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Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports

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World Journal of Clinical Cases 2024年第22期12卷 5208-5216页

作者： Qing-Mei Deng jian Zhang Yi-Yong Zhang Min Jia Du-Shan Ding Yu-Qin Fang Hong-Zhi wang Hong-cang Gu Science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230031Anhui ProvinceChina Institute of Health and Medical Technology Hefei Institutes of Physical ScienceChinese Academy of ScienceHefei 230031Anhui ProvinceChina Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefei 230031Anhui ProvinceChina

BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly *** culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only ***-generation nanopore sequencing technology provides new options for identifying *** SUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and *** sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural *** sodium sulbactam treatment was *** 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung *** treatment for Streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was *** 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six *** antibacterial treatment,her symptoms *** nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus *** patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with *** Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases.

关键词： Nanopore sequencing technology Third-generation sequencing technology Infection Pathogen Case report

滋阴凉血散瘀汤和激光联合疗法对糖尿病视网膜病变的长期纵向疗效研究

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国际眼科杂志 2009年第10期9卷 1904-1906页

作者：赵宁邸平会孙瑞雪王建仓中国医科大学附属第一医院眼科中国辽宁省沈阳市110001 中国河北省石家庄市第一医院眼科 050017

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后不同时间点的视力、视野及新生血管的变... 详细信息

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后不同时间点的视力、视野及新生血管的变化情况。结果:口服滋阴凉血散瘀汤联合光凝治疗组患者12mo时视力提高(62.3%vs56.9%,P=0.037)、视野改变(17.0±3.7vs14.9±3.7,P=0.002)及新生血管退缩情况(67.2%vs48.3%,P=0.036)均优于对照组患者。结论:滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变较单纯激光治疗更有效。

关键词：激光光凝滋阴凉血散瘀汤糖尿病视网膜病变

降雨对滑坡的激发作用实验研究——以蒋家沟流域滑坡堆积坡地为例

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水土保持学报 2001年第5期15卷 116-118,132页

作者：胡明鉴张平仓汪稔中国科学院武汉岩土力学研究所湖北武汉430071

蒋家沟部分滑坡是在老滑坡的基础上 ,经过后期条件改变如坡脚流水切割、降雨入渗激发而再次发生规模不等和形式不一的滑动。选择蒋家沟流域这一相对稳定的老滑坡体 ,通过人工降雨激发促使其二次滑动 ,观测滑坡滑移过程 ,分析描述实验过... 详细信息

蒋家沟部分滑坡是在老滑坡的基础上 ,经过后期条件改变如坡脚流水切割、降雨入渗激发而再次发生规模不等和形式不一的滑动。选择蒋家沟流域这一相对稳定的老滑坡体 ,通过人工降雨激发促使其二次滑动 ,观测滑坡滑移过程 ,分析描述实验过程中坡面出现的各种滑、溜、崩等现象 ,并进行部分有关的土力学实验。

关键词：老滑坡人工降雨激发

Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao wang Yunpeng Yang Jie Huang Jifeng Feng Wu Zhuang jianhua Chen Jun Zhao Wei Zhong Yanqiu Zhao Yiping Zhang Yong Song Yi Hu Zhuang Yu Youling Gong Yuan Chen Feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi Zhou Kewei Ma jian Fang Weineng Feng Yunpeng Liu Zhendong Zheng Gaofeng Li Huijie wang Shundong cang Ning Wu Wei Song Xiaoqing Liu Shijun Zhao Lieming Ding Giovanni Selvaggi Yang wang Shanshan Xiao Qian wang Zhilin Shen jianya Zhou jianying Zhou Li Zhang Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China Department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China Department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory Department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China Department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

渭河泥沙对水资源利用的影响——以宝鸡峡灌区为例

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水土保持学报 2001年第3期15卷 89-92页

作者：马斌解建仓汪妮李占斌马林阳西安理工大学陕西西安710048

根据渭河的水沙特点 ,通过对这条高含沙河流的多因素分析计算 ,说明了河流含沙量对宝鸡峡灌区水资源利用所产生的影响 ,这些结果为进一步有效利用和管理高含沙河流的水资源提供了参考依据。

关键词：宝鸡峡灌区沙限调节计算模型水资源利用渭河泥沙

Nucleation mechanisms of dynamic recrystallization for G3 alloy during hot compression

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Rare Metals 2016年第7期35卷 543-550页

作者： Jue wang jian-Xin Dong Mai-cang Zhang jiangsu Key Laboratory of Advanced Structural Materials andApplication Technology Nanjing 211167China School of Materials Science and Engineering Nanjing Instituteof TechnologyNanjing 211167China School of Materials Science and Engineering University ofScience and Technology BeijingBeijing 100083China

Dynamic recrystallization （DRX） mechanisms of a nickel-based corrosion-resistant alloy, G3, were investigated by hot compression tests with temperatures from 1050 to 1200 ℃ and strain rates from 0.1 to 5.0 s-1. Deformation microstructure was observed at the strain from 0.05 to 0.75 by electron backscatter diffraction （EBSD） and transmission electron microscope （TEM）. Work hardening rate curves were calculated to analyze the effect of deformation parameters on the nucleation process. Results indicate that strain-induced grain boundary migration is the principal mechanism of DRX. Large annealing twins promote nucleation by accumulating dis- locations and fragmenting into cell blocks. Continuous dynamic recrystallization is also detected to be an effective supplement mechanism, especially at low temperature and high strain rate.

关键词： G3 alloy Dynamic recrystallization Nucleation mechanism Annealing twins

视网膜光凝术联合中药治疗糖尿病性视网膜病变(英文)

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国际眼科杂志 2011年第4期11卷 577-580页

作者：赵宁万超邸平会孙瑞雪王建仓 Tristan Bice 徐俊杰中国医科大学附属第一医院眼科中国辽宁省沈阳市110001 石家庄市第一医院中国河北省石家庄市050017 中国医科大学附属第一医院艾滋病实验室中国辽宁省沈阳市110001

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变... 详细信息

目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变化情况。结果:口服滋阴凉血散瘀汤联合光凝治疗组患者12mo时视力提高(62.3%vs43.1%,P=0.037),视野改变(17.0±3.7vs14.9±3.7,P=0.002)及新生血管退缩情况(67.2%vs48.3%,P=0.036)均优于对照组患者。结论:滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变较单纯激光治疗更有效。

关键词：激光光凝滋阴凉血散瘀汤糖尿病性视网膜病变

Plant Growth,Yield Components,Economic Responses,and Soil Indigenous K Uptake of Two Cotton Genotypes with Different K-Efficiencies

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Agricultural Sciences in China 2011年第5期10卷 705-713页

作者： jianG Cun-cang XIA Ying CHEN Fang LU jian-wei wang Yun-hua College of Resources and Environment Huazhong Agricultural University Wuhan 430070 P.R.China Wuhan Botanical Garden Chinese Academy of Sciences Wuhan 430074 P.R.China

HG103,a high K-efficiency cotton cultivar with high-yield potential,and LG122,a low K-efficiency cotton cultivar with low-yield potential were used to study the genotypic variation on yield,economic responses,and soil indigenous K exploitation for cotton in pot and field conditions in 2006 and *** indicated that both the cultivars differed significantly in the rate of translocation of dry matter into reproductive organs and the time of running into reproductive *** yield and economic parameters of HG103 were much better than *** content in cotton shells reached the highest level at maturity stage for both *** also showed that the K content in each plant part of HG103 was lower than that of *** two genotypes showed different efficiencies and abilities on absorbing soil rapidly available K and slowly available ***122 showed higher absorption of K rate than HG103 after K fertilization,but on the contrary,HG103 uptake more soil indigenous K than LG122 in no K fertilization *** result indicated that HG103 could tolerant and absorb more soil indigenous K than LG122,under condition of soil K ***122 could grow well and absorb more K nutrient when soil K supply is *** results demonstrated that higher K content in plant tissues and higher K uptake by plant may not an exclusive condition for high yield planting with K *** translocation of more dry matters into reproductive organs is one of the key mechanisms of high K use efficiency in cotton.

关键词： cotton (Gossypium hirsutum L.) dry matter partitioning K depletion indigenous K uptake economic parameter

Resonance and Rectification in a Two-Dimensional Frenkel-Kontorova Model with Triangular Symmetry

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Chinese Physics Letters 2011年第3期28卷 31-34页

作者： YANG Yang wang cang-Long DUAN Wen-Shan CHEN jian-Min College of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000

The mode-locking phenomena in the dc-and ac-driven overdamped two-dimensional Frenkel-Kontorowa modelwith triangular symmetric structures are studied.'The obtained results show that the transvarse velocity(μz)increasas in a series of quantized steps nyua(n=0,1,2,3…).Moreover,the positive or negative rectification oflongitudinal velocity(μy)can occur when n is an odd *** is also found in our simulations that the criticaldepinning force ascillates with the amplitude of ac-driven force,i.e.,the systemn is dominated by the *** oscillatory behavior is strongly determined by the initial phase of ac force.

关键词： force number steps