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Secondary genomic findings in the 2020 China Neonatal Genomes Project participants

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World Journal of Pediatrics 2022年第10期18卷 687-694页

作者： Hui Xiao jian-tao zhang Xin-Ran Dong Yu-Lan Lu Bing-Bing Wu Hui-Jun Wang Zheng-Yan Zhao Lin Yang Wen-Hao Zhou Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina Center for Molecular Medicine Children’s Hospital of Fudan UniversityShanghaiChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Pediatric Endocrinology and Inherited Metabolic Diseases Children’s Hospital of Fudan UniversityShanghaiChina

Background During next generation sequencing(NGS)data interpretation in critically ill newborns,there is a potential for recognizing and reporting secondary findings(SFs).Early awareness of SFs may provide clues for disease *** this study,we assessed the frequency of SFs in the China Neonatal Genomes Project(CNGP)*** A total of 2020 clinical exome sequencing(CES)datasets were screened for variants from a list of 59 genes recommended by the American College of Medical Genetics and Genomics(ACMG)for secondary findings reporting v2.0(ACMG SF v2.0).Identified variants were classified according to the evidence-based guidelines reached by a joint consensus of the ACMG and the Association for Molecular Pathology(AMP).Results Among the 2020 CES datasets,we identified 23 ACMG-reportable genes in 61 individuals,resulting in an overall frequency of SFs at 3.02%.A total of 53 unique variants were identified,including 35 pathogenic and 18 likely pathogenic *** common disease categories of SFs associated were cardiovascular and cancer *** SF results affected the medical management and follow-up strategy in 49(80.3%)*** We presented the frequency of SFs and their impact on clinical management strategies in CNGP *** study demonstrated that SFs have important practical value in disease prevention and intervention at an early stage.

关键词： Genetics secondary findings Neonate Next generation sequencing

THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINING POLY(NISOPROPYLACRYLAMIDE)HYDROGELS CROSSLINKED BY Si—O—Si BONDS—SYNTHESIS,CHARACTERIZATION AND PROLONGING IN VITRO RELEASE OF 5-FLUOROURACIL

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Chinese Journal of Polymer Science 2005年第5期23卷 513-519页

作者： jian-tao zhang Shi-wen Huang Ya-nan Xue Ji Liu and Ren-xi Zhuo Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan University,Wuhan 430072,China Wuhan Univ Dept Chem Minist Educ Key Lab Biomed Polymers Wuhan 430072 Peoples R China

A series of novel p（N-isopropylacrylamide）（PNIPAM） hydrogels were synthesized by radical copolymerization of N-isopropylacrylamide （NIPAM） and 3-methacryloxypropyltrimethoxysilane （MPTMS）. The copolymers were then crosslinked through hydrolysis of the siloxane in acetic acid/water mixed solvent. Beta-cyclodextrin （Beta-CD） was introduced into the polymeric networks by condensation of 3-glycidoxypropyltrimethoxysilane derived beta-cyclodextrin （KH560-beta-CD） with MPTMS under acidic condition. These gels were heterogeneous, porous and exhibited fast deswelling kinetics when the temperature was elevated to above lower critical solution temperature （LCST）. The swelling ratios of the gels containing beta-CD at room temperature were higher than that of the normal PNIPAM hydrogel, which was caused by the lower crosslinking density in beta-CD contained gels. In comparison to that of the normal PNIPAM gel, the amount of loaded-drug in the hydrogel containing beta-CD was higher, and the release time of 5-fluorouracil （5-Fu） was prolonged, which was attributed to the formation of inclusion compounds between 5-Fu and beta-CD in gel network.

关键词： Hydrogel Thermal-sensitive Poly(N-isopropylacrylamide) Beta-Cyclodextrin Fast responsive.

