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Chinese Journal of Structural Chemistry 2007年第5期26卷 501-504页

作者： WANG jian-Guo xiao yong-Jun Li Zheng-Ming SONG Hai-Bin （Elemento-organic Chemistry hlstitute State Key Laboratory ofElemento-organic Chemistry Nankai University Tianjin 300071 China

The crystal structure of the title compound （C17H16N4O3S2, Mr = 388.46） has been determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c with a = 13.688（2）, b = 16.704（3）, c = 8.3308（12）A, β = 99.474（6）°, V = 1878.8（5） A^3, Mr = 388.46, Z = 4, Dc = 1.373 g/cm3, μ = 0.308 mm^–1, F（000） = 808, R = 0.0389 and wR = 0.0917. X-ray analysis reveals that the crystal structure involves intermolecular N–H…O and N–H…N hydrogen bonds, which link the molecules into a layer parallel to the ac plane.

关键词： X-ray diffraction crystal structure synthesis

THE SPATIAL DIVISION OF INDUSTRIES OF THE PEARL RIVER DELTA IN THE 1990s: CHARACTERISTICS AND TRENDSS

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Chinese Geographical Science 2001年第1期11卷 63-69页

作者： XU yong-jian,YAN xiao-pei,XU Xue-qiang (Center for Urban and Regional Studies, Zhongshan University, Guangzhou 510275, P. R. China) Center for Urban and Regional Studies Zhongshan University Guangzhou P. R. China

The article analyzed the spatial division of industries of the Pearl River Delta (PRD) in the 1990s, a period that witnessed the deepening of the reform and opening policies and continued rapid development of the region. By adopting the index of specialization, the extent of specialization, its change and its spatial distribution in the region are measured and demonstrated. The research revealed that, despite the trend of more balanced development of the secondary sector between the PRD and the rest of the province, in the PRD, it is the unbalanced development that dominated and the spatial division of the secondary sector has been shaped. The tertiary industry has also been experiencing unbalance development and the spatial division of the tertiary sector has been emerging, its extent of concentration appearing even more evident than that of the secondary sector. The author also discussed the linkage between the spatial division of the two sectors. In the end of the paper, the trends of the spatial division of the industries in the PRD are forecasted.

关键词： Pearl River Delta spatial division of industries characteristics and trends

Intracoronary pressure gradient measurement in acute myocardial infarction patients with the no-reflow phenomenon during primary percutaneous coronary intervention

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Chinese Medical Journal 2020年第7期133卷 766-772页

作者： Ming-Dong Gao En-Yuan Zhang Yuan-Ying Liu xiao-Wei Li jian-yong xiao Gen-Yi Sun Yin Liu Department of Coronary Care Unit Tianjin Chest HospitalTianjin 300222China

Background:Various experimental and clinical studies have reported on coronary microcirculatory dysfunction("no-reflow"phenomenon).Nevertheless,pathogenesis and effective treatment are yet to be fully *** study aimed to measure the intracoronary pressure gradient in the no-reflow artery during emergent percutaneous coronary intervention and explore the potential mechanism of ***:From September 1st,2018 to June 30th,2019,intracoronary pressure in acute myocardial infarction patient was continuously measured by aspiration catheter from distal to proximal segment in the Department of Coronary Care Unit,Tianjin Chest Hospital,respectively in no-reflow arteries(no-reflow group)and arteries with thrombolysis in myocardial infarction-3 flow(control group).At least 12 cardiac cycles were consecutively recorded when the catheter was pulled *** forward systolic pressure gradient was calculated as proximal systolic pressure minus distal systolic *** between groups was made using the Student t test,Mann-Whitney U-test or Chi-square test,as ***:Intracoronary pressure in 33 no-reflow group and 26 in control group were *** intracoronary forward systolic pressure gradient was-1.3(-4.8,0.7)and 3.8(0.8,8.8)mmHg in no-reflow group and control group(Z=-3.989,P<0.001),respectively,while the forward diastolic pressure gradient was-1.0(-3.2,0)and 4.6(0,16.5)mmHg in respective groups(Z=-3.851,P<0.001).Moreover,the intracoronary forward pressure gradient showed significant difference between that before and after nicorandil medication(Z=-3.668,P<0.001 in systolic pressure gradient and Z=-3.530,P<0.001 in diastolic pressure gradient).Conclusions:No reflow during emergent coronary revascularization is significantly associated with local hemodynamic abnormalities in the coronary *** nicorandil administration at the distal segment of a coronary artery with an aspiration catheter could improve the microcir

