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Combined endovascular brachytherapy, sorafenib, and transarterial chemobolization therapy for hepatocellular carcinoma patients with portal vein tumor thrombus

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World Journal of Gastroenterology 2017年第43期23卷 7735-7745页

作者： Zi-Han Zhang Qing-Xin Liu Wen Zhang Jing-Qin Ma jian-Hua Wang jian-jun luo Ling-Xiao Liu Zhi-Ping Yan Department of Interventional Radiology Zhongshan HospitalFudan University and Shanghai Institute of Medical Imaging

AIM To evaluate the safety and efficacy of combined endovascular brachytherapy(EVBT),transarterial chemoembolization(TACE),and sorafenib to treat hepatocellular carcinoma(HCC) patients with main portal vein tumor thrombus(MPVTT).METHODS This single-center retrospective study involved 68 patients with unresectable HCC or those who were unfit for liver transplantation and percutaneous frequency ablation according to the BCLC classification. All patients had Child-Pugh classification grade A or B,Eastern Cooperative Oncology Group(ECOG)performance status of 0-2,and MPVTT. The patients received either EVBT with stent placement,TACE,and sorafenib(group A,n = 37),or TACE with sorafenib(group B,n = 31). The time to progression(TTP) and overall survival(OS) were evaluated by propensity score *** In the entire cohort,the 6-,12-,and 24-mo survival rates were 88.9%,54.3%,and 14.1% in group A,and 45.8%,0%,and 0% in group B,respectively(P < 0.001). The median TTP and OS were significantly longer in group A than group B(TTP: 9.0 mo vs 3.4 mo,P < 0.001; OS: 12.3 mo vs 5.2 mo,P < 0.001). In the propensity score-matched cohort,the median OS was longer in group A than in group B(10.3 mo vs 6.0 mo,P < 0.001). Similarly,the median TTP was longer in group A than in group B(9.0 mo vs 3.4 mo,P < 0.001). Multivariate Cox analysis revealed that the EVBT combined with stent placement,TACE,and sorafenib strategy was an independent predictor of favorable OS(HR = 0.18,P < 0.001). CONCLUSION EVBT combined with stent placement,TACE,and sorafenib might be a safe and effective palliative treatment option for MPVTT.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Endovascular brachytherapy Main portal vein tumor thrombus Sorafenib

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Diagnosis and management of arterioportal fistula occurring after percutaneous transhepatic portal vein cannula-assisted TIPS

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 566-569页

作者： Guo-Ping Liu Kai Cheng jian-jun luo Xu-Jie Wang Yong-Ning Xin Shi-Ying Xuan Medical College of Qingdao University Qingdao 266071China Department of Interventional Radiology Qingdao Municipal HospitalQingdao 266071China Department of Interventional Radiology Zhongshan HospitalFudan University and Shanghai Institute of Medical ImagingShanghai 200032China Department of Gastroenterology Qingdao Municipal HospitalQingdao 266011China

To the Editor:Transjugularintrahepaticportosystemicshunt(TIPS)isusuallyconsideredthechoiceformanagingcomplicationsofportal hypertensionsuchasrefractoryascites,esophagogastricvariceal bleedingandrecurrentbleedinguncontrolledwithfirstline ***,TIPShasbeensuccessfullyusedto treat Budd-Chiari syndrome, hepatic hydrothorax, and portal vein *** of the key steps during TIPS is the portal vein puncture.

关键词： Diagnosis and management of arterioportal fistula occurring after percutaneous transhepatic portal vein cannula-assisted TIPS APF

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Enhancing transjugular intrahepatic portosystemic shunt procedure efficiency with digital subtraction angiography image overlay technology in esophagogastric variceal bleeding

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2870-2877页

作者： Xiao-Yan Li Yao Li Wen-Qiang Li Shuai Ju Zhi-Hui Dong jian-jun luo Vascular and Wound Center Jinshan HospitalFudan UniversityShanghai 201508China Department of Vascular Surgery Institute of Vascular SurgeryZhongshan Hospital Fudan UniversityShanghai 200032China Department of Interventional Radiology Zhongshan Hospital Fudan UniversityShanghai 20032China

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic *** To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS *** We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided *** analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the *** The study included 52 patients with esophagogastric varices due to chronic hepatic *** demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided ***,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both ***,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.

关键词： Portal hypertension Digital subtraction angiography Image overlay technology Hepatic artery labeling Transjugular intrahepatic portosystemic shunt

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Direct intrahepatic portacaval shunt: an experimental study

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World Journal of Gastroenterology 2003年第2期9卷 324-328页

作者： jian-jun luo Zhi-Ping Yan Kang-Rong Zhou Sheng Qian Department of Radiology, Affiliated Zhongshan Hospital, Fudan University Medical center, Shanghai 200032, China Deatrtment of Radiology Affiliated Zhongshan Hospital Medical Center of Fundan University 180 Fenglin Road Shanghai 200032 China. luojj2001@***

AIM: To determine the feasibility of creating directintrahepatic portacaval shurt (DIPS) in swine with punctureunder sonographic ***: DIPS was created in 10 domestic swine undersonographic guidance. Liver function, blood ammonia leveland portosystemic gradient (PSG) were compared beforeand after the procedure. Patency of shunt was followed byportography every 7 days after ***: DIPS was successfully established in all 10 swinewithout any complications. One day alter procedure thealanine aminotransferase (ALT), aspartate aminotransferase(AST), and blood ammonia level (BAL) of swine rose from5.40±0.69, 16.00+0.79 and 35.66+4.10 to 34.20±3.46,59.70±2.22 and 66.94±3.44 respectively. (P＜0.05). The PSGdecreased from 0.59±0.20 kPa to 0.24±0.11 kPa after DIPS(P＜0.05). The shunt of 10 swine was kept patent from 7-28days (median patency time was 14 days).CONCLUSION: This initial experience demonstrated thatcreating intrahepatic portacaval shunt from retrohepaticsegment of IVC to portal vein with puncture undersonographic guidance in swine is safe and feasible. Furtherstudies are necessary to perform DIPS in cirrhosis patients.

关键词：肝内门静脉吻合术门脉高压症围手术期手术方法

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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Radial Clearance Control and Internal Leakage Analysis of a Tri-Proportion Controller

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International Journal of Plant Engineering and Management 2009年第2期14卷 96-101页

作者： LI Dai-jin ZHANG Yu-wen TANG Hao DANG jian-jun luo Kai College of Marine Engineering Northwestern Polytechnic University Xi'an 710072 China

The tri-propellant thermal propulsion system is one of the hottest subjects in the field of underwater vehicles recently. To improve efficiency of underwater vehicles, a method of radial clearance control of the tri-proportion has been proposed. Based on analyzing the factors which influence the pressure decrease and leakage of the tri-proportion controller, a method is used for precision analysis and proportion adjustment by using the median optimizing theory. Analysis results show that accuracy of the proportion controller is dependent on all the leakage, while the leakage is decided by radial clearance and pressure; the leakage can be controlled effectively and the accuracy of the proportion can be improved with the radial clearance control method. The method of accuracy analysis and clearance control has value on the design of various hydraulic motors.

关键词： underwater thermal propulsion system proportion controller radial clearance internal leakage

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The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian LI jun WANG Xianhui CAO Laifu GONG jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-jian Wu Ying Cheng Xiao-jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG jian NIE Wei HUANG Jin ZHU Ke LIU Ruxia ZHANG Ruizhi luo Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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Study of signal pathway of histamine H3 receptor on AtT-20 cell

Study of signal pathway of histamine H3 receptor on AtT-20 c...

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2002全国青年药理学英文学术会议

作者： XIE jian-jun, luo Xiao-xing, ZHAO De-hua Department of Pharmacology, Fourth Military Medical University, 710032, Xi’an, China

AIM To investigate the signal pathway of histamine H receptors. METHOD Radio immunoassay assay was performed to detect ACTH levels in the supematants of AtT-20 cells after administrating reagents and different extracellular culture solutions with or without Ca;IP measured by [H]-inosital and anion exchanger chromatography;cAMP, cGMP, by radio immunoassay;PKC on the membrane, iNO, by immunohistorical essay;intracellular calcium, by laser confocal imaging microscopy. RESULTS (1)Histamine (HA)

关键词： histamine H3 receptor AtT-20 cell signal pathway R-( α )-methylhistamine

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