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Prognostic significance of ERCC1 expression in postoperative patients with gastric cancer

Chinese Journal of Cancer Research 2014年第3期26卷 323-330页

作者： jian Wang Xi-Qiao Zhou Jing-Ying Li jian-feng cheng Xiao-Ning Zeng Xiao Li Ping Liu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Department of Oncology The Second Affiliated Hospital of Nanchang University Gastroenterology Department of Internal MedicineCarolinas Medical CenterUniversity of North Carolina Charlotte Campus1000Blythe BlvdCharlotteNC 28203USA Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University

Aim： This study explored the correlation between the expression of excision repair cross-complementation group 1 （ERCC1） and the prognosis of gastric cancer patients. Methods： From January 2005 to December 2008, 605 patients who underwent radical surgery in The First Affiliated Hospital of Nanjing Medical University were enrolled. We conducted the follow-up every 6 months and its contents included a comprehensive medical history, tumor markers and abdominal ultrasound or CT and other imaging findings. Deadline was April 30, 2013 and follow-up time between 51 to 91 months. Survival time is calculated from the date of diagnosis to death or last follow-up date. Immunohistochemistry （IHC） was used to assess the expression of ERCCI in resected samples. The relationship between ERCCI expression and survival of patients was investigated. The comparison of count data were analyzed by Chi-square test. Median survival time （MST） and the 5-year survival rate were calculated by life table analysis. The Kaplan-Meier curves were used for survival analysis. Results： ERCC1 expression was positive in 412 patients （68.1%）. There is no significant difference between ERCCl-positive group and ERCCl-negative group in terms of the MST and 5-year survival rate （P=0.455）. The MST and 5-year survival rate have no significant difference （P=0.162） between group with chemotherapy and group with no chemotherapy in patients with ERCCl-positive expression. However, the MST and 5-year survival rate in patients with ERCCl-negative expression benefited more from with chemotherapy （P=0.019）. The ERCCl-positive patients survived longer than those ERCCl-negative patients （P=0.183） in subgroup with no adjuvant chemotherapy. In the subgroup analysis, ERCC 1 expression had no significant relationship with overall survival in patients with stage II or llI gastric cancer （P〉0.05）. Conclusions： ERCC1 might be a good prognostic factor for the patients of gastric cancer after radical resection. Patients with ER

关键词： Gastric cancer excision repair cross-complementation group 1 (ERCC 1) prognosis platinum drugs

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HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication

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World Journal of Gastroenterology 2010年第35期16卷 4476-4482页

作者： Lei-Min Sun Yan Shang Ya-Min Zeng Yan-Yong Deng jian-feng cheng Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Hangzhou 310016 Zhejiang Province China the First People’Hospital of Xiaoshan District Hangzhou 311200Zhejiang ProvinceChina Department of Gastroenterology Internal MedicineVirginia Commonwealth UniversityRichmondVA 23298United States

AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(***) ***:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after *** eradication and 255 controls) were prospectively *** chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys *** analysis was conducted by two-sample t test for continuous variables and χ2 test for categorical *** regression models were used to f ind the risk factors for gastric cancer and atrophic ***:Neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with gastric *** with the Ser/Ser genotype,odds ratio(OR) for Ser/Cys was 0.96,(95% CI:0.51-1.84) and OR for Cys/Cys was 1.1(95% CI:0.48-2.1).No association was detected between hOGG1 polymorphism and Lauren type of gastric cancer(P=0.61) ***,Ser/Cys and Cys/Cys were signif icantly associated with atrophic gastritis with OR:1.76 for Ser/Cys(95% CI:1.03-3.0) and 2.38 for Cys/Cys(95% CI:1.34-4.23).After controlling for age,gender,smoking and alcohol,there were still signif icant associations with OR:2.05 for Ser/Cys(95% CI:1.14-3.68) and 2.76 for Cys/Cys(95% CI:1.47-5.18).CONCLUSION:HOGG1 polymorphisms(Cys/Cys and Ser/Cys) are associated with atrophic *** significant association is detected between hOGG1 polymorphisms(Cys/Cys or Ser/Cys) and gastric cancer.

