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Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis:therapeutic potential for endogenous pulp regeneration

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International Journal of Oral Science 2022年第3期14卷 381-395页

作者： Cheng Liang Qingqing Liang Xun Xu Xiaojing Liu Xin gao Maojiao Li jian Yang Xiaotao Xing Haisen Huang Qi Tang Li Liao Weidong Tian State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Engineering Research Center of Oral Translational Medicine Ministry of Education&National Engineering Laboratory for Oral Regenerative MedicineWest China Hospital of StomatologySichuan UniversityChengduChina

Pulp loss is accompanied by the functional impairment of defense,sensory,and nutrition *** approach based on endogenous stem cells is a potential strategy for pulp ***,endogenous stem cell sources,exogenous regenerative signals,and neovascularization are major difficulties for pulp regeneration based on endogenous stem ***,the purpose of our research is to seek an effective cytokines delivery strategy and bioactive materials to reestablish an ideal regenerative microenvironment for pulp *** in vitro study,we investigated the effects of Wnt3a,transforming growth factor-beta 1,and bone morphogenetic protein 7(BMP7)on human dental pulp stem cells(h-DPSCs)and human umbilical vein endothelial cells.2D and 3D culture systems based on collagen gel,matrigel,and gelatin methacryloyl were fabricated to evaluate the morphology and viability of *** in vivo study,an ectopic nude mouse model and an in situ beagle dog model were established to investigate the possibility of pulp regeneration by implanting collagen gel loading *** concluded that BMP7promoted the migration and odontogenic differentiation of h-DPSCs and vessel *** gel maintained the cell adhesion,cell spreading,and cell viability of h-DPSCs in 2D or 3D *** transplantation of collagen gel loading BMP7 induced vascularized pulp-like tissue regeneration in *** injectable approach based on collagen gel loading BMP7 might exert promising therapeutic application in endogenous pulp regeneration.

关键词： therapeutic potential for endogenous pulp regeneration Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis

Enhancing transjugular intrahepatic portosystemic shunt procedure efficiency with digital subtraction angiography image overlay technology in esophagogastric variceal bleeding

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2870-2877页

作者： Xiao-Yan Li Yao Li Wen-Qiang Li Shuai Ju Zhi-Hui Dong jian-jun Luo Vascular and Wound Center Jinshan HospitalFudan UniversityShanghai 201508China Department of Vascular Surgery Institute of Vascular SurgeryZhongshan Hospital Fudan UniversityShanghai 200032China Department of Interventional Radiology Zhongshan Hospital Fudan UniversityShanghai 20032China

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic *** To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS *** We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided *** analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the *** The study included 52 patients with esophagogastric varices due to chronic hepatic *** demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided ***,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both ***,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.

关键词： Portal hypertension Digital subtraction angiography Image overlay technology Hepatic artery labeling Transjugular intrahepatic portosystemic shunt

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

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Acta Pharmaceutica Sinica B 2022年第2期12卷 581-599页

作者： Shenghua gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun jian Zhang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Ji’nan 250012China

Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 ***,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors wi... 详细信息

关键词： SARS-CoV-2 COVID-19 Antiviral drugs Drug design Medicinal chemistry strategies

Data processing and initial results from the CE-3 Extreme Ultraviolet Camera

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Research in Astronomy and Astrophysics 2014年第12期14卷 1664-1673页

作者： jian-Qing Feng jian-jun Liu Fei He Wei Yan Xin Ren Xu Tan Ling-Ping He Bo Chen Wei Zuo Wei-Bin Wen Yan Su Yong-Liao Zou Chun-Lai Li Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of Sciences Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences

The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium ions （He＋） at 30.4 nm, the EUVC images the entire plasmasphere with a time resolution of 10 min and a spatial resolution of about 0.1 Earth radius （RE） in a single frame. We first present details about the data processing from EUVC and the data acquisition in the commissioning phase, and then report some initial results, which reflect the basic features of the plas- masphere well. The photon count and emission intensity of EUVC are consistent with previous observations and models, which indicate that the EUVC works normally and can provide high quality data for future studies.

关键词： space vehicles: instruments: Extreme Ultraviolet Camera -- Earth: plas-masphere -- method: data processing

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一种新的局部判别投影方法

计算机学报 2011年第11期34卷 2243-2250页

作者：谢钧刘剑解放军理工大学指挥自动化学院南京210007 解放军理工大学通信工程学院南京210007

为解决多模数据的分类问题,局部化思想被引入到判别分析中,称为局部判别分析.该文以人工数据为例深入分析了近年来提出的较为成功的两种局部线性判别分析方法:LFDA(Local Fisher Discriminant Analysis)和MFA(Marginal Fisher Analysis... 详细信息

为解决多模数据的分类问题,局部化思想被引入到判别分析中,称为局部判别分析.该文以人工数据为例深入分析了近年来提出的较为成功的两种局部线性判别分析方法:LFDA(Local Fisher Discriminant Analysis)和MFA(Marginal Fisher Analysis)的不足.为克服这两种方法中没有充分考虑异类样本近邻关系的缺点,文中提出了一种新的局部判别投影方法.该方法采用与LFDA和MFA不同的局部化方法,其基本思想是寻找投影方向使同类近邻样本在投影后尽量紧凑,而异类近邻样本在投影后尽量分开.针对该思想,文中提出了两种优化目标(一种用样本间距离平方和来表示,另一种用样本类内与类间散度来表示)并做了分析和比较.实验结果表明,该文方法有效地克服了LFDA和MFA存在的固有问题,在人工数据集、UCI、USPS手写数字标准数据集和IDA标准数据集上均取得较好效果.

关键词：分类降维线性判别分析局部保持多模

Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model

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Journal of Integrative Medicine 2018年第4期16卷 283-289页

作者： Bin Luo Zu-jun Que Zhi-yi Zhou Qing Wang Chang-sheng Dong Yi jiang Bing Hu Hui Shi Yu Jin jian-wen Liu He-gen Li Lin Wang jian-hui Tian Department of Oncology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Oncology Institute of Traditional Chinese Medicine Institute of TCM Oncology School of Pharmacy East China University of Science and Technology Department of Nephrology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Objective： Escape from the body＇s immune response is a basic characteristic of lung cancer, and indoleamine-2,3-dioxygenase （IDO） plays a key role in mediating immune escape of non-small-cell lung cancer, which leads to recurrence and metastasis. Feiji Recipe, a compound Chinese herbal medicine, has the effect of stabilizing lesions and prolonging survival in patients with lung cancer. The purpose of this study was to investigate the mechanisms underlying the anticancer properties of Feiji Recipe. Methods： An orthotopic transplant model of mouse Lewis lung cancer, with stable expression of IDO gene, was established in C57BL/6 mice. Optical imaging was used to observe the effects of Feiji Recipe in the treatment of lung cancer in vivo. The effects of Feiji Recipe on the proliferation of mouse Lewis lung cancer cell line 2LL, 2LL-enhanced green fluorescent protein （2LL-EGFP） and 2LL-EGFP-IDO were investi- gated, and the apoptosis of T-cells was examined by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphenyl-2H-tetra zolium bromide using flow cytometry. Chemical composition of Feiji Recipe was validated by high- performance liquid chromatography. Results： Compared to the control group, the survival of animals treated with Feiji Recipe was significantly prolonged （P〈0.0074）, and the IDO protein level decreased （P=0.0072）; moreover, the percentages of CD4＋CD25＋ T-cells and Foxp3＋ T-cells were significantly decreased （P〈0.05）. The molecular mechanism of Feiji Recipe against lung cancer may relate to the regulation of immune cells, such as T-cells and reg- ulatory T-cells. Conclusion： The molecular mechanism of Feiji Recipe in treatment of lung cancer is to restore the function of T-cells in the cancer microenvironment through interfering with the IDO pathway.

关键词： Feiji Recipe Immune escape Orthotopic xenografts Indoleamine-2,3-dioxygenase

Anatomy and influence of the splenic artery in laparoscopic spleen-preserving splenic lymphadenectomy

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World Journal of Gastroenterology 2015年第27期21卷 8389-8397页

作者： Chao-Hui Zheng Mu Xu Chang-Ming Huang Ping Li jian-Wei Xie Jia-Bin Wang jian-Xian Lin jun Lu Qi-Yue Chen Long-Long Cao Mi Lin Department of Gastric Surgery Fujian Medical University Union Hospital

AIM: To investigate the splenic hilar vascular anatomy and the influence of splenic artery(Sp A) type in laparoscopic total gastrectomy with spleen-preserving splenic lymphadenectomy(LTGSPL).METHODS:The clinical anatomy data of 317 patients with upper- or middle-third gastric cancer who underwent LTGSPL in our hospital from January 2011 to December 2013 were collected. The patients were divided into two groups(concentrated group vs distributed group) according to the distance between the splenic artery's furcation and the splenic hilar region. Then, the anatomical layout, clinicopathologic characteristics, intraoperative variables, and postoperative variables were compared between the two ***: There were 205 patients with a concentrated type(64.7%) and 112 patients with a distributed type(35.3%) Sp A. There were 22 patients(6.9%) with a single branch of the splenic lobar vessels, 250(78.9%) with 2 branches, 43(13.6%) with 3 branches, and 2 patients(0.6%) with multiple branches. Eighty sevenpatients(27.4%) had type?Ⅰ?splenic artery trunk, 211(66.6%) had type Ⅱ, 13(4.1%) had type Ⅲ, and 6(1.9%) had type Ⅳ. The mean splenic hilar lymphadenectomy time(23.15 ± 8.02 vs 26.21 ± 8.84 min; P = 0.002), mean blood loss resulting from splenic hilar lymphadenectomy(14.78 ± 11.09 vs 17.37 ± 10.62 m L; P = 0.044), and number of vascular clamps used at the splenic hilum(9.64 ± 2.88 vs 10.40 ± 3.57; P = 0.040) were significantly lower in the concentrated group than in the distributed group. However, the mean total surgical time, mean total blood loss, and the mean number of harvested splenic hilar lymph nodes were similar in both groups(P > 0.05 for each comparison). There were also no significant differences in clinicopathological and postoperative characteristics between the groups(P > 0.05).CONCLUSION: It is of value for surgeons to know the splenic hilar vascular anatomy when performing LTGSPL. Patients with concentrated type Sp A may be optimal patients for training

关键词： Stomach neoplasms Spleen-preservation Laparoscopy Lymphadenectomy Vascular anatomy

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片上叠层式变压器的建模及参数提取（英文）

红外与毫米波学报 2016年第2期35卷 172-176页

作者：程冉陈波骆丹婷高建军华东师范大学信息科学技术学院上海市多维度信息处理重点实验室上海200241 上海微系统与信息技术研究所传感技术联合国家重点实验室上海200050

结合分析法和优化法,针对片上叠层式变压器提出了一种参数提取方法.分析法得出的参数值作为优化法的初始值,从而得出最终的模型参数值.结果表明,在100 MHz^60 GHz频率范围内,硅衬底的叠层式变压器S参数的仿真结果和测试结果吻合很好.

关键词：参数提取方法等效电路叠层式变压器

Synthesis and Herbicidal Activity of Novel Phenoxysulfonylureas Derivatives

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Chemical Research in Chinese Universities 2009年第5期25卷 648-652页

作者： ZHANG Xin-min ZHENG Liang-yu gao jun-long LIU Qing-wen SUN Guo-dong QIN Lin ZHANG Suo-qin College of Chemistry Jilin University Changchun 130021 P. R. China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China

Thirteen novel phenoxysulfonylureas derivatives were synthesized, and their structures were confirmed by MS, NMR and element analysis. The herbicidal activity and structure-activity relationship were also investigated... 详细信息

关键词： Phenoxysulfonylurea Acetohydroxyacid synthase Herbicidal activity