检索结果-南通市图书馆

C-reactive protein decreases interleukin-8 production in human endothelial progenitor cells by inhibition of p38 MAPK pathway

引用

Chinese Medical Journal 2009年第16期122卷 1922-1928页

作者： NAN Jing-long LI jian-jun he jian-guo Department of Cardiology Fu Wai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background C-reactive protein （CRP） has been reported to damage the vascular wall by inducing endothelial dysfunction and inflammation, and it is also speculated to have a role in attenuating angiogenic functions of human endothelial progenitor cells （EPCs）. Interleukin-8 （IL-8） is an important mediator of the paracrine mitogenic effect of EPCs which has direct angiogenic effects on mature endothelial cells. We, herein, investigated the direct effect of CRP on IL-8 production and gene expression in cultured human EPCs. Methods EPCs were isolated from the peripheral venous blood of healthy male volunteers. Cells were cultured in EndoCultTM liquid medium in the absence and presence of CRP at clinically relevant concentrations （5 to 25 μg/ml） for different durations （3 to 48 hours）. IL-8 protein and mRNA of cultured EPCs were evaluated using ELISA and real-time PCR. Results The results showed that CRP at a concentration of 10 μg/ml significantly reduced IL-8 secretion of cultured EPCs with a peak at 25 μg/ml, and also decreased mRNA expression in EPCs with a peak at 12 hours. In addition, preincubation of EPCs with SB203580, an inhibitor of p38 mitogen-activated protein kinase （MAPK） decreased CRP inhibition of IL-8 mRNA expression at 12 hours in EPCs. Conclusions Our study, for the first time, demonstrates that CRP directly inhibits EPCs IL-8 secretion, a key cytokine player of angiogenesis induced by EPCs. Inhibition occurred in part via an effect of CRP to active the p38 MAPK signal transduction pathway in EPC. The ability of CRP to inhibit EPCs IL-8 secretion may represent an important mechanism that further links inflammation to cardiovascular disease.

关键词： C-reactive protein endothelial progenitor cells interleukin-8

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

混合线控制动系统制动力精确调节控制策略

引用

汽车工程 2018年第4期40卷 457-464页

作者：陈志成吴坚赵健何睿齐世迁吉林大学汽车工程学院长春130022

鉴于电子液压制动(electronic hydraulic brake,EHB)系统液压管路复杂且难以集成驻车制动,而电子机械制动(electronic mechanical brake,EMB)很难满足失效备份的需求,本文提出了一种前轴采用EHB,后轴采用EMB的混合线控制动系统(hybrid b... 详细信息

鉴于电子液压制动(electronic hydraulic brake,EHB)系统液压管路复杂且难以集成驻车制动,而电子机械制动(electronic mechanical brake,EMB)很难满足失效备份的需求,本文提出了一种前轴采用EHB,后轴采用EMB的混合线控制动系统(hybrid brake by wire system,HBBW),研究了EHB的双闭环压力跟随PI控制算法和EMB的三闭环制动力跟随PI控制算法,使其制动力能快速准确地跟随目标值。在此基础上,提出了混合制动系统的制动力精确调节PI控制策略,最后基于d SPACE Autobox和Car Sim搭建了HBBW系统的硬件在环(Hi L)试验平台,进行了Hi L测试与算法验证。结果表明,混合线控制动系统可有效地协调工作,实现四轮制动力快速、精确调节,从而提高车辆制动性能。

关键词：混合线控制动系统电子液压制动电子机械制动制动力控制策略硬件在环试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

引用

Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

溶藻弧菌外膜蛋白(Va-OMP)的免疫原性及免疫保护性

引用

水产学报 2006年第4期30卷 538-543页

作者：黄志坚何建国中山大学生命科学学院中山大学生命科学学院广东广州510275

利用初步制备的溶藻弧菌外膜蛋白(outer membrane protein ofVibrio alginolyticus,Va-OMP)、溶藻弧菌蛋白分子量58kD外膜蛋白(Va-OMP58)和溶藻弧菌(Vibrio alginolyticus,Va)灭活菌苗、溶藻弧菌脂多糖(lipopolysaccharides ofVibrio alginolyticus,Va-LPS)菌苗等进行主动保护性和被动保护性的实验比较,Va-OMP、Va-OMP58免疫组小鼠免疫后用活菌攻击,免疫保护率为62.5%~86.7%,而Va-LPS组和Va灭活菌苗组的免疫保护率为50%~62.5%,对照组的免疫保护率仅为6.7%。用不同抗血清免疫小鼠,活菌攻击后,Va-OMP组存活率达到53.3%和66.7%,Va-OMP58组次之,存活率为40%和50%,Va灭活菌组的存活率为33.3%和46.7%,对照组为13.3%。与对照组相比较,Va-OMP组差异较显著,保护效果较好。溶藻弧菌外膜蛋白和蛋白分子量58kD外膜蛋白的保护性效果高于溶藻弧菌灭活菌苗和溶藻弧菌脂多糖的保护性效果,证明外膜蛋白(outer membrane protein,OMP)具有较强的免疫原性。迟发性超敏反应试验也证明,OMP能诱发变态反应,间接证明OMP具有较强的引起细胞介导免疫反应的能力。因此实验证明,Va-OMP、Va-OMP58是能在小鼠产生体液免疫和细胞介导免疫的保护性抗原。

关键词：溶藻弧菌外膜蛋白免疫原性免疫保护性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

In-flight Energy Calibration of the GECAM Gamma-ray Detectors

引用

Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-Ya Guo Wen-Xi Peng Yan-Qiu Zhang Shuo Xiao Shao-Lin Xiong Chao Zheng Chao-Yang Li Jia-Cong Liu Wang-Chen Xue jian-jian he Zheng-Hua An Da-Li Zhang Xin-Qiao Li Li-Ming Song Shi-Jie Zheng Ke Gong Ya-Qing Liu Xin-Ying Song Xiao-Yun Zhao Xiang-Yang Wen Yan-Bing Xu Xiang Ma Xiao-Bo Li Ping Wang Yue Huang Ce Cai Qi-Bin Yi Yi Zhao Chen-Wei Wang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

引用

Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En Zhou Yilin Li Xiaoming Lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

引用

World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang he Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于互联网+电动PE截止阀研发及应用

引用

节水灌溉 2018年第7期 76-78,84页

作者：高建新何建村白云岗新疆水利水电科学研究院乌鲁木齐830049

针对当前节水灌溉自动化田间终端控制阀在生产实际中运行的问题,分析了不同控制阀优缺点,开展了新型基于互联网+电动PE截止阀研发,新近研发的互联网+新型节水灌溉自动化控制系统终端电动阀可实现在不同灌溉水质处理水平下正常运行以及... 详细信息

针对当前节水灌溉自动化田间终端控制阀在生产实际中运行的问题,分析了不同控制阀优缺点,开展了新型基于互联网+电动PE截止阀研发,新近研发的互联网+新型节水灌溉自动化控制系统终端电动阀可实现在不同灌溉水质处理水平下正常运行以及系统故障维修更为简便快捷,即使一般灌溉控制人员也都能对其出现的故障及时进行排除,一定程度上解决了节水灌溉自动化技术在新疆发展的制约因素。

关键词：终端电动阀灌溉水质互联网+新型节水灌溉自动化控制系统维修简便

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery

引用

World Journal of Clinical Cases 2025年第3期13卷 20-23页

作者： Xue-jian Wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

The chronic occlusion of intracranial arteries generally has no or mild clinical symptoms,and the clinical symptoms of acute cerebral artery occlusion are mostly manifested as severe cerebral infarction symptoms,which often make early diagnosis difficult,thus losing the best treatment *** cerebral infarction occurs,the consequences are difficult to *** is also an important reason for the high misdiagnosis rate and mortality of this *** this paper,the characteristics of the disease were analyzed to provide clinical reference.

关键词： Chronic occlusion Misdiagnose Arterial occlusion Middle cerebral artery occlusion Aneurysm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于磁定位技术的滑坡监测试验研究

引用

长江科学院院报 2017年第3期34卷 45-49页

作者：陆丹陈池吴剑何建伟周蕊三峡大学土木与建筑学院湖北宜昌443002

滑坡的监测主要包括2个方面,即地表位移监测和深部位移监测。深部位移监测能够直观反映滑坡的内部状态,是滑坡监测技术的研究重点。针对目前深部位移监测技术存在的诸多问题,提出了一种新型的滑坡深层位移监测技术,即一维磁定位技术。... 详细信息

滑坡的监测主要包括2个方面,即地表位移监测和深部位移监测。深部位移监测能够直观反映滑坡的内部状态,是滑坡监测技术的研究重点。针对目前深部位移监测技术存在的诸多问题,提出了一种新型的滑坡深层位移监测技术,即一维磁定位技术。采用理论和试验相结合的分析手段,探索这一技术在滑坡深部位移监测中的可行性;通过对磁定位相关理论的分析,推导出了深部位移与磁感应强度之间的理论关系式,并采用试验验证了这一关系的正确性。最后随机选取了8个验证点进行定位验证试验,结果证明了一维磁定位技术在滑坡监测中的可行性,其定位精度能够达到mm级,满足滑坡监测精度要求。

关键词：滑坡监测磁定位技术磁偶极子永磁体磁感应强度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：