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Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media

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Chinese Chemical Letters 2013年第6期24卷 479-482页

作者： Qing Liu Guo-Ping Li dong-jian zhu Lin Xue Hua jiang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

A new fluorescent probe,DQCd2,based on 4-piperidinoquinoline has been synthesized as a fluorescent probe for Cd^2＋.It can ratiometrically respond to Cd^2＋ in PBS buffer by a remarkable emission intensity enhancement... 详细信息

关键词： Ratiometric Probe Fluorescence Cadmium Quinoline

Cascading decomposition of Boolean control networks:a graph-theoretical method

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Frontiers of Information Technology & Electronic Engineering 2020年第2期21卷 304-315页

作者： Yi-feng LI jian-dong zhu Institute of Mathematics School of Mathematical SciencesNanjing Normal UniversityNanjing 210023China

Two types of cascading decomposition problems of Boolean control networks are investigated using a graph-theoretical method.A new graphic concept called nested perfect equal vertex partition(NPEVP)is *** on NPEVP,the necessary and sufficient graphic conditions for solvability of the cascading decomposition problems are *** the proposed graphic conditions,the logical coordinate transformations are constructively obtained to realize the corresponding cascading decomposition ***,two illustrative examples are provided to validate the results.

关键词： Boolean control networks Semi-tensor product Cascading decomposition Graphic condition

Low-temperature synthesis of SiC nanowires with Ni catalyst

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Rare Metals 2019年第3期38卷 206-209页

作者： Wei-Li Xie Xiao-dong Zhang Wen-Hui Liu Qi Xie Guang-Wu Wen Xiao-Xiao Huang jian-dong zhu Fei-Xiang Ma School of Material Science and Engineering Harbin Institute of Technology Department of Prosthodontics School of StomatologyHarbin Medical University School of Material Science and Engineering Harbin Institute of Technology at Weihai

SiC nano wires were fabricated on the silicon substrate dipped with a layer of Ni catalyst at 900 ℃ by gas pressure annealing processing. The morphologies and crystal structures were determined by scanning electron microscopy(SEM), transmission electron microscopy(TEM)and X-ray diffraction(XRD). The results show that the assynthesized nanowires are β-SiC single crystalline with diameter range of 50-100 nm, and length of tens of micron by directly annealing at 900 ℃. The SiC nano wires grow along the [111] direction with highly uniform morphology. And the possible growth mechanism of SiC nano wires is *** present work provides an efficient strategy for the production of high-quality SiC nano wires.

关键词： SiC nanowires Single crystalline silicon Ni catalyst Growth mechanism

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Study on functional connections between supraoptic nucleus and stomach in rats

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Study on functional connections between supraoptic nucleus a...

Donor liver natural killer cells alleviate liver allograft acute rejection in rats

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Chang-Liang LU,Zhao-Ping LI,jian-Ping zhu,dong-Qin ZHAO,Hong-Bin AI~* College of Life Sciences,Shandong Normal University,Jinan,250014

＜正＞Objective:Many evidences support the standpoint that there are functional connections between the hypothalamic paraventricular nucleus（PVN） and the stomach,then what about the supraoptic nucleus（SON） which is similar with the PVN in the localization and the neurons organization is *** question was probed in the present ***:The rats were anesthetized and then divided into four groups randomly. GroupⅠ,the neuronal discharge was recorded extracellularly in the NTS,DMV or SON before and after the cold normal saline（4℃） was perfused into the stomach from esophagus and effused from the duodenum for 5 min. GroupⅡ,the rats were stimulated by cold saline as GroupⅠ,and 60 min later,the Fos expression of the NTS,DMV and SON was examined via immunohistochemistry technique,***Ⅲwas the control to GroupⅡand was not perfused with cold saline（4℃）.GroupⅣ,gastric motility was recorded continuously by inserting a latex balloon into pylorus through the forestomach which connected with pressure *** the amplitude, duration,frequency and motility index of gastric contraction waves within 10 min before and after microinjection of L-Glu into the SON were *** data represent the mean±***:In GroupⅠ,the discharge frequency caused by the gastric lower temperature increased in all the three nuclei,but differed in *** and SON had significant difference（P＜0.05） than before the perfusion of cold saline[e.g.,SON,（6.85±1.71） spikes/s vs （4.5±0.68） spikes/s,n=7],but NTS had no significant *** GroupⅡ,Fos expression in NTS,DMV and SON was respectively greater than that of GroupⅢ（P＜0.05 or＜0.01）（*** SON,the number of Fos-positive neurons is 188.23±16.45 vs 102.82±7.39,n=5）.In GroupⅣ,microinjection of L-Glu（5 nmol/L,n=7） into SON significantly inhibited gastric motility,motility index before injection was 1482.1±708.2 and 1185.5±639.2 after injection （P＜0.05）.Conclusion:These data strongly suggest that there are functional c

