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Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1347-1361页

作者： Dong-Yun Zhang jian-wei ku Xue-Ke Zhao Hai-Yan Zhang Xin Song Hong-Fang Wu Zong-Min Fan Rui-Hua Xu Duo You Ran Wang Ruo-Xi Zhou Li-Dong Wang State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology Nanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Endoscopy The Third Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Pathology The First Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Medical Oncology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450052Henan ProvinceChina Department of Biology University of RichmondRichmondVA 23173United States

BACKGROUND In China,it has been well recognized that some female patients with esophageal squamous cell carcinoma(ESCC)have different overall survival(OS)time,even with the same tumor-node-metastasis(TNM)stage,challenging the prognostic value of the TNM system *** effective predictive model is needed to accurately evaluate the prognosis of female ESCC *** To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC,and to assess the incremental prognostic value of the full model compared with the clinical model and TNM *** A new prognostic nomogram incorporating clinical and reproductive features was constructed based on univariatie and Cox proportional hazards survival analysis from a training cohort(n=175).The results were recognized using the internal(n=111)and independent external(n=85)validation *** capability of the clinical–reproductive model was evaluated by Harrell’s concordance index(C-index),Kaplan–Meier curve,time-dependent receiver operating characteristic(ROC),calibration curve and decision curve *** correlations between estrogen response and immune-related pathways and some gene markers of immune cells were analyzed using the TIMER 2.0 *** A clinical–reproductive model including incidence area,age,tumor differentiation,lymph node metastasis(N)stage,estrogen receptor alpha(ESR1)and beta(ESR2)expression,menopausal age,and pregnancy number was constructed to predict OS in female ESCC *** to the clinical model and TNM stage,the time-dependent ROC and C-index of the clinical–reproductive model showed a good discriminative ability for predicting 1-,3-,and 5-years OS in the primary training,internal and external validation *** on the optimal cut-off value of total prognostic scores,patients were classified into high-and low-risk groups with significantly different *** estrogen response was significantly associated with p53 and apop

关键词： Esophageal squamous cell carcinoma Female Nomogram Prognosis Estrogen receptor

Steady-state Voltage Security-constrained Optimal Frequency Control for Weak HVDC Sending-end AC Power Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 658-669页

作者： Qiangqiang Wang Liangzhong Yao jian Xu Yuping Zheng wei Li wei Wang School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network(Wuhan University) Wuhan 430072China State Key Laboratory of Smart Grid Protection and Control NARI Group Corporation(State Grid Electric Power Research Institute)Nanjing 211106China

Due to the fact that a high share of renewable energy sources(RESs)are connected to high-voltage direct current(HVDC)sending-end AC power systems,the voltage and frequency regulation capabilities of HVDC sending-end AC power systems have *** has resulted in potential system operating problems such as overvoltage and overfrequency,which occur simultaneously when block faults exist in the HVDC *** this study,a steady-state voltage security-constrained optimal frequency control method for weak HVDC sending-end AC power systems is *** integrated virtual inertia control of RESs is employed for system frequency *** dynamic reactive power compensation devices are utilized to control the voltage of all nodes meet voltage security ***,an optimization model that simultaneously considers the frequency and steady-state voltage security constraints for weak HVDC sending-end AC power systems is *** optimal control scheme with the minimum total cost of generation tripping and additional dynamic reactive power compensation required is obtained through the optimization *** are conducted on a modified IEEE 9-bus test system and practical Qing-Yu line commutated converter based HVDC(LCC-HVDC)sending-end AC power system to verify the effectiveness of the proposed method.

关键词： Renewable energy source(RES) high-voltage direct current(HVDC) AC power system optimal frequency control steady-state voltage security dynamic reactive power compensation

Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： wei Sun jian Li Rucong Yu Nina Li Yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

Quantitatively Evaluating the Erosion and Preservation of Supergene Oxide Zones:Evidence from the Yulong Porphyry Cu Deposit,Eastern Tibetan Plateau

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Journal of Earth Science 2024年第1期35卷 280-282页

作者： Xiao-Dong Deng jian-wei Li State Key Laboratory of Geological Processes and Mineral Resources and School of Earth ResourcesChina University of GeosciencesWuhan 430074China

*** and erosion of sulfide ore deposits are important for understanding the post-mineralization processes that have significant effects on the preservation of primary orebodies(Velasco et al.,2013;Braxton et al.,2009;Brimhall et al.,1985).Supergene oxide zones are often developed in sulfide ore deposits,and are mainly composed of iron oxides and hydroxides zones in weathering profile(Andrew,1984;Thornber et al.,1981).

