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LUPUS NEPHRITIS COMPliCATED WITH MAliGNANT HYPERTENSION:FROM RENAL VASCULAR PATHOLOGY TO CliNICAL RELEVANCE

Chinese Medical Sciences Journal 2008年第2期23卷 81-87页

作者： jian-ling tao Hang li Yu Tang Yu-bing Wen Xue-wang li Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the clinical and pathological characteristics of lupus nephritis patients complicated with malignant *** We retrospectively studied 19 patients with lupus nephritis complicated with malignant hypertension who underwent renal biopsy between January 2002 and December *** Of 19 patients,3 were men and 16 were women,with a mean age of 24.4±7.7 years *** had positive antinuclear antibodies and low serum complement was found in 13 *** were anemic and 12 of them were *** renal function was found in 17 patients with an average serum creatinine of 184.5±88.9 μmol/*** intrarenal arteriolar lesion was found in all *** patients had lupus vasculopathy,11 patients had renal thrombotic microangiopathy lesion,2 had severe *** patients received steroids and immunosuppressive drugs,15 received angiotensin-converting enzyme inhibitor(ACEI)/angiotensin receptor blocker(ARB)with resultant well-controlled blood *** and hemolytic anemia resolved *** renal function improved or recovered in 14 of 17 patients,and 3 developed end-stage renal disease on maintenance *** Severe intrarenal vascular lesion complicated with renal nephritis parallels clinical manifestation of malignant *** pathology is the key of treatment strategy emphasizing on the significance of renal vascular involvement and *** the basis of immunosuppressive drugs and steroids to control systemic lupus activity,timely initiation of ACEI/ARB could be of benefit to blood pressure control and long term renal survival.

关键词： lupus nephritis malignant hypertension renal pathology renal vascular involvement thrombotic microangiopathy

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Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention

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Journal of Geriatric Cardiology 2016年第4期13卷 299-305页

作者： Tian-Wen HAN Shan-Shan ZHOU jian-tao li Feng TIAN Yang MU Jing JING Yun-Feng HAN Yun-Dai CHEN Department of Cardiology Chinese PLA General Hospital Beijing China

Background The influence of homocysteine （Hcy） on the migration and proliferation of vascular smooth muscle cells has been well established. However, the impact of Hcy levels on the progression of non-culprit coronary lesions （NCCLs） is controversial. This study aims to evaluate whether the plasma level of Hcy is related to the progression of NCCLs after percutaneous coronary stent implantation in elderly patients with acute coronary syndrome （ACS）. Methods A total of 223 elderly patients （〉 65 years old） with ACS undergoing stent im- plantation and follow-up coronary angiography were enrolled. Laboratory determination comprised of blood sample evaluation for Hcy was carried out before baseline coronary intervention. The patients were classified into two groups according to the blood Hcy tertiles （〉 15 mmol/L or 〈 15 mmol/L）. Patients were followed up for 12.2 months. NCCL progression was assessed by three-dimensional quantitative coronary angiography. Results A significantly higher ratio of NCCL progression was observed in the group with baseline Hcy concentrations above 15 mmol/L compared to the group with concentrations below 15 mmol/L （41/127, 32.3% vs. 14/96, 14.6%, P = 0.002）. Multivariate Cox regression analysis showed that Hcy and diabetes mellitus were independent risk factors for NCCL progression. The crude haz- ard ratio （HR） of NCCL progression for Hcy level was 1.056 （95% CI： 1.01-1.104, P = 0.015）. The adjusted HR of NCCL progression for Hcy level was 1.024 （95% CI： 1.007-1.042, P = 0.007）. The adjusted HR of NCCL progression for diabetes mellitus was 1.992 （95% CI： 1.15-3.44, P = 0.013）. Conclusions Hcy is an independent risk factor for NCCL progression after 12 months of follow-up in elderly patients with ACS who has undergone percutaneous coronary stenting.

关键词： Coronary angiography Elderly patients Homocysteine Non-culprit coronary lesion Percutaneous coronary intervention

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Increase of peripheral Th17 lymphocytes during acute cellular rejection in liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 606-611页

作者： Hua Fan, li-Xin li, Dong-Dong Han, jian-tao Kou, Ping li, Qiang He Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

BACKGROUND: Although many human inflammatory and autoimmune diseases were previously considered to be mediated by T helper type 1 (Th1) cells, the recently described Th17 cells play dominant roles in several of these diseases. We and others speculated that allograft rejection after organ transplantation may also involve Th17 cells. Episodes of acute rejection occur in 30% of liver transplants. This study aimed to determine the frequency of circulating Th17 cells in patients who had received liver transplants for benign end-stage liver disease and to identify any association between acute rejection episodes and levels of Th17 cells in the peripheral blood. METHODS: A prospective study compared Th17 cells from 76 consecutive benign end-stage liver disease patients who had undergone orthotopic liver transplantation from 2007 to 2011 with those from 20 age-matched healthy individuals. Peripheral blood samples were collected at different time points within one year after transplant. Blood samples and liver biopsies were also collected at the diagnosis of acute rejection. Percentages of circulating CD4+ IL-17+ cells were measured by flow cytometry The transplant patients were classified into two groups: a rejection group consisting of 17 patients who had an episode of acute rejection, and a non-rejection group comprising the remaining 59 patients with no acute rejection episodes Percentages of circulating Th17 cells were compared between the two groups and controls. RESULTS: The levels of circulating CD4+ IL-17+ T cells in the rejection group were higher during acute rejection than those in the non-rejection group (2.56±0.43% versus 1.79±0.44% Pliver transplant recipients.

关键词： liver transplantation Th17 cells acute cellular rejection transplant immunology

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Idiopathic membranous nephropathy complicated with malignant hypertension:a case report

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Chinese Medical Journal 2007年第15期120卷 1369-1371页

作者： tao jian-ling li Hang WEN Yu-bing li Xue-wang Department of Nephrology Peking Union Medical College Hospital Peking Union Medical College ＆ Chinese Academy of Medical Sciences Beijing 100730 China

Membranous nephropathy （MN） is the most common cause of nephrotic syndrome in adults. Its insidious onset and progression often hinder timely renal biopsy and early diagnosis delaying treatment while worsening prognosis. The complication of malignant hypertension （MHT） is rarely seen in idiopathic MN. To provide a better understanding of the disease we report a case of idiopathic MN diagnosed by biopsy six years after onset.

关键词： glomerulonephritis, membranous hypertension, malignant

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Correlation between fragmented QRS and the short-term prognosis of patients with acute myocardial infarction

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第1期15卷 67-74页

作者： Qin-hui SHENG Chih-Chi HSU jian-ping li tao HONG Yong HUO Department of Cardiology Peking University First Hospital Beijing 100034 China

This study is aimed to investigate the clinical significance and the short-term prognostic value of frag- mented QRS （fQRS） for patients with acute myocardial infarction （AMI）. Three hundred patients with AMI were tested with retrospective analysis on the patients＇ clinical information, hospitalized treatment, fQRS onset time, location of lesions, and other relevant data, in order to assess the relationship between the presence of fQRS and its prognosis. The rates of malignant cardiac arrhythmia, left ventricular systolic dysfunction （LVSD）, and mortality in the positive fQRS group were 13.6%, 29.2%, and 23.7%, respectively, with all showing a p value 〈0.05. For the ST segment elevation myocardial infarction （STEMI） subgroup, all the rates showed significant differences with a p value 〈0.01, while for the non-STEMI （NSTEMI） subgroup showed no significant differences. In patients with a positive fQRS, there were no differences in malignant cardiac arrhythmia between patients with and without percutaneous coronary in- tervention （PCI）（p〉0.05）. As for the LVSD and mortality, the p values between patients with and without PCI were 0.031 and 0.000, respectively, suggesting statistical significance. The results imply that AMI patients with positive fQRS especially for the patients with STEMI had higher rates of malignant cardiac arrhythmia, LVSD, and mortality than the non-fQRS group. Patients of AMI with positive fQRS, who underwent early revascularization, could lower the incidence of the cardiovascular event. In addition, the presence of fQRS could be used as an indication of early in- tervention treatment for patients.

关键词： Fragmented QRS Acute myocardial infarction Short-term prognosis

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Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis

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World Journal of Gastroenterology 2003年第10期9卷 2251-2257页

作者： jian-Ping Yuan,tao li,Xiao-Dong Shi,Bao-Yu Hu,Gui-Zhen Yang,Shan-Qing Tong,Xiao-Kui Guo,Department of Microbiology and Parasitology,Shanghai Second Medical University,Shanghai 200025,China. Department of Microbiology and Parasitology Shanghai Second Medical University Shanghai 200025 China.

AIM: To construct a vacA-knockout Helicobacter pylori mutant strain, whose only difference from the wild strain is its disrupted vacA *** AND RESULTS: A clone containing kanamycin resistance gene used for homologous recombination was constructed in a directional cloning procedure into pBluescript ⅡSK, and then transformed into vacA+ H pylori by *** growing on the selective media containing kanamycin were harvested for chromosomal DNA extraction,and the allelic exchange was determined by polymerase chain reactions and sequencing. Loss of vacuolating activity of the vaci-knockout strain was confirmed by examining the gastric cells co-cultured with cell-free supernatants from H pylori wild strain or the ***: We constructed a vacA-knockout strain of H pylori through direct mutagenesis, which creates an important precondition for the future research on virulence comparison with gene expression analysis.

关键词： HP感染基因缺失基因突变细胞毒素克隆

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Medial support nail and proximal femoral nail antirotation in the treatment of reverse obliquity inter-trochanteric fractures(Arbeitsgemeinschaft fur Osteosynthesfrogen/Orthopedic Trauma Association 31-A3.1):a finite-element analysis

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Chinese Medical Journal 2020年第22期133卷 2682-2687页

作者： Shao-Bo Nie Yan-Peng Zhao jian-tao li Zhe Zhao Zhuo Zhang li-Cheng Zhang Pei-Fu Tang Department of Orthopaedics The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Orthopedics the Fourth Medical CentreChinese PLA General HospitalBeijing 100853China Department of Orthopaedics Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background:The reverse obliquity inter-trochanteric fracture is a distinct fracture pattern that is mechanically different from most inter-trochanteric fractures and the optional treatment of it is still *** purpose of this study was to compare differences in the efficacy of a novel nail(medial support nail[MSN-II])and proximal femoral nail anti-rotation(PFNA-II)in the treatment of reverse obliquity inter-trochanteric fractures(Arbeitsgemeinschaft fur Osteosynthesfrogen/Orthopedic Trauma Association[AO/OTA]31-A3.1)using finite-element ***:Modeling software was used to establish a three-dimensional model of MSN-II and PFNA-II and an A3.1 inter-trochanteric fracture *** software was used to implement different force loads to compare finite-element biomechanical parameters such as the maximum stress in implant and the displacement of fracture ***:The femoral stress,implant stress and fracture site displacement of MSN-II was less than that of *** results indicated that the maximal femoral stress was 581 MPa for PFNA-II and 443 MPa for the *** maximum stress values in the PFNA-II and MSN-II models were 291 and 241 MPa,*** maximal displacements of the fracture site were 1.47 and 1.16 mm in the PFNA-II and MSN-II models,***:Compared with PFNA-II for inter-trochanteric fracture(AO/OTA 31-A3.1),MSN-II which was designed with a triangular stability structure can provide better biomechanical *** MSN-II may be a feasible option for the treatment of reverse obliquity inter-trochanteric fracture.

关键词： Finite-element analysis Inter-trochanteric fracture Proximal femoral nail anti-rotation

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Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China life Sciences 2025年第1期68卷 309-310页

作者： tao Zhou lin li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： Xin li Yibo ZHOU tao ZHAO Xingjian HE Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin li jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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