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Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline

Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 395-400页

作者： Miao-Yan Chen jian-ting cai Qin Du Liang-Jing Wang Jia-Min Chen Li-Ming Shao Department of Gastroenterology and Hepatology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China.

BACKGROUND:Hepatic veno-occlusive disease(HVOD)is a severe complication of chemotherapy before hematopoietic stem cell transplantation and dietary ingestion of pyrrolizidine *** experimental models were established to study its mechanisms or therapy,but few are *** work aimed at evaluating a rat model of HVOD induced by monocrotaline to help advance research into this disease. METHODS:Thirty-two male rats were randomly classified into 5 groups,and PBS or monocrotaline was administered (100 mg/kg or 160 mg/kg).They were sacrificed on day 7(groups A,B and D)or day 10(groups C and E).Blood samples were collected to determine liver enzyme *** weight of the liver and body and the amount of ascites were *** changes of liver tissue on light microscopy were assessed by a modified Deleve scoring *** positivity of proliferating cell nuclear antigen(PCNA)was estimated. RESULTS:The rats that were treated with 160 mg/kg monocrotaline presented with severe clinical symptoms (including two deaths)and the histopathological picture of *** the other hand,the rats that were fed with 100 mg/kg monocrotaline had milder and reversible *** of the rats sacrificed on day 10 with those sacrificed on day 7 showed that the positivity of PCNA increased,especially that of ***:Monocrotaline induces acute,dose- dependent HVOD in *** model is potentially reversible with a low dose,but reliable and irreversible with a higher *** modified scoring system seems to be more accurate than the traditional one in reflecting the histopathology of *** enhancement of PCNA positivity may be associated with hepatic tissue undergoing recovery.

关键词： hepatic veno-occlusive disease monocrotaline proliferating cell nuclear antigen

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Overt gastrointestinal bleeding because of hookworm infection

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 331-332页

作者： Jia-Min Chen Xin-Mei Zhang Liang-Jing Wang Yan Chen Qin Du jian-ting cai Department of Gastroenterology Second Affiliated Hospital Zhejiang University College of Medicine

Hookworm infection is a relatively common cause of anemia in endemic *** most common hookworm species are Ancylostoma duodenale and Necator *** this report we present a case of overt gastrointestinal bleeding Wause of hookworm *** endoscopy revealed many hookworms in the lumen of proximal jejunum where active bleeding was seen. The patient was successfully treated with Albendazole.

关键词： Capsule endoscopy Hookworm infection Overt gastrointestinal bleeding

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Acquired double pylorus:A case report

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 503-504页

作者： Qing-Yu Chen Yan Chen Liang Jing Wang Qin Du jian-ting cai Jia-Min Chen Department of Gastroenterology Second Affiliated HospitalZhejiang University College of MedicineChina

Double pylorus is one of the rare anomalies of the gastrointestinal tract,it can be congenital or *** this case we report a case of double pylorus because of chronic peptic *** GI endoscopy revealed gastroduodenal fistula located on the lesser curve of the antrum,the patient’s symptoms were improved rapidly by intensive antiulcer treatment.

关键词： Acquired double pylorus Gastric endoscopy Gastroduodenal fistula

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Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer

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World Journal of Gastroenterology 2006年第19期12卷 3119-3122页

作者： Shu-Qing Shi jian-ting cai jian-Ming Yang Department of Gastroenterology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Gastroenterology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To study the expression of trefoil factor 1 （TFF1） and TFF2 in precancerous condition and gastric cancer and to explore the relationship between TFFs and tumorigenesis, precancerous condition and gastric cancer. METHODS： The expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 140 patients including 35 cases of chronic superficial gastritis （CSG）, 35 cases of gastric ulcer （GU）, 35 cases of chronic atrophic gastritis （CAG） and 35 cases of gastric cancer （GC）. RESULTS： TFF1 and TFF2 were located in cytoplasm of gastric mucous cells. In CSG, GU, CAG and GC, the level of TFF1 expression had a decreased tendency （P〈 0.05）. The expression of TFF2 was higher in GU than in CSG, but the difference was not significant. The expression of TFF2 also had a decreased tendency in GU, CAG, and GC （P〈 0.05）. CONCLUSION： The reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa. More investigations are needed to explore the mechanism of TFFs and the relationship between TFFs and gastric cancer.

关键词： Trefoil factor Gastric cancer Immunohistochemistry

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NaBH4-induced phase transition of CoSe_(2) with abundant Se deficiency for acidic oxygen reduction to hydrogen peroxide

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Rare Metals 2024年第2期43卷 500-510页

作者： cai-Di Han Yong-Chao Zhang Qian Zhang Jin-ting Wu jian Gao Ji-Jun Zou Xiao-Dong Zhu State Key Laboratory Base of Eco-Chemical Engineering College of Chemical Engineering Qingdao University of Science and TechnologyQingdao266042China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China

Electrocatalytic oxygen reduction(ORR)via the 2e−pathway to form H_(2)O_(2) in acidic medium has attracted extensive ***,the low activity,insufficient selectivity and high cost of catalysts have been the ***,CoSe_(2) with abundant Se deficiency was synthesized by a simple hydrothermal method,and the addition of NaBH4-induced CoSe_(2) phase transition from orthorhombic to cubic phase with more Se *** cubic phase CoSe_(2) with abundant Se deficiency can effectively regulate the surface electronic structure with suitable binding energies of*OOH and*O,which shows high activity,selectivity and long-term stability for acidic ORR to H_(2)O_(2).The onset potential is as low as 0.73 V *** hydrogen electrode(RHE),the H_(2)O_(2) selectivity is 84%(0 V ***),and the average electron transfer number is about ***,the H_(2)O_(2) yield measured using a flow cell is as high as 115.92 mmol·gcat.^(−1)·h^(−1) and the Faradaic efficiency is 70%at 0 V ***,which presents high potential in electrocatalytic acidic ORR to H_(2)O_(2) and organic pollutant degradation using the electron-Fenton process.

关键词： Se defected CoSe_(2) Crystal phase transition Electrocatalysis Acidic oxygen reduction Hydrogen peroxide

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Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi cai Long Qiu Zhenying Diao Lintao cai ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

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Endoscopic ultrasound features of gastric schwannomas with radiological correlation:A case series report

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World Journal of Gastroenterology 2012年第48期18卷 7397-7401页

作者： Dan-Dan Zhong cai-Hua Wang Jing-Hong Xu Miao-Yan Chen jian-ting cai Department of Gastroenterology and Hepatology Second Affiliated Hospital of Zhejiang University School of Medicine Department of Pathology Second Affiliated Hospital of Zhejiang University School of Medicine

Gastric schwannomas are rare mesenchymal tumors of the gastrointestinal *** are usually misdiagnosed as other submucosal tumors *** of the imaging features of gastric schwannomas is extremely *** this report,we summarize the features of a series of endoscopic ultrasound(EUS) images of gastric schwannomas in an effort to improve the diagnosis and differential diagnosis *** retrospectively reviewed the endosonographic features of four patients with gastric schwannomas and their computed tomography imaging *** schwannomas had heterogeneous hypoechogenicity or isoechogenicity,and a well-demarcated *** tumors originated from the fourth *** changes and calcification were *** hypoechoic haloes were observed in two *** results described here were different from those of previous *** the EUS evaluation,the internal echogenicity of gastric schwannomas was heterogeneous and low,but slightly higher than that of muscularis *** features might help us differentiate gastric schwannomas from other submucosal *** investigation is needed to differentiate these mesenchymal tumors.

关键词： Schwannomas Endosonography Stomach Radiological examination Imaging

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Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients

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World Journal of Gastroenterology 2008年第12期14卷 1914-1918页

作者： Shu-Jie Chen Liang-Jing Wang Qin Zhu jian-ting cai Tao Chen jian-Min Si Department ofGastroenterology Sir Run Run Shaw Hospital Zlaejiang UniversitySchool of Medicine Hangzhou 310016 Zhejiang Province China Department ofGastroenterology Second Affiliated Hospital Zhejiang UniversitySchool of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To investigate the relationship between H pylori infection, blood ammonia concentration and hepatic encephalopathy （HE）, and the effect of Hpylori eradication in cirrhotic patients. METHODS： From July 2003 to January 2005, 457 cirrhotic patients in five regions of Zhejiang Province were enrolled. Patients were evaluated for demographics, number connection test, Hpylori infection, liver impairment, blood ammonia concentration and HE. Patients with Hpylori infection were given I wk therapy with omeprazole plus clarithromycin and tinidazole. ^14C urea breath test was performed and mental symptoms and blood ammonia level were reassessed after RESULTS： Overall H pylori infection rate was 60.6%, and HE occurred in 47.5% of cirrhotic patients. Subclinical HE （SHE） was detected in 55 of 117 cirrhotic patients. Blood ammonia concentration in H pylori negative （n = 180） and positive （n = 277） cirrhotic patients was 53.8 ± 51.4 and 78.4 ± 63.6 μmol/L, respectively （P 〈 0.01）, which was significantly reduced to 53.5 ± 37.7 μmol/L after bacterium eradication （n = 126）（P 〈 0.01）. Blood ammonia was 97.5 ± 81.0 μmol/L in H pylori-positive cirrhotic patients, and this did not significantly change in those with persistent infection after Hpylori eradication （n = 11）. HE was more frequently observed in patients with H pylori infection than in those without （58.5% vs 30.6%, P 〈 0.01）. HE rate significantly dropped to 34.1% after H pylori eradiation （P 〈 0.01）. H pylori prevalence significantly differed among cirrhotic patients with HE （74.4%）, SHE （69.1%）, and those without HE （53.2%）（P 〈 0.05）. Blood ammonia level was significantly different among cirrhotic patients with HE （94.5 ± 75.6 μmol/L）, SHE （59.9 ± 49.2 μmol/L）, and without HE （47.3 ± 33.5 μmol/L）（P 〈 0.05）. Logistic regression analysis showed that blood ammonia concentration, Child-Pugh stage, upper gastrointestinal bleeding, electrolyte disturbance, and urea nitrogen were risk factors for HE. CONCLUSION： H pylori in

关键词： Cirrhosis Helicobacter Pylori Hepaticencephalopathy Hyperammonemia

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Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice

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World Journal of Gastroenterology 2008年第4期14卷 627-631页

作者： Hai-Bo Zhou Jin-Ming Chen jian-ting cai Qin Du Chan-Ni Wu Department Of Gastroenterology Second Affiliated Hospital ofZhejiang University Hangzhou 310009 Zhejiang Province China Department Of Gastroenterology Xiaoshan Hospitalof Zhejiang Hangzhou 310033 Zhejiang Province China

AIM： To investigate genistein-induced apoptosis of implanted tumors of SG7901 cells in nude mice, and the relationship between this apoptosis and expression of Bcl-2 and Bax. METHODS： Establishing a transplanted tumor model by injecting human SG7901 cells into subcutaneous tissue of nude mice. Genistein （0.5, 1 and 1.5 mg/kg） was directly injected adjacent to the tumor, six times at 2-d intervals. Then, changes in tumor volume were measured continuously and tumor inhibition rate of each group was calculated. We observed the morphological alterations by transmission electron microscopy （TEN）, measured the apoptotic rate by the TUNEL staining method, and detected the expression of apoptosisregulated gene Bcl-2 and bax by immunohistochemical staining and RT-PCR. RESULTS： Genistein 0.5, 1 and 1.5 mg/kg significantly inhibited carcinoma growth when it was injected near the tumor by 10.8%, 29.9% and 39.6%, respectively. Genistein induced implanted tumor cells to undergo apoptosis, with apoptotic characteristics seen by TEM. The apoptosis index was increased progressively with increasing genistein dose （28.9% ± 1.2%, 33.8% ±1.6% and 37.7% ±1.2%）. The positive rate of Bcl-2 protein was decreased progressively （11.9%± 0.9%, 5.9%± 0.7% and 4.2% ±0.6%）, and the positive rate of bax protein was increased progressively （0.9% ±1.7%, 24.9% ±0.8% and 29.6% ± 1.7%） by immunohistochemical staining, with increasing dose of genistein. The density of Bcl-2 mRNA decreased progressively and the density of bax mRNA increased progressively with elongation of time by RT-PCR. CONCLUSION： Genistein was able to induce apoptosisof transplanted tumor cells. This apoptosis may be mediated by down-regulation of the apoptosis-regulated gene Bcl-2 and up-regulation of apoptosis-regulated gene bax.

关键词： Genistein Gastric carcinoma Nude mice Apoptosis

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Reshaping force for deformed casing repairing with hydraulic rolling reshaper and its influencing factors

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Petroleum Science 2024年第4期21卷 2745-2757页

作者： Hong-Fei Li Min Luo ting-ting Xu Qiao-Zhen Li Cong-jian Huang School of Mechanical Science and Engineering Northeast Petroleum University

Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years. When it is used for well repair operation, the reshaping force provided by ground devices is generally determined by experience. However, too large reshaping force may destroy the deformed casing, and too small reshaping force may also prolong the construction period and affect the repairing effect. In this paper, based on Hertz contact theory and elastic-plastic theory, combined with the process parameters of shaping, and considering the structural characteristics of the deformed casing and reshaper, we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper. Meanwhile, the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method, and the reliability of the mathematical model is verified by several examples. On this basis, the control variable method is used to investigate the influence of each parameter on the reshaping force, and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis. The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction, but also provide a reference for the subsequent improvement of the shaping process.

关键词： Hydraulic rolling reshaper Reshaping force Deformed casing Casing reshaping Hertz contact theory

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