关键词： Acute myocardial infarction Coronary hemodynamics Intracoronary pressure gradient No-reflow Primary percutaneous coronary intervention

Frequency domain wave equation forward modeling using gaussian elimination with static pivoting

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Applied Geophysics 2011年第1期8卷 60-68,95页

作者： Song jian-yong Zheng xiao-Dong Zhang Yan Xu Ji-Xiang Qin Zhen Song Xue-Juan Research Department of Geophysics Research Institute of Petroleum Exploration and Development Beijing 10083 China

Frequency domain wave equation forward modeling is a problem of solving large scale linear sparse systems which is often subject to the limits of computational efficiency and memory storage. Conventional Gaussian elimination cannot resolve the parallel computation of huge data. Therefore, we use the Gaussian elimination with static pivoting （GESP） method for sparse matrix decomposition and multi-source finite-difference modeling. The GESP method does not only improve the computational efficiency but also benefit the distributed parallel computation of matrix decomposition within a single frequency point. We test the proposed method using the classic Marmousi model. Both the single-frequency wave field and time domain seismic section show that the proposed method improves the simulation accuracy and computational efficiency and saves and makes full use of memory. This method can lay the basis for waveform inversion.

关键词： Gaussian elimination with static pivoting frequency-domain wave equation forward modeling single-frequency distributed parallel

A Genetic Linkage Map of Brassica campestris ***. pekinensis (syn. B. rapa L. ssp. pekinensis)

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Agricultural Sciences in China 2003年第1期2卷 49-55页

作者： YU Shuan-cang, WANG yong-jian and ZHENG xiao-yingBeijing Vegetable Research Center, Beijing 100089 , P. R. China

A molecular genetic map of Chinese cabbage was constructed with a 102 recombinant inbred (RI) population from a cross of two cultivated Chinese cabbage lines 177 and 276, using AFLP and RAPD markers. 352 markers including 265 AFLP markers and 87 RAPD markers were integrated into 17 linkage groups. It covered a total of 2 665. 7 cM with an average interval of 7. 6 cM. AFLP marker is efficient for map construction while it easily forms clusters to cause big gaps in map. A total of 13.92 % abnormal segregation markers distributed in the map. The molecular genetic map is fundamental for gene localization, comparative genomics, and QTL mapping of important agronomic traits.

关键词： Brassica campestris L. ssp. pekinensis(syn. B. rapa L. ssp. pekinensis) Genetic linkage map AFLP RAPD

Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma:Report of an initial experience

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World Journal of Gastroenterology 2006年第19期12卷 3114-3118页

作者： jian Zhou Jia Fan Zheng Wang Zhi-Quan Wu Shuang-jian Qiu xiao-Wu Huang Yao Yu jian Sun yong-Sheng xiao Yi-Feng He Yu-Qi Wang Zhao-You Tang Liver Cancer Institute and Zhongshan Hospital Fudan University Shanghai 200032 China

AIM： To report a retrospective analysis of preliminary results of 36 patients who received sirolimus （SRL, Rapamune, rapamycin） in a consecutive cohort of 248 liver allograft recipients. METHODS： Thirty-six liver transplant patients with hepatocellular carcinoma （HCC） who were switched to SRL- based immunosuppression therapy from tacrolimus were enrolled in this study. The patients who were diagnosed as advanced HCC before orthotopic liver transplantation （OLT） were divided into group A （n = 11）, those who were found to have HCC recurrence and/or metastasis after OLT were assigned to group B （n = 18）, and those who developed renal insuffidency caused by caldneurin inhibitor （CNI） were assigned to group C （n = 7） after OLT. RESULTS： The patients were followed up for a median of 10.4 mo （range, 3.8-19.1 mo） after conversion to SRL therapy and 12.3 mo （range, 5.1-34.4 too） after OLT. Three patients developed mild acute cellular rejection 2 wk after initiating SRL therapy, which was fully reversed after prednisolone pulse therapy. In group A, only 1 patient was found to have HCC recurrence and metastasis 12 mo after OLT. In group B, 66.7% （12/18） patients （2 with progressive tumor, 7 with stable tumor and 3 without tumor） were still alive due to conversing to SRL and/ or resection for HCC recurrence at the end of a median follow-up of 6.8 mo post conversion and 10.7 mo posttransplant. In group C, no HCC recurrence was demonstrated in 7 patients, and renal function became normal after SRL therapy. Thrombocytopenia （n = 2）, anemia （n = 8）, and oral aphthous ulcers （n = 7） found in our cohort were easily manageable. CONCLUSION： The conversion to SRL-based immunosuppression may inhibit the recurrence and metastasis of HCC and improve CNI-induced renal insufficiency in OLT patients with HCC.

关键词： Sirolimus Orthotopic liver transplantation Hepatocellular carcinoma

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao yong Du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells

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Chinese Journal of Cancer 2011年第12期30卷 853-860页

作者： Qing-Qing Wang Zhi-Yi Zhang jian-yong xiao Chun Yi Lin-Zi Li Yan Huang Jing-Ping Yun estate Key Laboratory of Oncology in South China Department of Pathology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Biochemistry Guangzhou University of Chinese Medicine Guangzhou Guangdong 510060 P. R. China.

Nucleophosmin/B23 (NPM) is a universally expressed nucleolar phosphoprotein that participates in proliferation, apoptosis, ribosome assembly, and centrosome duplication; however, the role of NPM in cell cycle regulation is not well characterized. We investigated the mechanism by which NPM is involved in cell cycle regulation. NPM was knocked down using siRNA in HepG2 hepatoblastoma cells. NPM translocation following actinomycin D (ActD) treatment was investigated using immunofluorescent staining. Expression of NPM and other factors involved in cell cycle regulation was examined by Western blotting. Cell cycle distribution was measured using flow cytometry to detect 5-ethynyl-2′-deoxyuridine (EdU) incorporation. Cell proliferation was quantified by the MTT assay. Knockdown of NPM increased the percentage of HepG2 cells in S phase and led to decreased expression of P53 and P21Cip1/WAF1. S-phase arrest in HepG2 cells was significantly enhanced by ActD treatment. Furthermore, knockdown of NPM abrogated ActD-induced G2/M phase cell cycle arrest. Taken together, these data demonstrate that inhibition of NPM has a significant effect on the cell cycle.

关键词： HepG2细胞细胞周期调控机制 S期诱导免疫荧光染色细胞周期阻滞细胞增殖 siRNA

Security of a Novel Antitapeworm Drug:Arecoline Hydrobromide

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Animal Husbandry and Feed Science 2010年第2期2卷 26-28,31页

作者： ZHOU Xu-zheng ZHANG Ji-yu LI Jin-shan LI jian-yong WEI xiao-juan NIU jian-rong LI Bing Key Laboratory of New Animal Medicine Project Lanzhou Institute of Animal Husbandry and Veterinary Medicine Chinese Academy of Agricul-tural Sciences Lanzhou 730050 China

[Objective] To make an objective evaluation about security of a new veterinary drug-arecoline hydrobromide according to the research results and papers in recent years and supply science basis for clinical usage. [ Method] The security of arecoline hydrobromide was evaluated based on acute toxicity tests; the ranges of safe medication, tolerability and toxicity as well as ＂Three-induced＇ effects （carcinogensis, mutagene- sis and teratogenesis） and reproductive toxicity were summarized according to the combinations of experimental results, papers and clinical effects. E Result] The results of acute toxicity tests in mice and rats showed that LD^0 （50% lethal dosages） of arecoline hydrobromide in mice was 691.83 mg/（***） and 95% incredible range of its LDso was 642.92 -744.47 mg/（ kg. BW）, and LDso of arecoline hydrobromide in rats was 2 054 mg/（***） and 95% incredible range of its LDso was 1 908 -2 210 mg/（***）. Its LDso value was hundreds times higher than the recommen- ded clinical dosage [ 1 -5 mg/（kg-BW） ], therefore it is safe to apply in clinic. The research results of ranges of safe medication, tolerability and toxicity showed that arecoline hydrobromide could entirely dispel the dog Diphyllobothrium, Spirometra mansoni, Dipylidium mesocestoides, Linea- tus and Cysticercus at dosages of 2 -3 mg/（ ***）, and the same effects to Railletina tapeworm of chickens and Drepanidotaenia lanceolata of duck and goose at dosages of I -2 mg/（***）. The arecoline hydrobromide had muscarinic effects as side-effects and could cause vomiting, di- arrhea and other clinical symptoms to discharge the paralyzed worm from livestock body rapidly and completely. The arecoline hydrobromide had ＂Three-induced＂ effects and reproductive toxicity when it was used as antitapeworm drug with long-term, sustained and a large number of drug us- age, rather than used in clinical application with shorter time and lower dosage of administration. [ Conclusion] The arecoline hydrobromide is

关键词： Arecoline hydrobromide Acute toxicity "Three-induced" effects Reproductive toxicity

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-jian Wu Ying Cheng xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure