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Comparison between different reconstruction routes in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2012年第39期18卷 5616-5621页

作者： Yu-Zhen Zheng Shu-Qin Dai Wei Li Xun Cao Xin Wang jian-hua fu Peng Lin Lan-Jun Zhang Bin Lu Jun-Ye Wang Department of Thoracic Oncology Sun Yat-Sen University Cancer Center Guangzhou 510060 Guangdong Province China Department of Clinical Laboratory Sun Yat- Sen University Cancer Center Guangzhou 510060 Guangdong Province China Department of Anesthesia Sun Yat-Sen University Can-cer Center Guangzhou 510060 Guangdong Province China

AIM:To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction. METHODS:After obtaining approval from the Medical Ethics Committee of the Sun Yat-Sen University Cancer Center, we retrospectively reviewed data from 306 consecutive patients with histologically diagnosed esophageal squamous cell carcinoma who were treated between 2001 and 2011. All patients underwent radical McKeown-type esophagectomy with at least two-field lymphadenectomy. Regular follow-up was performed in our outpatient department. Postoperative complica-tions and long-term survival were analyzed by treatment modality, baseline patient characteristics, and operative procedure. Data from patients treated via the retrosternal and posterior mediastinal routes were compared. RESULTS:The posterior mediastinal and retrosternal reconstruction routes were employed in 120 and 186 patients, respectively. Pulmonary complications were the most common complications experienced during the postoperative period (46.1% of all patients; 141/306). Compared to the retrosternal route, the posterior mediastinal reconstruction route was associated with a lower incidence of anastomotic stricture (15.8% vs 27.4%, P = 0.018) and less surgical bleeding (242.8 ± 114.2 mL vs 308.2 ± 168.4 mL, P < 0.001). The median survival time was 26.8 mo (range:1.6-116.1 mo). Upon uni/multivariate analysis, a lower preoperative albumin level (P = 0.009) and a more advanced pathological stage (pT; P = 0.006; pN; P < 0.001) were identified as independent factors predicting poor prognosis. The reconstruction route did not influence prognosis (P = 0.477). CONCLUSION:The posterior mediastinal route of reconstruction reduces incidence of postoperative complications but does not affect survival. This route is recommended for resectable esophageal squamous cell carcinoma.

关键词： Esophageal carcinoma Route of reconstruc-tion Posterior mediastinal Retrosternal Comparison

Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

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Acta Pharmacologica Sinica 2007年第1期28卷 52-57页

作者： jian-xun LIU~2 Zhen YU Xin-zhi LI jian-hua fu Xiao-hong SHANG Ai-guo YAN Yue SHI Yan-lei MA Department of Pharmacology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China DepartmentofPharmacology XiyuanHospitalChinaAcademyofChineseMedicalSciencesBeijing100091China

Aim:To develop a new model of myocardial ischemia in Chinese miniature swineand reevaluate the cardioprotective effects of ***:Myocardialischemia was induced by injecting self-embolus into the left anterior descending(LAD)coronary artery in qualified miniature ***(5 ***-1.d-1)wasorally administered to the swine by mixing into normal pig diet from 1 to 6 d afterself-embolus *** coronary angiography,30 point body surface electro-cardiogram(BS-ECG),hemodynamics,biochemistry,quantitative histology andpathohistology were determined 6 d after self-embolus ***:Embo-lization occurred in the LAD coronary artery of the Chinese miniature swine in-jected by *** were significant myocardial ischemia and largecardiac muscle infarction in the Chinese miniature swine,which were accompa-nied with increased BS-ECG,decreased hemodynamic indexes of the cardiac output,cardiac index,left cardiac work and left cardiac work index,and increased systemicvascular resistance *** analysis revealed myocardial degen-eration,necrosis,fibrosis,inflammatory cell infiltration and granulation tissuehyperblastosis(n=6).Diltiazem diminished the extent of the LAD embolism,ame-liorated myocardial ischemia,improved the hemodynamic indexes,increased theplasma superoxide dismutase activity,decreased the plasma malondialdehydecontent,narrowed the myocardial ischemic area and weakened the pathohistologicaldamage in the cardiac muscle(n=6).Conclusion:Myocardial ischemia induced byinjecting self-embolus into the LAD coronary artery in Chinese miniature swine isquite close to clinical pathophysiological *** is effective toinhibit the myocardial ischemia and restore the heart function in this novel model.

关键词： myocardial ischemia diltiazem animal models Chinese miniature swine

Fibrin sealant for esophageal anastomosis:A phase II study

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 651-662页

作者： Yao-Bin Lin jian-hua fu Yan huang Yi-huai Hu Kong-Jia Luo Ke-Xi Wang AmosÉla Bella Dong-Rong Situ Ji-Yang Chen Ting Lin Xavier B D’Journo Nuria M Novoa Alessandro Brunelli Hiran C Fernando Robert J Cerfolio Mahmoud Ismail Hong Yang 无 Department of Thoracic Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Thoracic Surgery Avicenne HospitalBobigny 93000France Department of Surgery and Specialties Faculty of Medicine and Biomedical SciencesUniversity of YaoundéIYaoundéCameroon Department of Surgery Royal Darwin HospitalNorthern Territory 0811Australia Department of Thoracic Surgery and Diseases of Esophagus Aix-Marseille UniversityHôpital NordMarseille 13915France Thoracic Surgery Service University Hospital of SalamancaSalamanca 37007Spain Department of Thoracic Surgery St James's University HospitalLeeds LS97TFUnited Kingdom Section of Thoracic Surgery Inova Fairfax Medical CenterInova Schar Cancer InstituteFalls ChurchVA 22042United States Department of Cardiothoracic Surgery New York University Langone HealthNew YorkNY 10016United States Department of Thoracic Surgery Academic Hospital of the Charité–UniversitätsmedizinHumboldt University BerlinBerlin 10117Germany the AME Thoracic Surgery Collaborative Group

BACKGROUND Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer(EC or EJC).Postoperative anastomotic leakage(AL)remains *** use of fibrin sealant(FS)may improve the strength of esophageal anastomosis and reduce the incidence of *** To assess the efficacy and safety of applying FS to prevent AL in patients with EC or *** In this single-arm,phase II trial(*** identifier:NCT03529266),we recruited patients aged 18-80 years with resectable EC or EJC clinically staged as *** open or minimally invasive McKeown esophagectomy was performed with a circular stapled *** performing the anastomosis,2.5 mL of porcine FS was applied *** primary endpoint was the proportion of patients with AL within 3 *** From June 4,2018,to December 29,2018,57 patients were *** the data cutoff date(June 30,2019),three(5.3%)of the 57 patients had developed AL,including two(3.5%)with esophagogastric AL and one(1.8%)with gastric *** incidence of anastomotic stricture and other major postoperative complications was 1.8%and 17.5%,*** median time needed to resume oral feeding after operation was 8 d(Interquartile range:7.0-9.0 d).No adverse events related to FS were *** deaths occurred within 90 d after *** Perioperative sealing with porcine FS appears safe and may prevent AL after esophagectomy in patients with resectable EC or *** phase III studies are warranted.

关键词： Esophageal cancer McKeown esophagectomy Fibrin sealant Anastomotic leakage Postoperative complications Prevention

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

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Science China Life Sciences 2025年

作者： Ziyi Han jian fu Aiyan Gong Wenkai Ren State Key Laboratory of Livestock and Poultry Breeding College of Animal Science South China Agricultural University Animal Disease-resistant Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University China Institute of Veterinary Drug Control

The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid(IPA) downregulates interleukin-1beta(IL-1β) production in M1 macrophages through inhibition of nuclear factor-kappa B(NF-κB) signaling. Mechanistically, IPA binds specifically with methionine adenosyltransferase 2A(MAT2A) to promote S-adenosylmethionine(SAM) synthesis, which facilitates the DNA methylation of ubiquitin-specific peptidase 16(USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4(TLR4) ubiquitination and NF-κB inhibition. furthermore,IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides(LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. Collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.

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基于“三权分置”的“城市反哺农村”发展模式

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深圳大学学报（人文社会科学版） 2017年第5期34卷 86-92页

作者：陈建华刘福健顾鹏深圳大学经济学院广东深圳518060

我国农村土地制度从"两权分离"到"三权分置"的改革放活了土地经营权,对破解"三农"问题以及优化农业产业结构是一个重大突破。"三权分置"改革的实质是解决农村土地资源扭曲配置问题,它为"城市反哺农村"发展模式的实施提供了可能。通过政... 详细信息

我国农村土地制度从"两权分离"到"三权分置"的改革放活了土地经营权,对破解"三农"问题以及优化农业产业结构是一个重大突破。"三权分置"改革的实质是解决农村土地资源扭曲配置问题,它为"城市反哺农村"发展模式的实施提供了可能。通过政府引导和支持城镇投资者到农村创办富有特色的新型农业企业来带动农村经济的发展,同时实现城镇投资者资本的自身增值,是"城市反哺农村"发展模式的核心,这种发展模式对于解决农业产业结构不合理、经营方式落后、土地经营权流转不合理等问题意义重大。由于它是一个创新性、长久性、系统性的工程,基于我国地域辽阔,农业人口众多,区域间资源禀赋差异较大等现实情况,因此,该发展模式的实施要做到因地制宜、因时制宜,先试点、后推广,扎扎实实、稳步推进,逐步形成具有我国特色社会主义新农村建设的基本路径。

关键词： “三农问题” 三权分置城市反哺农村发展模式土地流转新型农业企业

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新生儿低血糖脑损伤的临床研究

中华儿科杂志 2007年第7期45卷 518-522页

作者：毛健陈丽英富建华李娟薛辛东中国医科大学附属第二医院儿科沈阳110004 中国医科大学附属第二医院放射科沈阳110004

目的探讨低血糖脑损伤的临床表现与早期影像学特征,为诊断与预后判定提供依据。方法 6例入院时血糖为0.48～1.70 mmol/L。胎龄35周^+5至40周,出生体重1545～3900 g。均无窒息史、败血症、颅内感染、遗传代谢及内分泌性疾病。在入院24～4... 详细信息

目的探讨低血糖脑损伤的临床表现与早期影像学特征,为诊断与预后判定提供依据。方法 6例入院时血糖为0.48～1.70 mmol/L。胎龄35周^+5至40周,出生体重1545～3900 g。均无窒息史、败血症、颅内感染、遗传代谢及内分泌性疾病。在入院24～48 h 完成 T1WI、T2WI 和DWI 磁共振扫描。结果 6例均有明显的临床表现,以惊厥、萎靡最为常见,其次为呼吸暂停,4例血糖正常时仍有惊厥发生。5例低血糖发生在生后6～53 h,1例在生后12 d。低血糖持续时间[(47.7±38.8)(4～96)]h,最低值[(1.05±0.44)(0.48～1.70)]mmol/L。首次 MRI 检查1例在生后15 d,余在生后2～5 d,受累部位为枕叶(6例)和顶叶(3例)皮层及皮层下白质:DWI 上表现为高信号6例,T1WI 为低信号4例,T2WI 高信号1例。3例在生后第2周接受第2次检查,1例 DWI 转为低信号,余信号正常;3例此时 T1WI 和 T2WI 分别表现为低信号和高信号,局部水肿明显减轻。1例3个月随访发育正常,未见顶枕部萎缩,但内囊后枝和视放射髓鞘化不良。结论枕顶叶是新生儿低血糖脑损伤的主要受累部位,DWI 可以早期反映脑损伤的改变。

关键词：婴儿新生低血糖症脑损害慢性磁共振成像

220例完全切除Ⅱ期非小细胞肺癌术后患者的生存分析(英文)

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Chinese Journal of Cancer 2010年第5期29卷 538-544页

作者：戴云苏晓东龙浩 State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060P.R.China Department of Thoracic Surgery Sun Yat-sen University Cancer Center Lung Cancer Research Center Sun Yat-sen University Cancer Center

Background and Objective:Surgery is the main therapy for patients with stage-Ⅱ non-small cell lung cancer(NSCLC),but patients still have an unsatisfactory prognosis even though complete resection is usually *** chemotherapy provides low rates of clinical benefit as *** retrospectively analyzed prognostic factors of patients with completely resected stage-Ⅱ NSCLC to find patients with unfavorable factors for proper ***:Clinical data of 220 patients with complete resections of stage-Ⅱ NSCLC at the Sun Yat-sen University Cancer Center between January 1998 and December 2004 were retrospectively *** survival was analyzed by the Kaplan-Meier method and compared by log-rank *** was analyzed by the Cox proportional hazards ***:The overall 3-and 5-year survival rates were 58.8% and 47.9%,*** 3-and 5-year disease-free survival rates were 45.8% and 37.0%,*** the 220 patients,86(39.1%) had recurrence or metastasis.A univariate analysis demonstrated that age(> 55 years),blood type,the presence of symptoms,chest pain,tumor volume(> 20 cm3),total number of removed lymph nodes(≥ 10),number of involved N1 lymph nodes(≥3),total number of removed N2 lymph nodes(> 6),and the ratio of involved N1 lymph nodes(≥ 35%) were significant prognostic factors for 5-year *** the multivariate analysis,age(> 55 years),chest pain,tumor volume(> 20 cm3),total number of removed lymph nodes(≥ 10),and number of involved N1 lymph nodes(≥ 3) were independent prognostic factors for 5-year ***:For patients with completely resectable stage-II NSCLC,having > 55 years,presenting chest pain,tumor volumes > 20 cm3,and ≥ 3 involved N1 lymph nodes were adverse prognostic factors,and ≥ 10 removed lymph nodes was a favorable *** with poor prognoses might be treated by individual adjuvant therapy for better survival.

关键词：非小细胞肺癌生存分析患者

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新生儿舌甲状舌管囊肿的早期诊断10例报告

中华儿科杂志 2009年第1期47卷 23-25页

作者：富建华薛辛东范国光毛健尤凯任莹中国医科大学附属盛京医院儿科沈阳110004 中国医科大学附属盛京医院放射线科沈阳110004

目的使新生儿医生认识和重视新生儿舌甲状舌管囊肿（LTDC），从而避免将LTDC误诊为先天性单纯性喉喘鸣（即喉软化症）。方法总结2004年12月至2007年8月，我院新生儿科收治的10例LTDC患儿，本组10例在院外均误诊为先天性喉喘鸣。入院后5... 详细信息

目的使新生儿医生认识和重视新生儿舌甲状舌管囊肿（LTDC），从而避免将LTDC误诊为先天性单纯性喉喘鸣（即喉软化症）。方法总结2004年12月至2007年8月，我院新生儿科收治的10例LTDC患儿，本组10例在院外均误诊为先天性喉喘鸣。入院后5例进行了喉镜检查，10例全部进行了喉部CT扫描，7例进行组织病理学检查。结果10例均证实为LTDC。喉喘鸣为新生儿LTDC的首发症状，吸气性的呼吸困难是其主要表现；喉镜检查：可见舌根部圆形囊性肿物，色略灰白，表面光滑柔软；喉部CT扫描显示：舌根部圆形低密度灶，直径约0．8～2em，边界清楚，凸入气道；组织学检查：囊肿壁由鳞状上皮和柱状上皮组成。结论LTDC是新生儿甲状舌管囊肿的常见形式，喘鸣及呼吸困难是其主要表现；喉镜检查可作为新生儿LTDC的初筛手段，而喉部CT扫描则提供重要的诊断依据；囊肿穿刺虽可缓解症状，手术切除是LTDC的根治方法。

关键词：婴儿新生支气管源性管囊肿呼吸音

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan huaNG Yin YANG hua WANG Xintian SHI jianping LIU Lixia fu Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique