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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-Yuan Wang Jing-Hang Wang Run-Kai Chen Zhen Yuan Hao cui Bo Wei jian-xin cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

Can a single-port robot be safely used for robotic total gastrectomy for advanced gastric cancer?First experience using the da Vinci SP platform

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Gastroenterology Report 2022年第1期10卷 363-369页

作者： Hao cui jian-xin cui Ke-Cheng Zhang Wen-Quan Liang Shu-Yan Li Jun Huang Lin Chen Bo Wei Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijingP.R.China School of Medicine Nankai UniversityTianjinP.R.China Foreign Languages College Shandong University of Traditional Chinese MedicineJinanShandongP.R.China

Background Many studies have shown the operative feasibility and safety of robotic *** are pursuing single-port(SP)surgery to leverage the advantages of minimally invasive *** purpose of this study was to describe technical considerations and short-term outcomes from the first reported SP robotic total gastrectomy(RTG)using the da Vinci SP *** A 75-year-old patient with a body-mass index of 19.8 kg/m^(2) and clinical stage III cancer(cT3NtM0)underwent SP RTG on 22 January 2022 at the Department of General Surgery,the Chinese PLA General *** procedures were performed successfully using the da Vinci SP robotic *** The SP RTG was successfully performed with D2 lymphadenectomy including No.10 lymph-nodes dissection and extracorporeal Roux-en-Y *** for subcutaneous emphysema,no severe adverse events occurred during the *** to a visual analogue scale(VAS),the subjective feeling of post-operative pain was given a VAS score of 3 of 10 on Post-Operative Day 1(POD 1),1 of 10 on POD 3,and 1 of 10 on POD *** removed the gastric tube on POD 2 and advised sipping water,a liquid diet,and a soft diet on PODs 2,4,and 6,*** patient was discharged without any complications on POD *** RTG is technically feasible and safe using the da Vinci SP robotic *** our knowledge,this is the first study using the da Vinci SP platform in RTG for advanced gastric cancer in elderly *** verify its superior operative outcomes,further clinical trials are needed.

关键词： gastric cancer single port robot gastrectomy da Vinci SP platform

Comparison between laparoscopic and open surgery for large gastrointestinal stromal tumors:A meta-analysis

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 48-55页

作者： jian-xin cui Yun-He Gao Hong-Qing Xi Ai-Zhen Cai Ke-Cheng Zhang Ji-Yang Li Bo Wei Lin Chen Department of General Surgery Chinese PLA General Hospital

AIM To investigate whether laparoscopic surgery is as safe and feasible as open resection for patients with larger gastrointestinal stromal tumors(GISTs)(≥ 5 cm).METHODS A systematic search of Pub Med, EMBASE, Web of Science and the Cochrane Library database was performed. Relevant studies of laparoscopic and open surgery for GISTs of > 5 cm published before December 2016 were identified from these databases. The quality of the studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The tumor size, operation time, blood loss, postoperative hospital stay, complication rate, and disease-free survival rate were assessed. The software Stata(version 12.0) was used for the *** Five clinical trials comprising 209 patients with GISTs of similar larger sizes were evaluated. The pooled analysis of 100 patients in the laparoscopic resection group and 109 patients in the open resection group demonstrated that laparoscopic surgery was significantly associated with a shorter postoperative hospital stay(P < 0.001)and less blood loss(P = 0.002). Moreover, there were no statistically significant differences in the operation time(P = 0.38), postoperative complication rate(P = 0.88), or disease-free survival rate(P = 0.20) between two groups. CONCLUSION Our findings revealed that for patients with large GISTs of comparable sizes, laparoscopic surgery did not significantly influence the operation factors or clinical outcomes compared with open surgery. This suggests that laparoscopic resection is as acceptable as open surgery for treatment of large gastric GISTs.

