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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule Zhu Yumin wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Morphology control of magnetic properties in cobalt nanowires

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Rare Metals 2023年第6期42卷 1994-1999页

作者： Huan-Huan Xu Qiong wu Ming Yue Cheng-Lin Li hong-jian Li College of Materials Science and Engineering Beijing University of TechnologyBeijing100124China

Cobalt nanowires with different shapes and sizes were synthesized by reduction of carboxylate salts of Co^(Ⅱ) in 1,2-butanediol using a solvothermal chemical *** well-crystallized Co nanowires with hexagonal closepacked(hep) phase are observed and the(002) crystalline direction is along the long axis of nano *** morphology control is strongly dependent on the reaction *** varying the amount of capping agent in proper ranges,the effect of reaction parameters on controlling the size and shape of Co nanowires is *** the amount of capping agent increasing,the aspect ratio of Co nanowires increases ***,the magnetic measurement of cobalt nanowires shows that the coercivity of the Co nanocrystals does not increase with the increase in aspect ratio monotonously,which suggests that the tip shape and micros tructure also play an important role in the magnetization reversal process of the Co nanocrystals,and the aspect ratio plays a much less role as the ratio value exceeds *** further understand the effect of size on the magnetic properties in the Co nanowires,micromagnetic simulations were performed,which confirms that the magnetic properties are barely affected by the aspect ratio larger than *** highest coercivity of624 kA·m^(-1) is obtained for ellipsoid nano wires with a mean length of 200 nm,which also displays a strong magnetic *** a result,the highest energy product of the wires reaches 248 kJ·m^(-3).

关键词： Co nanowires Morphology control Tip shape High energy product

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Case Report:Granulomatous hypophysitis:two case reports and literature review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第7期10卷 552-558页

作者： jian SHI jian-min ZHANG Qun wu Gao CHEN hong ZHANG Wen-liang BO Department of Neurosurgepy the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Neurosurgery Suichang People's Hospital Suichang 323000 China

Granulomatous hypophysitis （GRH） is extremely rare and commonly presents with chronic inflammatory of the enlarged pituitary gland. In our study, 66-year-old and 57-year-old women, both Chinese, were diagnosed with GRH presenting preoperatively definite imageology characters as pituitary adenoma. The 66-year-old woman presented with a year of headache, half a year of gradual decrease of visual acuity, and one month of right ptosis. Serum prolaetin level was slightly elevated. Screening computed tomography （CT） scanning revealed typical low density mass found on the enlarged sella, which demonstrated invasive extension from the sella to the right cavernous sinus by contrast enhanced magnetic resonance imaging （MRI）. Consequently, the patient was diagnosed with probable invasive pituitary adenoma. The other 57-year-old woman complained a light headache and had been previously treated as nonfunctional pituitary adenoma in other hospital. Finally these two patients underwent transsphenoidal microsurgery and were diagnosed with GRH according to postoperative histopathology. They then were treated with steroid. During the follow-up, the clinical symptoms such as headache, visual damage, and ptosis vanished, and the mass of the sellae dramatically shrank on repeated MR images. Clinically and radiologically, GRH is a rare sellar entity easily to be misdiagnosed as a pituitary adenoma. Trans-sphenoidal surgery can decompress the optical nerve or oculomotornerve as a therapeutic strategy, and support biopsy or further pathological diagnosis. However, the hormonal therapy should be emphasized both as diagnostic and therapeutic strategies. Conservative and tentative steroid treatment should be performed in preoperative period without acute nerve damage.

关键词： Granulomatous hypophysitis Steroid treatment Imageology Trans-sphenoidal surgery

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Potential of extracellular vesicles and exosomes as diagnostic markers for cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 436-438页

作者： Linping Cao Jiawei hong jian wu Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina

Cholangiocarcinoma(CCA),a malignant carcinoma originating from biliary epithelium,is the second largest primary liver malignancy,accounting for 10-15%of hepatobiliary ***,CCA is a fatal malignancy,with a 5-year survival rate of less than 10%(1).The lack of typical symptoms and signs makes early CCA difficult to identify and diagnose by early health *** diagnosis of CCA mainly relies on radiography,tumor biomarkers,invasive diagnosis,as well as pathological examination,which results in the majority of patients being detected in the middle and late stages,and only about one-third of CCA patients have access to treatment(1).

