain reaction（PCR）was adopted to determine PPARγ,UCP2 and FXR m RNA *** blot was adopted to determine protein levels of collagenⅠ,α-SMA,PPARγ,UCP2 and ***：Compared with the model group,TFA increased the ratio of liver/body weight（low-TFA group P〈0.05,high-TFA group P〈0.01）,improved liver biochemical indices（P〈0.01 for ALT,AST,GGT in both groups,P〈0.05 for albumin and TBil in the high-TFA group）and reduced liver tissue hydroxproline content（P〈0.01 in both groups）in treatment groups *** staining showed that TFA alleviated liver pathological changes markedly and Sirus red staining showed that TFA reduced collagen deposition,alleviated formation and extent of liver ***Ⅰandα-SMA immunohistochemical staining showed that staining area and extent markedly decreased in TFA groups compared with the model *** could increase PPARγ,it regulated target UCP2,and FXR levels significantly compared with the model group（in the low-TFA group all P〈0.05,in t

关键词： total flavonoids of Astmgali Radix dimethylnitrosamine liver cirrhosis peroxisome proliferator-activated receptor γ uncoupling protein 2 farnesoid X receptor rat

CT联合肿瘤标志物预测肺结节低分化腺癌的模型构建

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中国胸心血管外科临床杂志 2025年第1期32卷 73-79页

作者：蒋捷刘锋王波王芹钟健南京医科大学附属脑科医院胸外科南京210029

目的根据CT影像及肿瘤标志物结果,建立低分化腺癌预测模型,并进行内部验证。方法选择2023年在南京医科大学附属脑科医院胸外科行手术治疗的实性与部分实性肺结节患者,按照7∶3比例将患者随机分为训练集和验证集。收集患者CT特征,包括结... 详细信息

目的根据CT影像及肿瘤标志物结果,建立低分化腺癌预测模型,并进行内部验证。方法选择2023年在南京医科大学附属脑科医院胸外科行手术治疗的实性与部分实性肺结节患者,按照7∶3比例将患者随机分为训练集和验证集。收集患者CT特征,包括结节平均密度值、最大直径、胸膜牵拉征和支气管充气征,以及肿瘤标志物结果。依据术后病理结果,将患者分为低分化腺癌组和非低分化腺癌组。对训练集采用单因素分析和logistic回归分析,并以此建立预测模型,采用受试者工作特征(receiver operating characteristic,ROC)曲线评估模型区分度,校准曲线评估模型的一致性,绘制决策曲线评估该模型的临床价值,并在验证集中校验模型。结果共纳入299例患者,其中男103例、女196例,中位年龄57.00(51.00,67.25)岁;训练集211例,验证集88例。多因素分析显示癌胚抗原(CEA)值[OR=1.476,95%CI(1.184,1.983),P=0.002]、细胞角蛋白19片段抗原(CYFRA21-1)值[OR=1.388,95%CI(1.084,1.993),P=0.035]、肿瘤最大直径[OR=6.233,95%CI(1.069,15.415),P=0.017]、肿瘤平均密度[OR=1.083,95%CI(1.020,1.194),P=0.040]是实性与部分实性肺结节低分化腺癌的独立危险因素。基于此构建预测模型,ROC曲线下面积为0.896[95%CI(0.810,0.982)],最大约登指数对应截点值为0.103,灵敏度为0.750,特异度为0.936。Bootstrap法抽样1000次,校准曲线图预测概率与实际风险一致。决策曲线分析表明,在全预测概率下均有正收益,有较好临床价值。结论对于实性与部分实性肺结节患者,术前使用CT测量肿瘤平均密度值、最大直径,同时联合肿瘤标志物CEA、CYFRA21-1值可有效预测结节是否为低分化腺癌,以尽早予以干预。

关键词：计算机断层显像肿瘤标志物肺结节低分化腺癌预测模型列线图

Protein Requirements in Healthy Adults: A Meta-analysis of Nitrogen Balance Studies

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Biomedical and Environmental Sciences 2014年第8期27卷 606-613页

作者： LI Min SUN feng PIAO jian Hua yang Xiao Guang Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention School of public health Peking university

Objective The goal of this study was to analyze protein requirements in healthy adults through a meta-analysis of nitrogen balance studies. Methods A comprehensive search for nitrogen balance studies of healthy adults published up to October 2012 was performed, each study were reviewed, and data were abstracted. The studies were first evaluated for heterogeneity. The average protein requirements were analyzed by using the individual data of each included studies. Study site climate, age, sex, and dietary protein source were compared. Results Data for 348 subjects were gathered from 28 nitrogen balance studies. The natural logarithm of requirement for 348 individuals had a normal distribution with a mean of 4.66. The estimated average requirement was the exponentiation of the mean of the log requirement, 105.64 mg N/kg·d. No significant differences between adult age, source of dietary protein were observed. But there was significant difference between sex and the climate of the study site （P〈0.05）. Conclusion The estimated average requirement and recommended nutrient intake of the healthy adult population was 105.64 mg N/kg·d （0.66 g high quality protein/kg·d） and 132.05 mg N/kg·d （0.83 g high quality protein/kg·d）, respectively.

关键词： Protein requirement Nitrogen balance Estimated average requirement Recommendednutrient intake

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan yang Ming-Han Cheng Hai-feng Pan jian Gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

内镜逆行胰胆管造影联合内镜下鼻胆管引流时限差异对Mirizzi综合征外科治疗的临床应用价值

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中国内镜杂志 2021年第3期27卷 1-6页

作者：周海斌邵杭锋金杭斌黄海涛王晖楼奇峰金正杨建锋张筱凤浙江大学医学院附属杭州市第一人民医院城北院区消化内科浙江杭州310022 浙江大学医学院附属杭州市第一人民医院消化内科浙江杭州310006

目的探讨内镜逆行胰胆管造影(ERCP)联合内镜下鼻胆管引流术(ENBD)引流时限差异对Mirizzi综合征外科治疗的临床应用价值。方法采用回顾性队列研究收集2008年10月-2018年9月37例在浙江大学医学院附属杭州市第一人民医院接受ENBD及外科手... 详细信息

目的探讨内镜逆行胰胆管造影(ERCP)联合内镜下鼻胆管引流术(ENBD)引流时限差异对Mirizzi综合征外科治疗的临床应用价值。方法采用回顾性队列研究收集2008年10月-2018年9月37例在浙江大学医学院附属杭州市第一人民医院接受ENBD及外科手术治疗的Mirizzi综合征患者的资料,按引流时间(7 d为界)分为短时组(≤7 d,n=19)和长时组(>7 d,n=18),比较两组外科手术前胆红素情况、术中术式变化、术后并发症发生率、住院天数和治疗费用等情况。结果短时组胆红素下降幅度为4.40(0.00,25.20)mmol/L,明显小于长时组的33.55(5.18,87.33)mmol/L(Z=-2.05,P=0.040);两组各5例腹腔镜转开腹手术;短时组术后感染发生率15.8%(3/19)较长时组(0.0%)高,但两组比较,差异无统计学意义(χ^(2)=3.09,P=0.079);虽然长时组住院时间较短时组略长,但并未增加住院总费用。结论ERCP联合ENBD引流时间延长(>7 d)可增加胆红素下降程度,同时可能降低Mirizzi综合征外科术后感染率,且不增加住院费用,值得临床借鉴。

关键词：内镜逆行胰胆管造影鼻胆管引流 Mirizzi综合征时限外科治疗

Selective propylene epoxidation in liquid phase using highly dispersed Nb catalysts incorporated in mesoporous silicates

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1278-1284页

作者： Wenjuan Yan Yuhui Wu Xiang feng Chaohe yang Xin Jin jian Shen State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of Petroleum Department of Environmental Science and Engineering Xiangtan University

Selective propylene epoxidation to propylene oxide(PO) with hydrogen peroxide(H_2O_2) was carried out in a catalytic semi-batch *** propylene epoxidation activity(44 h^(-1)) was observed over Nb based mesoporous silicate materials Nb-TUD-1 under mild operating *** physical and chemical properties of the Nb based silicates characterized using BET,FTIR,TPD,TEM and UV–Vis revealed that the site isolation and surface acidity are crucial for PO *** synthesis methods were investigated for their effects on PO productivity,PO selectivity and H_2O_2 utilization *** is found that Nb-TUD-1 material synthesized by the sol–gel method is more active and selective than impregnated materials for liquid phase propylene *** characterization confirms that thus synthesized Nb-TUD-1 catalysts have more Lewis acidity and less Bronsted acidity compared to the catalysts by impregnation.

关键词： Propylene Epoxidation Propylene oxide TUD-1 Niobium mesoporous materials