关键词： Laparoscopic resection Open resection Gastrointestinal stromal tumor Meta-analysis Clinical outcome

Could neoadjuvant chemotherapy increase postoperative complication risk of laparoscopic total gastrectomy? A monoinstitutional propensity score-matched study in China

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 429-442页

作者： Hao cui jian-xin cui Yu-Ning Wang Bo Cao Huan Deng Ke-Cheng Zhang Tian-Yu Xie Wen-Quan Liang Yi Liu Lin Chen Bo Wei School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery Institute of General SurgeryChinese PLA General HospitalBeijing 100853China First Medical Center Chinese PLA General HospitalBeijing 100853China

The potential survival benefit of neoadjuvant chemotherapy(NC)in patients with advanced gastric cancer has been widely *** the development of minimally invasive surgery,which is represented by laparoscopy,the effect of NC on the safety of laparoscopic gastrectomy remains to be further *** To compare the short-term outcomes of laparoscopic total gastrectomy(LTG)after NC(NC-LTG)with LTG *** A total of 92 patients who underwent NC-LTG and 381 patients who received LTG alone at the Chinese PLA General Hospital between September 2015 and September 2020 were retrospectively included in our *** used propensityscore matching(PSM)to balance baseline *** 1:1 PSM,73 patients were included in each group with no statistically significant difference in baseline *** The NC-LTG group exhibited a longer operation time(244.10±48.13 min vs 225.74±45.33 min,P=0.019)and increased intraoperative blood loss[150(100-300)mL vs 100(100-200)mL,P=0.011]compared to the LTG *** 30-d postoperative morbidity of the NC-LTG group was 20.5%(15/73),and that of the LTG group was 13.7%(10/73).There were no significant differences in 30-d severe complication rates or anastomotic leakage *** analysis showed that the patients with pTNM(pathological tumor-node-metastasis classification)T0N0-II in the NC-LTG group underwent a longer operation than the LTG group,while no significant difference was found in any perioperative index for the pTNM III patients.A multivariate analysis showed that an operation time longer than 240 min was an independent risk factor(odds ratio=3.021,95%confidence interval:1.160-7.868,P=0.024),while NC was not an independent risk factor for postoperative complications in *** Despite a longer operation time and more blood loss after NC-LTG,which indicate surgical difficulty,NC-LTG exhibits acceptable short-term outcomes compared to LTG,suggesting the safety and feasibility of NC-LTG.

关键词： Neoadjuvant chemotherapy Gastric cancer Laparoscope Total gastrectomy Morbidity

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang xin Liu jian Zhang Ya Gao Shuyue Li cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Serum HER2 as a predictive biomarker for tissue HER2 status and prognosis in patients with gastric cancer

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World Journal of Gastroenterology 2017年第10期23卷 1836-1842页

作者： Hong-Zhi Shi Yu-Ning Wang Xiao-Hui Huang Ke-Cheng Zhang Hong-Qing Xi jian-xin cui Guo-Xiao Liu Wen-Tao Liang Bo Wei Lin Chen Department of General Surgery Chinese PLA General Hospital Department of General Surgery General Hospital of Armed Police Force Department of Surgery Chinese PLA General Hospital Institute of General Surgery Chinese PLA General Hospital

AIM To investigate the association between serum human epidermal growth factor receptor 2(HER2) extracellular domain(ECD) and tissue HER2 status, and the prognostic value of serum HER2 ECD in patients with gastric *** A total of 239 patients with gastric cancer were enrolled from December 2012 to June 2013. Serum HER2 ECD was determined by chemiluminescent assay, and tissue HER2 status was evaluated by immunohistochemistry and fluorescence in situ hybridization assay. A receiver operating characteristic(ROC) curve was plotted to identify the optimal cut-off value for serum HER2 ECD assay for predicting survival in gastric cancer *** Serum HER2 ECD was significantly correlated with tissue HER2 status(P < 0.001), tumor size(P < 0.001), and intestinal type of gastric cancer(P =0.021). Serum HER2 ECD levels differed significantly between patients with HER2-positive tissue expression and those with HER2-negative tissue expression. ROC analysis yielded an area under the curve value of 0.79(95%CI: 0.71-0.87, P < 0.001), with a sensitivity and specificity of 0.54(95%CI: 0.37-0.70) and 0.93(95%CI: 0.88-0.96), respectively. With a cut-off value of 24.75 ng/m L, high serum HER2 ECD had a negative impact on overall survival of the patients(HR: 1.93, 95%CI: 1.32-4.38, P = 0.006). CONCLUSION Serum HER2 ECD could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer. Optimal cut-off criteria for predicting survival should be established.

