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“Zero ischemia”laparoscopic partial nephrectomy by high-power GreenLight laser enucleation for renal carcinoma:A single-center experience

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World Journal of Clinical Cases 2022年第17期10卷 5646-5654页

作者： Xiang-Min Zhang Ji-Dong Xu jian-Min Lv Xiu-Wu Pan jian-wei cao jian Chu Xin-Gang Cui Department of Urology Xinhua HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200092China Department of Urology Shanghai Baoshan Luodian HospitalShanghai 201908China Department of Urology Gongli Hospital of The Second Military Medical UniversityShanghai 200135China Department of Urology Shanghai The Seventh People's HospitalShanghai 200137China

BACKGROUND Laparoscopic partial nephrectomy has been widely used in renal cell carcinoma *** efficacy of GreenLight laser on Laparoscopic partial nephrectomy is still *** To present the first series of laparoscopic partial nephrectomy(LPN)by GreenLight laser enucleation without renal artery *** to the excellent coagulation and hemostatic properties of the laser,laser-assisted LPN(LLPN)makes it possible to perform a“zero ischemia”*** Fifteen patients with T1a exogenous renal tumors who received high-power GreenLight laser non-ischemic LPN in our hospital were retrospectively *** clinical information,surgical and post-operative data,complications,pathological and functional outcomes were *** Surgery was successfully completed in all patients,and no open or radical nephrectomy was *** renal artery was not clamped,leading to no ischemic *** blood transfusions were required,the average hemoglobin level ranged from 96.0 to 132.0 g/L and no postoperative complications *** mean operation time was 104.3±8.2 *** postoperative removal of negative pressure drainage time ranged from 5.0 to 7.0 d,and the mean postoperative hospital stay was 6.5±0.7 *** serious complications *** pathological results showed clear cell carcinoma in 12 patients,papillary renal cell carcinoma in 2 patients,and hamartoma in 1 *** mean creatinine level was 75.0±0.8μmol/L(range 61.0-90.4μmol/L)at 1 mo after surgery,and there were no statistically significant differences compared with pre-operation(P>0.05).The glomerular filtration rate ranged from 45.1 to 60.8 mL/min,with an average of 54.0±5.0 mL/min,and these levels were not significantly different from those before surgery(P>0.05).CONCLUSION GreenLight laser has extraordinary cutting and sealing advantages when used for small renal tumors(exogenous tumors of stage T1a)during ***,use of this technique can lead to the generation

关键词： GreenLight laser Zero ischemia Partial nephrectomy Laparoscopy Renal tumor

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Radioiodine labeled SP-4 as an imaging agent foratherosclerotic plaques

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Nuclear Science and Techniques 2000年第4期11卷 234-239页

作者： ZHANG Yong-Xue, WU Zhi-jian, cao wei (Union Hospital, Huazhong University of Science and Technology, Wuhan 430022) 华中科技大学湖北武汉 430022

The clinical prospect of radioiodinated SP-4 as an atherosclerotic plaque imaging agent was studied. The SP-4 was synthesized by a solid phase method and identified by an amino acid analysis after purification with HPLC. SP-4 was labeled with 131I and 125I by the Chloramine--T method and purified through Sephadex G25 column. Tewlve New Zealand rabbits were divided into an atherosclerotic group (n = 7, AR) and a control group (n = 5, NR ). All of the atherosclerotic rabbits were intravenous administrated with bovine serum albumin, then fed with high cholesterol and fat diet. 125I-SP-4 was intravenous administrated to the rabbits of both groups. The biodistribution of 125I-SP-4 in rabbits was investigated. The uptakes (%ID/g) in blood and thoracic aorta and abdominal aorta were calculated 4 hours postinjection. Macroautoradiography and microautoradiography were performed in 2 AR atheroscle-rotic abdominal aortas. The clearance of radioactivity from plasma was very rapid. 125I-SP-4 was mainly excreted through kidneys. The radioactive uptakes of abdominal aorta and thoracic aorta of AR at 4hours postinjection were significantly higher than that of NR. The films of macroautoradiography showed focal accumulation of the radioactivity in the areas of a newly formed edges of atherosclerotic plaques. On the slices of microautoradiography, the obvious radioactive accumulation could be found in the atherosclerotic plaques. Thus it was seen that the SP-4 remained its biological activity after radioiodination and was located at atherosclerotic lesions, it is potentially useful as an atherosclerotic plaque imaging agent.

关键词：放射性碘标记 SP-4 临床应用放射性显像药物诊断动脉粥样硬化实验兔动物实验

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SYNTHESES AND PROPERTIES OF 3-METHOXY-DIPHENYLAMINE-4-DIAZONIUM SALTS AND THEIR DIAZO RESINS

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Chinese Science Bulletin 1989年第20期34卷 1709-1712页

作者：曹建伟曹维孝冯新德 Department of Chemistry Peking University

This note reports for the first time the preliminary results concerning the syntheses of 3-methoxy-dephenylamine-4-diazonium salts (M DADS)and the structures and properties of diazo resins produced by them and 4,4′-d... 详细信息

关键词： diazo resins photosensitivity thermostability nucleophilic substitution light sensitive printing plate

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van der Waals Interactions in Bimolecular Reactions

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Chinese Journal of Chemical Physics 2019年第2期32卷 157-166,I0002页

作者： jian-wei cao Feng-yi Li Wen-sha Xia Wen-sheng Bian Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

The van der Waals (vdW) interaction is very important in fields of physics, biology and chemistry, and its role in reaction dynamics is an issue of great interest. In this review, we focus on the recent progresses in the theoretical and experimental studies on the vdW interaction in bimolecular reactions. In particular, we review those studies that have advanced our understanding of how the vdW interaction can strongly influence the dynamics in both direct activated and complex-forming reactions, and further extend the discussion to the polyatomic reactions involving more atoms and those occurring at cold and ultracold temperatures. We indicate that an accurate description of the delicate vdW structure and long-range potential remains a challenge nowadays in either ab initio calculations or the fitting of the potential energy surfaces. We also present an explanation on the concept of vdW saddle proposed by us recently which may have general importance.

关键词： van der Waals interaction Complex-forming reactions Reaction mechanisms Ultracold chemical reactions Ab initio potential energy surfaces

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A NEW ARTIFICIAL PHOTOSYNTHESIS COMPOUND FOR PHOTOELECTRIC CONVERSION

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Chinese Chemical Letters 1991年第4期2卷 281-284页

作者： Xiang Dong WANG Bao Wen ZHANG jian wei BAI Yi cao Xu Rui XIAO Jing Mei XU Institute of Photographic Chemistry,Academia Sinica,Beijing,100101

A new triad model compound porphyrin-viologen-carbazole was synthesized to mimic photosynthesis.A mechanism including photoinduced electron transfer and two-step charge separation was *** triad compound was easy to form LB film and rather high photodriven voltage and current were obtained with only one layer of LB film On the surface of SnO_2 conductive glass.

关键词： A NEW ARTIFICIAL PHOTOSYNTHESIS COMPOUND FOR PHOTOELECTRIC CONVERSION

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对韭菜迟眼蕈蚊幼虫高毒力Bt资源筛选及效果评价

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应用昆虫学报 2016年第6期53卷 1217-1224页

作者：宋健曹伟平冯书亮杜立新河北省农林科学院植物保护研究所/河北省农业有害生物综合防治工程技术研究中心/农业部华北北部作物有害生物综合治理重点实验室保定071000

【目的】为开发防治韭菜迟眼蕈蚊Bradysia odoriphaga的生物杀虫剂，本研究评价了185株苏云金芽胞杆菌Bacillus thuringiensis对韭菜迟眼蕈蚊幼虫的杀虫活性。【方法】采用浸叶饲喂法对供试菌株进行室内生物学测定，用盆栽试验对筛选到... 详细信息

【目的】为开发防治韭菜迟眼蕈蚊Bradysia odoriphaga的生物杀虫剂，本研究评价了185株苏云金芽胞杆菌Bacillus thuringiensis对韭菜迟眼蕈蚊幼虫的杀虫活性。【方法】采用浸叶饲喂法对供试菌株进行室内生物学测定，用盆栽试验对筛选到的对韭菜迟眼蕈蚊高毒力的FPT3菌株进行防效验证，通过SDS-PAGE电泳技术对FPT3菌株的杀虫晶体蛋白进行分析，并采用Biolog微生物自动分析系统对FPT3菌株进行了生理生化测定。【结果】在1＆#215;108 cfu/mL浓度下，对韭菜迟眼蕈蚊2龄幼虫3 d的校正死亡率在80%以上的菌株有12株，其中FPT3菌株对韭菜迟眼蕈蚊2龄幼虫的杀虫活性最高；FPT3菌株表达70 ku左右蛋白，具有典型的苏云金芽胞杆菌的生理生化特征；FPT3菌株对韭菜迟眼蕈蚊1龄和2龄幼虫具有较高的杀虫活性，LC50分别为1.206＆#215;106 cfu/mL 和2.577＆#215;106 cfu/mL，室内盆栽试验明确了 FPT3菌株对韭菜迟眼蕈蚊的防治效果达77.76%。【结论】 FPT3菌株能有效地控制韭菜迟眼蕈蚊的发生，具有良好的应用前景。

关键词：韭菜迟眼蕈蚊苏云金芽胞杆菌毒力生理生化

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei Li jian-Hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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