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基于临床药师动态监测的药物超常预警临床实践

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药物流行病学杂志 2023年第11期32卷 1225-1230页

作者：郑婷婷李锦毛璐陈宁张威甄健存首都医科大学附属北京积水潭医院药学部北京100035

介绍临床药师在动态监测和超常预警中承担的工作,包括医嘱审核、药物重整、用量分析及异常增长监控、科室指标的解读及实施、持续监测、超常预警的后续跟进与反馈等工作,通过比较2020—2022年我院销售金额排名前20位药品类别变化、重点... 详细信息

介绍临床药师在动态监测和超常预警中承担的工作,包括医嘱审核、药物重整、用量分析及异常增长监控、科室指标的解读及实施、持续监测、超常预警的后续跟进与反馈等工作,通过比较2020—2022年我院销售金额排名前20位药品类别变化、重点监控药品用药金额变化、次均药费和例均药费增幅变化,评估临床药师在此管理中发挥的作用。结果显示,2020—2022年我院销售金额排名前20位药品类别组成更加合理;重点监控药品用药金额、门急诊次均药品费用和住院例均药品费用呈现逐年递减趋势,2022年重点监控药品用药金额较2021年降低10.07%;门急诊次均药品费用较2021年下降了7.20%;住院例均药品费用较2021年下降了17.70%。由此可以看出临床药师在药品动态监测和超常预警中发挥了重要作用,有效控制了医院用药成本,促进了临床合理用药。

关键词：合理用药超常预警动态监测临床药师

恩沙替尼、安罗替尼、培美曲塞、唑来膦酸联用致重度贫血1例

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药物流行病学杂志 2023年第9期32卷 1071-1075页

作者：郑婷婷王晓芳徐钰张威甄健存首都医科大学附属北京积水潭医院药剂科北京100035 首都医科大学附属北京积水潭医院呼吸与危重症医学科北京100035

1例42岁男性Ⅳ期右肺腺癌患者,病史9年,既往曾予多种化疗和靶向药物,因疾病进展,靶向治疗调整为盐酸恩沙替尼胶囊,联合安罗替尼、培美曲塞二钠和唑来膦酸抗肿瘤治疗。患者连续服用恩沙替尼胶囊82 d后,无明显诱因突发乏力,血红蛋白从用... 详细信息

1例42岁男性Ⅳ期右肺腺癌患者,病史9年,既往曾予多种化疗和靶向药物,因疾病进展,靶向治疗调整为盐酸恩沙替尼胶囊,联合安罗替尼、培美曲塞二钠和唑来膦酸抗肿瘤治疗。患者连续服用恩沙替尼胶囊82 d后,无明显诱因突发乏力,血红蛋白从用药前的132 g·L^(-1)降至59 g·L^(-1),确诊为重度贫血,考虑与恩沙替尼、安罗替尼、培美曲塞以及唑来膦酸相关,不良反应关联性评价为“可能”。经停药、对症支持治疗后,入院第6天血红蛋白恢复至97 g·L^(-1)。恩沙替尼在我国上市时间较短,出现重度贫血的相关报道较少。该病例提示临床治疗中应重点关注使用经验较为有限的药物,及时发现其少见的不良反应。

关键词：恩沙替尼安罗替尼培美曲塞唑来膦酸重度贫血药品不良反应

Chinese Cyber Threat Intelligence Named Entity Recognition via RoBERTa-wwm-RDCNN-CRF

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Computers, Materials & Continua 2023年第10期77卷 299-323页

作者： zhen zhen jian Gao School of Information Network Security People’s Public Security University of ChinaBeijing100038China Key Laboratory of Safety Precautions and Risk Assessment Ministry of Public SecurityBeijing102623China