关键词： Gastric cancer Serum HER2 extracellular domain Tissue HER2 status Prognosis

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu xin Ma Shaojie Tian Qinghe cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

Preoperative albumin levels predict prolonged postoperative ileus in gastrointestinal surgery

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World Journal of Gastroenterology 2020年第11期26卷 1185-1196页

作者： Wen-Quan Liang Ke-Cheng Zhang Hua Li jian-xin cui Hong-Qing Xi Ji-Yang Li Ai-Zhen Cai Yu-Hua Liu Wang Zhang Lan Zhang Bo Wei Lin Chen Department of General Surgery&Institute of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Surgical Oncology Xing Tai People's HospitalXingtai 054001Hebei Province China Institute of Army Hospital Management Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Prolonged postoperative ileus(PPOI) is a prolonged state of "pathological"gastrointestinal(GI) tract dysmotility. There are relatively few studies examining the influence of preoperative nutritional status on the development of PPOI in patients who underwent GI surgery. The association between preoperative albumin and PPOI has not been fully studied. We hypothesized that preoperative albumin may be an independent indicator of *** To analyze the role of preoperative albumin in predicting PPOI and to establish a nomogram for clinical risk *** Patients were drawn from a prospective hospital registry database of GI surgery.A total of 311 patients diagnosed with gastric or colorectal cancer between June 2016 and March 2017 were included. Potential predictors of PPOI were analyzed by univariate and multivariable logistic regression analyses, and a nomogram for quantifying the presence of PPOI was developed and internally *** The overall PPOI rate was 21.54%. Advanced tumor stage and postoperative opioid analgesic administration were associated with PPOI. Preoperative albumin was an independent predictor of PPOI, and an optimal cutoff value of 39.15 was statistically calculated. After adjusting multiple variables, per unit or per SD increase in albumin resulted in a significant decrease in the incidence of PPOI of 8%(OR = 0.92, 95%CI: 0.85-1.00, P = 0.046) or 27%(OR = 0.73, 95%CI:0.54-0.99, P = 0.046), respectively. Patients with a high level of preoperative albumin(≥ 39.15) tended to experience PPOI compared to those with low levels(< 39.15)(OR = 0.43, 95%CI: 0.24-0.78, P = 0.006). A nomogram for predicting PPOI was developed [area under the curve(AUC) = 0.741] and internally validated by bootstrap resampling(AUC = 0.725, 95%CI: 0.663-0.799).CONCLUSION Preoperative albumin is an independent predictive factor of PPOI in patients who underwent GI surgery. The nomogram provided a model to screen for early indications in the clinic

关键词： Albumin Prolonged postoperative ileus Gastrointestinal surgery Nomogram Complications

Nomogram to predict prolonged postoperative ileus after gastrectomy in gastric cancer

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World Journal of Gastroenterology 2019年第38期25卷 5838-5849页