关键词： Human oxoguanine glycosylase 1 polymorphism Atrophic gastritis Gastric cancer

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Mosaic Trisomy 21 and Trisomy 14 as Acquired Cytogenetic Abnormalities without GATA1 Mutation in A Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

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Chinese Journal of Cancer Research 2011年第3期23卷 239-241页

作者： Yi Xiao Jia Wei Jin-huan Xu jian-feng Zhou Yi-cheng Zhang Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

One case of acute megakaryoblastic leukemia （AMKL） with trisomy 21,trisomy 14 and unmutated GATA1 gene in a phenotypically normal girl was *** patient experienced transient myelodysplasia before the onset of *** bone marrow blasts manifested typical morphology of megakaryoblast both by the May-Giemsa staining and under the electronic *** cells were positive for CD13,CD33,CD117,CD56,CD38,CD41 and CD61 in flow cytometry *** study showed karyotype of 48,XX,＋14,＋21 in 40% *** mutations of GATA1 gene in Down syndrome or acquired trisomy 21 were not detected in this case.

关键词： Acute megakaryoblastic leukemia Myelodysplasia Cytogenetics GATA1

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Multi-objective optimization and evaluation of supercritical CO_(2) Brayton cycle for nuclear power generation

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Nuclear Science and Techniques 2024年第2期35卷 183-209页

作者： Guo-Peng Yu Yong-feng cheng Na Zhang Ping-jian Ming Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle *** models of four Brayton cycle layouts are developed in this study for different reactors to reduce the cost and increase the thermohydraulic performance of nuclear power generation to promote the commercialization of nuclear *** analysis,multi-objective optimizations,and four decision-making methods are applied to obtain each Brayton scheme’s optimal thermohydraulic and economic *** show that for the same design thermal power scale of reactors,the higher the core’s exit temperature,the better the Brayton cycle’s thermo-economic *** the four-cycle layouts,the recompression cycle(RC)has the best overall performance,followed by the simple recuperation cycle(SR)and the intercooling cycle(IC),and the worst is the reheating cycle(RH).However,RH has the lowest total cost of investment(C_(tot))of$1619.85 million,and IC has the lowest levelized cost of energy(LCOE)of 0.012$/(kWh).The nuclear Brayton cycle system’s overall performance has been improved due to *** performance of the molten salt reactor combined with the intercooling cycle(MSR-IC)scheme has the greatest improvement,with the net output power(W_(net)),thermal efficiencyη_(t),and exergy efficiency(η_(e))improved by 8.58%,8.58%,and 11.21%,*** performance of the lead-cooled fast reactor combined with the simple recuperation cycle scheme was optimized to increase C_(tot) by 27.78%.In comparison,the internal rate of return(IRR)increased by only 7.8%,which is not friendly to investors with limited *** the nuclear Brayton cycle,the molten salt reactor combined with the recompression cycle scheme should receive priority,and the gas-cooled fast reactor combined with the reheating cycle scheme should be considered carefully.

关键词： Supercritical CO_(2)Brayton cycle Nuclear power generation Thermo-economic analysis Multi-objective optimization Decision-making methods

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Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan Yang Ming-Han cheng Hai-feng Pan jian Gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

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Endoscopic papillary large balloon dilation vs endoscopic sphincterotomy for retrieval of common bile duct stones:A meta-analysis

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World Journal of Gastroenterology 2014年第18期20卷 5548-5556页

作者： Piao-Piao Jin jian-feng cheng Dan Liu Mei Mei Zhao-Qi Xu Lei-Min Sun Department of Gastroenterology Sir Run Run Shaw HospitalSchool of MedicineZhejiang University Internal Medicine Division of GastroenterologyCarolinas Medical CenterCharlotteNC 28203United States Department of Statistics Texas A and M UniversityCollege StationTX 77843United States Doppler Ultrasonic Department The Second Affiliated Hospital of Zhejiang University School of Medicine Fifth People’s Hospital of Yuhang District

AIM: To compare the efficacy and safety of endoscopic papillary large balloon dilation (EPLBD) with endoscopic sphincterotomy (EST) in retrieval of common bile duct stones (≥ 10 mm).

关键词： Endoscopic papillary large balloon dilation Endoscopic sphincterotomy Mechanical lithotripsy Common bile duct stones Meta analysis.

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Induction of Bladder Lesion by Terephthalic Acid and Its Mechanism

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Biomedical and Environmental Sciences 2005年第4期18卷 211-219页

作者： GUI-DONG DAI LUN-BIAO CUI LING SONG REN-ZHEN ZHAO jian-feng cheng MEI-XIA LIU jian-WEI ZHOU HANG XIAO XIN-RU WANG Institute of Toxicology Nanfing Medical University Nanfing 210029 Jiangsu China

To provide more information for rational evaluation of potential risks of terephthalic acid （TPA）, we studied the effects of TPA on rats＇ bladders in 90 days after TPA exposure. Methods Sprague Dawley rats were subdivided into five groups, ingesting 0 %, 0.04 %, 0.2 %, 1%, and 5 % TPA respectively for a sub-chronic feeding study lasting for 90 days. Urine, serum and samples of brain, liver, lung, kidney, bladder, etc. were collected and analyzed. Results TPA ingesting decreased the value of urinary pH, and increased the contents of Ca^2＋, Zn^2＋, Mg^2＋, Na^＋, K^＋ in urine. The volume of 24 h urine was significantly increased in male rats in the 1% and 5 % TPA groups. Urinary white sediment was found in both sexes, and its formation in male rats seemed more susceptible than that in female rats. Alpha 2u-globulin （AUG） in serum and urine of male rats was markedly increased in a dose-dependent manner. Fifteen cases of hyperplasia （simple or atypical） were determined in the 5 % TPA ingesting group, 14/52 in male rats and 1/23 in female rats. Among them 3 male rats had no stone or calculus. Those with either bladder stones or hyperplasia were accompanied with urinary white sediments. Conclusion White sediment accompanied with elevated urine AUG is the basis of TPA induced urolith formation, and is also associated with TPA induced bladder epithelial cell proliferation. It can act as an early biomarker for the potential toxic effect of TPA.

关键词： Terephthalic acid Bladder Uroliths Hyperplasia Sediment Alpha 2μ-globulin

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Incidence,Risk Factors,and Prognosis of Patients with Hepatocellular Carcinoma and Brain Metastases

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Current Medical Science 2024年第1期44卷 180-186页

作者： Jin-cheng feng Ying HE Georgios Polychronidis jian XIN Shen YOU Jun XIONG Department of Liver Transplantation Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Transplant Engineering and Immunology Laboratory of Liver TransplantationFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of General Visceral and Transplant SurgeryUniversity of HeidelbergIm Neuenheimer Feld 110Heidelberg 69120Germany Department of Hepatobiliary and Pancreatic Surgery Fujian Provincial HospitalFuzhou 350001China

Objective Brain metastases significantly impact the clinical course of patients with hepatocellular carcinoma(HCC).This study aimed to examine the age-related incidence,demographics,and survival of patients with HCC and brain *** Data of HCC patients from 2010 to 2015 in the Surveillance,Epidemiology,and End Results(SEER)Registry were screened for the presence of brain *** were stratified by age and *** logistic and Cox regression analyses were used to identify factors associated with brain metastases and those with overall survival(OS)and liver cancer-specific survival(CSS),*** A total of 141 HCC patients presenting with brain metastases were identified,accounting for 0.35% of all HCC patients and 2.37% of patients with metastatic *** all HCC patients,the incidence rate was the highest among patients aged 30-49 years old(0.47%).Ethnicity was not associated with the presence of brain metastases at the time of HCC ***,African-American patients presented with a significantly lower disease-specific survival[median time:1 month;interquartile range(IQR):0-3.0 months].Initial lung or bone metastasis was independently associated with an increased risk of the presence of brain metastases[odds ratio(OR):12.62,95% confidence interval(CI):8.40-18.97]but was not associated with a worse OS or CSS among those with brain *** This study identified the age-related incidence and risk factors of brain metastases in HCC *** results may contribute to the consideration of brain screening among patients with initial metastatic HCC with lung or bone metastases,and influence the counseling of this patient population regarding their prognosis.

关键词： brain metastases hepatocellular carcinoma age-related incidence cancer-specific survival overall survival

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Quantum phase transition of the Jaynes-Cummings model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 1-9页

作者： cheng Liu Jin-feng Huang Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China

Herein,we propose an experimentally feasible scheme to show the quantum phase transition of the Jaynes-Cummings(JC)model by modulating the transition frequency of a two-level system in a quantum Rabi model with strong *** tuning the modulation frequency and amplitude,the ratio of the effective coupling strength of the rotating terms to the effective cavity(atomic transition)frequency can enter the deep-strong coupling regime,while the counter-rotating terms can be ***,a deep-strong JC model is *** ratio of the coupling strength to resonance frequencies in the deep-strong JC model is two orders of magnitude larger than the corresponding ratio in the original quantum Rabi *** scheme can be employed in atom-cavity resonance and off-resonance cases,and it is valid over a broad *** nonzero average cavity photons of the ground state indicate the emergence of a quantum phase ***,we demonstrate the dependence of the phase diagram on the atom-cavity detuning and modulation *** the parameters used in our scheme are within the reach of current experimental *** scheme provides a new mechanism for investigating the critical phenomena of finite-sized systems without requiring classical field limits,thereby opening a door for studying fundamental quantum phenomena occurring in the ultrastrong and even deep-strong coupling regimes.

关键词： Jaynes-Cummings model quantum phase transition frequency modulation

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Substantial increase of heat-induced labor and economic loss in China under rapid economic and environmental temperature growth

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Advances in Climate Change Research 2024年第4期15卷 708-716页

作者： Bo-Wen CHU jian-feng LUO Ke-Xin WANG Zhen-cheng XING Hai-Kun WANG Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjing 210023China Collaborative Innovation Center of Climate Change Jiangsu ProvinceNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China Nanjin-Helski Insiute in Amosperc and Earth System Sciences Nanjing UniversityNanjing 210023China

Exposure to heat stress causes diminished work performance and leads to economic *** the last two decades,China has experienced both rapid economic development and environmental warming;however,the spatiotemporal variations of association between environmental heat and labor loss have been rarely investigated behind this double ***,we evaluated the variation in China's heat-induced labor productivity loss and related economic cost from 2001 to 2019 and investigated the effect of economic development and regional *** found that decline in labor productivity because of heat stress increased significantly(p<0.05 for heavy-intensity work),and the corresponding economic loss also exhibited a drastic increase by 6-to *** relative economic loss showed a slight but nonsignificant increase with an average value of 0.54%of the annual total *** the sub-regional and sectoral level,adverse effects were more prominent in the southeast region,and the secondary industry sectors,such as construction and manufacturing,contributed to larger proportions of economic *** transformation of industrial structure made economic sectors more vulnerable to heat exposure,and increasingly preventive effects of air-conditioning use were noted on economic damage due to heat-induced productivity decline(36.0%relative economic benefits in 2019 compared to 9.7%in 2001).Our findings could provide a deep insight into heat burden on occupational health and heat adaptation strategies regionally under climate change,especially in developing areas with higher temperature and humidity environment.

关键词： Heat stress Labor loss Wet bulb globe temperature China Economic impact

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