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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-ming Pan Wei Li Rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Practical Green’s function for the thermal stress field induced by a heat source in plane thermoelasticity

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Applied Mathematics and Mechanics(English Edition) 2020年第4期41卷 543-550页

作者： jian HUA ming dai State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The classical Green’s functions used in the literature for a heat source in a homogeneous elastic medium cannot lead to ?nite remote thermal stresses in the medium,so that they may not work well in practical thermal stress analyses. In this paper, we develop a practical Green’s function for a heat source disposed eccentrically into an elastic disk/cylinder subject to plane deformation. The edge of the disk/cylinder is assumed to be thermally permeable and traction-free. The full thermal stress ?eld induced by the heat source in the disk/cylinder is determined exactly and explicitly via the Cauchy integral techniques. In particular, a very simple formula is obtained to describe the hoop thermal stress on the edge of the disk/cylinder, which may be conveniently useful for analyzing the thermal stresses in microelectronic components.

关键词： heat source Green’s function thermal stress finite matrix

Context-Based Moving Object Trajectory Uncertainty Reduction and Ranking in Road Network

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Journal of Computer Science & Technology 2016年第1期31卷 167-184页

作者： jian dai Zhi-ming Ding Jia-Jie Xu School of Computer Science Beijing University of Technology Beijing 100124 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Software Chinese Academy of Sciences Beijing 100190 China School of Computer Science and Technology Soochow University Suzhou 215000 China

To support a large amount of GPS data generated from various moving objects, the back-end servers usually store low-sampling-rate trajectories. Therefore, no precise position information can be obtained directly from the back-end servers and uncertainty is an inherent characteristic of the spatio-temporal data. How to deal with the uncertainty thus becomes a basic and challenging problem. A lot of researches have been rigidly conducted on the uncertainty of a moving object itself and isolated from the context where it is derived. However, we discover that the uncertainty of moving objects can be efficiently reduced and effectively ranked using the context-aware information. In this paper, we focus on context- aware information and propose an integrated framework, Context-Based Uncertainty Reduction and Ranking （CURR）, to reduce and rank the uncertainty of trajectories. Specifically, given two consecutive samplings, we aim to infer and rank the possible trajectories in accordance with the information extracted from context. Since some context-aware information can be used to reduce the uncertainty while some context-aware information can be used to rank the uncertainty, to leverage them accordingly, CURR naturally consists of two stages： reduction stage and ranking stage which complement each other. We also implement a prototype system to validate the effectiveness of our solution. Extensive experiments are conducted and the evaluation results demonstrate the efficiency and high accuracy of CURR.

关键词： moving object trajectory uncertainty reduction road network context-aware information

Cage-like radiotherapy system for noncoplanar radiotherapy

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Nuclear Science and Techniques 2021年第2期32卷 1-10页

作者： Chuan-Meng Niu ming-Hui Li jian-Rong dai Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The aim of this study was to design a cage-like radiotherapy system(CRTS)to further promote the clinical application of noncoplanar *** CRTS comprises two stands,two O-rings,several arc girders,an X-ray head,an imaging subsystem,and a treatment *** X-ray head rotates with O-rings around the patient’s body and slides along the arc *** with the C-arm linear accelerator(C-Linac),the clinically available spatial irradiation angle ranges(SIARs)of the CRTS for the head,chest,and abdomen were 33%,63.6%,and 62.6%larger,***,according to a preliminary planning comparison based on the dose distribution simulation method,the CRTS achieved much better protection of normal tissue than the ***,the CRTS enabled accurate noncoplanar irradiation without movement of the body being irradiated,allowed automatic control of the movements of different parts without risk of collisions,and provided continuous radiation over an angle that considerably exceeded a full *** advantages make CRTS very promising for noncoplanar radiotherapy.

关键词： Radiotherapy system Noncoplanar radiotherapy Spatial irradiation angle range Spherical surface area

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Ore-blending optimization model for sintering process based on characteristics of iron ores

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 217-224页

作者： Sheng-li Wu Dauter Oliveira Yu-ming dai jian Xu School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China VALE Shanghai Office Shanghai 200070 China

An ore-blending optimization model for the sintering process is an intelligent system that includes iron ore characteristics, expert knowledge and material balance. In the present work, 14 indices are proposed to represent chemical composition, granulating properties and high temperature properties of iron ores. After the relationships between iron ore characteristics and sintering performance are established, the ＂two-step＂ method and the simplex method are introduced to build the model by distinguishing the calculation of optimized blending proportion of iron ores from that of other sintering materials in order to improve calculation efficiency. The ore-blending optimization model, programmed by Access and Visual Basic, is applied to practical production in steel mills and the results prove that the present model can take advantage of the available iron ore resource with stable sinter yield and quality performance but at a lower cost.

关键词： ore-blending optimization mathematical model sintering process iron ores

Local Area Quotas for Industrial Emissions along Reaches of the Pearl River in Guangdong

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Chinese Journal of Population,Resources and Environment 2008年第1期6卷 72-78页

作者： dai ming Qin jian dai Xie＇er Research Centre for Regional and Urban Development Jinan University Guangzhou Guangdong 510632 China Faculty of Mathematics Sun Yat-sen University Guangzhou Guangdong 510275 China

There is an obvious departure from the regional equi-librium of developments between the upper and lower reaches of the Pearl River in Guangdong, which resulted in "the effects of contra-geography-grads development". It is mainly because the upriver mountainous areas have been deeply stuck in industriali-zation delay and marginalization plights, so that nearly 40 million local people have conceived a dream to get rid of "the vicious circle of poverty" by speeding up industrial development. But the problem is that such industrialization efforts on a large scale in mountainous areas are encountering the bottleneck of environ-mental capacity that strictly limits industrial emissions along the upper reaches of any water system. As a solution, an institutional arrangement called "the Local Area Quotas for Industrial Emis-sions along the Pearl River" is put forward supposed to give cor-responding compensation to the rights of industrial development yielded by some areas with lower environmental capacity through the distribution and trading of IDQs.

关键词： Pearl River regional developments in equilibrium industrial discharge quotas (IDQs) local area quotas (LAQs)

Comparisons of EVD and DVD

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The Journal of China Universities of Posts and Telecommunications 2006年第2期13卷 74-78页

作者： YAN ming dai jian-hua HU Guo-rong GxSOC Research Institute Communication University of China Beijing 100024 P.R. China

The goal of the Enhanced Versatile Disc （EVD） standard is to define an advanced high definition disc competing with Digital Versatile Disc （DVD）. The EVD standard consists of the physical specification, the file system .specification, and the specification for audio/video data and Enhanced （ x ） Audio Coding （ExAC） technology. EVD is an integrated .system similar to DVD. Comprehensive comparisons of EVD and DVD are given in this paper. Their key differences include disc formats, file system structures, data structures, audio/video coding, and other issues. Among them, we emphasize on the logic structure of EVD data and its enhanced audio coding method ExAC. We can draw conclusions through these comparisons that EVD is more the advantageous.

关键词： EVD DVD logic structure ExAC MPEG-2

Leukocyte cell-derived chemotaxin 2 inhibits development of atherosclerosis in mice

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Zoological Research 2019年第4期40卷 317-323页

作者： Wen-ming He Ting dai Jiong Chen jian-An Wang Department of Cardiology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou Zhejiang 310009China Department of Cardiology the Affiliated Hospital of Medical School of Ningbo UniversityNingbo Zhejiang 315010China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingbo Zhejiang 315832China

Leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional hepatokine, is involved in many pathological conditi ons. However, its role in atherosclerosis remains undefined. In this study, we admimistered vehicle or LECT2 to male Apoe^-/- mice fed a Western diet for 15 weeks. Atherosclerotic lesions were visualized and quantified with Oil-red O and hematoxylin staining. The mRNA expression levels of MCP-1, MMP-1, IL-8 IL-1β, and TNF-a were analyzed by quantitative real-time polymerase chain reaction. Serum TNF-a, IL-1β, IL-8, MCP-1, and MMP-1 concentrations were measured by en zyme-li nked immuno sorbent assay. CD68, CD31, and a-SMA, markers of macrophages, endothelial cells, and smooth muscle cells, respectively, were detected by immuno staining. Results showed that LECT2 reduced total cholesterol and low-density lipoprotein concentrations in serum and inhibited the development of atherosclerotic lesions, accompanied by reductions in inflammatory cytokines and lower MCP-1, MMP-1, TNF-a, IL-8, and IL-1β mRNA abundanee. Furthermore, LECT2 decreased CD68, but in creased cr SMA in atherosclerotic lesi ons, suggesting an in crease in smooth muscle cells and reduction in macrophages. In summary, LECT2 inhibited the development of atherosclerosis in mice, accompanied by reduced serum total cholesterol concentration and lower inflammatory responses.

关键词： Leukocyte cell-derived chemotaxin 2(LECT2) Atherosclerosis Inflammation Lipid metabolism