作者： Wen-Quan Liang Ke-Cheng Zhang jian-xin cui Hong-Qing Xi Ai-Zhen Cai Ji-Yang Li Yu-Hua Liu Jie Liu Wang Zhang Peng-Peng Wang Bo Wei Lin Chen Department of General Surgery&Institute of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China Institute of Army Hospital Management Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Vascular and Endovascular Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Prolonged postoperative ileus(PPOI)is one of the common complications in gastric cancer patients who underwent *** on the predictors of PPOI after gastrectomy is limited and few prediction models of nomogram are used to estimate the risk of *** hypothesized that a predictive nomogram can be used for clinical risk estimation of PPOI in gastric cancer *** To investigate the risk factors for PPOI and establish a nomogram for clinical risk *** Between June 2016 and March 2017,the data of 162 patients with gastrectomy were obtained from a prospective and observational registry *** data of patients who fulfilled the criteria were *** and multivariable logistic regression models were performed to detect the relationship between variables and PPOI.A nomogram for PPOI was developed and verified by bootstrap *** calibration curve was employed to detect the concentricity between the model probability curve and ideal *** clinical usefulness of our model was evaluated using the net benefit *** This study analyzed 14 potential variables of PPOI in 162 gastric cancer patients who underwent *** incidence of PPOI was 19.75%in patients with *** older than 60 years,open surgery,advanced stage(III–IV),and postoperative use of opioid analgesic were independent risk factors for *** developed a simple and easy-to-use prediction nomogram of PPOI after *** nomogram had an excellent diagnostic performance[area under the curve(AUC)=0.836,sensitivity=84.4%,and specificity=75.4%].This nomogram was further validated by bootstrapping for 500 *** AUC of the bootstrap model was 0.832(95%CI:0.741–0.924).This model showed a good fitting and calibration and positive net benefits in decision curve *** We have developed a prediction nomogram of PPOI for gastric *** novel nomogram might serve as an essential early war

关键词： Prolonged postoperative ileus Gastric cancer Complication Nomogram Bootstrap

Comparison of Therapeutic Efficacy between Gastrectomy with Transarterial Chemoembolization Plus Systemic Chemotherapy and Systemic Chemotherapy Alone in Gastric Cancer with Synchronous Liver Metastasis

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Chinese Medical Journal 2015年第16期128卷 2194-2201页

作者： Sen-Feng Liu Can-Rong Lu Hai-Dong Cheng Hong-Qing Xi jian-xin cui Ji-Yang Li Wei-Song Shen Lin Chen Department of General Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background：Systemic chemotherapy （SC） is the recommended treatment for gastric cancer with liver ***,the improvement in survival has been *** aim of this study was to compare the therapeutic efficacy of gastrectomy with transarterial chemoembolization plus SC （GTC） and SC alone for gastric cancer with synchronous liver ***：From January 2008 to December 2013,107 gastric cancer patients with synchronous liver metastasis attending the four participating centers were enrolled in this multicenter,ambispective,controlled cohort *** who underwent GTC （n =32） were compared with controls who were received SC alone （n =75）.The primary endpoints of the study were overall survival （OS） and progression-free survival （PFS）.The secondary endpoints were response rate to treatment and treatment-related adverse ***：The median OS was 14.0 months （95% confidence interval [CI]：13.1-14.9 months） in the GTC treatment group and 8.0 months （95% CI：6.6-9.4 months） in SC group,this difference being statistically significant （P 〈 0.001）.The median PFS was significantly longer in the GTC than in the SC group （5 months,95% CI：2.2-7.8 months vs.3 months,95% CI：2.3-3.4 months,respectively）（P 〈 0.001）.The rate of response to treatment was significantly better in the GTC than the SC group （59.4% vs.37.4%,respectively）（P =0.035）.According to multivariate analysis,OS in patients receiving combination treatment was significantly correlated with the size （P =0.037） and extent of liver metastases （P 〈 0.001）.PFS was also correlated with the extent of liver metastases （P =0.003）.Conclusions：GTC is more effective than SC alone in patients with gastric cancer with synchronous liver *** therapy prolongs the survival of selected gastric cancer patients with synchronous liver metastasis.

关键词： Chemotherapy Gastrectomy Gastric Cancer Liver Metastases Transcatheter Arterial Chemoembolization