In recent years,cyber attacks have been intensifying and causing great harm to individuals,companies,and *** mining of cyber threat intelligence(CTI)can facilitate intelligence integration and serve well in combating cyber *** Entity Recognition(NER),as a crucial component of text mining,can structure complex CTI text and aid cybersecurity professionals in effectively countering ***,current CTI NER research has mainly focused on studying English *** the limited studies conducted on Chinese text,existing models have shown poor *** fully utilize the power of Chinese pre-trained language models(PLMs)and conquer the problem of lengthy infrequent English words mixing in the Chinese CTIs,we propose a residual dilated convolutional neural network(RDCNN)with a conditional random field(CRF)based on a robustly optimized bidirectional encoder representation from transformers pre-training approach with whole word masking(RoBERTa-wwm),abbreviated as *** are the first to experiment on the relevant open source dataset and achieve an F1-score of 82.35%,which exceeds the common baseline model bidirectional encoder representation from transformers(BERT)-bidirectional long short-term memory(BiLSTM)-CRF in this field by about 19.52%and exceeds the current state-of-the-art model,BERT-RDCNN-CRF,by about 3.53%.In addition,we conducted an ablation study on the encoder part of the model to verify the effectiveness of the proposed model and an in-depth investigation of the PLMs and encoder part of the model to verify the effectiveness of the proposed *** RoBERTa-wwm-RDCNN-CRF model,the shared pre-processing,and augmentation methods can serve the subsequent fundamental tasks such as cybersecurity information extraction and knowledge graph construction,contributing to important applications in downstream tasks such as intrusion detection and advanced persistent threat(APT)attack detection.

关键词： Cybersecurity cyber threat intelligence named entity recognition

Verification of a Similar Cycle Prediction for the Ascending and Peak Phases of Solar Cycle 23

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Chinese Journal of Astronomy and Astrophysics 2002年第5期2卷 396-398页

作者： Jia-Long Wang jian-cun Gong 等 NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 CenterforSpaceScienceandAppliedResearch ChineseAcademyofSciencesBeijing100080

Reviews of long-term predictions of solar cycles have shown that a precise prediction with a lead time of 2 years or more of a solar cycle remains an unsolved problem. We used a simple method, the method of similar cycles, to make long-term predictions of not only the maximum amplitude but also the smoothed monthly mean sunspot number for every month of Solar Cycle 23. We verify and compare our prediction with the latest available observational results.

关键词： Sun: sunspots - solar-terrestrial relations

Analysis of Sheet Metal Extrusion Process Using Finite Element Method

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International Journal of Automation and computing 2010年第3期7卷 295-302页

作者： Xin-cun Zhuang Hua Xiang zhen Zhao Department of Plasticity Technology Shanghai Jiao Tong University Shanghai 200030 PRC

Sheet bulk metal forming processes have been widely developed to the facilitate manufacture of complicated 3D parts. However, there is still not enough know-how available. In this paper, as one of the typical sheet bulk metal forming processes, the sheet metal extrusion process was studied. A reasonable finite element method （FEM） model of sheet metal extrusion process taking the influence of flow-stress curve with wide range of plastic strain and ductile damage into consideration was established and simulated by an arbitrary Lagrangian-Eulerian （ALE） FEM implemented in ***. Validated by comparing the results with experiment, some phenomenological characteristics, such as metal flow behavior, shrinkage cavity, and the influence of different combinations of diameter of punch, diameter of extrusion outlet, and diameter of pre-punched hole were analyzed and concluded, which can be used as theoretical fundamental for the design of the sheet metal extrusion process.

关键词： Sheet bulk metal forming extrusion ductile damage arbitrary Lagrangian-Eulerian (ALE) metal flow behavior.

Reduction of die roll height in duplex gears through a sheet-bulk metal forming method

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Advances in Manufacturing 2019年第1期7卷 42-51页

作者： Xiao-Long Sun Xin-cun Zhuang Feng-Chun Yang zhen Zhao Institute of Forming Technology and Equipment School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200030 People's Republic of China National Engineering Research Center of Die & Mold CAD Shanghai Jiao Tong University Shanghai 200030 People's Republic of China

In the existing shearing processes for fabricating parts such as duplex gears, die roll is difficult to avoid. Accordingly, a method based on sheet-bulk metal forming for fabricating a duplex gear with extremely small die roll in one stroke is proposed in the current work. The process could be divided into three stages according to the forming features: upsetting and shearing stage, lateral extrusion stage, and local filling stage. The die roll appeared in the shearing stage, which could be reduced in the subsequent extrusion and local filling stages. To reveal the underground mechanism, material flows under two situations, as a key factor to influence the forming quality, were compared and investigated. The results revealed that by controlling material flow, one could avoid the defects and reduce the die roll.

关键词： Die roll Duplex gear part Sheet-bulk metal forming Lateral extrusion Material flow

Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4092-4103页

作者： Zhuo-Ran Wang cun-zhen Zhang Zhan Ding Yi-Zhuo Li jian-Hua Yin Nan Li Department of Hepatic Surgery I(Ward I)Shanghai Eastern Hepatobiliary Surgery Hospital Navy Medical UniversityShanghai 200433China Key Laboratory of Biological Defense Ministry of EducationNavy Medical UniversityShanghai 200433China Shanghai Key Laboratory of Medical Bioprotection Navy Medical UniversityShanghai 200433China Department of Epidemiology Faculty of Navy MedicineNavy Medical UniversityShanghai 200433China Department of Oncology 905 Hospital of People’s Liberation Army NavyShanghai 200050China Department of Hepatobiliary Surgery The Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ***-associated immune cells are critical for tumor development and *** main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for *** To establish 1-year and 3-year prognostic models for ICC after surgical *** Immunohistochemical staining was performed for CD4,CD8,CD20,pan-cytokeratin(CK),and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative *** of variables was based on regression diagnostic procedures and goodness-of-fit tests(PH assumption).Clinical parameters and pathological diagnoses,combined with the distribution of immune cells in tumors and paired adjacent tissues,were utilized to establish 1-and 3-year prognostic *** This is an important application of immune cells in the tumor ***4,CD8,CD20,and CK were included in the establishment of our prognostic model by stepwise selection,whereas CD68 was not significantly associated with the prognosis of *** integrating clinical data associated with ICC,distinct prognostic models were derived for 1-and 3-year survival outcomes using variable *** 1-year prediction model yielded a C-index of 0.7695%confidence interval(95%CI):0.65-0.87 and the 3-year prediction model produced a C-index of 0.69(95%CI:0.65-0.73).Internal validation yielded a C-index of 0.761(95%CI:0.669-0.853)for the 1-year model and 0.693(95%CI:0.642-0.744)for the 3-year *** We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection,which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment an

关键词： Intrahepatic cholangiocarcinoma Tumor immune cells Biomarkers Prognosis Prediction models

Time-domain training sequences design for MIMO OFDM channel estimation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第4期9卷 464-469页

作者： zhen LU jian-hua GE Department of Electronic Engineering Shanghai Jiao Tong Universiry Shanghai 200240 China Department of Communications Engineering Xidian University Xi＇an 710071 China

This paper describes a Least Squares (LS) channel estimation scheme for MIMO OFDM systems based on time-domain training sequence. We first compute the minimum mean square error (MSE) of the LS channel estimation, and then derive the optimal criteria of the training sequence with respect to the minimum MSE. It is shown that optimal time-domain training sequence should satisfy two criteria. First, the autocorrelation of the sequence transmitted from the same antenna is an impulse function in a region longer than the channel maximum delay. Second, the cross-correlation between sequences transmitted from different antennas is zero in this region. Simulation results show that the estimator using optimal time-domain training sequences has better performance than that using optimal frequency training sequence at low signal-to-noise ratio (SNR). To reduce the training overhead, a suboptimal training sequence is also proposed. Comparing with optimal training sequence, it has low computation complexity and high transmission efficiency at the expense of little performance degradation.

关键词： MIMO OFDM Channel estimation Time-domain training sequence

Rapid growth of ZnO hexagonal tubes by direct microwave heating

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International Journal of Minerals,Metallurgy and Materials 2010年第1期17卷 80-85页

作者： zhen-qi Zhu jian Zhou School of Materials Science and Technology Wuhan University of Technology Wuhan 430070 China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

Zinc oxide hexagonal tubular crystals were synthesized by direct microwave heating from ZnO powders within 5 min without any metal catalysts or transport agents. ZnO source materials were evaporated from the high-temperature zone in an enclosure, and crystals were grown on the self-source substrate in an appropriate condition. The ZnO vapor formed in the high-temperature zone can deposit and grow on the powders located in the low-temperature zone to form crystals. The scanning electron microscopy （SEM） reveals that these products are hexagonal tube crystals with 80 ~rn in diameter and 250 μm in length, having a well faceted end and side surface. A possible growth mechanism and the influence of reaction temperature on the formation of crystalline ZnO hexagonal tubes were presented. The photoluminescence （PL） exhibits strong ultraviolet emission at room temperature, indicating the potential applications in short-wave light-emitting photonic devices.

关键词： ZnO crystal microwave heating vapor growth photoluminescence (PL)