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Ginsenoside enhances synapsin Ⅰ phosphorylation and glutamate release through PKA and MAPK cascades

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Ginsenoside enhances synapsin Ⅰ phosphorylation and glutama...

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

全国生化与分子药理学药物靶点研讨会

作者： Ming ZHAO Zhi-jun LIU Yi-yue zhang jian-fei XUE yun zhang Nai-hong CHEN (Institute of Material Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China Beijing Hospital of the Ministry of Health,Beijing 100050,China)

To investigate whether cAMP-dependent protein kinase(PKA)and/or Ca-calmodulin-dependent protein kinase(CaMKII)is/are involved in Rb and Rg-enhanced synapsinⅠphosphorylation and glutamate release in PC12 cells,differentiated or undifferentiated PC12 cells were incubated with Rb and Rg,following a 30-min pretreatment with or without H89,an inhibitor of PKA or W7,of calmodulin.

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo yun Chen Hao zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei zhang jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

1522号台风外围强龙卷CINRAD/SA气象产品特征研究

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成都信息工程大学学报 2018年第5期33卷 490-497页

作者：张建云张持岸葛元朱君鉴北京敏视达雷达有限公司北京100094 山东省气象台山东济南250031

利用新一代天气雷达CINRAD/SA雷达系统的探测资料和气象产品,分析了2015年10月4日发生在广东佛山台风外围强龙卷的特征。龙卷发生在距离台风中心约350 km雨带中的小型超级单体中,风暴单体的回波顶发展到12 km左右。龙卷发生前,大于50 d... 详细信息

利用新一代天气雷达CINRAD/SA雷达系统的探测资料和气象产品,分析了2015年10月4日发生在广东佛山台风外围强龙卷的特征。龙卷发生在距离台风中心约350 km雨带中的小型超级单体中,风暴单体的回波顶发展到12 km左右。龙卷发生前,大于50 d BZ的强反射率因子核发展到5.5 km;龙卷发生后,强中心高度下降,强反射率因子核的高度降低到3.5 km。风暴单体的低层后方出现钩状回波,钩状回波的末端出现高达65 d BZ的强反射率因子。风暴单体的中气旋发展高度低,延伸厚度浅薄,切变强烈。无辐合辐散的纯气旋性环流层的高度在1.2 km左右,其下方是辐合气旋性流场,上方是辐散气旋性流场。与经典超级单体中的中气旋相比,就如垂直方向上压缩了的中气旋。中气旋下方,低层辐合的强弱,与龙卷的强弱变化密切相关,在龙卷发展到最强之前,低层辐合很强,随着低层辐合的减弱,龙卷也随之减弱。中气旋适配参数的阈值用雷达系统的缺省值时,第一次算出中气旋的时间比龙卷出现的时间提前16 min,而适当降低阈值后,算出第一个中气旋的时间比龙卷出现的时间提前了58 min。雷达系统输出第一个龙卷涡旋特征(TVS)产品比实际龙卷发生的时间提前了4 min。因为距离雷达很近,在1536(北京时,HHMM,下同)和1542时次,雷达探测到了表征龙卷碎片特征(TDS)的高反射率因子。

关键词： CINRAD/SA 中气旋龙卷涡旋特征龙卷碎片特征

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农牧交错带草地植被的水土保持作用研究

水土保持学报 2004年第4期18卷 24-28页

作者：韩永伟韩建国张蕴薇王堃中国农业大学草地研究所北京100094

在农牧交错带以小麦地为对照,研究退耕建植草地植被及天然草地植被的水土保持作用。结果表明,退耕建植草地植被可以明显减轻土壤风蚀程度,并有利于土壤在雨季对降水的蓄积;天然草地植被与农田植被相比,可以较好地减轻水蚀的发生。

关键词：农牧交错带草地植被水土保持作用风蚀水蚀

阿托伐他汀联合氯吡格雷对颅内大动脉狭窄进展性脑梗死患者临床疗效

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海南医学院学报 2017年第12期23卷 1726-1729页

作者：张晓艳沈建昀张生张国欣遵化市人民医院河北唐山064200 香河县人民医院河北廊坊065400 迁西县人民医院河北唐山064300

目的:研究阿托伐汀联合氯吡格雷对颅内大动脉狭窄进展性脑梗死患者临床疗效。方法:研究对象选取我院收治的颅内大动脉狭窄进展性脑梗死患者88例,随机分为研究组和研究组,每组各44例。对照组患者口服氯吡格雷治疗,在此基础上研究组患者... 详细信息

目的:研究阿托伐汀联合氯吡格雷对颅内大动脉狭窄进展性脑梗死患者临床疗效。方法:研究对象选取我院收治的颅内大动脉狭窄进展性脑梗死患者88例,随机分为研究组和研究组,每组各44例。对照组患者口服氯吡格雷治疗,在此基础上研究组患者加用阿托伐他汀治疗,所有患者均连续治疗4周。比较两组患者的治疗总有效率、不良反应发生率及血脂水平,同时比较两组治疗前后的神经功能缺损(NIHSS)评分和日常生活能力(ADL)评分。结果:研究组的治疗总有效率明显高于对照组(P0.05)。结论:氯吡格雷联合阿托伐他汀对颅内大动脉狭窄SIP患者的疗效显著,改善患者神经功能及生活质量且安全可靠,值得临床推广。

关键词：氯吡格雷阿托伐他汀进展性脑梗死 NIHSS评分 ADL评分颅内大动脉狭窄

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu yun-Bo Ruan Yang zhang Shu-Juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

On a Class of Weak Nonhomogeneous Affine Bi-frames for Reducing Subspaces of L^2(R^d)

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Acta Mathematica Sinica,English Series 2017年第10期33卷 1339-1351页

作者： jian Ping zhang yun zhang LI College of Applied Sciences Beijing University of Technology Beijing 100124 P. R. China

For refinable functiombased affine bi-frames, nonhomogeneous ones admit fast algorithms and have extension principles as homogeneous ones. But all extension principles are based on some restrictions on refinable functions. So it is natural to ask what are expected from general refinable functions. In this paper, we introduce the notion of weak nonhomogeneous affine bi-frame （WNABF）. Under the setting of reducing subspaces of L2（Rd）, we characterize WNABFs and obtain a mixed oblique extension principle for WNABFs based on general refinable functions.

关键词： Frame reducing subspace weak affine bi-frame weak nonhomogeneous affine bi-frame,extension principle