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Association between fetal macrosomia and risk of obesity in children under 3 years in Western China: a cohort study

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World Journal of Pediatrics 2019年第2期15卷 153-160页

作者： Xiong-Fei Pan li Tang Andy H.Lee Colin Binns Chun-Xia Yang Zhu-Ping Xu jian-li zhang Yong Yang Hong Wang Xin Sun Chinese Evidence-based Medicine Center Center for Clinical Epidemiology and Evidence-based MedicineWest China HospitalSichuan UniversityNo.37 Guoxue AlleyChengdu 610041SichuanChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Research and Education Sichuan Jinxin Women's and Children's HospitalChengduChina Department of Epidemiology and Biostatistics School of Public HealthCurtin UniversityPerthWAAustralia Department of Epidemiology and Biostatistics West China School of Public HealthSichuan UniversityChengduSichuanChina Shuangliu Maternal and Child Health Hospital ChengduSichuanChina Wenjiang Maternal and Child Health Hospital ChengduSichuanChina Longquan Maternal and Child Health Hospital ChengduSichuanChina Pidu Maternal and Child Health Hospital ChengduSichuanChina

Background Fetal macrosomia,defined as birth weight equal or over 4000 g,is a major concern for both neonatal and maternal health.A rapid increasing trend in fetal macrosomia is observed in different regions of *** aimed to examine the association between fetal macrosomia and risk of childhood obesity in Western *** All macrosomic live singletons (≥ 4000 g),and a random sample of singletons with normal birth weight (2500-3999 g) born in four districts of Chengdu,Western China,in 2011 were included in the cohort *** demographics,obstetric factors,labor and delivery summary at baseline were extracted from the Chengdu Maternal and Child Health Management *** measurements before 3 years and infant feeding information at around 6 months were also *** obesity under 3 years was primarily defined as a weight-for-length/height z score ≥ 1.645 using the WHO growth *** definitions were based on weight-for-age and body mass index (BMI)-for-age over the same *** A total of 1767 infants were included in the analyses,of whom 714 were *** controlling for maternal age,parity,gestational age and anemia at the first antenatal visit,pre-pregnancy BMI,gestational weight gain,gestational age at birth,baby age and sex,and breastfeeding practices at 6 months,the risk of childhood obesity defined according to weight-for-length/height among macrosomic babies was 1.90 (95% confidence interval 1.04-3.49) times that of babies with normal birth *** risk of childhood obesity for macrosomic babies was 3.74 (1.96-7.14) and 1.64 (0.89-3.00) times higher based on weight-for-age and BMI-for-age,*** Fetal macrosomia is associated with increased risk of obesity in children under 3 years in Western China.

关键词： Birth weight Child growth China Fetal macrosomia Obesity

Risk factors for mortality after coronary artery bypass grafting in patients with low left ventricular ejection fraction

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Chinese Medical Journal 2007年第4期120卷 317-322页

作者： WANG Jin XIAO Feng REN jian li Yan zhang Ming-li Department of Cardiac Surgery Peking University First Hospital Beijing 100034 China

Background We managed to assess and confirm the risk factors for mortality after coronary artery bypass grafting （CABG） operations so as to map out the proper guidance of surgical strategy especially in patients with low left ventncular ejection fraction （LVEF） in domestic polyclinic like ours. Methods Five hundred and forty-eight consecutive patients underwent CABG from December 1999 through August 2005 were analyzed retrospectively. Eighty-nine cases had an LVEF of 40% or less. All together twenty-two candidate factors were evaluated for their association with perioperative death using univariate and multivariate stepwise Logistic analysis. Results When data from all the patients who had undergone CABG were taken into account, LVEF, left ventricular end diastolic diameter （LVEDD）, mitral regurgitation, aneurysm of the heart wall, mitral repair/replacement, resection of aneurysm, concomitant aortic valve replacement, and perioperative intra-aortic balloon counter-pulsation （IABP）, left ventricular assist device （LVAD） and cardiopulmonary bypass （CPB） all showed an association with perioperative death in univariate analysis, while an LVEF of 〉40%, on the other hand, appeared to be a protective factor. In multivariate analysis, moderate to severe mitral regurgitation, aneurysm of the heart wall, repair of septal perforation and aortic regurgitation were proved to be risk factors. When the analysis was restricted to patients with an LVEF of 40% or less, such variables as age, LVEDD, mitral regurgitation, mitral repair/replacement, IABP, and CPB were qualified as risk factors in a univariate analysis. Age, moderate mitral regurgitation, aneurysm of the heart wall, CPB, left main coronary artery disease and female were associated with pefioperative death in a multivariate logistic regression analysis. Conclusions Concerning the prognosis, patients who undergo CABG would have different risk factors when data from all the enrolled patients or data from patients with

关键词： ventricular dysfunction, left coronary artery bypass risk factors

Transesterified Chinese Spicehush (lindera communis) seed oil as a biodiesel fuel

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Forestry Studies in China 2007年第2期9卷 132-136页

作者： Wang Wei-gang Ma Lei jiang jian-xin jiang li zhang Zhi-xiang College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Studies were carried out on the transesterification of the Chinese Spicehush （lindera communis） seed （LCS） oil with methanol for the production of biodiesel. The methyl esters of LCS oil were compared with soybean esters to determine biodiesel fuel performance and properties. The fatty acids content in the seed kernel oil （LKO） and coat oil （LCO） were quantified by gas chromatography and mass spectrometry method （C-C-MS）. LKO contains 95.1% saturated acids （capric, lauric, myristic and palmitic） and 2.3% unsaturated acids （oleic）. LCO contains 24.6% saturated acids （palmitic and stearic） and 73.6% unsaturated acids （oleic, linoleic and palmitoleic）. The kinematic viscosity, cold filter plugging point, cloud point, flash point and cetane index were determined. The methyl esters of LKO had a higher kinematic viscosity and a lower cold filter plugging point value, so it has better performance in cold weather. The biodiesel of LCS oil has fuel properties within the limits prescribed by American （ASTM D 6751-02） standards, except for a slightly lower flash point of LKO biodiesel than that prescribed by these standards （130℃）. Thus, LKO and LCO biodiesel have great potential to be used on a large scale as fuel for diesel engines.

关键词： biodiesel lindera communis oil transesterification property

Aging mechanism of GaN-based yellow LEDs with V-pits

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Chinese Physics B 2019年第6期28卷 384-388页

作者： Tian-Ran zhang Fang Fang Xiao-Lan Wang jian-li zhang Xiao-Ming Wu Shuan Pan Jun-lin liu Feng-Yi jiang National Institute of LED on Silicon Substrate Nanchang University

GaN-based yellow light-emitting diodes(LEDs) on Si substrates are aged at a direct current density of 50 A/cm^2 for500 h. After the aging process, it can be found that the LEDs have a stable electrical property but their light output power is decayed by 4.01% at 35 A/cm^2. Additionally, the aging mechanism of GaN-based yellow LED is analyzed. It is found that the decay of light output power may be attributed to the following two reasons: one is the increase of Shockley–Rrad–Hall recombination and the other is the change of the transport path of holes via V-pits after aging, which may induce the radiative recombination current to decrease. In this paper, not only the aging mechanism of GaN-based yellow LED is investigated, but also a new possible research direction in LED aging is given.

关键词： GaN-based yellow LED aging mechanisms V-pits

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需求点随机的分批配送VRP模型与算法研究

控制与决策 2017年第2期32卷 213-222页

作者：石建力张锦西南交通大学交通运输与物流学院成都610031

针对城市配送中需求点不确定的现象,在分批配送车辆路径问题中引入随机需求点进行研究.建立带修正的随机规划模型,采用先验优化策略,根据分批配送的特点,在自适应大邻域搜索算法中引入改进的分割插入算子进行求解.在调整的Solomon算例... 详细信息

针对城市配送中需求点不确定的现象,在分批配送车辆路径问题中引入随机需求点进行研究.建立带修正的随机规划模型,采用先验优化策略,根据分批配送的特点,在自适应大邻域搜索算法中引入改进的分割插入算子进行求解.在调整的Solomon算例上进行的测试表明,允许分批配送在大部分算例中的费用低于不允许分批配送的情形.通过分析计算过程中各个算子权重变化,确定性最差删除算子和随机删除算子在求解此类问题时表现较好;贪婪插入算子、后悔插入算子表现较好;而分割插入算子虽然权重较低,但能对解产生质的影响.

关键词：需求点随机分批配送车辆路径问题自适应大邻域搜索先验优化

Effect of Mg-Preflow for p-AlGaN Electron Blocking Layer on the Electroluminescence of Green LEDs with V-Shaped Pits

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Chinese Physics Letters 2018年第2期35卷 88-92页

作者： Ai-Xing li Chun-Lan Mo jian-li zhang Xiao-Lan Wang Xiao-Ming Wn Guang-Xu Wang Jun-lin liu Feng-Yi jiang National Institute of LED on Silicon Substrate Nanchang University

In GaN-based green light-emitting diodes（LEDs） with and without Mg-preflow before the growth of p-Al GaN electron blocking layer（EBL） are investigated experimentally.A higher Mg doping concentration is achieved in the EBL after Mg-preflow treatment,effectively alleviating the commonly observed efficiency collapse and electrons overflowing at cryogenic ***,unexpected decline in quantum efficiency is observed after Mg-preflow treatment at room *** conclusions are drawn such that the efficiency decline is probably the result of different emission *** Mg doping concentration in the EBL after Mg-preflow treatment will make it easier for a hole to be injected into multiple quantum wells with emission closer to pGaN side through the（8-plane rather than the V-shape pits,which is not favorable to luminous efficiency due to the preferred occurrence of accumulated strain relaxation and structural defects in upper QWs closer to *** this framework,apparently disparate experimental observations regarding electroluminescence properties,in this work,are well reconciled.

关键词： GaN EBL Effect of Mg-Preflow for p-AlGaN Electron Blocking Layer on the Electroluminescence of Green LEDs with V-Shaped Pits

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan zhang Xin liu jian zhang Ya Gao Shuyue li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu Xiandeng li Mi li Xian Wu Xiaohui Huang Ajing Xu Yan liu jian zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Optical Spectroscopy of Pr3+ Ion Singly Doped liLuF4 Single Crystal by Bridgman Method

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Chinese Journal of Chemical Physics 2019年第6期32卷 661-666,I0002页

作者： li-zhi Fang Xiong Zhou Hai-ping Xia jian-xu Hu jian-li zhang Bao-jiu Chen Key laboratory of Photo-electronic Materials Ningbo UniversityNingbo 315211China Department of Physics Dalian Maritime UniversityDalian 116026China

High quality liLuF4 single crystals doped with various Pr3+ ions were synthesized by a vertical Bridgman method in completely sealed platinum crucibles. The excitation spectra spans from 420 nm to 500 nm. The prepared single crystals exhibit a blue band at 480 nm(3P0→3H4), a green band at 522 nm (3P1→3H5), and a red band at 605 nm (1D2→3H4)when excited at 446 nm;their corresponding average lifetimes are 38.5μs, 37.3μs, and 36.8μs, respectively, which are much longer than those in oxide single crystals. The effects of excitation wavelength and doping concentration on emission intensities and chromaticity coordinates are investigated. The optimal Pr3+ concentration is confirmed to be 0.5%.The temperature dependent emission shows that the emission intensity constantly decreases with the increase of temperature from 298 K to 443 K due to the enhancement of nonradiative quenching at high temperature. The 3P0→3H4 transition is the most vulnerable to temperature, followed by the 3P1→3H5 transition and 1D2→3H4 transition.

关键词： Pr3+ ion liLuF4 single crystal Optical spectroscopy