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Scaphoid metastasis as the first sign of occult gastroesophageal junction cancer:A case report

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World Journal of Clinical Cases 2020年第7期8卷 1287-1294页

作者： Yu-Jie Zhang Yan-Yan Wang Qi Yang jian-bing li Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Oncology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Metastatic tumors of the hand are very *** are usually late manifestations of massive advanced ***,a small portion of acrometastases are indications of occult primary ***,we report an extremely rare case in which a scaphoid bone lesion was the initial manifestation and was found to be a metastasis from gastroesophageal junction(GEJ)*** SUMMARY A 57-year-old male patient presented with ongoing left wrist pain and swelling after *** was initially misdiagnosed with infection of the scaphoid bone and treated with antibiotics and anti-inflammatory *** radiographic investigations showed a scaphoid pathological fracture,indicating a metastatic tumor derived from the GEJ and/or right lung *** failed to identify the pathology of the mass at the GEJ,which grew in an exophytic pattern.A lung puncture biopsy was not performed because the patient refused the *** relieve his wrist pain and obtain a definite pathology,we resected the scaphoid *** on the clinical and pathological results,the patient was finally diagnosed with multiple metastases of advanced GEJ *** underwent chemotherapy and died 6 mo after his initial *** Despite the rareness of the disease,orthopedic surgeons should consider the possibility of metastasis to the bones of the hand when patients complain of persistent and progressive pain in the hand.

关键词： Hand metastasis Scaphoid Gastroesophageal junction cancer Diagnosis Case report

Accuracy of eight intraocular lens power calculation formulas for segmented multifocal intraocular lens

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1378-1384页

作者： Jing Zhao liang-Ping liu Huan-Huan Cheng jian-bing li Xiao-Tong Han Yu liu Ming-Xing Wu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the accuracy of eight different intraocular lens(IOL)power calculation formulas for a segmented multifocal ***:A total of 53 eyes of 41 adult cataract patients who underwent phacoemulsification and implantation with the SBL-3 segmented multifocal IOL between January 1,2017 and January 31,2019 were included in this retrospective *** biometry measurements were obtained using an IOL *** refraction was performed at least 4 wk *** of the eight formulas[Barrett Universal II,Emmetropia Verifying Optical(EVO),Haigis,Hill-RBF 2.0,Hoffer Q,Holladay 1,Kane,and SRK/T]was ***:Using current lens constants,all formulas exhibited errors of slight myopic shift in refractive *** Barrett Universal II formula had a significantly lower median absolute error(MedAE)than did Holladay 1(P=0.02),Kane(P=0.001)and Hill-RBF 2.0(P<0.001)*** Haigis formula had a lower MedAE value than did the Hill-RBF 2.0 formula(P=0.005).Differences in MedAE values among SRK/T,EVO and Hoffer Q formulas were not *** optimizing lens constants,the MedAE values of all formulas were reduced;significant changes were noted for EVO(P=0.022),Haigis(P=0.048);Hill-RBF 2.0(P=0.014),Holladay 1(P=0.045)and Kane(P=0.022)*** formulas performed equally well after optimization of lens constants(P=0.203).CONCLUSION:All eight formulas tend to result in a myopic shift when using current lens *** lens constants improve the accuracy of these formulas among adult Chinese patients.

关键词： accuracy intraocular lens formulas lens constants segmented multifocal intraocular lens

Vitreoretinal surgeons'experience and time interval from pars-plana vitrectomy to cataract extraction

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 120-126页

作者： Yan-Xin Xu liang-Ping liu jian-bing li Huan-Huan Cheng Min Hou lin Lu Ming-Xing Wu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To identify the association of the vitreoretinal surgeons'experience with the time interval between parsplana vitrectomy(PPV)and cataract extraction(CE).METHODS:Eyes with prior PPV and following CE were included in this retrospective cohort *** years of practice and the annual case volume were used to describe the surgeons'*** linear regression analysis was used to investigate the relationship between surgeons'experience and the time interval adjusted for the patients age,gender,intraocular tamponade,and case ***:Of 132430 eyes,1445 eyes were included in this *** multivariable linear regression analysis,cases performed by surgeons with>20 practice years had longer time intervals compared with surgeons withlicated surgery,the higherpractice-year surgeons had longer time interval than lowerpractice-year ***:The time intervals from PPV to CE is longer in higher-practice-year *** surgeons'practice years may have a greater effect on the time interval than annual case volume in high-complexity *** the complexity of vitreoretinal diseases with the surgeons'practice year should be considered.

关键词： pars-plana vitrectomy cataract time interval experience annual case volume

Security of a Novel Antitapeworm Drug:Arecoline Hydrobromide

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Animal Husbandry and Feed Science 2010年第2期2卷 26-28,31页

作者： ZHOU Xu-zheng ZHANG Ji-yu li Jin-shan li jian-yong WEI Xiao-juan NIU jian-rong li bing Key Laboratory of New Animal Medicine Project Lanzhou Institute of Animal Husbandry and Veterinary Medicine Chinese Academy of Agricul-tural Sciences Lanzhou 730050 China

[Objective] To make an objective evaluation about security of a new veterinary drug-arecoline hydrobromide according to the research results and papers in recent years and supply science basis for clinical usage. [ Method] The security of arecoline hydrobromide was evaluated based on acute toxicity tests; the ranges of safe medication, tolerability and toxicity as well as ＂Three-induced＇ effects （carcinogensis, mutagene- sis and teratogenesis） and reproductive toxicity were summarized according to the combinations of experimental results, papers and clinical effects. E Result] The results of acute toxicity tests in mice and rats showed that LD^0 （50% lethal dosages） of arecoline hydrobromide in mice was 691.83 mg/（***） and 95% incredible range of its LDso was 642.92 -744.47 mg/（ kg. BW）, and LDso of arecoline hydrobromide in rats was 2 054 mg/（***） and 95% incredible range of its LDso was 1 908 -2 210 mg/（***）. Its LDso value was hundreds times higher than the recommen- ded clinical dosage [ 1 -5 mg/（kg-BW） ], therefore it is safe to apply in clinic. The research results of ranges of safe medication, tolerability and toxicity showed that arecoline hydrobromide could entirely dispel the dog Diphyllobothrium, Spirometra mansoni, Dipylidium mesocestoides, linea- tus and Cysticercus at dosages of 2 -3 mg/（ ***）, and the same effects to Railletina tapeworm of chickens and Drepanidotaenia lanceolata of duck and goose at dosages of I -2 mg/（***）. The arecoline hydrobromide had muscarinic effects as side-effects and could cause vomiting, di- arrhea and other clinical symptoms to discharge the paralyzed worm from livestock body rapidly and completely. The arecoline hydrobromide had ＂Three-induced＂ effects and reproductive toxicity when it was used as antitapeworm drug with long-term, sustained and a large number of drug us- age, rather than used in clinical application with shorter time and lower dosage of administration. [ Conclusion] The arecoline hydrobromide is

关键词： Arecoline hydrobromide Acute toxicity "Three-induced" effects Reproductive toxicity

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin li jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En Zhou Yilin li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion batteries(liBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(liBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Effects of Arecoline Hydrobromide on Taeniasis and Cysticercosis in Domestic Animals

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Animal Husbandry and Feed Science 2010年第6期2卷 30-32,35页

作者： ZHOU Xu-zheng ZHANG Ji-yu li jianoyong li Jin-shan WEI Xiao-juan NIU jian-rong li bing Key Laboratory of New Animal Medicine Project Lanzhou Institute of Animal Husbandry and Veterinary Medicine Chinese Academy of Agricultural Sciences Lanzhou 730050 China

Taeniasis and cysticercosis in domestic animals belong to zoonosis and seriously threaten the public health security. Especially the cysticercosis and echinococcosis caused by the tapeworm eggs have great harms to bodies because they can attack many organs of body. According to the combination of experimental results and literature materials, the morphology and transmission mode of taenia and cysticercus, the prevalence status and monitoring of taeniasis and cysticercosis as well as the antitapeworm mechanism, comparative analysis to other drugs, expelling tapeworm tests in vitro, dose determining tests and usage notes of arecoline hydrobromide were expounded in detail. It provides a theoretical basis for prevention of taeniasis and cysticarcosis and more scientific usage of arecoline hydrobromide and thus relieves the harms of taeniasis and cysticercosis and ensuring the public health security.

关键词： Taeniasis Cysticercosis Arecoline hydrobromide

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li Jun WANG Xianhui CAO Laifu GONG jian li Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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中国马克思实践本体论研究的进程

理论探讨 2017年第2期 68-72页

作者：冯建华李冰江苏师范大学当代中国马克思主义哲学研究范式创新研究中心江苏徐州221116 黄河科技学院中华文化创新研究院郑州450063

中国马克思实践本体论研究伴随着中国市场经济的确立、发展而兴起、转型、式微。实践本体论出现于20世纪80年代市场经济取向的改革中,其目的是呼唤和论证市场经济,确立与之相适应的时代精神。其前期形态是主体性实践本体论,它以主体性... 详细信息

中国马克思实践本体论研究伴随着中国市场经济的确立、发展而兴起、转型、式微。实践本体论出现于20世纪80年代市场经济取向的改革中,其目的是呼唤和论证市场经济,确立与之相适应的时代精神。其前期形态是主体性实践本体论,它以主体性为根本原则,高扬人的个性独立和自由、弱化了传统物质本体论;其后期形态是生存论实践本体论,它流行于新旧世纪更替的十余年中,基本追求是凸显人的生命意义、价值意义,以缓解市场经济初期带来的意义迷茫问题。近年来,随着市场经济深入推进、中国发展道路和发展理念新内涵的确立,实践本体论研究式微,马克思主义哲学研究重新回归历史唯物主义视域,以聚焦中国道路,提炼时代精神,凸显马克思哲学内含的历史维度、现实精神。

关键词：实践本体论研究进程历史唯物主义主体性实践本体论生存论实践本体论