关键词： Eastern Tibetan weathering

Optimization Mechanism of Mechanical Properties of Basalt Fiber-Epoxy Resin Composites by Interfacially Enriched Distribution of Nano-Starch Crystals

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 289-296页

作者： Yanpeng wei Jiale Zhao jian Zhuang Peng Zhang Zhiwu Han College of Biological and Agricultural Engineering Jilin UniversityChangchun 130025China Key Laboratory of Bionics Engineering Ministry of EducationJilin UniversityChangchun 130025China weichai Lovol Heavy Industry Co. LTDWeifang 261031China

Fibre reinforced polymer composites have become a new generation of structural materials due to their unique advantages such as high specific strength,designability,good dimensional stability and ease of large-area monolithic ***,the problem of interfacial bonding between the resin matrix and the fibres limits the direct use of reinforcing fibres and has become a central difficulty in the development of basalt fibre-epoxy *** paper proposes a solution for enhancing the strength of the fibre-resin interface using maize starch nanocrystals,which are highly yield and ***,in this paper,corn starch nanocrystals(SNC)were prepared by hydrolysis,and were deposited on the surface of basalt fibers by electrostatic *** that,in order to maximize the modification effect of nano-starch crystals on the interface,the basalt fiber-epoxy resin composite samples were prepared by mixing in a pressureless molding *** test results shown that the addition of basalt fibers alone led to a reduction in the strength of the *** of 0.1 wt%SNC on the surface of basalt fibers can make the strength consistent with pure epoxy *** the adsorption amount of SNC reached 0.5 wt%,the tensile strength of the samples was 23.7%higher than that of pure epoxy *** is due to the formation of ether bond homopolymers between the SNC at the fibre-epoxy interface and the epoxy resin,which distorts the originally smooth interface,leading to increased stress concentration and the development of *** enhances the binding of basalt *** conclusions of this paper can provide an effective,simple,low-cost and non-polluting method of interfacial enhancement modification.

关键词： Basalt fibres Epoxy resin Fibre reinforced composites Starch nanocrystals Eco-friendly

Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

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Acta Geochimica 2024年第3期43卷 441-458页

作者： Qing-Qing Zhang You-wei Chen jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic *** low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

The Influence of Different Solar System Planetary Ephemerides on Pulsar Timing

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Research in Astronomy and Astrophysics 2024年第8期24卷 87-101页

作者： jian-Peng Dai wei Han Na Wang School of Physical Science and Technology Xinjiang University Xinjiang Astronomical Observatory Chinese Academy of Sciences University of Chinese Academy of Sciences Xinjiang Key Laboratory of Radio Astrophysics

Pulsar timing offers a comprehensive avenue for exploring diverse topics in physics and *** solar system planetary ephemeris is crucial for pulsar timing as it provides the positions and velocities of solar system planets including the ***,it is inevitable that inherent inconsistencies exist in these *** between various ephemerides can significantly impact pulsar timing and parameter ***,pulsar timing highly depends on the JPL DE ephemeris,for instance,the Pulsar Timing Array data analysis predominantly utilizes *** this study,we examine inconsistencies across various ephemeris series,including JPL DE,EPM,and ***,discrepancies emerge particularly between the current ephemeris DE436 and the earliest released ephemeris DE200,as well as the most recent ephemerides,e.g.,DE440,INPOP21A,and *** detailed analysis of the effects of ephemeris on geometric correction procedures for the conversion of measured topocentric times of arrival is presented in this *** researches reveal that variations in the Roemer delays across different ephemerides lead to distinct *** timing residuals and the fact that these discrepancies can be readily incorporated into the subsequent pulsar parameters,leading to inconsistent fitting estimates,suggest that the influence of errors in the ephemeris on the timing process might currently be underappreciated.

关键词： (stars:) pulsars: general ephemerides Planetary Systems time

New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： wei Wang Hang-Yuan Cheng jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： wei-jian Guo Ao Zhou Wen-Wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber