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0^+ tetraquark states from improved QCD sum rules:delving into X(5568)

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Chinese Physics C 2018年第4期42卷 76-86页

作者： jian-rong zhang Jing-Lan Zou Jin-Yun Wu Department of Physics College of Liberal Arts and Sciences National University of Defense Technology Changsha 410073 China College of Optoelectronic Science and Engineering National University of Defense Technology Changsha 410073 China College of Liberal Arts and Sciences National University of Defense Technology Changsha 410073 China

In order to investigate the possibility of the recently observed X（5568） being a 0＋ tetraquark state, we make an improvement to the study of the related various configuration states in the framework of the QCD sum rules. Particularly, to ensure the quality of the analysis, condensates up to dimension 12 are included to inspect the convergence of operator product expansion （OPE） and improve the final results of the studied states. We note that some condensate contributions could play an important role on the OPE side. By releasing the rigid OPE convergence criterion, we arrive at the numerical value 5.57-0.23＋0.35 GeV for the scalar-scalar diquark-antidiquark 0＋ state, which agrees with the experimental data for the X（5568） and could support its interpretation in terms of a 0＋ tetraquark state with the scalar-scalar configuration. The corresponding result for the axial-axial current is calculated to be 5.77-0.33＋0.44 GeV, which is still consistent with the mass of X（5568） in view of the uncertainty. The feasibility of X（5568） being a tetraquark state with the axial-axial configuration therefore cannot be definitely excluded. For the pseudoscalar-pseudoscalar and the vector-vector cases, their unsatisfactory OPE convergence make it difficult to find reasonable work windows to extract the hadronic information.

关键词： tetraquark states QCD sum rules X(5568)

Acid-degradable gadolinium-based nanoscale coordination polymer： A potential platform for targeted drug delivery and potential magnetic resonance imaging

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Nano Research 2018年第2期11卷 929-939页

作者： Zhimei He Penghui zhang Yan Xiao Jingjing Li Fang Yang Yang Liu jian-rong zhang Jun-Jie Zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and Technology Bioinspired Engineering and Biomechanics Center (BEBC) Xi’an Jiaotong University Xi’an China School of Medical Imaging Xuzhou Medical University Xuzhou China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences and Medical Engineering Southeast University Nanjing China

During conventional chemotherapy for cancer, nonspecific drug distribution, which causes serious side effects in normal tissues, is a serious limitation. Thus, it is desirable to develop a tumor or intracellular microenvironment-responsive nanosystem for targeted and on-demand drug release. In the present study, we engineered an intelligent pH-activatable nanosystem, in which a gadolinium- doxorubicin-loaded nanoscale coordination polymer （Gd-Dox NCPs） was the core and hyaluronic acid was the targeting shell. Taking advantage of CD44 receptor-mediated recognition, the nanoparticles were internalized selectively into human cervical carcinoma （HeLa） cells, and trapped within acidic compartments where the fluorescence of Dox recovered, along with the acid dismantling of the Gd NCPs, allowing real-time monitoring of drug release. In vitro experiments also showed that the Gd NCPs present enhanced T1 signals after acid-triggered degradation, suggesting their potential use as contrast agents for magnetic resonance imaging. Such nanocarriers, which feature high biodegradation, selective targeting ability, and rapid response to stimulus, demonstrated enhanced therapeutic efficacy in targeted cancer cells and ＂turned on＂T1 signals in vitro, showing great promise for diagnosis and treatment.

关键词： nanoscale coordinationpolymer drug delivery magnetic resonanceimaging stimuli-responsivenanocarriers

Micro-Pulse Lidar Measurements of Aerosol Vertical Structure over the Loess Plateau

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Atmospheric and Oceanic Science Letters 2008年第1期1卷 8-11页

作者： HUANG jian-Ping HUANG Zhong-Wei BI jian-rong zhang Wu zhang Lei College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China

Knowledge of the vertical distribution of aerosols in the free troposphere is important for estimating their impact on climate. In this study, direct observations of the vertical distribution of aerosols in the free troposphere are made using surface Micro-Pulse Lidar (MPL) measurements. The MPL measurements were made at the Loess Plateau (35.95°N, 104.1°E), which is near the major dust source regions of the Taklimakan and Gobi deserts. The vertical distribution of the MPL backscattering suggested that nondust aerosols floated from ground level to an altitude of approximately 9 km around the source regions. Early morning hours are characterized by a shallow aerosol layer of a few hundred meters thick. As the day progresses, strong convective eddies transport the aero- sols vertically to more than 1500 m.

关键词： lidar aerosol vertical structure Loess Plateau

Clinical significance of combined determination of serum PGⅠ , PGⅡ and GAS for diagnosis of gastric cancer

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Nuclear Science and Techniques 2005年第4期16卷 217-220页

作者： jianG Meng-Jun LI Wen-Xin XIAO Zhi-jian zhang rong-Jun CAI Gang-Ming State Key Laboratory of Nuclear Medicine Jiangsu Institute of Nuclear Medicine. Wuxi 214063

To evaluate the clinical value of combined determination of serum PGⅠ, PGⅡ and GAS for early diag-nosis of gastric cancer, the serum levels of PGⅠ, PGⅡ and GAS in 190 healthy controls and 129 patients with gas-tric disorders were measured by RIA. The 129 patients include 68 cases of gastric cancer. The results showed that the serum levels of PGⅠ and PGⅠ/PGⅡ ratio in gastric cancer patients were obviously lower than those in healthy controls, while comparing with controls, the serum GAS levels were significantly higher. The diagnostic accuracy of the determinations for gastric cancer was evaluated by receiver operating characteristic (ROC) curve analysis. The area under the curve (AUC) levels of serum PGⅠ, PGⅠ/PGⅡ ratio and GAS were 0.833, 0.842 and 0.851, respec-tively. As serum PGⅠ or PGⅠ/PGⅡ ratio or GAS were combined, the sensitivity and specificity of determination for gastric cancer diagnosis were 94.2% and 73.4%, respectively. All these results indicated that the combined deter-mination of serum PGⅠ, PGⅡ and GAS levels may be used as a tool for primary screening of gastric cancer.

关键词：免疫血清诊断方法胃癌放射性疗法实验室诊断放射性同位素

Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

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Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： jian-Guo Li Bai-Shan Hu Shuang zhang Fu-rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

Empirical likelihood for spatial cross-sectional data models with matrix exponential spatial specification

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 125-139页

作者： LIU Yan rong jian-rong QIN Yong-song Nanning University Nanning 530200China Center for Applied Mathematics of Guangxi and College of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004China

In this paper,we study spatial cross-sectional data models in the form of matrix exponential spatial specification(MESS),where MESS appears in both dependent and error *** empirical likelihood(EL)ratio statistics are established for the parameters of the MESS *** is shown that the limiting distributions of EL ratio statistics follow chi-square distributions,which are used to construct the confidence regions of model *** experiments are conducted to compare the performances of confidence regions based on EL method and normal approximation method.

关键词： MESS empirical likelihood con dence region

Efficient Dynamic Locomotion of Quadruped Robot via Adaptive Diagonal Gait

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Journal of Bionic Engineering 2024年第1期21卷 126-136页

作者： jian Bi Teng Chen Xuewen rong Guoteng zhang Guanglin Lu Jingxuan Cao Han jiang Yibin Li The Center for Robotics School of Control Science and EngineeringShandong UniversityJi Nan 250000China

Quadruped animals in the nature realize high energy efficiency locomotion by automatically changing their gait at different *** by this character,an efficient adaptive diagonal gait locomotion controller is designed for quadruped robot.A unique gait planning method is proposed in this *** the speed of robot varies,the gait cycle time and the proportion of stance and swing phase of each leg are adjusted to form a variety of *** optimal joint torque is calculated by the controller combined with Virtual Model Control(VMC)and Whole-Body Control(WBC)to realize the desired *** gait and step frequency of the robot can automatically adapt to the change of *** experiments are done with a quadruped robot made by our laboratory to verify that the gait can change automatically from slow-trotting to flying-trot during the period when speed is from 0 to 4 m/*** ratio of swing phase is from less than 0.5 to more than 0.5 to realize the running motion with four feet off the *** have shown that the controller can indeed consume less energy when robot runs at a wide range of speeds comparing to the basic controller.

关键词： Quadruped robot Gait transition Adaptive gait Energy efficiency

Reconstructing cell lineage trees with genomic barcoding:approaches and applications

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Journal of Genetics and Genomics 2024年第1期51卷 35-47页

作者： Zizhang Li Wenjing Yang Peng Wu Yuyan Shan Xiaoyu zhang Feng Chen Junnan Yang jian-rong Yang Advanced Medical Technology Center The First Affiliated HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Genetics and Biomedical Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdong 510080China

In multicellular organisms,developmental history of cell divisions and functional annotation of terminal cells can be organized into a cell lineage tree(CLT).The reconstruction of the CLT has long been a major goal in developmental biology and other related *** technological advancements,especially those in editable genomic barcodes and single-cell high-throughput sequencing,have sparked a new wave of experimental methods for reconstructing *** we review the existing experimental approaches to the reconstruction of CLT,which are broadly categorized as either image-based or DNA barcode-based *** addition,we present a summary of the related literature based on the biological insight pro-vided by the obtained ***,we discuss the challenges that will arise as more and better CLT data become available in the near *** barcoding-based CLT reconstructions and analyses,due to their wide applicability and high scalability,offer the potential for novel biological discoveries,especially those related to general and systemic properties of the developmental process.

关键词： Cell lineage tree Developmental regulation Biotechnology Computational biology

U-Net Models for Representing Wind Stress Anomalies over the Tropical Pacific and Their Integrations with an Intermediate Coupled Model for ENSO Studies

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Advances in Atmospheric Sciences 2024年第7期41卷 1403-1416页

作者： Shuangying Du rong-Hua zhang Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing210044China Laosan Laboratory Qingdao266237China University of Chinese Academy of Sciences Beijing100049China

El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been developed to simulate and predict *** some simplified coupled ocean-atmosphere models,the relationship between sea surface temperature(SST)anomalies and wind stress(τ)anomalies can be constructed by statistical methods,such as singular value decomposition(SVD).In recent years,the applications of artificial intelligence(AI)to climate modeling have shown promising prospects,and the integrations of AI-based models with dynamical models are active areas of *** study constructs U-Net models for representing the relationship between SSTAs andτanomalies in the tropical Pacific;the UNet-derivedτmodel,denoted asτUNet,is then used to replace the original SVD-basedτmodel of an intermediate coupled model(ICM),forming a newly AI-integrated ICM,referred to as *** simulation results obtained from ICM-UNet demonstrate their ability to represent the spatiotemporal variability of oceanic and atmospheric anomaly fields in the equatorial *** the ocean-only case study,theτUNet-derived wind stress anomaly fields are used to force the ocean component of the ICM,the results of which also indicate reasonable simulations of typical ENSO *** results demonstrate the feasibility of integrating an AI-derived model with a physics-based dynamical model for ENSO modeling ***,the successful integration of the dynamical ocean models with the AI-based atmospheric wind model provides a novel approach to ocean-atmosphere interaction modeling studies.

关键词： U-Net models wind stress anomalies ICM integration of AI and physical components