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Chronology of coastal aeolian deposition and its paleo-environmental implications on the Liuao Peninsula of South China

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Journal of Mountain Science 2019年第12期16卷 2754-2769页

作者： JIN jian-hui LI Zhi-zhong LING Zhi-yong ZHENG Fei XU Xiao-lin cheng Yan CAO Xiang-dong LI Zhi-xing ZHANG Wen-jing REN Yong-qing Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350007China Institute of Geography Fujian Normal UniversityFuzhou 350007China School of Geographical Sciences Fujian Normal UniversityFuzhou 350007China Qinghai Institute of Salt Lakes Chinese Academy of SciencesXi'ning 810008China Xinjiang Teacher's college(Xinjiang education Institute) Urumqi 830043China

Coastal dunes are a common geomorphic type in sandy coastal *** are a record of the coupled evolutionary processes of the wind and ocean *** coastal dune fields have developed on the east coast of Fujian China and now occur as widespread typical coastal aeolian sand landforms on the Liuao Peninsula,Gulei Peninsula and Dongshan Island,but it is difficult to evaluate the dynamic geomorphologic process of sandy coast due to the lack of systematic and accurate chronological *** this study,we selected the Hutoushan(HTS)aeolian dune on the Liuao Peninsula as the research *** dating and grain-size analysis were applied to sand samples from the aeolian sequence of a profile of the HTS *** results show that the ages of seven samples of this profile were in the range of 37.8–0.19 ka from 4.0 to 0.2 m *** correspond to the Marine Isotope Stage 3(MIS3),abrupt climatic change events of 4.2 and 1.1 ka and the Little Ice Age(LIA),*** samples displayed evidence of a longer-term climate trend in this *** period of formation of this coastal aeolian dune corresponds to a cold and arid climate associated with the East Asia Winter Monsoon(EAWM).Periods of dune fixation and rubification are evidence of a hot and humid *** and stabilization of the aeolian dune is an important characteristic of the coastal evolution in South China since the late Pleistocene.

关键词： Aeolian sand Optically Stimulated Luminescence Grain size Coastal dune Environmental evolution

Down-regulation of HIV-1 Infection by Inhibition of the MAPK Signaling Pathway

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Virologica Sinica 2011年第2期26卷 114-122页

作者： jian gong Xi-hui Shen Chao Chen Hui Qiu Rong-ge Yang The State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China School of Life Science Huzhou Teachers College Huzhou 313000 China

The human immunodeficiency virus type 1 （HIV-1） can interact with and exploit the host cellular machinery to replicate and propagate itself. Numerous studies have shown that the Mitogen-activated protein kinase （MAPK） signal pathway can positively regulate the replication of HIV-1, but exactly how each MAPK pathway affects HIV-1 infection and replication is not understood. In this study, we used the Extracellular signal-regulated kinase （ERK） pathway inhibitor, PD98059, the Jun N-terminal kinase （JNK） pathway inhibitor, SP600125, and the p38 pathway inhibitor, SB203580, to investigate the roles of these pathways in HIV-1 replication. We found that application of PD98059 results in a strong VSV-G pseudotyped HIV-1NL4-3 luciferase reporter virus and HIV-1NL4-3 virus inhibition activity. In addition, SB203580 and SP600125 also elicited marked VSV-G pseudotyped HIV-INL4-3 luciferase reporter virus inhibition activity but no HIV-1NL4-3 virus inhibition activity. We also found that SB203580 and SP600125 can enhance the HIV-1 inhibition activity of PD98059 when cells were treated with all three MAPK pathway inhibitors in combination. Finally, we show that HIV-1 virus inhibition activity of the MAPK pathway inhibitors was the result of the negative regulation of HIV-1 LTR promoter activity.

关键词： HIV-1 inhibition Mitogen-activated protein kinase (MAPK) Extracellular signal-regulated kinase (ERK) Jun N-terminal kinase (JNK) p38 LTR activation

Degradable Hybrid CuS Nanoparticles for Imaging-Guided Synergistic Cancer Therapy via Low-Power NIR-II Light Excitation

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CCS Chemistry 2021年第5期3卷 1336-1349页

作者： Yidan Sun Hua Shi Xiaoyang cheng Luyan Wu Yuqi Wang Zhengyang Zhou jian He Hong-Yuan Chen Deju Ye State Key Laboratory of Analytical Chemistry for Life Science Chemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 Department of Radiology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008

