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Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale

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Chinese Journal of Chemistry 2023年第4期41卷 392-398页

作者： Yao-yue Fan Cheng-Yu Zheng Bin Zhou Flavia M.Zimbres Maria B.Cassera jian-Min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203 China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandong264117 China Research Units of Discovery of New Drug Lead Molecules Chinese Academy of Medical SciencesShanghai201203 China Department of Biochemistry and Molecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia30602 United States

Chemical investigation of Hedyosmum orientale led to the identification of two terpenoid derivatives,dyosmunoids A and B(1 and 2)featuring two different 3/5/6/6/5-fused pentacyclic ring systems,respectively.Compound 1 is the second natural product of this C_(25) terpenoid compound class,and compound 2 is a rare dinor-C25 terpenoid with a peroxide bridge.Their structural elucidation was achieved by the comprehensive analysis of spectroscopic data,single-crystal X-ray diffraction,and ECD calculation.Putative biosynthetic pathways for compounds 1 and 2 are proposed.Compound 2 exhibited strong antimalarial activity with an IC_(50) value of 0.42μmol·L^(-1).

关键词： Natural products C_(25)Terpenoids Structure elucidation Biosynthetic pathway hypothesis Antimalarial activity

梅蓄电站二期上引水洞爆破开挖诱发空气超压对上库事故闸门的影响分析

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爆破 2024年第2期41卷 177-184页

作者：郑晶星黄文锋陈明陈光泽潘鑫豪郑建月南方电网调峰调频发电有限公司工程建设管理分公司广州511402 武汉大学水资源工程与调度全国重点实验室武汉430072

爆破开挖过程中产生的空气超压可能会影响周边建构筑物的安全。梅州抽水蓄能电站二期引水平洞的爆破作业区,距离在一期工程中已建好并投入运行的二期工程引水上平洞上库钢质事故闸门仅81 m,爆破作业可能会影响事故闸门的稳定运行。为此... 详细信息

爆破开挖过程中产生的空气超压可能会影响周边建构筑物的安全。梅州抽水蓄能电站二期引水平洞的爆破作业区,距离在一期工程中已建好并投入运行的二期工程引水上平洞上库钢质事故闸门仅81 m,爆破作业可能会影响事故闸门的稳定运行。为此,以梅州抽水蓄能电站二期引水上平洞的爆破开挖为对象,开展了爆破空气超压现场监测工作,分析了爆破空气超压的分布规律及其对梅州抽水蓄能电站上库事故闸门的安全影响,为分析爆破空气超压对上库事故闸门的安全影响提供了支撑。现场的爆破空气超压监测数据表明:距离爆破掌子面约80 m的事故闸门前的空气超压水平分布在0.63~3.46 kPa,远小于建议的相应的爆破安全控制标准100 kPa;闸门前使用胶帘等防护设施可以有效减小闸门位置的空气超压,实测的第4次和第5次爆破空气超压减小了55%以上;单段装药量及总装药量得到有效控制时,实测的空气超压值远低于建议的控制标准;现场宏观调查及其他检测数据也未见异常,爆破施工未影响上库事故闸门的安全运行。

关键词：爆破开挖空气超压事故闸门安全影响现场测试

Selective construction of molecular Solomon links and figure-eight knots by fine-tuning unsymmetrical ligands

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Science China Chemistry 2023年第10期66卷 2885-2891页

作者： Qiu-Shui Mu Xiang Gao Zheng Cui yue-jian Lin Guo-Xin Jin State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsDepartment of ChemistryFudan UniversityShanghai 200433China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Using the strategy of ligand fine-tuning by steric hindrance, we successfully obtained Solomon links(4_(1)^(2)) and figure-eight knots(4_(1)) with half-sandwich organometallic unit and amino-acid embedded ligands. The two curved bidentate ligands exhibit subtle differences, whereas they result in totally distinct entanglement modes. An alcoholysis reaction with the ligands leads to the formation of a molecular tweezer. Notably, unsymmetrical ligands were utilized in the self-assembly process to explore the formation of directional molecules, and the reactions exhibited selectivity due to comprehensive π interactions and multiple hydrogen bonds. The topologies and behavior of the above structures were confirmed through single-crystal X-ray diffraction,nuclear magnetic resonance techniques and mass spectrometry.

关键词： interlocked molecule figure-eight knot solomon link supramolecular self-assembly

规划体系整合背景下课程思政建设路径探讨——以“土地利用规划学”为例

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教育教学论坛 2024年第20期 54-57页

作者：陈月娇卢新海王月健李文珺石河子大学理学院新疆石河子832003 华中科技大学公共管理学院湖北武汉430074 伦敦大学学院教育学院英国伦敦WC1H 0AL

高校思想政治教育的根本任务是立德树人,课程思政要求教师在专业课程的教育中充分发挥育人功能,将思政教育融入专业教育。在国土空间规划体系整合的背景下,以“土地利用规划学”课程思政建设为研究对象,阐释了课程思政建设的原则和目标... 详细信息

高校思想政治教育的根本任务是立德树人,课程思政要求教师在专业课程的教育中充分发挥育人功能,将思政教育融入专业教育。在国土空间规划体系整合的背景下,以“土地利用规划学”课程思政建设为研究对象,阐释了课程思政建设的原则和目标,探索了思政元素融入的路径,研讨了融入思政教育的教学设计,以期为土地资源管理专业中“土地利用规划学”课程思政的建设提供依据和方向。

关键词：土地利用规划学思政教育教学改革国土空间规划体系

Octanuclear Palladacycles with B(3)-H Bond Activation of o-Carborane

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Chinese Journal of Chemistry 2023年第3期41卷 307-313页

作者： Run-Ze Yuan Peng-Fei Cui yue-jian Lin Guo-Xin Jin State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsDepartment of ChemistryFudan University2005 Songhu RoadShanghai200433 China

Herein,we describe the synthesis of a carborane-supported octanuclear palladacycle complex,Pd_(8)(o-C_(2)B_(10)H_(10)CS_(2)CH_(3))_(4)Cl_(4)(CH_(3)CN)_(4)(complex 1),with B(3)-H activations on o-carborane ligand.The substitution reaction of 1 has been explored,and three of its substituted complexes Pd_(8)(o-C_(2)B_(10)H_(10)CS_(2)CH_(3))_(4)Cl_(4)(L)4(L=^(t)BuNC,2;L=C_(5)H_(5)N,3;L=C_(4)H_(8)S,4)have been synthesized.The m-and p-carborane disubstituted ligands m-and p-C_(2)B_(10)H_(10)(CS_(2)CH_(3))_(2)(ligands 5 and 6)as well as their B—H activated carborane complexes[m-C_(2)B_(10)H_(9)(CS_(2)CH_(3))_(2)PdCl](7)and[p-C_(2)B_(10)H_(8)(CS_(2)CH_(3))_(2)][PdCl(^(t)BuNC)]_(2)(8)have also been synthesized by the similar method.All of these complexes have been characterized,including X-ray single crystal diffraction,NMR spectroscopy,IR spectroscopy and elemental analysis methods.

关键词： Carborane Palladacycle Regioselective B-H activation Polynuclear complex Dithioester chemistry

Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: a meta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 205-212页

作者： Xue Bai Miao Wang Xun Niu Hong Yu jian-Xin yue Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Scienceand TechnologyWuhan430022China

N-acetyl-cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise-induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N-acetylcysteine, and sensorineural hearing loss. Studies which included assessment of hearing loss with pure-tone threshold (PTA) data were selected. Eligible studies regarding the effects of NAC treatment on patients with hearing loss were collected by two independent reviewers. A total of 1197 individuals were included from seven published studies. Two studies reported data for a sudden idiopathic sensorineural hearing loss (SISNHL) group. Three studies reported data for a NIHL group. Other studies reported data for drug-induced hearing loss. The meta-analysis demonstrated that the overall effect of NAC treatment on sensorineural hearing loss was invalid. However, NAC treatment was linked with improved patient outcomes of hearing tests in cases of sudden hearing loss, but did not prevent hearing loss induced by noise or ototoxicity. However, there is a need for better-designed studies with larger samples to further prove the correlation between the effect of NAC and hearing loss.

关键词： Hearing loss Meta-analysis N-acetyl-cysteine

回归职校属性:校企合作的现实困境与路径探索——基于中职学生“升学热”视角

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天津中德应用技术大学学报 2024年第2期 38-44页

作者：王胜乔宇马嘉林朱跃建汪彬浙江师范大学浙江金华321000 长兴县职业技术教育中心学校浙江湖州313100

在中职学生升学诉求日益增长背景下,升学成为阻碍中职学校与企业深度合作的重要因素,寻找升学与就业的平衡点成为突破口。分析中职学校与企业合作中存在学生留企与管理难、中职教师缺乏企业实践经验与行业认知、学生实操课时不足且课时... 详细信息

在中职学生升学诉求日益增长背景下,升学成为阻碍中职学校与企业深度合作的重要因素,寻找升学与就业的平衡点成为突破口。分析中职学校与企业合作中存在学生留企与管理难、中职教师缺乏企业实践经验与行业认知、学生实操课时不足且课时分配不均匀等问题,提出提升学生综合岗位能力以适应轮岗要求、增加教师的企业经验与技能,技能主导升学考试、深化校企合作等建议。

关键词：中等职业教育升学导向校企合作

超声引导下穿刺抽脓术与超声引导下置管引流冲洗术治疗不同脓腔直径乳腺脓肿的效果对比研究

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临床和实验医学杂志 2024年第7期23卷 767-772页

作者：蒲宝平岳建玲周步琴嘉峪关市第一人民医院超声医学科甘肃嘉峪关735100 嘉峪关市第一人民医院影像中心甘肃嘉峪关735100 兰州新区第一人民医院超声科甘肃兰州730087

目的对比超声引导下穿刺抽脓冲洗术与超声引导下置管引流冲洗术治疗不同脓腔直径乳腺脓肿的效果。方法对2021年3月至2023年3月嘉峪关市第一人民医院收治的90例乳腺脓肿患者进行回顾性研究,根据治疗方式不同将患者分成穿刺抽脓组(n=40)... 详细信息

目的对比超声引导下穿刺抽脓冲洗术与超声引导下置管引流冲洗术治疗不同脓腔直径乳腺脓肿的效果。方法对2021年3月至2023年3月嘉峪关市第一人民医院收治的90例乳腺脓肿患者进行回顾性研究,根据治疗方式不同将患者分成穿刺抽脓组(n=40)和置管引流组(n=50)。穿刺抽脓组患者接受超声引导下穿刺抽脓冲洗术,置管引流术组患者接受超声引导下置管引流冲洗术治疗。比较2组的不同脓腔直径(脓腔直径≤5 cm、脓腔直径>5 cm)围手术期相关指标[手术时间、术中引流量、术中单次出血及累计出血量、切口长度、引流时间、引流总量、康复时间、瘢痕长度和及术后单次和累及视觉模拟评分法(VAS)评分]、治疗满意度、治愈率、不良反应发生情况、术后复发及继续哺乳情况。结果脓腔直径≤5 cm的乳腺脓肿:2组的脓腔大小、引流总量、康复时间、治愈率比较,差异均无统计学意义(P>0.05);置管引流组的手术时间、术中引流量、术中单次出血量、术中累计出血量、切口长度、瘢痕长度、术后单次VAS评分均显著高于穿刺抽脓组,差异均有统计学意义(P5 cm的乳腺脓肿:2组的脓腔大小、术中累计出血、引流总量比较,差异均无统计学意义(P>0.05);置管引流组的手术时间、术中引流量、术中单次出血量、切口长度、瘢痕长度、术后单次VAS评分、满意度评分和治愈率均显著高于穿刺抽脓组,差异均有统计学意义(P0.05)。术后6个月,置管引流组术后复发率为2.00%,显著低于穿刺抽脓组(12.50%),差异有统计学意义(P5 cm的术后复发率和继续哺乳率比较,差异均无统计学意义(P>0.05)。结论对于脓腔直径≤5 cm的乳腺脓肿,穿刺抽脓可缩短手术时间,减少术中出血量、切口大小及瘢痕长度,患者满意度更高;对于脓腔直径>5 cm的乳腺脓肿,置管引流可缩短康复时间,提高治愈率和患者满意度。

关键词：脓肿引流术超声引导穿刺抽脓置管脓腔直径乳腺

A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3414-3424页

作者： Kailong Ji Wei Liu Weihang Yin Xiangrong Kong Honghong Xu Zeng-Wei Lai Jing-Ya Li jian-Min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China

A new class of potent liver injury protective compounds,phychetins A-D(1-4)featuring an unique 6/6/5/6/5 pentacyclic framework,were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus franchetianus.Compounds 2-4 are three pairs of enantiomers that were initially obtained in a racemic manner,and were further separated by chiral HPLC preparation.Compounds 1-4 were proposed to be originated biosynthetically from a coexisting lignan via an intramolecular Friedel-Crafts reaction as the key step.A bioinspired total synthesis strategy was thus designated,and allowed the effective syntheses of compounds 2-4 in high yields.Some of compounds exhibited significant anti-inflammatory activities in vitro via suppressing the production of pro-inflammatory cytokine IL-1β.Notably,compound 4,the most active enantiomeric pair in vitro,displayed prominent potent protecting activity against liver injury at a low dose of 3 mg/kg in mice,which could serve as a promising lead for the development of acute liver injury therapeutic agent.

关键词： Phychetins Phyllanthusfranchetianus Structural elucidation Total synthesis Liver injury protection Anti-inflammation