Ginsenoside enhances synapsin Ⅰ phosphorylation and glutamate release through PKA and MAPK cascades

作     者：Ming ZHAO Zhi-jun LIU Yi-yue ZHANG Jian-fei XUE Yun ZHANG Nai-hong CHEN (Institute of Material Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China Beijing Hospital of the Ministry of Health,Beijing 100050,China) 

会议名称：《全国生化与分子药理学药物靶点研讨会》

会议日期：2008年

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Basic Research Program(973 program,Grant No.2004CB518906) Program for Yangtze River Scholars and Innovative Research Team in University(PCSIRT,Grant No.IRT0514) 

摘      要：To investigate whether cAMP-dependent protein kinase(PKA)and/or Ca-calmodulin-dependent protein kinase(CaMKII)is/are involved in Rb and Rg-enhanced synapsinⅠphosphorylation and glutamate release in PC12 cells,differentiated or undifferentiated PC12 cells were incubated with Rb and Rg,following a 30-min pretreatment with or without H89,an inhibitor of PKA or W7,of calmodulin.