Near-infrared(NIR)-II light-excitable photonic agents capable of generating tumor hyperthermia and cytotoxic free radicals are promising for synergistic phototherapy of ***,the lack of NIR-II excitable agents makes it challenging to achieve combinational tumor ***,the authors have reported on a tumor-targeting and degradable hybrid copper sulfide(CuS)nanoparticle(AIBA@CuS-FA)via loading a hydrophilic Azo initiator(AIBA)into an amphiphilic lipid-encapsulating CuS ***@CuS-FA shows high photothermal conversion efficiency(PCE≈47.5%)at 1064 nm,enabling heat production to trigger tumor hyperthermia and thermal decomposition of AIBA into cytotoxic free alkyl radicals upon irradiation with a 1064-nm laser under low-power density(0.5 W/cm2).Moreover,alkyl radicals can drive degradation of AIBA@CuS-FA and embedded CuS nanodisks,releasing Cu^(2+)ions that can catalyze a Fenton-like reaction for hydroxyl radical(•OH)production to promote tumor *** demonstrate promise for combinational photothermal therapy(PTT),oxygen-independent alkyl radical therapy,and chemodynamic therapy(CDT)of tumors.

关键词： NIR-II copper sulfide alkyl radical synergistic therapy imaging

Lipoprotein(a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography

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Biomedical and Environmental Sciences 2018年第4期31卷 253-260页

作者： SUN Di ZHAO Xi LI Sha ZHANG Yan WU Na Qiong ZHU cheng Gang GUO Yuan Lin GAO Ying QING Ping LIU Geng DONG Qian LI jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College

Objective Low-density lipoprotein cholesterol（LDL-C） has been well known as the risk factor of coronary artery disease（CAD）. However, the role of lipoprotein（a） [Lp（a）] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp（a） on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. Methods We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD. Gensini score（GS） was used to assess the severity of CAD. Lp（a） was measured by immunoturbidimetric method. Results Patients with CAD had higher level of LDL-C and Lp（a） compared with non-CAD（P 〈 0.05）. Multivariable logistic regression revealed that Lp（a）〉 205 mg/L（highest tertile） predicted 1.437-fold risk for CAD（95% CI： 1.108-1.865, P = 0.006） and 1.480-fold risk for high GS（95% CI： 1.090-2.009, P = 0.012） respectively. Interestingly, concomitant elevated level of Lp（a） and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI： 1.339-2.541, P 〈 0.001] and severity [OR = 1.736, 95% CI： 1.188-2.538, P = 0.004] of CAD. Conclusion Lipoprotein（a） is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C.

关键词： Lipoprotein(a) LDL-C Coronary artery disease Chinese

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长白山天池火山顶部黄色物质成因的初步探讨

地震地质 2012年第4期34卷 739-742页

作者：尹功明樊祺诚中国地震局地质研究所地震动力学国家重点实验室北京100029

长白山天池火山是中国著名的火山,全新世以来有过多次喷发。在长白山天池火山顶部局部地区发育1套黄色碎屑物质。但是,对于这套黄色物质的成因,一直存有争议。根据1980年5月18日美国圣海伦斯火山喷发的研究成果,以及长白山天池火山顶部... 详细信息

长白山天池火山是中国著名的火山,全新世以来有过多次喷发。在长白山天池火山顶部局部地区发育1套黄色碎屑物质。但是,对于这套黄色物质的成因,一直存有争议。根据1980年5月18日美国圣海伦斯火山喷发的研究成果,以及长白山天池火山顶部黄色物质的化学成分、产出特征等,我们初步推测其成因为"千年喷发"时热水交代作用的产物,而不是一次独立的火山喷发事件的产物。

关键词：长白山天池火山黄色物质成因热水交代作用

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分布式形态学的最新进展

当代语言学 2016年第1期18卷 97-119页

作者：程工李海浙江大学外国语言文化学院浙江杭州紫金港校区310058 解放军外国语学院

分布式形态学是1990年代初期出现的一个语言学理论框架,目前已具有较强的学术影响力。其突出特色是反对词库论(即认为句法和形态是相互独立的两个模块),主张单引擎论(即句法不仅作用于词以上单位,也是词内部结构的主要决定因素)。本文... 详细信息

分布式形态学是1990年代初期出现的一个语言学理论框架,目前已具有较强的学术影响力。其突出特色是反对词库论(即认为句法和形态是相互独立的两个模块),主张单引擎论(即句法不仅作用于词以上单位,也是词内部结构的主要决定因素)。本文从其基本理论框架、构词的结构途径、推导的区域限制、理论的语义蕴涵和音系推导等五个方面,较为全面地介绍其发展现状,同时尽量客观地分析其理论得失。

关键词：分布式形态学构词结构途径区域限制

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人字齿轮承载接触分析与试验

航空动力学报 2010年第3期25卷 718-722页

作者：王成方宗德谷建功贾海涛西北工业大学机电学院西安710072 中国船舶重工集团公司第703研究所哈尔滨150036

根据人字齿轮均载传动的特点,提出了人字齿轮承载接触分析的方法.首先,通过有限元法计算得到齿面柔度矩阵和轴变形产生的附加柔度矩阵,将两者叠加获得人字齿轮系统的齿面法向柔度矩阵.其次,将有限元、柔度矩阵、数学规划和齿轮(一般为小... 详细信息

根据人字齿轮均载传动的特点,提出了人字齿轮承载接触分析的方法.首先,通过有限元法计算得到齿面柔度矩阵和轴变形产生的附加柔度矩阵,将两者叠加获得人字齿轮系统的齿面法向柔度矩阵.其次,将有限元、柔度矩阵、数学规划和齿轮(一般为小轮)的轴向移动结合在一起,计算得到人字齿轮副的承载啮合过程.最后,以一对试验人字齿轮为例,通过对齿面轻载印痕和承载传动误差的比较,结果验证了所提出的人字齿轮承载接触分析方法的正确性.

关键词：人字齿轮承载接触分析法向柔度矩阵承载传动误差

基于小波变换和邻域特征的多聚焦图像融合算法

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西北工业大学学报 2011年第3期29卷 454-459页

作者：郭雷程塨赵天云西北工业大学自动化学院陕西西安710072

提出了一种基于小波变换和邻域特征的多聚焦图像融合算法。该算法首先采用小波变换对源图像进行多尺度分解,得到低频和高频子图像;然后对低频子图像采用基于邻域归一化梯度的方法得到低频融合系数,对高频子图像采用基于邻域方差的方法... 详细信息

提出了一种基于小波变换和邻域特征的多聚焦图像融合算法。该算法首先采用小波变换对源图像进行多尺度分解,得到低频和高频子图像;然后对低频子图像采用基于邻域归一化梯度的方法得到低频融合系数,对高频子图像采用基于邻域方差的方法得到高频融合系数;最后进行小波重构得到融合图像。采用均方根误差、信息熵以及峰值信噪比等评价标准,将该算法与传统融合方法的融合效果进行了比较。实验结果表明,该算法所得融合图像的效果和质量均有明显提高。

关键词：图像融合小波变换多聚焦图像邻域归一化梯度邻域方差

Clinical features of coronary artery ectasia in the elderly

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Journal of Geriatric Cardiology 2014年第3期11卷 185-191页

作者： Qiao-Juan HUANG Yan ZHANG Xiao-Lin LI Sha LI Yuan-Lin GUO cheng-Gang ZHU Rui-Xia XU Li-Xin jianG Meng-Hua CHEN jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College BeiLiShi Road 167 Beijing 100037 China Department of Cardiology Institute of Cardiovascular Diseases the First Affiliated Hospital Guangxi Medical University Nanning Guangxi 530021 China

Objective To investigate the incidence, imaging and clinical characteristics in elderly patients with coronary artery ectasia （CAE）. Methods A retrospective analysis was conducted on patients with CAE who underwent coronary angiography between January 2006 and December 2012. According to age, the enrolled patients were divided into two groups （elderly group, age≥ 65 years; non-elderly group, age 〈 65 years）. The clinical feature, imaging characteristics and the 5-year survival rate of the two groups were *** The preva-lence of CAE in elderly patients was 0.33%. Patients in elderly group were found to have significantly higher proportion of female （30.1%vs. 10.1%,P〈 0.001）, three-vessel disease （60.5%vs. 45.2%,P = 0.003） and localized ectasia （55.0%vs. 40.2%,P = 0.003）. In addition, body mass index （20.90 ± 2.71 kg/m2vs. 22.31 ± 2.98 kg/m2,P 〈 0.001） and percentage of current smokers （45.0%vs. 64.6%,P 〈 0.001） were significantly lower in elderly group. Cumulative survival curves demonstrated reduced 5-year cumulative survival at the follow-up in the elderly group compared with the non-elderly group （88.0%vs. 96.0%,P = 0.002）. But the 5-year event free survival rate failed to show a significant difference between the two groups （31.0%vs. 35.0%,P= 0.311）.ConclusionThe prevalence of CAE in elderly patients was 0.33%, which was about 1/3 of the entire numbers of CAE patients. There were significant differences between the elderly and the non-elderly patients with CAE in terms of coronary artery disease risk factors and coronary artery ectatic characteristics. CAE might be asso-ciated with increased mortality risk in the elderly.

关键词： Coronary artery ectasia Elderly patients Clinical feature