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Incidence,prognosis,and risk factors of sepsis-induced cardiomyopathy

World Journal of Clinical Cases 2021年第31期9卷 9452-9468页

作者： Yan-Wen Liang You-Feng Zhu rui Zhang Min Zhang Xiao-Ling Ye jian-rui wei Department of Intensive Care Unit Guangzhou Red Cross HospitalGuangzhou 510220Guangdong ProvinceChina Department of Geriatrics The Affiliated Hospital of Qingdao UniversityQingdao 270000Shandong ProvinceChina Guangzhou Women and Children’s Medical Center Guangzhou 510000Guangdong ProvinceChina

BACKGROUND At present,large-scale studies on the clinical characteristics of sepsis-induced cardiomyopathy(SIC)are *** To investigate the clinical characteristics of *** Based on the analysis of the MIMIC-III public database,we performed a largescale retrospective study involving sepsis patients who were admitted to the intensive care unit(ICU)and had no concomitant cardiac *** used propensity score matching analysis and multivariate logistic regression to ensure the robustness of the *** primary outcome was hospital mortality,and the secondary outcomes included the number of patients who received mechanical ventilation or renal replacement therapy during their hospital stay,the number of patients administered with vasopressors,the length of ICU stay,and the length of hospital *** In the present study,after screening 38605 patients,3530 patients with sepsis were included.A total of 997 patients met the SIC diagnostic criteria,and the incidence of SIC was 28.20%(95%confidence interval[CI]:26.80%-29.70%).Compared to patients in the non-SIC group,patients in the SIC group were of older age and had a higher Simplified Acute Physiology Score(SAPS)-Ⅰ score,SAPS-Ⅱ score,and Elixhauser comorbidity index(ECI).A total of 367(36.8%)of 997 patients in the SIC group and 818(32.3%)of 2533 patients in the non-SIC group died in the hospital,which resulted in a significant between-group difference(odds ratios=1.22,95%CI:1.05-1.42;P=0.011).For the secondary outcomes,more patients in the SIC group received mechanical ventilation and *** logistic regression analysis showed that age,male sex,ECI,hemoglobin level,diabetes,and mechanical ventilation use on the first day of ICU admission were risk factors for *** Compared with non-SIC patients,hospital mortality is higher in SIC patients.

关键词： Sepsis-induced cardiomyopathy Sepsis Septic shock Incidence Hospital mortality MIMIC-Ⅲ

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping CHENG jian wei Chao YUAN Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-Ming Pan wei Li rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei Li jian-Hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts

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World Journal of Pediatrics 2024年第10期20卷 1079-1089页

作者： Yuan-Yuan Pei Hong-Li Wang Gen-Quan Yin Yi Xu jian-Hao Tan Xin-Hua Liang Hui-Ying Wu Xun-Tao Yin Chun-Xiao Fang Jun-Zheng Peng Zhi-Yuan Wu Yi Sun Run Dang Yu-Feng Liang Hong-Mei Tang You-Yi Li Zhong-Xiang Qiao Zhi-Cheng Liang jian-Ping Tang Fan-Sen Zeng Ke-Lu Zheng Yi-Ru Zeng Xiao-Jun Cao Hui-Min Xia jian-rui wei Jin-Ling Tang Si-Tang Gong Clinical Data Center Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Internal Medicine Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Infectious Diseases Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Information Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China School of Pediatrics Guangzhou Medical UniversityGuangzhou 510623China Imaging Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Respiratory Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Pediatric Intensive Care Unit Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510623China Neonatal Intensive Care Unit Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Rehabilitation Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China General Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou510623China Emergency Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Neurology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Key Laboratory of Structural Birth Defects Research in Guangdong Province Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Cardiovascular Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShen

Background SARS-CoV-2 continues to mutate over time,and reports on children infected with Omicron BA.5 are *** aimed to analyze the specific symptoms of Omicron-infected children and to improve patient *** We selected 315 consecutively hospitalized children with Omicron BA.5 and 16,744 non-Omicron-infected febrile children visiting the fever clinic at our hospital between December 8 and 30,*** convulsions and body temperatures were compared between the two *** analyzed potential associations between convulsions and vaccination,and additionally evaluated the brain damage among severe Omicron-infected *** Convulsion rates(97.5%vs.4.3%,P<0.001)and frequencies(median:2.0 vs.1.6,P<0.001)significantly differed between Omicron-infected and non-Omicron-infected febrile *** body temperatures of Omicron-infected children were significantly higher during convulsions than when they were not convulsing and those of non-Omicron-infected febrile children during convulsions(median:39.5 vs.38.2 and 38.6℃,both P<0.001).In the three Omicron-subgroups,the temperature during convulsions was proportional to the percentage of patients and significantly differed(P<0.001),while not in the three non-Omicron-subgroups(P=0.244).The convulsion frequency was lower in the 55 vaccinated children compared to the 260 non-vaccinated children(average:1.8 vs.2.1,P<0.001).The vaccination dose and convulsion frequency in Omicron-infected children were significantly correlated(P<0.001).Fifteen of the 112 severe Omicron cases had brain *** Omicron-infected children experience higher body temperatures and frequencies during convulsions than those of non-Omicron-infected febrile *** additionally found evidence of brain damage caused by infection with omicron *** and prompt fever reduction may relieve symptoms.

关键词： Body temperature Brain damage:Children:Convulsion Omicron BA.5.Vaccination

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Low Shear Stress Regulating Autophagy Mediated by the p38 Mitogen Activated Protein Kinase and p53 Pathways in Human Umbilical Vein Endothelial Cells

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Chinese Medical Journal 2018年第9期131卷 1132-1133页

作者： Hui-Zhen Liu Li Li Shao-Liang Chen jian-rui wei Jun-Xia Zhang Jia Liu Jie-Wen Guo Xin-Liang Qu Peng Chu Department of Cardiology Guangzhou Red Cross Hospital Jinan University affiliated Guangzhou Red Cross Hospital Guangzhou Guangdong 510000 China Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China

To the Editor：Autophagy is reported to play a critical role in low shear stress （LSS）-induced endothelial cell injury and the formation of atherosclerotic plaques.[1] However,the corresponding mechanisms remain unclear.[2-8] This study was to investigate the changes and mechanism of LSS-induced autophagy in human umbilical vein endothelial cells （HUVECs）.HUVECs were treated with LSS of 5 dyn/cm2 for 0,5,15,30,and 60 min in a parallel plate flow chamber *** chain （LC） Ⅱ,LC3 Ⅰ,and p62,p38 mitogen-activated protein kinase （MAPK） and their protein of phosphorylation of p38 （p-p38） were detected with Western blot *** protein levels of p-p53 （ser15） and their distribution were detected by immunofluorescence （IF）.

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG jian NIE wei HUANG Jin ZHU Ke LIU Ruxia ZHANG ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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基于多分辨率分级分块处理的边缘检测方法

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陕西师范大学学报（自然科学版） 2007年第S2期35卷 126-128页

作者：唐宏震潘建寿魏瑞斌西北大学信息科学与技术学院陕西西安710069

为了有效提取运动目标的特征,在目标检测的基础上,要对其进行边缘检测.由于传统逐点扫描方法运算量大,提出一种基于多分辨率分级分块思想的边缘检测算法.该方法先把图像分为多个子块后根据其四个顶点判断该子块是否包含目标,再对目标子... 详细信息

为了有效提取运动目标的特征,在目标检测的基础上,要对其进行边缘检测.由于传统逐点扫描方法运算量大,提出一种基于多分辨率分级分块思想的边缘检测算法.该方法先把图像分为多个子块后根据其四个顶点判断该子块是否包含目标,再对目标子块进行扫描确定目标的边缘.实验结果表明,此方法准确地确定目标的边缘,同时检测速度比传统逐点扫描法有一定程度的提高.

关键词：目标跟踪多分辨率分级分块二值图像边缘检测

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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