基于多体动力学模型集成的深海采矿系统联动仿真

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机械工程学报 2017年第4期53卷 155-160页

作者：戴瑜张健张滔刘少军中南大学机电工程学院长沙410083 上海交通大学海洋工程国家重点实验室上海200240 中南大学深圳研究院深圳518000

采用多体动力学建模仿真程序Recur Dyn/Track构建海底履带式集矿机多体动力学模型,实现了海底底质特殊力学模型在集矿机多体动力学模型中的二次开发与集成。开展小型履带式试验样车行走性能测试,与相应二次开发多体动力学模型仿真结果... 详细信息

采用多体动力学建模仿真程序Recur Dyn/Track构建海底履带式集矿机多体动力学模型,实现了海底底质特殊力学模型在集矿机多体动力学模型中的二次开发与集成。开展小型履带式试验样车行走性能测试,与相应二次开发多体动力学模型仿真结果相比较,进一步验证二次开发建模方法的计算准确性。基于多体离散元法,应用Recur Dyn Process Net平台进行二次开发,采用C#语言编写建立超长采矿管线多体离散元动力学模型的自动参数化建模计算程序。集成海底履带式集矿机多体动力学模型与采矿管线系统多体离散元动力学模型,实现了深海采矿整体系统的多体动力学模型集成构建与联动仿真,获得并分析联动过程各子系统空间运动状态变化、子系统间相互作用力变化等动力学特性,为实际深海采矿系统的整体集成设计、性能预测及作业操控提供了参考。

关键词：深海采矿系统海底履带式集矿机二次开发试验验证采矿管线多体动力学模型

Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases

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World Journal of Gastroenterology 2012年第11期18卷 1257-1261页

作者： Yuan Hu Li-Hua He Di Xiao Guo-Dong Liu Yi-Xin Gu Xiao-Xia tao jian-Zhong zhang State Key Laboratory forInfectious Disease Prevention and Control National Institute forCommunicable Disease Control and Prevention Chinese Centerfor Disease Control and Prevention Beiiing 102206 China

AIM： To investigate the non-He/icobacterpy/ori （H. pylori） bacterial flora concurrent with H. pylori infection.METHODS： A total of 103 gastric biopsy specimens from H. pylori positive patients were selected for bacterial culture. All the non-H, pylori bacterial isolates were identified by matrix assisted laser desorption ionization time-of-flight mass spectrometry （MALDI-TOF MS）.RESULTS： A total of 201 non-H, pyiori bacterial isolates were cultivated from 67 （65.0%） of the 103 gastric samples, including 153 isolates identified successfully at species level and 48 at genus level by MALDI-TOF MS. The dominant species were Streptococcus, Neisseria, Rothla and Staphylococcus, which differed fromthe predominantly acid resistant species reported previously in healthy volunteers. The prevalence of non-H. pylori bacteria was higher in non-ulcer dyspepsia group than in gastric ulcer group （100% vs 42.9%, P 〈 0.001）. Six bacterial species with urease activity （Staphylococcus epidermidis, Staphylococcus warneri, Staphylococcus capitis, Staphylococcus aureus, Brevibacteriurn spp. and Klebsiella pneumoniae） were also isolated.CONCLUSION： There is a high prevalence of the non-H, pylori bacteria concurrent with H. pylori infection, and the non-H, pylori bacteria may also play important as-yet-undiscovered roles in the pathogenesis of stomach disorders.

关键词： Non-Helicobacter pylori', Bacterial flora Gastrointestinal diseases Matrix-assisted laser desorp-tion ionization time-of-flight mass spectrometry

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企业建模框架的比较研究

系统工程理论与实践 2001年第9期21卷 16-21,72页

作者：祁连顾新建张涛谭建荣浙江大学机械系浙江杭州310027

首先讨论了企业建模的重要性 ,然后在对一些主要企业建模框架进行分析和比较的基础上 ,提出了理想企业建模框架应该具备的特性 .本文的最后部分对 ARIS框架进行了扩展 ,并以此为实例对理想企业建模框架作了进一步的研究 .

关键词：企业建模框架市场竞争制造企业计算机集成制造系统

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无人机空中加油自主会合的制导与控制

飞行力学 2017年第2期35卷 39-43页

作者：王健张涛李亮东南大学仪器科学与工程学院江苏南京210096 哈尔滨工程大学自动化学院黑龙江哈尔滨150001

针对无人机空中加油的自主会合问题,进行了相应制导律和非线性控制器的设计。通过改进的带角度约束的三维比例制导律实现对航向角的控制,以协调转弯的方式将航迹角指令转化为姿态角指令。基于无人机六自由度的动力学模型,针对无人机的... 详细信息

针对无人机空中加油的自主会合问题,进行了相应制导律和非线性控制器的设计。通过改进的带角度约束的三维比例制导律实现对航向角的控制,以协调转弯的方式将航迹角指令转化为姿态角指令。基于无人机六自由度的动力学模型,针对无人机的姿态控制,采用时标分离的方法设计了慢子系统和快子系统,并对这两个子系统分别进行动态逆控制设计。同时,基于滑模控制的方法设计了满足自主会合要求的速度控制律。在保证无人机飞行稳定的基础上,实现了对控制和制导指令的精确跟踪。仿真结果表明,所设计的制导律和控制律能够实现无人机空中加油的自主会合,具有良好的动态特性。

关键词：自主空中加油会合比例导引动态逆滑模

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基于接触有限元的齿轮副扭转共振分析

航空动力学报 2017年第1期32卷 162-167页

作者：范俊王建军张涛肖阳陈策北京航空航天大学能源与动力工程学院北京100191 陆航研究所机体发动机室北京101121

以典型斜齿轮副为对象,基于接触有限元法,先模拟其准静态啮合过程并求解啮合刚度,并与国家标准偏差值进行了对比,证明了分析方法的正确性.再模拟其动态啮合过程,通过对啮合力响应进行频谱分析识别出扭转振动的固有频率,并与绘制频响曲... 详细信息

以典型斜齿轮副为对象,基于接触有限元法,先模拟其准静态啮合过程并求解啮合刚度,并与国家标准偏差值进行了对比,证明了分析方法的正确性.再模拟其动态啮合过程,通过对啮合力响应进行频谱分析识别出扭转振动的固有频率,并与绘制频响曲线的识别结果一致.在此基础上,数值模拟了该齿轮副扭转共振的发生、发展和稳定过程,定量分析了共振状态下的典型动力学参数响应.结果表明:脱离啮合现象的发生使齿轮副的啮合冲击更为显著,共振状态下的最大应力值相比啮合频率为3 000Hz时增大了20%.

关键词：齿轮副扭转共振接触有限元法参数振动频谱分析频响分析

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian zhang Chenhao zhang tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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FGH4097合金热等静压成形数值模拟

材料热处理学报 2017年第7期38卷 173-179页

作者：瞿宗宏刘建涛张国星张义文陶宇钢铁研究总院高温材料研究所北京100081 高温合金新材料北京市重点试验室北京100081

基于连续介质理论,应用Shima模型描述FGH4097合金粉末热等静压的致密化变形规律,采用有限元分析软件***对装FGH4097合金粉末圆柱包套的热等静压过程进行了数值模拟和试验验证,分析了包套的变形规律以及温度场对坯料致密化过程的影响。... 详细信息

基于连续介质理论,应用Shima模型描述FGH4097合金粉末热等静压的致密化变形规律,采用有限元分析软件***对装FGH4097合金粉末圆柱包套的热等静压过程进行了数值模拟和试验验证,分析了包套的变形规律以及温度场对坯料致密化过程的影响。结果表明:在热等静压过程中,Shima模型对描述FGH4097合金粉末的致密化过程具有较高的精度,圆柱包套的数值模拟结果和试验结果的尺寸误差控制在2%以内;包套的厚度以及边角效应对热等静压过程中坯料的收缩变形有着显著的影响;热等静压过程中坯料内温度梯度所导致的应力状态差异使得坯料的收缩偏离各向同性。

关键词： FGH4097合金热等静压数值模拟 Shima模型致密化