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Asian Journal of Andrology 2009年第4期11卷 451-459页

作者： Ying Zhou Xiang-Qian Xiao Lin-Feng Chen Rui Yang jian-dang shi Xiao-Ling Du Helmut Klocker Irwin Park Chung Lee Ju Zhang Department of Biochemistry and Molecular Biology College of Life Sciences Bioactive Materials Key Lab of Ministry of Education Nankai University Tianjin 300071 China Department of Medical Oncology Dana Farber Cancer Institute Harvard Medical School Boston MA 02115 USA Department of Urology Innsbruck Medical University Anichstrasse 35 A-6020 Innsbruck Austria The Department of Urology Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

It is known that human benign prostatic hyperplasia might arise from an estrogen/androgen （E/T） imbalance. We studied the response of castrated rat prostate to different ratios of circulating E/T. The castrated male Wistar rats were randomly injected with E/T at different ratios for 4 weeks. The prostates of E/T （1：100） group showed a distinct prostatic hyperplasia response by prostatic index, hematoxylin and eosin staining, and quantitative immunohistochemical analysis of a-smooth muscle actin （SMA）. In this group, cells positive for Vimentin, non-muscle myosin heavy chain （NMMHC） and proliferating cell nuclear antigen （PCNA） increased in the stroma and epithelium. Furthermore, the mRNA levels of smooth muscle myosin heavy chain （SMMHC） and NMMHC increased. So E/T at a ratio of 1：100 can induce a stromal hyperplastic response in the prostate of castrated rats. The main change observed was an increase of smooth muscle cells, whereas some epithelial changes were also seen in the rat prostates.

关键词： androgens castration estrogen prostatic hyperplasia rat stromal cells

Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 735-743页

作者： Rui Yang Yu-Xia Ma Lin-Feng Chen Ying Zhou Zhan-Po Yang Yan Zhu Xiao-Ling Du jian-dang shi Hong-Shun Ma Ju Zhang Bioactive Materials Key Lab of Ministry of Education Department of Biochemistry and Molecular Biology College of Life Sciences Nankai University Tianjin 300071 China Dana Farber Cancer Institute Harvard Medical School Boston MA 02445 USA Department of Urology Tianjin First Central Hospital Tianjin 300192 China Molecular Cardiology Research Institute Tufts Medical Center Tufts University School of Medicine Boston MA 02111 USA

Estrogen has important roles in the initiation and development of benign prostatic hyperplasia （BPH）. Regulators of the estrogen receptor （ER） are tissue- and cell-specific. We evaluated the effect of estrogen antagonist, raloxifene （Ral）, on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines： a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally evaluated its effect on prostatic hyperplasia induced by estrogen and androgen in a rat model. The effect of Ral on the prevention of prostatic hyperplasia was analyzed by haematoxylin and eosin staining and quantitative immunohistochemistry （IHC） for proliferating cell nuclear antigen and α-smooth muscle actin. In vitro and in vivo, tamoxifen （Tam）, another anti-estrogen drug, and finasteride （Fin）, a drug for the clinical treatment of BPH, served as efficacy controls. The in vitro data showed that neither Ral nor Tam alone affected the proliferation of WPMY-1 and BPH-1, but both antagonized the effect of oestradiol in promoting the proliferation of the two cells. Results from the IHC staining of the rat prostates indicated that, similar to Tam and Fin, Ral inhibited the proliferation of stromal cells in vivo. Interestingly, in contrast to Tam, both Ral and Fin inhibited the proliferation of epithelial cells. Furthemore, Ral treatment much strongly decreased the number of prostatic acini and the surrounding layers of smooth muscle cells than Fin （P 〈 0.05）. Our data showed for the first time that Ral may have a role in the response of the rat prostate to selective ER modulators.

关键词： estrogen prostatic hyperplasia raloxifene rats

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li jian-Hong shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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基于热压处理的聚芳醚介电损耗降低

大连理工大学学报 2025年第1期65卷 10-16页

作者：石龙威王锦艳蹇锡高大连理工大学化工学院辽宁大连116024

限制极性分子的运动是降低聚合物介电损耗的有效手段.合成了含杂萘联苯结构的聚芳醚,随后进行热压处理以降低其自由体积,限制分子链段运动,从而降低材料的介电损耗.实验结果表明,系列聚芳醚薄膜在热压处理后的介电损耗明显降低,降低率... 详细信息

限制极性分子的运动是降低聚合物介电损耗的有效手段.合成了含杂萘联苯结构的聚芳醚,随后进行热压处理以降低其自由体积,限制分子链段运动,从而降低材料的介电损耗.实验结果表明,系列聚芳醚薄膜在热压处理后的介电损耗明显降低,降低率最大为10.27%;材料自由体积的降低也使其玻璃化转变温度提高,提高率最大为13.0%.采用XRD测试并计算材料的分子链间距以反映材料自由体积的变化,应用Materials Studio软件模拟聚芳醚于热压前后的自由体积分数的变化,二者均与材料的介电损耗、玻璃化转变温度变化规律相符,证明通过热压处理降低材料自由体积以提升其性能是一种可行手段.

关键词：聚芳醚介电损耗热压分子模拟

Joint Beamforming for Intelligent Reflecting Surface Aided Wireless Communication Using Statistical CSI

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China Communications 2020年第8期17卷 147-157页

作者： jian dang Zaichen Zhang Liang Wu National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China Purple Mountain Laboratories Nanjing 211111China

A joint beamforming algorithm is proposed for intelligent reflecting surface(IRS) aided wireless multiple-input multiple-output(MIMO) communication using statistical channel state information(CSI). The beamforming is done by alternatively optimizing the IRS reflecting coefficients and the covariance matrix of the transmit symbol vector, such that the ergodic rate of the system is maximized. The algorithm utilizes only the second order momentum of the random channel matrices and does assume any specific channel distribution, leading to a general framework for ergodic rate evaluation. A practical channel correlation model is configured to validate the performance gain. It is found that the rate can be enlarged by the joint optimization algorithm, however, the gain over that of randomly deployed reflecting coefficients depends highly on the relative correlation distance of the IRS elements and the spatial position of the IRS. In particular, the results suggest that IRS should be placed in the vicinity of either the transmitter or the receiver. Placing IRS far away from those positions is non-beneficial.

关键词： MIMO beamforming statistical CSI intelligent reflecting surface(IRS) ergodic rate

Detection of 16 Small Glitches in Nine Pulsars

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Research in Astronomy and Astrophysics 2022年第9期22卷 88-97页

作者： Zu-Rong Zhou Jing-Bo Wang Na Wang jian-Ping Yuan Fei-Fei Kou shi-Jun dang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Radio Astrophysics Urumgi 830ollChina Key Lab of Radio Astronomy Chinese Academy of SciencesBeijing l0010lChina School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China

Pulsar timing measurements with a 26 m radio telescope at Nanshan between 2000 and 2014 were used to search for glitch events. The data span of nine pulsars ranges from 11.6 to 14.2 yr, and 16 new glitch events were identified in nine pulsars. Glitch parameters were determined through fitting the timing residuals data. All 16 glitches have a small fractional size. Six new glitches have been detected in PSR J1833-0827, making it another frequent glitching pulsar. Some of the 16 glitches may experience exponential or linear recovery, but it is unlikely for us to make further analyses with the large gap in the data set. All the glitch rates obtained from Nanshan are higher than that from Jodrell Bank Observatory. The small glitch size and high glitch rate could possibly attribute to the high observation cadence.

关键词： stars:neutron methods:data analysis (stars:)pulsars:general

Upper bounds on the capacity for optical intensity channels with AWGN

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Science China(Information Sciences) 2017年第2期60卷 165-176页

作者： Yingying YU Zaichen ZHANG Liang WU jian dang National Mobile Communications Research Laboratory Southeast University

The channel capacity of the optical wireless communication(OWC) systems is still a problem that has not an optimal and close-form expression, in spite of OWC can be used to achieve high data rates. This paper presents novel upper bounds on the channel capacity of an optical intensity modulated and directed detection(IM/DD) system under peak-power and average-power constraints. The channel is modeled as an additive white Gaussian noise(AWGN) optical channel. The bounds are derived based on sphere-based signal space argument. Simulation results show the proposed bounds are tight at both high and low signal-to-noise ratios(SNRs). Compared to those reported bounds, the derived bounds are better at high SNRs region in particular, and the expressions are simpler and unique for the whole range of average-to-peak-power ratio.

关键词： channel capacity optical communication AWGN sphere-based signal space high signal-to-noise ratios(SNRs)

Polymer nanoparticles with dendrimer-Ag shell and its application in catalysis

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Particuology 2013年第3期11卷 346-352页

作者： Gaofei dang Yan shi Zhifeng Fu Wantai Yang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

Polymer nanoparticles with dendrimer-Ag shell were prepared and their application in catalytic reduction of 4-nitrophenol （4-NP） was investigated. Cross-linked polystyrene （PS） microspheres were prepared through dispersion copolymerization of styrene, acrylic acid and crosslinking monomer 1, 2- divinylbenzene. PS microspheres with average size of 450 nm and narrow size distribution were used as support for the immobilization of dendrimer-Ag shell, The polyamidoamine （PAMAM） dendrimer shell was successively grafted onto the surface ofPS microspheres through repetitive Michael addition reaction of methyl acrylate （MA） and amidation of the obtained esters with large excess of ethylenediamine （EDA）. Silver nanoparticles were formed directly inside the PAMAM shell through reduction with NaBH4. The resulting PS@PAMAM-Ag nanopartides were packed in a stainless steel column and used successfully for catalytic reduction of 4-NP. This technique for packing catalytic polymer particles in a column could imnrove the efficiency of using the metal catalyst and the tedious seuaration in catalytic reaction.

关键词： Polymer nanoparticles Polyamidoamine dendrimer Dendrimer-metal Catalytic column Silver nanocatalyst

An effective and green H2O2/H2O/O3 oxidation method for carbon nanotube to reinforce epoxy resin

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Journal of Materials Science & Technology 2020年第5期40卷 24-30页

作者： Qi Wang Wen shi Bo Zhu dang Sheng Su School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Shenyang National Laboratory for Materials Science Shenyang 110016China jiangsu Gunuo New Materials Technology Go. Ltd.Yancheng 224051China

Facile green oxidation methods are always desired to functionalize carbon nanotubes(CNTs)in the production of advanced CNT/epoxy *** the present work,an optimized H2O2/H2O/O3 oxidation method was developed,and performances of the H2O2/H2O/O3 oxidized CNT in epoxy matrix were tested and compared with that of the H2O/O3 oxidized CNT and the most commonly used concentrated HNO3 oxidized *** physical and chemical characteristics of the obtained oxidized CNTs were systematically characterized via transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS)and *** performances of the obtained composites were explored by tensile tests,impact tests,dynamic mechanical analysis(DMA)and fracture toughness *** was found that the H2O2/H2O/O3 oxidized CNT exhibited all-around overwhelming advantages over the concentrated HNO3 oxidized CNT on reinforcing the epoxy matrix,while the H2O/O3 oxidized CNT only improved the material *** mechanisms for the different methods oxidized CNTs were studied and *** optimized H2O2/H2O/O3 oxidation method makes scaled production possible,avoids environment pollutions,and holds great potentials to replace the most commonly used concentrated HNO3 oxidation method to oxidize CNT during the preparation of the advanced CNT/epoxy composite.

关键词： Green oxidation method Carbon nanotube Epoxy composite Mechanical properties Interfacial interaction