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Echo State Network Based on Improved Knowledge Distillation for Edge Intelligence

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Chinese Journal of Electronics 2024年第1期33卷 101-111页

作者： jian zhou Yuwen jiang Lijie XU Lu ZHAO Fu XIAO College of Computer Nanjing University of Posts and Telecommunications jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks

Echo state network(ESN) as a novel artificial neural network has drawn much attention from time series prediction in edge intelligence. ESN is slightly insufficient in long-term memory, thereby impacting the prediction performance. It suffers from a higher computational overhead when deploying on edge devices. We firstly introduce the knowledge distillation into the reservoir structure optimization, and then propose the echo state network based on improved knowledge distillation(ESN-IKD) for edge intelligence to improve the prediction performance and reduce the computational overhead. The model of ESN-IKD is constructed with the classic ESN as a student network, the long and short-term memory network as a teacher network, and the ESN with double loop reservoir structure as an assistant network. The student network learns the long-term memory capability of the teacher network with the help of the assistant network. The training algorithm of ESN-IKD is proposed to correct the learning direction through the assistant network and eliminate the redundant knowledge through the iterative pruning. It can solve the problems of error learning and redundant learning in the traditional knowledge distillation process. Extensive experimental simulation shows that ESN-IKD has a good time series prediction performance in both long-term and short-term memory, and achieves a lower computational overhead.

关键词： Knowledge engineering Training Performance evaluation Computational modeling Time series analysis Artificial neural networks Reservoirs

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Emergent Geometry of KP Hierarchy

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Acta Mathematica Sinica,English Series 2024年第1期40卷 3-25页

作者： jian zhou Department of Mathematical Sciences Tsinghua UniversityBeijng 100084P.R.China

We explain how to construct a quantum deformation of a spectral curve associated to a tau-function of the KP *** construction is applied to Witten-Kontsevich tau-function to give a natural explanation of some earlier ... 详细信息

关键词： KP hierarchy tau-functions spectral curves

Generalized Inverses and Units in a Unitary Ring

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1000-1014页

作者： Yu Kun zhou jian Long CHEN School of Mathematics Southeast UniversityNanjing 210096P.R.China

Let R be a unitary ring and a,b∈R with ab=*** find the 2/3 property of Drazin invertibility:if any two of a,b and a+b are Drazin invertible,then so is the third ***,we combine the 2/3 property of Drazin invertibility to characterize the existence of generalized inverses by means of *** applications,the need for two invertible morphisms used by You and Chen to characterize the group invertibility of a sum of morphisms is reduced to that for one invertible morphism,and the existence and expression of the inverse along a product of two regular elements are obtained,which generalizes the main result of Mary and Patricio(2016)about the group inverse of a product.

关键词： Leftπ-regular element stronglyπ-regular element group inverse Drazin inverse inverse along an element

High-efficiency sodium storage of Co_(0.85)Se/WSe_(2) encapsulated in N-doped carbon polyhedron via vacancy and heterojunction engineering

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Carbon Energy 2024年第1期6卷 94-107页

作者： Ya Ru Pei Hong Yu zhou Ming Zhao jian Chen Li Xin Ge Wei Zhang Chun Cheng Yang Qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchunChina Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy Materials Electron Microscopy CenterJilin UniversityChangchunChina

With the advantage of fast charge transfer,heterojunction engineering is identified as a viable method to reinforce the anodes'sodium storage ***,vacancies can effectively strengthen the Na+adsorption ability and provide extra active sites for Na+***,their synchronous engineering is rarely ***,a hybrid of Co_(0.85)Se/WSe_(2) heterostructure with Se vacancies and N-doped carbon polyhedron(CoWSe/NCP)has been fabricated for the first time via a hydrothermal and subsequent selenization *** aberration-corrected transmission electron microscopy confirms the phase interface of the Co_(0.85)Se/WSe_(2) heterostructure and the existence of Se *** functional theory simulations reveal the accelerated charge transfer and enhanced Na+adsorption ability,which are contributed by the Co_(0.85)Se/WSe_(2) heterostructure and Se vacancies,*** expected,the CoWSe/NCP anode in sodium-ion battery achieves outstanding rate capability(339.6 mAh g^(−1) at 20 A g^(−1)),outperforming almost all Co/W-based selenides.

关键词： Co_(0.85)Se/WSe_(2)heterostructure density functional theory simulations N-doped carbon polyhedron Se vacancies sodium-ion batteries

Mechanism of plant-soil feedback in a degraded alpine grassland on the Tibetan Plateau

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JOURNAL OF PLANT ECOLOGY 2024年第2期17卷 188-199页

作者： zhou, Tiancai Sun, jian Shi, Peili Chinese Acad Sci Inst Geog Sci & Nat Resources Res Key Lab Ecosyst Network Observat & Modelling Beijing 100101 Peoples R China Chinese Acad Sci Inst Tibetan Plateau Res State Key Lab Tibetan Plateau Earth Syst Resources Beijing 100101 Peoples R China Minist Educ Key Lab Biodivers & Environm Qinghai Tibet Plateau Lhasa 850011 Peoples R China Tibet Res Acad Ecoenvironm Sci Lhasa 850000 Peoples R China Univ Chinese Acad Sci Coll Resources & Environm Beijing 100049 Peoples R China

Although biotic and abiotic factors have been confirmed to be critical factors that affect community dynamics, their interactive effects have yet to be fully considered in grassland degradation. Herein, we tested how soil nutrients and microbes regulated plant-soil feedback (PSF) in a degraded alpine grassland. Our results indicated that soil total carbon (STC; from 17.66 to 12.55 g/kg) and total nitrogen (STN; from 3.16 to 2.74 g/kg) exhibited significant (P < 0.05) decrease from non-degraded (ND) to severely degraded (SD). Despite higher nutrients in ND soil generating significantly (P < 0.05) positive PSF (0.52) on monocots growth when the soil was sterilized, a high proportion of pathogens (36%) in ND non-sterilized soil resulted in a strong negative PSF on monocots. In contrast, the higher phenotypic plasticity of dicots coupled with a higher abundance of mutualists and saprophytes (70%) strongly promoted their survival and growth in SD with infertile soil. Our findings identified a novel mechanism that there was a functional group shift from monocots with higher vulnerability to soil pathogens in the ND fertile soil to dicots with higher dependence on nutritional mutualists in the degraded infertile soil. The emerging irreversible eco-evolutionary in PSF after degradation might cause a predicament for the restoration of degraded grassland.

关键词： plant-soil feedback plant function groups degradation alpine grassland Tibetan Plateau LITTER DECOMPOSITION COMMUNITY TRAITS DIVERSITY COMPETITION DEPENDENCE ECOSYSTEM DYNAMICS DRIVERS CARBON

From molecule to cell:the expanding frontiers of plant immunity

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Journal of Genetics and Genomics 2024年第7期51卷 680-690页

作者： Lei Li Jing Liu jian-Min zhou Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

In recent years,the field of plant immunity has witnessed remarkable *** the co-evolution between plants and pathogens,plants have developed a wealth of intricate defense mechanisms to safeguard their *** identified immune receptors have added unexpected complexity to the surface and intracellular sensor networks,enriching our understanding of the ongoing plant–pathogen *** the molecular mechanisms of resistosome shapes our understanding of these mysterious molecules in plant ***,technological innovations are expanding the horizon of the plant–pathogen battlefield into spatial and temporal *** the development provides new opportunities for untangling the complex realm of plant immunity,challenges remain in uncovering plant immunity across spatiotemporal dimensions from both molecular and cellular levels.

关键词： Plant immunity Calcium Spatiotemporal Biomolecular condensate Immune receptor Resistosome

Neosophoflavonoids A–C, A class of highly oxidized hybrid flavonoids from Sophora flavescens with antidiabetic effects

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Chinese Chemical Letters 2024年第10期35卷 321-324页

作者： Xu Zhang jiang Li Kai-zhou Lu Ya-Nan Yang jian-Shuang jiang Xiang Yuan Zi-Ming Feng Fei Ye Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Three highly oxidized hybrid flavonoids neosophoflavonoids A–C（1, 2a, and 2b） were isolated from the roots of Sophora flavescens. Neosophoflavonoid A possesses a unique highly oxidized heptacyclic6/6/6/6/6/6/5 system. Neosophoflavonoids B and C are isomers and share the same highly oxidized hexacyclic 6/6/6/6/6/6 systems. Their planar structures were elucidated from 1D/2D nuclear magnetic resonance（NMR）, ultraviolet spectroscopy（UV）, infrared spectroscopy（IR）, and high resolution electrospray ionization mass spectroscopy（HRESIMS） data. Their absolute configurations were determined by thorough GIAO13C NMR（DP4+） calculation protocol and electronic circular dichroism（ECD） calculation *** plausible biosynthetic routes for the compounds were also proposed. All compounds exhibited significant protein tyrosine phosphatase-1B（PTP1B） inhibitory activity with half maximal inhibitory concentration(IC50) values 3.94 ± 0.01, 0.38 ± 0.13, and 0.70 ± 0.01 μmol/L, respectively. In addition, compared to a positive control fenofibrate（Feno） at 20 μmol/L, compounds 2a and 2b exhibited stronger inhibitory effects on lipid accumulation in the oleic acid（OA）-induced cell model at 5 and 10 μmol/L.

关键词： Highly oxidized hybrid flavonoids Lipid accumulation inhibition Neosophoflavonoids A–C PTP1B inhibition Sophora flavescens

Evolutionary mechanisms and practical significance of reproductive success and clonal diversity in unisexual vertebrate polyploids

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Science China(Life Sciences) 2024年第3期67卷 449-459页

作者： Meng Lu Li zhou jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Hubei Hongshan Laboratorythe Innovation Academy of Seed DesignInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Unisexual reproduction is generally relevant to polyploidy, and unisexual vertebrates are often considered an evolutionary “dead end” due to the accumulation of deleterious mutations and absence of genetic diversity. However, some unisexual polyploids have developed strategies to avoid genomic decay, and thus provide ideal models to unveil unexplored evolutionary mechanisms, from the reproductive success to clonal diversity creation. This article reviews the evolutionary mechanisms for overcoming meiotic barrier and generating genetic diversity in unisexual vertebrates, and summarizes recent research advancements in the polyploid Carassius complex. Gynogenetic gibel carp(Carassius gibelio) is a unique amphitriploid that has undergone a recurrent autotriploidy and has overcome the bottleneck of triploid sterility via gynogenesis. Recently, an efficient strategy in which ploidy changes, including from amphitriploid to amphitetraploid, then from amphitetraploid to novel amphitriploid, drive unisexual-sexual-unisexual reproduction transition and clonal diversity has been *** on this new discovery, multigenomic reconstruction biotechnology has been used to breed a novel strain with superior growth and stronger disease resistance. Moreover, a unique reproduction mode that combines both abilities of ameiotic oogenesis and sperm-egg fusion,termed as ameio-fusiongensis, has been discovered, and it provides an efficient approach to synthesize sterile allopolyploids. In order to avoid ecological risks upon escape and protect the sustainable property rights of the aquaculture seed industry, a controllable fertility biotechnology approach for precise breeding is being developed by integrating sterile allopolyploid synthesis and gene-editing *** review provides novel insights into the origin and evolution of unisexual vertebrates and into the attempts being made to exploit new breeding biotechnologies in aquaculture.

关键词： unisexual vertebrates polyploidy reproduction transition clonal diversity precise breeding genomic reconstruction controllable fertility

Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment

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Chinese Journal of Natural Medicines 2024年第6期22卷 501-514页

作者： CHEN chiwei HUANG Renlun WANG Neng ZHENG Yifeng zhou jianfu YANG Bowen WANG Xuan ZHANG Juping PAN Bo CHEN Zhiqiang WANG Shengqi WANG Zhiyu XIANG Songtao The Research Center of Integrative Cancer Medicine Discipline of Integrated Chinese and Western Medicinethe Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510000China The First Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510000China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangdong Provincial Academy of Chinese Medical SciencesGuangdong Provincial Hospital of Chinese MedicineGuangzhou 510000China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou 510000China The Research Center for Integrative Medicine School of Basic Medical SciencesGuangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China

Prostate cancer(PCa)is the second most common malignancy among men *** Fu-Zheng-Yi-Liu(FZYL)Formula has been widely utilized in the treatment of *** study investigates whether the FZYL Formula can inhibit PCa by tar-geting the TAMs/CCL5 *** conducted in vitro co-cultures and in vivo co-injections of PCa cells and TAMs to mimic their *** showed that the FZYL Formula significantly reduced the proliferation,colony formation,subpopulations of PCSCs,and sphere-formation efficacy of PCa cells,even in the presence of TAM ***,the Formula markedly decreased the migration,invasion,and epithelial-mesenchymal transition(EMT)of PCa cells induced by *** FZYL Formula also reversed M2 phenotype polarization in TAMs and dose-dependently reduced their CCL5 expression and secretion,with minimal cytotoxicity *** studies confirmed that the TAMs/CCL5 axis is a critical target of the FZYL Formula,as the addition of exogen-ous CCL5 partially reversed the formula’s inhibitory effects on PCSCs self-renewal in the co-culture ***,the Formula also significantly inhibited the growth of PCa xenografts,bone metastasis,and PCSCs activity in vivo by targeting the TAMs/CCL5 ***,this study not only elucidates the immunomodulatory mechanism of the FZYL Formula in PCa therapy but also highlights the TAMs/CCL5 axis as a promising therapeutic target.

关键词： Traditional Chinese medicine Tumor-associated macrophages Prostate cancer stem cells CCL5 Tumor microenvironment