关键词： diagnosis epithelium malignancy

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小叶女贞不同扦插育苗技术研究

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草业与畜牧 2011年第12期 17-18,33页

作者：刘晓霞舒健虹吴佳海贵州省草业研究所贵州贵阳550006

以JH9816小叶女贞不同茎粗、不同切面进行扦插试验,根据根长、根系数、生根率、成苗率等因素观测比较,结果认为JH9816小叶女贞整个枝条都可用于扦插,不同茎粗扦插苗在一定土壤温湿度条件下易形成植株;不同切面扦插的根长和生长高度差异... 详细信息

以JH9816小叶女贞不同茎粗、不同切面进行扦插试验,根据根长、根系数、生根率、成苗率等因素观测比较,结果认为JH9816小叶女贞整个枝条都可用于扦插,不同茎粗扦插苗在一定土壤温湿度条件下易形成植株;不同切面扦插的根长和生长高度差异不显著,根系数差异达极显著。三个处理中J处理效果最好,前期生根较快、根系多而长。

关键词：扦插育苗小叶女贞

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Reduction of Carbon-bearing Pellets of Oolitic Hematite in a Shaft Furnace

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Journal of Iron and Steel Research International 2016年第3期23卷 210-219页

作者： Wei wu jian-jun GAO Jia-qing ZENG Yuan-hong QI jian-chang WANG Xi-dong ZHANG Metallurgical Technology Research Department Central Iron and Steel Research Institute State Key Laboratory for Advanced Iron and Steel Processes and Products Central Iron and Steel Research Institute wu Xi Zhao Shun Stainless Steel Middle Plate Co. Ltd.

When carbon-bearing pellets of oolitic hematite are treated in a shaft furnace,some problems are typically encountered：the metallization ratio of the metal pellets is low;the carbon-bearing pellets bond with each other at high temperatures;and the separation of phosphorus from iron is *** solve these problems,experiments were conducted on oolitic hematite reduction in a resistance furnace and semi-industrial test shaft *** results showed that the metallization rate reached 90% or greater under the conditions of a reduction temperature of 1 150℃,an atmosphere of simulated flue gas,and a reduction time between 1.5and *** problem of high-temperature bonding among pellets can be solved by increasing the strength of the pellets,coating their surface with a surface transfer agent and maintaining an even temperature inside the shaft *** basicity of the ore blend exerted no obvious effect on the magnetic concentrate and phosphorus *** phosphorus content in the magnetic concentrate can be further reduced by improving the grinding capacity of the ball mills used in the *** the basis of the experimental results related to oolitic hematite reduction with carbon-bearing pellets in a shaft furnace,the experimental requirements were satisfied with an average 88.27%total Fe content and 0.581% P content in the pellets.

关键词： oolitic hematite carbon-bearing pellet metallization rate high temperature bonding resistance furnace shaft furnace phosphorus separation

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Evaluation of hydraulic fracturing of horizontal wells in tight reservoirs based on the deep neural network with physical constraints

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Petroleum Science 2023年第2期20卷 1129-1141页

作者： hong-Yan Qu jian-Long Zhang Fu-jian Zhou Yan Peng Zhe-Jun Pan Xin-Yao wu State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Artificial Intelligence China University of PetroleumBeijing102249China Unconventional Oil and Gas Institute China University of PetroleumBeijing102249China School of Petroleum Engineering China University of PetroleumBeijing102249China Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development Ministry of EducationNortheast Petroleum UniversityDaqingHeilongjiang163318China Engineering Technology Research Institute PetroChina Xinjiang Oilfield CompanyKaramayXinjiang834000China

Accurate diagnosis of fracture geometry and conductivity is of great challenge due to the complex morphology of volumetric fracture network. In this study, a DNN (deep neural network) model was proposed to predict fracture parameters for the evaluation of the fracturing effects. Field experience and the law of fracture volume conservation were incorporated as physical constraints to improve the prediction accuracy due to small amount of data. A combined neural network was adopted to input both static geological and dynamic fracturing data. The structure of the DNN was optimized and the model was validated through k-fold cross-validation. Results indicate that this DNN model is capable of predicting the fracture parameters accurately with a low relative error of under 10% and good generalization ability. The adoptions of the combined neural network, physical constraints, and k-fold cross-validation improve the model performance. Specifically, the root-mean-square error (RMSE) of the model decreases by 71.9% and 56% respectively with the combined neural network as the input model and the consideration of physical constraints. The mean square error (MRE) of fracture parameters reduces by 75% because the k-fold cross-validation improves the rationality of data set dividing. The model based on the DNN with physical constraints proposed in this study provides foundations for the optimization of fracturing design and improves the efficiency of fracture diagnosis in tight oil and gas reservoirs.

关键词： Evaluation of fracturing effects Tight reservoirs Physical constraints Deep neural network Horizontal wells Combined neural network

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Intestinal erosion caused by meshoma displacement:A case report

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 114-120页

作者： Jin-Feng wu jian Chen Fang hong Department of General Surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Gynaecology and Obstetrics Zhejiang University School of Medicine Sir Run Run Shaw HospitalHangzhou 310016Zhejiang ProvinceChina

BACKGROUND A meshoma formation and erosion to the small intestine is ***,we report one case of a meshoma that was not treated early;causing it to displace and erode the small intestine,with infection,complete control of symptoms was achieved after removal of the infected patch mass,no recurrence of hernia after 2 years of *** SUMMARY A 62-year-old male patient presented with recurrent abdominal pain repeatedly for 1 wk,which has worsened 2 d before admition,accompanied by *** years before presentation he underwent right inguinal hernia Plug and patch repair *** years ago,a computed tomography scan revealed a right lower abdominal mass with soft tissue density,measuring approximately 30 mm×17 mm,which was diagnosed as meshoma that was not *** patient had poorly controlled diabetes in the past *** The formation of meshoma is rare,and that if not treated in time it might erode and require resection of the involved organ.

关键词： Tension-Free mesh repair Polypropylene mesh Meshoma Mesh infection Bowel resection Case report

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Effect of electric field on the spectrum and the persistent current of a quantum ring with two electrons （II） additional effect of a charged impurity

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Chinese Physics B 2008年第8期17卷 3026-3034页

作者： wu hong Department of Physics School of Sciences Jimei University Xiamen 361021 China

This paper studies the effect of a charged impurity together with or without an external homogeneous electric field on a quantum ring threaded by a magnetic field B and containing two electrons. The potential caused by the impurity has been plotted which is helpful to the understanding of the electronic structures inside the ring. The deep valley appearing in the potential curve is the source of localization, which affects seriously the Aharonov-Bohm oscillation （ABO） of the energy and persistent current. It also causes the fluctuation of the total orbital angular momentum L of the pair of electrons. It is found that the appearance of the impurity reduces the domain of the fractional ABO. During the increase of B, the domain of the integral ABO may appear earlier when B is even quite small. The transition from the localized states to extended states has also been studied. Furthermore, it has deduced a set of related formulae for a transformation, by which an impurity with a charge ep placed at an arbitrary point Rp is equivalent to an impurity with a revised charge ep placed at the X-axis with a revised radial distance Rp. This transformation facilitates the calculation and make the analysis of the physical result clearer.

关键词： charged impurity quantum ring ABO potential

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Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice

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World Journal of Gastroenterology 2008年第18期14卷 2832-2837页

作者： Ping-Guo Liu Song-Qing He Yan-hong Zhang jian wu Department of Internal Medicine Transplant Research Program University of California Davis Medical Center Sacramento CA 95817 United States Department of Hepatic-Biliary Surgery Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM: To determine the effects of allopurinol, an inhibitor of xanthine oxidase, and apocynin, an inhibitor of NADPH oxidase, on oxidant stress and liver injury caused by hepatic ischemia/reperfusion (I/R) procedure in mice. METHODS: Mice were pretreated with a xanthine oxidase inhibitor, allopurinol, or NADPH oxidase (NOX) inhibitor, apocynin before the hepatic I/R procedure. Then treated or untreated mice underwent the hepatic I/R procedure. The effects on hepatic injury and superoxide anions were determined after starting reperfusion. RESULTS: A standard warm hepatic I/R procedure led to a marked increase in superoxide anion production as indicated by a superoxide anion tracer, MCLA. At the same time, the procedure caused profound acute liver injury, as indicated by elevated serum alanine aminotransferase and tumor necrosis factor-α levels, reduced liver glutathione levels and elevated malondialdehyde contents, as well as a high apoptotic cell count. All these changes were reversed by the use of apocynin or allopurinol prior to the hepatic I/R procedure. CONCLUSION: Allopurinol and apocynin exerted protective effects on hepatic ischemia/reperfusion injury. The protection is associated with blocking the generationof superoxide anions during the hepatic I/R procedure by inhibiting xanthine oxidase and NADPH oxidase activity.

关键词： Ischemia/reperfusion Reactive oxygen species Allopurinol Apocynin NADPH oxidase Xanthine oxidase

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