关键词： supraoptic nucleus neuronal discharge c-Fos expression gastric motility

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 386-392页

作者： jian-dong Yu,Tian-zhu Long,Guo-Lin Li,Li-Hong Lv,Hao-Ming Lin,Yong-Heng Huang,Ya-Jin Chen and Yun-Le Wan Department of Hepatobiliary Surgery,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China Department of Breast Surgery,Guangzhou Women and Children’s Medical Center,Guangzhou 510120,China Department of Hepatobiliary Surgery Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China Department of Breast Surgery Guangzhou Women and Children's Medical Center Guangzhou 510120 China

BACKGROUND:Liver enriched natural killer (NK) cells are of high immune ***,the function of donor liver NK cells in allogeneic liver transplantation (LTx) remains ***:Ten Gy of whole body gamma-irradiation (WBI) from a 60 Co source at 0.6 Gy/min was used for depleting donorderived leukocytes,and transfusion of purified liver NK cells isolated from the same type rat as donor (donor type liver NK cells,dtl NKs) through portal vein was performed immediately after grafting the irradiated ***-transplant survival observation on recipients and histopathological detection of liver grafts were adoptive to evaluate the biological impact of donor liver NK cells on recipients’ survival in rat ***:Transfusion of dtl NKs did not shorten the survival time among the recipients of spontaneous tolerance model (BN to LEW rat) after rat LTx,but prolonged the liver graft survival among the recipients depleted of donor-derived leukocytes in the acute rejection model (LEW to BN rat).Compared to the recipients in the groups which received the graft depleted of donor-derived leukocytes,better survival and less damage in the allografts were also found among the recipients in the two different strain combinations of liver allograft due to transfusion of dtl ***:Donor liver NK cells alone do not exacerbate liver allograft acute ***,they can alleviate it,and improve the recipients’ survival.

关键词： liver transplantation natural killer cell donor transfusion graft rejection

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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厦门市思明区青少年实践基地方案设计

工程建设与设计 2017年第18期 14-15页

作者：殷建栋朱祯毅杭州中联筑境建筑设计有限公司杭州310000

随着教育改革逐渐深入和素质教育的全面推进,实践教育作为素质教育的一部分,越来越受到人们的关注。青少年实践基地作为实践教育的重要载体,在培养青少年性格、特长和品质等方面都起到了至关重要的作用。近年来,我国此类项目的建设数量... 详细信息

随着教育改革逐渐深入和素质教育的全面推进,实践教育作为素质教育的一部分,越来越受到人们的关注。青少年实践基地作为实践教育的重要载体,在培养青少年性格、特长和品质等方面都起到了至关重要的作用。近年来,我国此类项目的建设数量逐渐增多。然而,由于缺乏深入思考,在青少年实践基地建设过程中也暴露出设计同质化、脱离环境及人文关怀缺失等诸多问题。如何在设计规划中理清思路,解决问题,成为一项意义深远的工作。论文通过厦门市思明区青少年实践基地的设计工作,对此类项目进行了深入的探索。

关键词：地域性自然性多样性活力之环

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway